|
US4151042A
(en)
|
1977-03-31 |
1979-04-24 |
Takeda Chemical Industries, Ltd. |
Method for producing maytansinol and its derivatives
|
|
US4137230A
(en)
|
1977-11-14 |
1979-01-30 |
Takeda Chemical Industries, Ltd. |
Method for the production of maytansinoids
|
|
US4265814A
(en)
|
1978-03-24 |
1981-05-05 |
Takeda Chemical Industries |
Matansinol 3-n-hexadecanoate
|
|
JPS5562090A
(en)
|
1978-10-27 |
1980-05-10 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS5566585A
(en)
|
1978-11-14 |
1980-05-20 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS55164687A
(en)
|
1979-06-11 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS55162791A
(en)
|
1979-06-05 |
1980-12-18 |
Takeda Chem Ind Ltd |
Antibiotic c-15003pnd and its preparation
|
|
JPS55164685A
(en)
|
1979-06-08 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS55164686A
(en)
|
1979-06-11 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
US4309428A
(en)
|
1979-07-30 |
1982-01-05 |
Takeda Chemical Industries, Ltd. |
Maytansinoids
|
|
JPS5645483A
(en)
|
1979-09-19 |
1981-04-25 |
Takeda Chem Ind Ltd |
C-15003phm and its preparation
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
WO1994012520A1
(en)
|
1992-11-20 |
1994-06-09 |
Enzon, Inc. |
Linker for linked fusion polypeptides
|
|
NZ334148A
(en)
|
1996-08-12 |
2001-12-21 |
Celgene Corp |
3-Substituted phenyl-ethyl or ethenyl derivatives terminated with a nitrile, alkane, carboxyl or carbamoyl group useful to reduce cytokine levels
|
|
US5969516A
(en)
|
1997-07-25 |
1999-10-19 |
Ntc, Inc. |
Electrical circuit interrupter device locator
|
|
EP1243276A1
(en)
|
2001-03-23 |
2002-09-25 |
Franciscus Marinus Hendrikus De Groot |
Elongated and multiple spacers containing activatible prodrugs
|
|
EP1499885B1
(en)
|
2001-08-01 |
2009-10-21 |
Cellomics, Inc. |
Novel fusion proteins and assays for molecular binding
|
|
US6660510B2
(en)
|
2001-12-17 |
2003-12-09 |
Food Industry Research And Development |
Transglutaminase gene of Streptoverticillium ladakanum and the transglutaminase encoded therefrom
|
|
EP2289942B1
(en)
|
2002-04-10 |
2013-07-31 |
Genentech, Inc. |
Anti-HER2 antibody variants
|
|
WO2004043493A1
(en)
|
2002-11-14 |
2004-05-27 |
Syntarga B.V. |
Prodrugs built as multiple self-elimination-release spacers
|
|
DK1599278T3
(da)
|
2003-01-17 |
2011-07-18 |
Danisco |
Fremgangsmåde til fremstilling af en hydroxysyreester
|
|
US7955814B2
(en)
|
2003-01-17 |
2011-06-07 |
Danisco A/S |
Method
|
|
US7871607B2
(en)
|
2003-03-05 |
2011-01-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
|
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
|
CA2556752C
(en)
|
2004-02-23 |
2016-02-02 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
AU2008215422B2
(en)
|
2007-02-15 |
2011-07-14 |
Ajinomoto Co., Inc. |
Transglutaminase having disulfide bond introduced therein
|
|
US20100087371A1
(en)
|
2007-02-22 |
2010-04-08 |
Sean Hu |
Transglutaminase Variants with Improved Specificity
|
|
PE20090943A1
(es)
|
2007-07-16 |
2009-08-05 |
Genentech Inc |
Anticuerpos anti-cd79b e inmunoconjugados
|
|
WO2009072004A2
(en)
|
2007-09-26 |
2009-06-11 |
Gemin X Pharmaceuticals Canada, Inc. |
Compositions and methods for effecting nad+ levels using a nicotinamide phosphoribosyl transferase inhibitor
|
|
KR101607346B1
(ko)
|
2008-01-31 |
2016-03-29 |
제넨테크, 인크. |
항-cd79b 항체 및 면역접합체 및 사용 방법
|
|
ES2784829T3
(es)
|
2009-04-08 |
2020-10-01 |
Faulstich Heinz Dr |
Componentes de unión a la superficie de células terapéuticas provistos de amatoxina diseñados para terapia de tumores
|
|
AU2010234335A1
(en)
|
2009-04-08 |
2011-10-13 |
Deutsches Krebsforschungszentrum |
Amatoxin-armed target-binding moieties for the treatment of cancer
|
|
WO2011077388A1
(en)
|
2009-12-22 |
2011-06-30 |
Lifebond Ltd |
Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
|
|
WO2013040142A2
(en)
|
2011-09-16 |
2013-03-21 |
Iogenetics, Llc |
Bioinformatic processes for determination of peptide binding
|
|
EP4012714A1
(en)
|
2010-03-23 |
2022-06-15 |
Iogenetics, LLC. |
Bioinformatic processes for determination of peptide binding
|
|
AR082886A1
(es)
|
2010-09-03 |
2013-01-16 |
Forma Therapeutics Inc |
Compuestos y composiciones farmaceuticas que los contienen
|
|
MX347954B
(es)
|
2010-09-29 |
2017-05-19 |
Agensys Inc |
Conjugados de anticuerpo farmaco (adc) que enlazan a proteinas 191p4d12.
