JP2023539828A - コール酸誘導体およびそのための出発物質を製造する方法 - Google Patents

コール酸誘導体およびそのための出発物質を製造する方法 Download PDF

Info

Publication number
JP2023539828A
JP2023539828A JP2023512277A JP2023512277A JP2023539828A JP 2023539828 A JP2023539828 A JP 2023539828A JP 2023512277 A JP2023512277 A JP 2023512277A JP 2023512277 A JP2023512277 A JP 2023512277A JP 2023539828 A JP2023539828 A JP 2023539828A
Authority
JP
Japan
Prior art keywords
formula
optionally substituted
compound
alkyl
oxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023512277A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023539828A5 (enExample
Inventor
リード，ジェイ．，グレゴリー
レッディ，ジャヤチャンドラ，ピー．
ジェイ． ポール，バ－ナード
サマド ホセイン，スク
Original Assignee
サンドヒル ワン，エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by サンドヒル ワン，エルエルシー filed Critical サンドヒル ワン，エルエルシー
Publication of JP2023539828A publication Critical patent/JP2023539828A/ja
Publication of JP2023539828A5 publication Critical patent/JP2023539828A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
JP2023512277A 2020-08-21 2021-08-11 コール酸誘導体およびそのための出発物質を製造する方法 Pending JP2023539828A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063068498P 2020-08-21 2020-08-21
US63/068,498 2020-08-21
PCT/US2021/045467 WO2022039983A2 (en) 2020-08-21 2021-08-11 Methods of making cholic acid derivatives and starting materials therefor

Publications (2)

Publication Number Publication Date
JP2023539828A true JP2023539828A (ja) 2023-09-20
JP2023539828A5 JP2023539828A5 (enExample) 2024-08-20

Family

ID=80269315

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023512277A Pending JP2023539828A (ja) 2020-08-21 2021-08-11 コール酸誘導体およびそのための出発物質を製造する方法

Country Status (7)

Country Link
US (1) US11384116B2 (enExample)
EP (1) EP4200311A4 (enExample)
JP (1) JP2023539828A (enExample)
CN (1) CN115884978A (enExample)
AU (1) AU2021328142A1 (enExample)
CA (1) CA3190433A1 (enExample)
WO (1) WO2022039983A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023081658A2 (en) 2021-11-02 2023-05-11 Sandhill One, Llc High purity non-animal derived tudca
CN116836213B (zh) * 2022-03-25 2026-05-05 苏州恩泰新材料科技有限公司 一种7-酮石胆酸中间体及其合成方法和应用
CN116836214B (zh) * 2022-03-25 2024-07-09 苏州恩泰新材料科技有限公司 一种7-酮石胆酸中间体的合成方法和应用
KR20240151228A (ko) * 2022-03-25 2024-10-17 수저우 엔텍 뉴-머티리얼 테크놀로지 컴퍼니 리미티드 7-케토리토콜산 중간체 및 이의 합성 방법과 응용
CN115819491A (zh) * 2022-12-22 2023-03-21 江苏佳尔科药业集团股份有限公司 7-酮基石胆酸及熊去氧胆酸的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020128541A1 (en) * 2018-12-20 2020-06-25 Equip-Test Kft. Connector structure for connecting optical conduits, crimping device and push-out device therefor, and light-blocking element for a connector part

