JP2023532950A5 - - Google Patents

Info

Publication number
JP2023532950A5
JP2023532950A5 JP2023500016A JP2023500016A JP2023532950A5 JP 2023532950 A5 JP2023532950 A5 JP 2023532950A5 JP 2023500016 A JP2023500016 A JP 2023500016A JP 2023500016 A JP2023500016 A JP 2023500016A JP 2023532950 A5 JP2023532950 A5 JP 2023532950A5
Authority
JP
Japan
Prior art keywords
crystalline
deuterium
pharmaceutical substance
deuterium chloride
chloride salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023500016A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023532950A (ja
Filing date
Publication date
Priority claimed from US17/314,538 external-priority patent/US11319313B2/en
Application filed filed Critical
Publication of JP2023532950A publication Critical patent/JP2023532950A/ja
Publication of JP2023532950A5 publication Critical patent/JP2023532950A5/ja
Pending legal-status Critical Current

Links

JP2023500016A 2020-06-30 2021-06-24 重水素濃縮化ピオグリタゾンの結晶体 Pending JP2023532950A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063046309P 2020-06-30 2020-06-30
US202063046304P 2020-06-30 2020-06-30
US63/046,304 2020-06-30
US63/046,309 2020-06-30
US17/314,538 US11319313B2 (en) 2020-06-30 2021-05-07 Crystalline forms of deuterium-enriched pioglitazone
US17/314,538 2021-05-07
PCT/IB2021/000661 WO2022003426A1 (en) 2020-06-30 2021-06-24 Crystalline forms of deuterium-enriched pioglitazone

Publications (2)

Publication Number Publication Date
JP2023532950A JP2023532950A (ja) 2023-08-01
JP2023532950A5 true JP2023532950A5 (enExample) 2024-06-11

Family

ID=79032413

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023500016A Pending JP2023532950A (ja) 2020-06-30 2021-06-24 重水素濃縮化ピオグリタゾンの結晶体

Country Status (13)

Country Link
US (2) US11319313B2 (enExample)
EP (2) EP4285900B1 (enExample)
JP (1) JP2023532950A (enExample)
KR (1) KR20230058609A (enExample)
CN (1) CN116018330B (enExample)
AU (1) AU2021300003A1 (enExample)
BR (1) BR112022026843A2 (enExample)
CA (1) CA3184123A1 (enExample)
ES (1) ES2968512T3 (enExample)
IL (1) IL299549A (enExample)
MX (1) MX2023000189A (enExample)
TW (1) TW202216704A (enExample)
WO (1) WO2022003426A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11767317B1 (en) * 2020-06-30 2023-09-26 Poxel Sa Methods of synthesizing enantiopure deuterium-enriched pioglitazone