|
|
ES2402254T3
(es)
|
2010-09-30 |
2013-04-30 |
Heidelberg Pharma Ag |
Conjugados de amatoxinas con ligadores mejorados
|
|
CA2813411C
(en)
|
2010-11-05 |
2016-08-02 |
Rinat Neuroscience Corporation |
Engineered polypeptide conjugates and methods for making thereof using transglutaminase
|
|
EP2497499A1
(en)
|
2011-03-10 |
2012-09-12 |
Heidelberg Pharma GmbH |
Amatoxin-conjugates with improved linkages
|
|
WO2013049830A2
(en)
|
2011-09-30 |
2013-04-04 |
The Washington University |
Tip-1 and grp-78 binding peptides and method of identifying peptide receptors
|
|
EP2793947B1
(en)
|
2011-12-23 |
2021-02-03 |
Innate Pharma |
Enzymatic conjugation of polypeptides
|
|
US10132799B2
(en)
|
2012-07-13 |
2018-11-20 |
Innate Pharma |
Screening of conjugated antibodies
|
|
EP2774624A1
(en)
|
2013-03-04 |
2014-09-10 |
Heidelberg Pharma GmbH |
Amatoxin derivatives
|
|
EP2777714A1
(en)
|
2013-03-15 |
2014-09-17 |
NBE-Therapeutics LLC |
Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
|
|
US10611824B2
(en)
|
2013-03-15 |
2020-04-07 |
Innate Pharma |
Solid phase TGase-mediated conjugation of antibodies
|
|
CN105517577A
(zh)
|
2013-06-21 |
2016-04-20 |
先天制药公司 |
多肽的酶促偶联
|
|
WO2015015448A2
(en)
|
2013-07-31 |
2015-02-05 |
Rinat Neuroscience Corp. |
Engineered polypeptide conjugates
|
|
EP3055304A1
(en)
|
2013-10-09 |
2016-08-17 |
Eli Lilly and Company |
Novel pyridyloxyacetyl tetrahydroisoquinoline compounds useful as nampt inhibitors
|
|
US11376333B2
(en)
|
2013-12-23 |
2022-07-05 |
Covalab |
mTG substrates for covalent conjugation of compounds
|
|
PT3134127T
(pt)
|
2014-04-25 |
2020-04-09 |
Rinat Neuroscience Corp |
Conjugados de anticorpo-fármaco com alta carga de fármaco
|
|
WO2015191883A1
(en)
|
2014-06-12 |
2015-12-17 |
Dophen Biomedical |
Homogenous antibody drug conjugates via enzymatic methods
|
|
PL3185908T3
(pl)
|
2014-08-28 |
2020-09-07 |
Pfizer Inc. |
Łączniki modulujące stabilność do stosowania z koniugatami przeciwciało-lek
|
|
WO2016100735A1
(en)
|
2014-12-19 |
2016-06-23 |
Roche Nimblegen, Inc. |
Microbial transglutaminases, substrates therefor and methods for the use thereof
|
|
EP3256166A1
(en)
|
2015-02-09 |
2017-12-20 |
NBE Therapeutics AG |
Maytansine-drug conjugates of her- 2 specific binding proteins generated by site specific sortase-enzyme mediated conjugation
|
|
JP2018510864A
(ja)
|
2015-03-10 |
2018-04-19 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
トランスグルタミナーゼによって結合可能な抗体およびそれによって製造される結合体
|
|
EP3069734A1
(en)
|
2015-03-17 |
2016-09-21 |
Exiris S.r.l. |
Cryptophycin-based antibody-drug conjugates with novel self-immolative linkers
|
|
EP3313523A2
(en)
|
2015-06-23 |
2018-05-02 |
Bayer Pharma Aktiengesellschaft |
Targeted conjugates of ksp inhibitors
|
|
ES2855998T3
(es)
|
2015-08-07 |
2021-09-27 |
Merck Patent Gmbh |
Etiqueta transglutamina para bioconjugación específica de sitio eficiente
|
|
TWI727380B
(zh)
|
2015-11-30 |
2021-05-11 |
美商輝瑞股份有限公司 |
位點專一性her2抗體藥物共軛體
|
|
UA124622C2
(uk)
|
2015-12-18 |
2021-10-20 |
ЕЙСАЙ Ар ЕНД Ді МЕНЕДЖМЕНТ КО., ЛТД. |
Кон'юговані імуноглобуліни з c-кінцевим лізином
|
|
EP3272864A1
(en)
|
2016-07-20 |
2018-01-24 |
Paul Scherrer Institut |
Solid-phase immobilization of microbial transglutaminase mtg on microbeads for protein conjugation
|
|
BR112019005964A2
(pt)
|
2016-09-27 |
2019-06-18 |
Epicentrx, Inc. |
proteínas de fusão imunomoduladoras
|
|
KR20230008269A
(ko)
|
2017-08-07 |
2023-01-13 |
엔비이-테라퓨틱스 아게 |
생체 내 내성이 높은 항체 약물 결합체
|
|
NZ762376A
(en)
*
|
2017-09-19 |
2022-08-26 |
Scherrer Inst Paul |
Transglutaminase conjugation method and linker
|
|
MX2020004381A
(es)
|
2017-10-27 |
2020-08-20 |
Pfizer |
Anticuerpos y conjugados de anticuerpo-farmaco especificos para cd123 y usos de los mismos.
|
|
CA3128571A1
(en)
*
|
2019-03-19 |
2020-09-24 |
Paul Scherrer Institut |
Transglutaminase conjugation method with a glycine based linker
|
|
KR20230069211A
(ko)
|
2020-09-18 |
2023-05-18 |
아라리스 바이오테크 아게 |
아미노산-기반 링커를 사용한 트란스글루타미나제 접합 방법
|