JP2023542286A5 - - Google Patents
Info
- Publication number
- JP2023542286A5 JP2023542286A5 JP2023515576A JP2023515576A JP2023542286A5 JP 2023542286 A5 JP2023542286 A5 JP 2023542286A5 JP 2023515576 A JP2023515576 A JP 2023515576A JP 2023515576 A JP2023515576 A JP 2023515576A JP 2023542286 A5 JP2023542286 A5 JP 2023542286A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- compound
- impairment
- tumor
- haloethylamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911324466 | 2019-12-20 | ||
| CNPCT/CN2020/114519 | 2020-09-10 | ||
| PCT/CN2020/114519 WO2021120717A1 (zh) | 2019-12-20 | 2020-09-10 | 抗癌化合物及其医药用途 |
| PCT/CN2021/101870 WO2022052564A1 (zh) | 2019-12-20 | 2021-06-23 | 乏氧活化的dna烷化剂及其医药用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023542286A JP2023542286A (ja) | 2023-10-06 |
| JP2023542286A5 true JP2023542286A5 (https=) | 2023-11-02 |
Family
ID=76477075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023515576A Pending JP2023542286A (ja) | 2019-12-20 | 2021-06-23 | 低酸素活性化ｄｎａアルキル化剤およびその医学的使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20230026163A1 (https=) |
| EP (2) | EP4079738A4 (https=) |
| JP (1) | JP2023542286A (https=) |
| KR (1) | KR20230065309A (https=) |
| CN (2) | CN114466853B (https=) |
| TW (4) | TWI837402B (https=) |
| WO (2) | WO2021120717A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI837402B (zh) * | 2019-12-20 | 2024-04-01 | 大陸商深圳艾欣達偉醫藥科技有限公司 | 含氟化合物、含氟化合物之製備方法及其抗癌醫藥用途 |
| EP4428138A4 (en) * | 2021-11-05 | 2025-08-27 | Ascentawits Pharmaceuticals Ltd | AKR1C3-ACTIVATED DNA ALKYLATING AGENT AND ITS MEDICAL USE |
| CN114106042B (zh) * | 2021-11-12 | 2022-09-16 | 深圳艾欣达伟医药科技有限公司 | 一种氘代化合物及其制备方法和应用 |
| US20250186468A1 (en) | 2022-03-15 | 2025-06-12 | Ascentawits Pharmaceuticals, Ltd. | Method for treating patient with brca-mutated cancer |
| CN119233822A (zh) | 2022-05-23 | 2024-12-31 | 深圳艾欣达伟医药科技有限公司 | 烷化剂前药与细胞周期抑制剂联用治疗癌症的方法 |
| CN115626938B (zh) * | 2022-09-02 | 2026-04-17 | 温州医科大学 | 一种化合物rx4及其在抗结肠癌药物中的作用 |
| CN119894521A (zh) | 2022-09-22 | 2025-04-25 | 深圳艾欣达伟医药科技有限公司 | 乏氧激活的化合物在制备治疗癌症患者的药物中的用途 |
| KR20260009356A (ko) * | 2023-05-11 | 2026-01-19 | 아센타위츠 파마슈티컬즈 리미티드 | 주사액 제제 및 이의 제조 방법, 및 상용성 약액 및 이의 제조 방법 |
| WO2025026214A1 (zh) | 2023-07-28 | 2025-02-06 | 深圳艾欣达伟医药科技有限公司 | 治疗p53基因突变或缺陷阴性癌症、肿瘤患者 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4617398A (en) * | 1982-04-12 | 1986-10-14 | The Research Foundation Of State University Of New York | Phosphoaziridine compounds useful for treatment of tumors |
| AU5935600A (en) * | 1999-07-14 | 2001-01-30 | Richard F. Borch | Phosphoramide compounds |
| WO2004062596A2 (en) * | 2003-01-09 | 2004-07-29 | Zeneus Pharma Limited | Antineoplastic ether lipid compounds having a four carbon backbone |