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4421865A (en) 1981-06-08 1983-12-20 Standard Oil Company (Sohio) Selective hydrogen-deuterium interchange using ion exchange resins
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
AR240698A1 (es) 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
US5149820A (en) 1987-03-11 1992-09-22 Norsk Hydro A.S. Deuterated compounds
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
WO1992018501A1 (en) 1991-04-11 1992-10-29 The Upjohn Company Thiazolidinedione derivatives, production and use thereof
US5441971A (en) 1991-04-11 1995-08-15 The Upjohn Company Thiazolidinedione derivatives, production and use thereof
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
CN1087725C (zh) 1994-03-25 2002-07-17 同位素技术有限公司 用氘代方法增强药物效果
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
US6221335B1 (en) 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
KR100666887B1 (ko) 1997-10-08 2007-01-10 상꾜 가부시키가이샤 치환 축합 복소환 화합물
US6191154B1 (en) 1998-11-27 2001-02-20 Case Western Reserve University Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
US6440710B1 (en) 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
US7407978B2 (en) 1999-04-06 2008-08-05 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
TWI284533B (en) 1999-05-24 2007-08-01 Sankyo Co Pharmaceutical composition for treating hyperglycemia, impaired glucose tolerance, diabetes complications and for improving insulin resistant
DK1104760T3 (da) 1999-12-03 2003-06-30 Pfizer Prod Inc Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler
AU2002337749A1 (en) * 2001-09-28 2003-04-07 Teva Pharmaceutical Industries Ltd. Pioglitazone hydrochloride
WO2003033494A1 (en) 2001-10-17 2003-04-24 Sankyo Company, Limited Benzimidazole derivative
US20030220374A1 (en) 2002-01-14 2003-11-27 Pharmacia Corporation Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
TW200413273A (en) 2002-11-15 2004-08-01 Wako Pure Chem Ind Ltd Heavy hydrogenation method of heterocyclic rings
GB0303609D0 (en) 2003-02-17 2003-03-19 Glaxo Group Ltd Novel therapeutic method and compositions
FR2854078B1 (fr) 2003-04-28 2008-01-11 Univ Toulouse Procede de fabrication d'une composition therapeutique immuno-stimulante.
HUP0304096A2 (hu) 2003-12-19 2005-08-29 Richter Gedeon Vegyészeti Gyár Rt. Eljárás pioglitazon hidrogénklorid előállítására és intermedierjei
BRPI0519015A2 (pt) 2004-12-15 2008-12-23 Daiichi Sankyo Co Ltd composiÇço farmacÊutica, agente profilÁtico ou agente terapÊutico, agentes para melhorar a funÇço das cÉlulas b no pÂncreas, e para a reduÇço da razço da hemoglobina glicosilada, e, usos da 5-[4-(6-metàxi-1-metil-1h-benzimidazol-2-ilmetàxi)benzi l] tiazolidina-2,4-diona ou de um sal farmacologicamente aceitÁvel da mesma e de um inibidor de fbpase, e do 2-amino-5-isobutil-4-[2-[5-(n,n'-bis((s)-1etoxicarbonil)eti l) fosfonamido] furanil} tiazol ou de um sal farmacologicamente aceitÁvel do mesmo
US7759493B2 (en) 2005-01-31 2010-07-20 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
EP1889618A4 (en) 2005-05-27 2010-11-24 Daiichi Sankyo Co Ltd Combined drug for treating diabetes
TW200740802A (en) 2005-07-08 2007-11-01 Sankyo Co Pharmaceutical composition containing thiazolidinedione compound
US7598273B2 (en) 2005-10-06 2009-10-06 Auspex Pharmaceuticals, Inc Inhibitors of the gastric H+, K+-ATPase with enhanced therapeutic properties
EP1982718A4 (en) 2006-02-09 2010-05-12 Daiichi Sankyo Co Ltd PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OF CANCER
US7750168B2 (en) 2006-02-10 2010-07-06 Sigma-Aldrich Co. Stabilized deuteroborane-tetrahydrofuran complex
TW200745099A (en) 2006-03-02 2007-12-16 Sankyo Co Optically active thiazolidinedione derivatives
CA2646207C (en) 2006-03-16 2016-01-19 Metabolic Solutions Development Company Thiazolidinedione analogues for the treatment of metabolic inflammation mediated disease
