JP2023543125A5 - - Google Patents
Info
- Publication number
- JP2023543125A5 JP2023543125A5 JP2023513298A JP2023513298A JP2023543125A5 JP 2023543125 A5 JP2023543125 A5 JP 2023543125A5 JP 2023513298 A JP2023513298 A JP 2023513298A JP 2023513298 A JP2023513298 A JP 2023513298A JP 2023543125 A5 JP2023543125 A5 JP 2023543125A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- aav
- vector according
- aav vector
- fusion protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063069500P | 2020-08-24 | 2020-08-24 | |
| US63/069,500 | 2020-08-24 | ||
| PCT/US2021/047411 WO2022046815A1 (en) | 2020-08-24 | 2021-08-24 | Viral vectors encoding glp-1 receptor agonist fusions and uses thereof in treating metabolic diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023543125A JP2023543125A (ja) | 2023-10-13 |
| JP2023543125A5 true JP2023543125A5 (cg-RX-API-DMAC7.html) | 2024-09-02 |
| JP7840319B2 JP7840319B2 (ja) | 2026-04-03 |
Family
ID=78032497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023513298A Active JP7840319B2 (ja) | 2020-08-24 | 2021-08-24 | Ｇｌｐ－１受容体アゴニスト融合物をコードするウイルスベクター及び代謝性疾患の治療におけるその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230372539A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP4200429A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7840319B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN116438312A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2021332235A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112023003310A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3190399A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2023002293A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2022046815A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119173269A (zh) * | 2022-03-03 | 2024-12-20 | 宾夕法尼亚州大学信托人 | 用于递送glp-1受体激动剂融合物的aav载体 |
| GB202403805D0 (en) * | 2024-03-15 | 2024-05-01 | Ucl Business Ltd | Compositions and methods of treatment |
| CN119351440B (zh) * | 2024-12-25 | 2025-04-25 | 浙江大学衢州研究院 | 表达glp-1的重组载体、重组酵母及应用 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
| US6268213B1 (en) | 1992-06-03 | 2001-07-31 | Richard Jude Samulski | Adeno-associated virus vector and cis-acting regulatory and promoter elements capable of expressing at least one gene and method of using same for gene therapy |
| US5478745A (en) | 1992-12-04 | 1995-12-26 | University Of Pittsburgh | Recombinant viral vector system |
| US5869305A (en) | 1992-12-04 | 1999-02-09 | The University Of Pittsburgh | Recombinant viral vector system |
| US6204059B1 (en) | 1994-06-30 | 2001-03-20 | University Of Pittsburgh | AAV capsid vehicles for molecular transfer |
| US5741683A (en) | 1995-06-07 | 1998-04-21 | The Research Foundation Of State University Of New York | In vitro packaging of adeno-associated virus DNA |
| US6093570A (en) | 1995-06-07 | 2000-07-25 | The University Of North Carolina At Chapel Hill | Helper virus-free AAV production |
| US6548286B1 (en) | 1997-04-14 | 2003-04-15 | Cell Genesys, Inc. | Methods for increasing the efficiency of recombinant AAV product |
| US6146874A (en) | 1998-05-27 | 2000-11-14 | University Of Florida | Method of preparing recombinant adeno-associated virus compositions |
| AU780231B2 (en) | 1998-11-10 | 2005-03-10 | University Of North Carolina At Chapel Hill, The | Virus vectors and methods of making and administering the same |
| CA2379166C (en) | 1999-08-09 | 2013-03-26 | Targeted Genetics Corporation | Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms instrastrand base pairs |
