MX2023002293A - Vectores virales que codifican fusiones de agonistas del receptor de glp-1 y usos de estos en el tratamiento de enfermedades metabólica. - Google Patents

Vectores virales que codifican fusiones de agonistas del receptor de glp-1 y usos de estos en el tratamiento de enfermedades metabólica.

Info

Publication number
MX2023002293A
MX2023002293A MX2023002293A MX2023002293A MX2023002293A MX 2023002293 A MX2023002293 A MX 2023002293A MX 2023002293 A MX2023002293 A MX 2023002293A MX 2023002293 A MX2023002293 A MX 2023002293A MX 2023002293 A MX2023002293 A MX 2023002293A
Authority
MX
Mexico
Prior art keywords
receptor agonist
metabolic diseases
fusions
treating metabolic
viral vectors
Prior art date
Application number
MX2023002293A
Other languages
English (en)
Inventor
Christian Hinderer
James M Wilson
Makoto Horiuchi
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of MX2023002293A publication Critical patent/MX2023002293A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Abstract

Se proporcionan composiciones y métodos para tratar enfermedades metabólicas en un sujeto. Se proporciona un vector viral que incluye una molécula de ácido nucleico que comprende una secuencia que codifica una proteína de fusión del agonista del receptor de GLP-1 y secuencias reguladoras que dirigen la expresión de esta.
MX2023002293A 2020-08-24 2021-08-24 Vectores virales que codifican fusiones de agonistas del receptor de glp-1 y usos de estos en el tratamiento de enfermedades metabólica. MX2023002293A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063069500P 2020-08-24 2020-08-24
PCT/US2021/047411 WO2022046815A1 (en) 2020-08-24 2021-08-24 Viral vectors encoding glp-1 receptor agonist fusions and uses thereof in treating metabolic diseases

Publications (1)

Publication Number Publication Date
MX2023002293A true MX2023002293A (es) 2023-05-19

Family

ID=78032497

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023002293A MX2023002293A (es) 2020-08-24 2021-08-24 Vectores virales que codifican fusiones de agonistas del receptor de glp-1 y usos de estos en el tratamiento de enfermedades metabólica.

Country Status (9)

Country Link
US (1) US20230372539A1 (es)
EP (1) EP4200429A1 (es)
JP (1) JP2023543125A (es)
CN (1) CN116438312A (es)
AU (1) AU2021332235A1 (es)
BR (1) BR112023003310A2 (es)
CA (1) CA3190399A1 (es)
MX (1) MX2023002293A (es)
WO (1) WO2022046815A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023168411A1 (en) * 2022-03-03 2023-09-07 The Trustees Of The University Of Pennsylvania Aav vectors for delivery of glp-1 receptor agonist fusions

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US5436146A (en) 1989-09-07 1995-07-25 The Trustees Of Princeton University Helper-free stocks of recombinant adeno-associated virus vectors
US6268213B1 (en) 1992-06-03 2001-07-31 Richard Jude Samulski Adeno-associated virus vector and cis-acting regulatory and promoter elements capable of expressing at least one gene and method of using same for gene therapy
US5869305A (en) 1992-12-04 1999-02-09 The University Of Pittsburgh Recombinant viral vector system
US5478745A (en) 1992-12-04 1995-12-26 University Of Pittsburgh Recombinant viral vector system
US6204059B1 (en) 1994-06-30 2001-03-20 University Of Pittsburgh AAV capsid vehicles for molecular transfer
US5741683A (en) 1995-06-07 1998-04-21 The Research Foundation Of State University Of New York In vitro packaging of adeno-associated virus DNA
US6093570A (en) 1995-06-07 2000-07-25 The University Of North Carolina At Chapel Hill Helper virus-free AAV production
JP4135120B2 (ja) 1997-04-14 2008-08-20 セル ジェネシス，インコーポレーテッド 組換えａａｖ生産の効率を上昇させる方法
EP1080218A1 (en) 1998-05-27 2001-03-07 University of Florida Method of preparing recombinant adeno-associated virus compositions by using an iodixanol gradient
ES2340230T3 (es) 1998-11-10 2010-05-31 University Of North Carolina At Chapel Hill Vectores viricos y sus procedimientos de preparacion y administracion.
EP1204739B1 (en) 1999-08-09 2008-08-06 Targeted Genetics Corporation Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms intrastrand base pairs
AU2001268149B2 (en) 2000-06-01 2005-08-18 University Of North Carolina At Chapel Hill Methods and compounds for controlled release of recombinant parvovirus vectors
CN103555678B (zh) 2001-11-13 2018-02-09 宾夕法尼亚大学托管会 检测和/或鉴定腺伴随病毒(aav)序列以及分离所鉴定的新型序列的方法
EP2359869B1 (en) 2001-12-17 2018-12-26 The Trustees Of The University Of Pennsylvania Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same and uses therefor
WO2003104413A2 (en) 2002-06-05 2003-12-18 University Of Florida Production of pseudotyped recombinant aav virions
AU2004251145C1 (en) 2003-06-12 2011-04-14 Eli Lilly And Company GLP-1 analog fusion proteins
ES2874298T3 (es) 2003-09-30 2021-11-04 Univ Pennsylvania Clados de virus adenoasociados (AAV), secuencias, vectores que contienen el mismo, y usos de los mismos
DK2359867T3 (en) 2005-04-07 2015-01-05 Univ Pennsylvania A method for increasing an AAV vector function
EP1777906A1 (en) 2005-06-09 2007-04-25 Matsushita Electric Industrial Co., Ltd. Amplitude error compensating apparatus and orthogonality error compensating apparatus
EP2007795B1 (en) 2006-03-30 2016-11-16 The Board Of Trustees Of The Leland Stanford Junior University Aav capsid proteins
SG10201908848RA (en) 2010-03-29 2019-10-30 Univ Pennsylvania Pharmacologically induced transgene ablation system
US9315825B2 (en) 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
FR2977562B1 (fr) 2011-07-06 2016-12-23 Gaztransport Et Technigaz Cuve etanche et thermiquement isolante integree dans une structure porteuse
US9719106B2 (en) 2013-04-29 2017-08-01 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
FI3589730T3 (fi) 2017-02-28 2024-02-22 Univ Pennsylvania Kladin f adenoassosioitunut virus (aav) -vektori ja sen käyttötapoja
CN110964116A (zh) * 2018-09-26 2020-04-07 北京辅仁瑞辉生物医药研究院有限公司 GLP1-Fc融合蛋白及其缀合物
WO2020184941A1 (en) * 2019-03-08 2020-09-17 Genexine, Inc. Glp-1 fusion proteins and uses thereof
JP2022530633A (ja) 2019-04-29 2022-06-30 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 新規ａａｖカプシドおよびそれを含む組成物