TWI407959B (zh) 2006-05-23 2013-09-11 Takeda Pharmaceutical 口服製劑
TW200838512A (en) 2007-02-08 2008-10-01 Daiichi Sankyo Co Ltd Crystalline forms of a thiazolidinedione compound and manufacturing methods thereof
NZ597381A (en) 2007-09-14 2013-03-28 Metabolic Solutions Dev Co Llc Thiazolidinedione analogues for the treatment of diabetes and inflammatory diseases
US20090076093A1 (en) 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched rosiglitazone
US8722710B2 (en) * 2007-09-26 2014-05-13 Deuterx, Llc Deuterium-enriched pioglitazone
US8236786B2 (en) 2008-08-07 2012-08-07 Pulmagen Therapeutics (Inflammation) Limited Respiratory disease treatment
DK2222272T3 (da) 2008-08-07 2013-02-11 Pulmagen Therapeutics Inflammation Ltd Behandling af luftvejssygdom
WO2010150014A1 (en) 2009-06-24 2010-12-29 Pulmagen Therapeutics (Inflammation) Limited 5r- 5 -deuterated glitazones for respiratory disease treatment
WO2011017244A1 (en) 2009-08-05 2011-02-10 Metabolic Solutions Development Company Polymorphs of 5-(4-(2-(5-ethylpyridin-2-yl)-2-oxoethoxy)benzyl)-1,3-thiazolidine-2,4-dione (mitoglitazone)
EP2505587A1 (en) 2009-11-26 2012-10-03 Daiichi Sankyo Company, Limited Method for manufacturing a 6-substituted-1-methyl-1h-benzimidazole derivative, and manufacturing intermediate from said method
WO2011098746A1 (en) * 2010-02-09 2011-08-18 Pulmagen Therapeutics (Inflammation) Limited Crystalline acid addition salts of ( 5r) -enanti0mer of pioglitazone
GB201002224D0 (en) 2010-02-10 2010-03-31 Argenta Therapeutics Ltd Respiratory disease treatment
GB201002243D0 (en) 2010-02-10 2010-03-31 Argenta Therapeutics Ltd Respiratory disease treatment
WO2011100685A2 (en) 2010-02-12 2011-08-18 Case Western Reserve University Methods of generating hyper inos expressing cells and uses thereof
AU2011242955A1 (en) 2010-04-19 2012-11-01 Metabolic Solutions Development Company, Llc Novel synthesis for thiazolidinedione compounds
CA2841757A1 (en) 2011-07-15 2013-01-24 Etzer Darout Gpr 119 modulators
JP2014528486A (ja) 2011-10-13 2014-10-27 ケース ウエスタン リザーブ ユニバーシティ Rxrアゴニスト化合物および方法
US20150018396A1 (en) 2012-03-08 2015-01-15 President And Fellows Of Harvard College Prevention and treatment of respiratory infection with peroxisome proliferator activator receptor delta agonist
US20140221369A1 (en) 2013-02-01 2014-08-07 Deuterx, Llc 5-deutero-2,4-thiazolidinedione and 5-deutero-2,4-oxazolidinedione derivatives and compositions comprising and methods of using the same
JP6800013B2 (ja) 2013-03-14 2020-12-16 ポクセル・ソシエテ・アノニムPoxel SA 重水素化2,4−チアゾリジンジオン及び治療方法
US10188639B2 (en) 2014-01-15 2019-01-29 Deuterx, Llc Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone
US9123444B2 (en) 2014-02-03 2015-09-01 Freescale Semiconductor, Inc. Method of testing coherency of data storage in multi-processor shared memory system
SG11201608218QA (en) 2014-04-02 2016-10-28 Minoryx Therapeutics S L 2,4-thiazolidinedione derivatives in the treatment of central nervous system disorders
WO2016153952A1 (en) 2015-03-20 2016-09-29 Deuterx, Llc Methods of treating bacterial infections and fungal infections using enantiopure deuterium-enriched pioglitazone
WO2016153948A1 (en) 2015-03-20 2016-09-29 Deuterx, Llc Combination therapy using enantiopure, oxy-substituted, deuterium-enriched 5-(benzyl)-5-deutero-thiazolidine-2, 4-diones for treatment of medical disorders
WO2016153951A1 (en) 2015-03-20 2016-09-29 Deuterx, Llc 5-deutero-thiazolidinyldione compounds and methods of treating medical disorders using same
WO2016153949A1 (en) 2015-03-20 2016-09-29 Deuterx, Llc 5-deutero-thiazolidine-2,4-dione compounds and methods of treating medical disorders using same
IL266530B2 (en) * 2016-11-10 2024-09-01 Galmed Res And Development Ltd Aramchol for use in fibrosis treatment
CN110357871A (zh) * 2019-07-03 2019-10-22 天津大学 二甲双胍-吡格列酮盐及其制备方法和应用

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