| AU2005325676A1 (en) * | 2004-12-23 | 2006-08-03 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| CA2592118C (en) * | 2004-12-23 | 2015-11-17 | Deciphera Pharmaceuticals, Llc | Urea derivatives as enzyme modulators |
| CN1948311A (zh) * | 2006-11-09 | 2007-04-18 | 上海交通大学 | 2－碘代苯基－6－三氟甲基咪唑并[1,2－a]吡啶－3－乙酰胺类化合物及制备方法 |
| US9278904B2 (en) * | 2013-12-31 | 2016-03-08 | Chemapotheca, Llc | Synthesis of chiral amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds |
| CN104098432B (zh) * | 2014-06-30 | 2016-03-30 | 福建师范大学福清分校 | 一种三氟甲基化芳烃的合成方法 |
| TWI674258B (zh) * | 2015-03-10 | 2019-10-11 | 大陸商深圳艾欣達偉醫藥科技有限公司 | Ｄｎａ烷化劑 |
| JP7327900B2 (ja) * | 2015-06-24 | 2023-08-16 | スレッシュホールド ファーマシューティカルズ， インコーポレイテッド | アジリジン含有ｄｎａアルキル化剤 |
| EP3390415B1 (en) * | 2015-11-16 | 2020-02-26 | Obi Pharma, Inc. | (r)- and (s)-1-(3-(3-n,n-dimethylaminocarbonyl)phenoxyl-4-nitrophenyl)-1-ethyl-n,n'-bis (ethylene)phosphoramidate, compositions and methods for their use and preparation |
| CN106279321A (zh) | 2016-08-09 | 2017-01-04 | 南京医科大学 | 吉西他滨ProTide乏氧活化前药及其应用 |
| CN107118231B (zh) * | 2017-03-17 | 2019-06-07 | 北京大学 | 萘醌磷酰胺类化合物及其在作为细胞铁死亡诱导剂中的用途 |
| WO2018184003A1 (en) * | 2017-03-31 | 2018-10-04 | Dana-Farber Cancer Institute, Inc. | Modulating dsrna editing, sensing, and metabolism to increase tumor immunity and improve the efficacy of cancer immunotherapy and/or modulators of intratumoral interferon |
| CN107513057A (zh) | 2017-09-06 | 2017-12-26 | 南京医科大学 | 一类乐伐替尼的乏氧活化前药及其应用 |
| TW201919644A (zh) * | 2017-09-29 | 2019-06-01 | 台灣浩鼎生技股份有限公司 | 治療血癌的方法 |
| WO2020022868A1 (ko) * | 2018-07-27 | 2020-01-30 | 에스케이이노베이션 주식회사 | 입자 균일도가 우수한 모데나이트 제올라이트 및 그 제조방법 |
| TWI837402B (zh) * | 2019-12-20 | 2024-04-01 | 大陸商深圳艾欣達偉醫藥科技有限公司 | 含氟化合物、含氟化合物之製備方法及其抗癌醫藥用途 |
-
2020
- 2020-07-17 TW TW109124210A patent/TWI837402B/zh active
- 2020-09-10 CN CN202080067311.3A patent/CN114466853B/zh active Active
- 2020-09-10 US US17/778,828 patent/US20230026163A1/en not_active Abandoned
- 2020-09-10 EP EP20903427.1A patent/EP4079738A4/en active Pending
- 2020-09-10 WO PCT/CN2020/114519 patent/WO2021120717A1/zh not_active Ceased
- 2020-12-18 TW TW109144974A patent/TWI833055B/zh active
- 2020-12-18 TW TW113101890A patent/TW202421161A/zh unknown
-
2021
- 2021-06-23 EP EP21865622.1A patent/EP4212538A4/en not_active Withdrawn
- 2021-06-23 US US18/044,433 patent/US20230339991A1/en active Pending
- 2021-06-23 WO PCT/CN2021/101870 patent/WO2022052564A1/zh not_active Ceased
- 2021-06-23 CN CN202180036541.8A patent/CN115667278A/zh active Pending
- 2021-06-23 KR KR1020237011813A patent/KR20230065309A/ko active Pending
- 2021-06-23 JP JP2023515576A patent/JP2023542286A/ja active Pending
- 2021-09-08 TW TW110133419A patent/TWI893202B/zh active
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