Also Published As

Publication number Publication date
AU2021332235A1 (en) 2023-03-23
WO2022046815A1 (en) 2022-03-03
US20230372539A1 (en) 2023-11-23
WO2022046815A9 (en) 2022-05-19
BR112023003310A2 (pt) 2023-05-02
EP4200429A1 (en) 2023-06-28
CN116438312A (zh) 2023-07-14
CA3190399A1 (en) 2022-03-03
JP2023543125A (ja) 2023-10-13

Similar Documents

Publication Publication Date Title
Gill et al. The identification of the Escherichia coli fts Y gene product: an unusual protein
Fontao et al. Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus
MX2022015080A (es) Variantes de hsd17b13 y usos de las mismas.
FI3536797T3 (fi) Siirtogeenin tehostettu ilmentäminen ja prosessointi
MY191030A (en) Gdf15 fusion proteins and uses thereof
MX2023002293A (es) Vectores virales que codifican fusiones de agonistas del receptor de glp-1 y usos de estos en el tratamiento de enfermedades metabólica.
JP2016053091A5 (es)
MX343830B (es) Molecula de acido nucleico que codifica la proteina nuclear del virus de la hepatitis b y vacuna que comprende la misma.
Galanis et al. Duplication of leader sequence for protein targeting to mitochondria leads to increased import efficiency
RU2014145441A (ru) Векторы
SV2017005545A (es) Fusiones de variante iii del receptor de factor de crecimiento epidermico-mesotelina y metodos para usar los mismos
DK1543160T3 (da) Frakobling af DNA-propagering og ekspression af protein for fag-display
MX2022007546A (es) Interferon-alfa-2 modificado que tiene inmunogenicidad reducida.
PH12020551955A1 (en) Anti-cd63 antibodies, conjugates, and uses thereof
Wei et al. Identification, prokaryote expression of medaka gdnfa/b and their biological activity in a spermatogonial cell line
MX2021002125A (es) Receptores de celulas t restringidos a mr1 para inmunoterapia contra el cancer.
CZ621580A3 (en) Process for preparing a vector for dna transfer
NZ589806A (en) Variant hedgehog-interacting protein (hhip1) and methods and uses thereof
JP2017524366A5 (es)
Xu et al. Identification and functional analysis of two interferon regulatory factor 3 genes and their involvement in antiviral immune responses in the Chinese giant salamander Andrias davidianus
Hernandez-Cuebas et al. Expression of a biologically-active conotoxin PrIIIE in Escherichia coli
WO2023168403A3 (en) Viral vectors encoding parathyroid hormone fusions and uses thereof in treating hypoparathyroidism
RU2006110371A (ru) Вакцинная композиция для профилактики и лечения онкологических заболеваний, генетические конструкции и способ получения компонентов этой композиции
AR114481A1 (es) Anticuerpos injertados con péptido natriurético auricular
DK2257623T3 (da) Plasmidvektor