| US7201898B2 (en) | 2000-06-01 | 2007-04-10 | The University Of North Carolina At Chapel Hill | Methods and compounds for controlled release of recombinant parvovirus vectors |
| MX359371B (es) | 2001-11-13 | 2018-09-25 | Univ Pennsylvania | Un metodo para detectar y/o identificar secuencias del virus adeno-asociado y aislamiento de secuencias novedosas identificadas de ese modo. |
| PT1453547T (pt) | 2001-12-17 | 2016-12-28 | Univ Pennsylvania | Sequências do vírus adeno-associado (aav) do serotipo 8, vetores contendo as mesmas, e utilizações destas |
| AU2003274397A1 (en) | 2002-06-05 | 2003-12-22 | University Of Florida | Production of pseudotyped recombinant aav virions |
| DK1641823T3 (da) | 2003-06-12 | 2011-12-12 | Lilly Co Eli | GLP-1-analog fusionsproteiner |
| EP2345731B1 (en) | 2003-09-30 | 2015-10-21 | The Trustees of the University of Pennsylvania | Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof |
| ES2525067T3 (es) | 2005-04-07 | 2014-12-17 | The Trustees Of The University Of Pennsylvania | Método de incremento de la función de un vector de AAV |
| JP4495210B2 (ja) | 2005-06-09 | 2010-06-30 | パナソニック株式会社 | 振幅誤差補償装置及び直交度誤差補償装置 |
| US7588772B2 (en) | 2006-03-30 | 2009-09-15 | Board Of Trustees Of The Leland Stamford Junior University | AAV capsid library and AAV capsid proteins |
| US9315825B2 (en) | 2010-03-29 | 2016-04-19 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
| WO2011126808A2 (en) | 2010-03-29 | 2011-10-13 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
| FR2977562B1 (fr) | 2011-07-06 | 2016-12-23 | Gaztransport Et Technigaz | Cuve etanche et thermiquement isolante integree dans une structure porteuse |
| WO2015012924A2 (en) | 2013-04-29 | 2015-01-29 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof |
| CN104327187B (zh) * | 2014-10-11 | 2018-06-08 | 上海兴迪金生物技术有限公司 | 一种重组人GLP-1-Fc融合蛋白 |
| WO2017024198A1 (en) * | 2015-08-06 | 2017-02-09 | The Trustees Of The University Of Pennsylvania | Glp-1 and use thereof in compositions for treating metabolic diseases |
| PT3589730T (pt) | 2017-02-28 | 2024-02-28 | Univ Pennsylvania | Vetor de vírus adenoassociado (aav) de clado f e suas utilizações |
| WO2018166461A1 (en) * | 2017-03-14 | 2018-09-20 | Sunshine Lake Pharma Co., Ltd. | Dual-target fusion proteins comprising the fc portion of an immunoglobulin |
| CA3112473A1 (en) * | 2018-09-12 | 2020-03-19 | Quiapeg Pharmaceuticals Ab | Releasable glp-1 conjugates |
| CN110964116A (zh) * | 2018-09-26 | 2020-04-07 | 北京辅仁瑞辉生物医药研究院有限公司 | GLP1-Fc融合蛋白及其缀合物 |
| WO2020184941A1 (en) * | 2019-03-08 | 2020-09-17 | Genexine, Inc. | Glp-1 fusion proteins and uses thereof |
| SG11202111375RA (en) | 2019-04-29 | 2021-11-29 | Univ Pennsylvania | Novel aav capsids and compositions containing same |
| WO2021081217A1 (en) * | 2019-10-23 | 2021-04-29 | The Trustees Of The University Of Pennsylvania | Compositions for drg-specific reduction of transgene expression |
-
2021
- 2021-08-24 CA CA3190399A patent/CA3190399A1/en active Pending
- 2021-08-24 MX MX2023002293A patent/MX2023002293A/es unknown
- 2021-08-24 AU AU2021332235A patent/AU2021332235A1/en active Pending
- 2021-08-24 WO PCT/US2021/047411 patent/WO2022046815A1/en not_active Ceased
- 2021-08-24 US US18/042,726 patent/US20230372539A1/en active Pending
- 2021-08-24 CN CN202180072447.8A patent/CN116438312A/zh active Pending
- 2021-08-24 EP EP21783619.6A patent/EP4200429A1/en active Pending
- 2021-08-24 BR BR112023003310A patent/BR112023003310A2/pt unknown
- 2021-08-24 JP JP2023513298A patent/JP7840319B2/ja active Active
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