JP2023536158A - 抗インテグリンβ７抗体製剤及び装置 - Google Patents

抗インテグリンβ７抗体製剤及び装置 Download PDF

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Publication number
JP2023536158A
JP2023536158A JP2023506189A JP2023506189A JP2023536158A JP 2023536158 A JP2023536158 A JP 2023536158A JP 2023506189 A JP2023506189 A JP 2023506189A JP 2023506189 A JP2023506189 A JP 2023506189A JP 2023536158 A JP2023536158 A JP 2023536158A
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JP
Japan
Prior art keywords
hvr
formulation
seq
amino acid
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023506189A
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English (en)
Japanese (ja)
Inventor
ジェニファー プーリー，
メイナー タオ タン，
スワティ トール，
ヘレン ティレル，
マリアム アブフセイン，
ヘマンス アマルチンタ，
オードリー ブルーフカ，
ハン ティン ティン，
ヘザー エル． フローレス，
グレン スコット ギース，
レナート ラヴァネロ，
ウェンホイ チャン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
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Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of JP2023536158A publication Critical patent/JP2023536158A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2023506189A 2020-07-31 2021-07-29 抗インテグリンβ７抗体製剤及び装置 Pending JP2023536158A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063059427P 2020-07-31 2020-07-31
US63/059,427 2020-07-31
PCT/US2021/043690 WO2022026699A1 (fr) 2020-07-31 2021-07-29 Formulations d'anticorps anti-intégrine bêta7 et dispositifs

Publications (1)

Publication Number Publication Date
JP2023536158A true JP2023536158A (ja) 2023-08-23

Family

ID=77693570

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023506189A Pending JP2023536158A (ja) 2020-07-31 2021-07-29 抗インテグリンβ７抗体製剤及び装置

Country Status (11)

Country Link
EP (1) EP4188958A1 (fr)
JP (1) JP2023536158A (fr)
KR (1) KR20230041071A (fr)
AR (1) AR123085A1 (fr)
AU (1) AU2021316017A1 (fr)
BR (1) BR112023001734A2 (fr)
CA (1) CA3190109A1 (fr)
IL (1) IL300133A (fr)
MX (1) MX2023001157A (fr)
TW (1) TW202222832A (fr)
WO (1) WO2022026699A1 (fr)

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
SG48759A1 (en) 1990-01-12 2002-07-23 Abgenix Inc Generation of xenogenic antibodies
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
EP0861893A3 (fr) 1991-09-19 1999-11-10 Genentech, Inc. Expression de haut niveau d'immunoglobulines
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
KR100654645B1 (ko) 1995-04-27 2007-04-04 아브게닉스, 인크. 면역화된 제노마우스 유래의 인간 항체
CA2219486A1 (fr) 1995-04-28 1996-10-31 Abgenix, Inc. Anticorps humains derives de xeno-souris immunisees
KR20080059467A (ko) 1996-12-03 2008-06-27 아브게닉스, 인크. 복수의 ｖｈ 및 ｖｋ 부위를 함유하는 사람 면역글로불린유전자좌를 갖는 형질전환된 포유류 및 이로부터 생성된항체
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
KR100797667B1 (ko) 1999-10-04 2008-01-23 메디카고 인코포레이티드 외래 유전자의 전사를 조절하는 방법
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
AU2002213441B2 (en) 2000-10-12 2006-10-26 Genentech, Inc. Reduced-viscosity concentrated protein formulations
US20050158303A1 (en) 2003-04-04 2005-07-21 Genentech, Inc. Methods of treating IgE-mediated disorders comprising the administration of high concentration anti-IgE antibody formulations
SI1784426T1 (sl) 2004-09-03 2012-03-30 Genentech Inc Humanizirani antagonisti proti beta in njihove uporabe
CA2723614C (fr) 2008-05-16 2015-07-14 Genentech, Inc. Utilisation de biomarqueurs pour evaluer le traitement de troubles inflammatoires gastro-intestinaux avec des antagonistes de l'integrine beta7
RU2011140498A (ru) 2009-03-06 2013-04-20 Дженентек, Инк. Препарат антител
PE20141672A1 (es) * 2011-05-02 2014-11-26 Millennium Pharm Inc FORMULACION PARA ANTICUERPO ANTI-alfa4�7
CA2839496C (fr) 2011-06-17 2016-02-09 Shl Group Ab Dispositif d'injection
US9022982B2 (en) 2011-06-17 2015-05-05 Shl Group Ab Injection device
SG11201507974RA (en) 2013-03-27 2015-10-29 Genentech Inc Use of biomarkers for assessing treatment of gastrointestinal inflammatory disorders with beta7 integrin antagonists
CA2939246A1 (fr) 2014-03-27 2015-10-01 Genentech, Inc. Methodes permettant le diagnostic et le traitement d'une maladie inflammatoire de l'intestin
KR20170120601A (ko) * 2015-02-26 2017-10-31 제넨테크, 인크. 인테그린 베타7 길항제 및 크론병을 치료하는 방법
EP3810085A1 (fr) * 2018-06-20 2021-04-28 Progenity, Inc. Traitement d'une maladie du tractus gastro-intestinal par un inhibiteur de l'intégrine

Also Published As

Publication number Publication date
AU2021316017A1 (en) 2023-02-16
BR112023001734A2 (pt) 2023-02-28
TW202222832A (zh) 2022-06-16
KR20230041071A (ko) 2023-03-23
AR123085A1 (es) 2022-10-26
EP4188958A1 (fr) 2023-06-07
CA3190109A1 (fr) 2022-02-03
IL300133A (en) 2023-03-01
WO2022026699A1 (fr) 2022-02-03
MX2023001157A (es) 2023-02-22

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