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1204429B (it) 1986-01-09 1989-03-01 Blaschim Spa Riduzione stereoselettiva in acidi biliari
US5595996A (en) * 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
CN101018802A (zh) * 2004-07-13 2007-08-15 三菱化学株式会社 甾类化合物的制备方法
WO2006006718A1 (ja) * 2004-07-13 2006-01-19 Mitsubishi Chemical Corporation ステロイド化合物の製造方法
CN102791876B (zh) 2009-11-30 2016-06-08 细胞制药有限公司 新的7β-羟类固醇脱氢酶及它们的用途
US20130261317A1 (en) * 2010-09-27 2013-10-03 Kythera Biopharmaceuticals, Inc. Methods for preparing synthetic bile acids and compositions comprising the same
WO2017019524A1 (en) * 2015-07-30 2017-02-02 Intercept Pharmaceuticals, Inc. Methods for preparation of bile acids and derivatives thereof
KR20180067699A (ko) * 2015-11-06 2018-06-20 인터셉트 파마슈티컬즈, 인크. 오베티콜산 및 이의 유도체의 제조 방법
CN111072744B (zh) 2019-12-03 2021-09-14 江苏佳尔科药业集团股份有限公司 一种以ba为原料合成熊去氧胆酸的方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020128541A1 (en) * 2018-12-20 2020-06-25 Equip-Test Kft. Connector structure for connecting optical conduits, crimping device and push-out device therefor, and light-blocking element for a connector part

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARCH. PHARM. RES., vol. 32, JPN6025036939, 2009, pages 857 - 862, ISSN: 0005683327 *
STEROIDS, vol. 33, JPN6025036936, 1979, pages 693 - 718, ISSN: 0005683325 *
STEROIDS, vol. 58, JPN6025036938, 1993, pages 524 - 526, ISSN: 0005683326 *
TETRAHEDRON LETT., vol. 33, JPN6025036940, 1992, pages 3235 - 3236, ISSN: 0005683328 *

Also Published As

Publication number Publication date
US11384116B2 (en) 2022-07-12
CN115884978A (zh) 2023-03-31
EP4200311A4 (en) 2024-11-20
WO2022039983A3 (en) 2022-03-31
EP4200311A2 (en) 2023-06-28
US20220056070A1 (en) 2022-02-24
CA3190433A1 (en) 2022-02-24
AU2021328142A1 (en) 2023-03-16
WO2022039983A2 (en) 2022-02-24

Similar Documents

Publication Publication Date Title
US11384116B2 (en) Methods of making cholic acid derivatives and starting materials therefor
JP6479912B2 (ja) エステトロール中間体を製造するための方法
SU973025A3 (ru) Способ получени 17 @ -алкилстероидов
CN111560045A (zh) 一种以ba为原料合成石胆酸的方法
CN106749466A (zh) 一种高纯度奥贝胆酸的制备方法
US20220372065A1 (en) Synthesis of cholesterol and vitamin d3 from phytosterols
US20220298202A1 (en) Methods of making cholic acid derivatives and starting materials therefor
JPH05112525A (ja) ４−ヒドロキシ−２−オキソ−ピロリジン−１−イル−アセトアミドの製造方法
WO2022228080A1 (zh) 一种以ba为原料合成7-酮基石胆酸的方法
JP2004529160A (ja) 胆汁酸の製造
WO2018010651A1 (zh) 一种奥贝胆酸及其中间体的制备方法
JP6248202B2 (ja) シロドシン及びその中間体の製造方法
EP0338065B1 (fr) Derives de la 19-nor progesterone, leur preparation et leur utilisation
CN103848879B (zh) 一种以1，4－雄烯二酮为原料制备黄体酮的方法
EP4423104A1 (en) Stereoselective steroidal reductions
JP7857399B2 (ja) ステロイド系化合物、その調製方法及びその使用
MX2012009251A (es) Un proceso para introducir un enlace doble en la posicion 15, 16 de un esteroide.
JP7344983B2 (ja) ケノデオキシコール酸誘導体の調製方法
JPS6355520B2 (enExample)
EP1539751A1 (en) Process for the preparation of imidazo(1,2-a)pyridine-3-acetamides
TWI570131B (zh) 製備１７－經取代類固醇之方法
CN115819491A (zh) 7-酮基石胆酸及熊去氧胆酸的合成方法
JP2893473B2 (ja) （＋）―エキレニンの製造法および中間体
CN117917425A (zh) 一种植物源熊去氧胆酸的合成方法
唐瑞仁 et al. Stereoselective asymmertric synthesis and characterization of 17α-acetoxy-19-nor-progesterone

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240809

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240809

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250909

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20260303