|
US3536809A
(en)
|
1969-02-17 |
1970-10-27 |
Alza Corp |
Medication method
|
|
US3598123A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US3845770A
(en)
|
1972-06-05 |
1974-11-05 |
Alza Corp |
Osmatic dispensing device for releasing beneficial agent
|
|
US3916899A
(en)
|
1973-04-25 |
1975-11-04 |
Alza Corp |
Osmotic dispensing device with maximum and minimum sizes for the passageway
|
|
US4008719A
(en)
|
1976-02-02 |
1977-02-22 |
Alza Corporation |
Osmotic system having laminar arrangement for programming delivery of active agent
|
|
US4421865A
(en)
|
1981-06-08 |
1983-12-20 |
Standard Oil Company (Sohio) |
Selective hydrogen-deuterium interchange using ion exchange resins
|
|
IE58110B1
(en)
|
1984-10-30 |
1993-07-14 |
Elan Corp Plc |
Controlled release powder and process for its preparation
|
|
AR240698A1
(es)
|
1985-01-19 |
1990-09-28 |
Takeda Chemical Industries Ltd |
Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
|
|
US5149820A
(en)
|
1987-03-11 |
1992-09-22 |
Norsk Hydro A.S. |
Deuterated compounds
|
|
US5073543A
(en)
|
1988-07-21 |
1991-12-17 |
G. D. Searle & Co. |
Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
|
|
IT1229203B
(it)
|
1989-03-22 |
1991-07-25 |
Bioresearch Spa |
Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
|
|
US5120548A
(en)
|
1989-11-07 |
1992-06-09 |
Merck & Co., Inc. |
Swelling modulated polymeric drug delivery device
|
|
KR0166088B1
(ko)
|
1990-01-23 |
1999-01-15 |
. |
수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
|
|
US5733566A
(en)
|
1990-05-15 |
1998-03-31 |
Alkermes Controlled Therapeutics Inc. Ii |
Controlled release of antiparasitic agents in animals
|
|
WO1992018501A1
(en)
|
1991-04-11 |
1992-10-29 |
The Upjohn Company |
Thiazolidinedione derivatives, production and use thereof
|
|
US5441971A
(en)
|
1991-04-11 |
1995-08-15 |
The Upjohn Company |
Thiazolidinedione derivatives, production and use thereof
|
|
US5580578A
(en)
|
1992-01-27 |
1996-12-03 |
Euro-Celtique, S.A. |
Controlled release formulations coated with aqueous dispersions of acrylic polymers
|
|
US5591767A
(en)
|
1993-01-25 |
1997-01-07 |
Pharmetrix Corporation |
Liquid reservoir transdermal patch for the administration of ketorolac
|
|
CN1087725C
(zh)
|
1994-03-25 |
2002-07-17 |
同位素技术有限公司 |
用氘代方法增强药物效果
|
|
US6334997B1
(en)
|
1994-03-25 |
2002-01-01 |
Isotechnika, Inc. |
Method of using deuterated calcium channel blockers
|
|
US6221335B1
(en)
|
1994-03-25 |
2001-04-24 |
Isotechnika, Inc. |
Method of using deuterated calcium channel blockers
|
|
IT1270594B
(it)
|
1994-07-07 |
1997-05-07 |
Recordati Chem Pharm |
Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
|
|
KR100666887B1
(ko)
|
1997-10-08 |
2007-01-10 |
상꾜 가부시키가이샤 |
치환 축합 복소환 화합물
|
|
US6191154B1
(en)
|
1998-11-27 |
2001-02-20 |
Case Western Reserve University |
Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
|
|
US6440710B1
(en)
|
1998-12-10 |
2002-08-27 |
The Scripps Research Institute |
Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
|
|
US7407978B2
(en)
|
1999-04-06 |
2008-08-05 |
Theracos, Inc. |
Heterocyclic analogs of diphenylethylene compounds
|
|
TWI284533B
(en)
|
1999-05-24 |
2007-08-01 |
Sankyo Co |
Pharmaceutical composition for treating hyperglycemia, impaired glucose tolerance, diabetes complications and for improving insulin resistant
|
|
DK1104760T3
(da)
|
1999-12-03 |
2003-06-30 |
Pfizer Prod Inc |
Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler
|
|
AU2002337749A1
(en)
*
|
2001-09-28 |
2003-04-07 |
Teva Pharmaceutical Industries Ltd. |
Pioglitazone hydrochloride
|
|
WO2003033494A1
(en)
|
2001-10-17 |
2003-04-24 |
Sankyo Company, Limited |
Benzimidazole derivative
|
|
US20030220374A1
(en)
|
2002-01-14 |
2003-11-27 |
Pharmacia Corporation |
Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
|
|
TW200413273A
(en)
|
2002-11-15 |
2004-08-01 |
Wako Pure Chem Ind Ltd |
Heavy hydrogenation method of heterocyclic rings
|
|
GB0303609D0
(en)
|
2003-02-17 |
2003-03-19 |
Glaxo Group Ltd |
Novel therapeutic method and compositions
|
|
FR2854078B1
(fr)
|
2003-04-28 |
2008-01-11 |
Univ Toulouse |
Procede de fabrication d'une composition therapeutique immuno-stimulante.
|
|
HUP0304096A2
(hu)
|
2003-12-19 |
2005-08-29 |
Richter Gedeon Vegyészeti Gyár Rt. |
Eljárás pioglitazon hidrogénklorid előállítására és intermedierjei
|
|
BRPI0519015A2
(pt)
|
2004-12-15 |
2008-12-23 |
Daiichi Sankyo Co Ltd |
composiÇço farmacÊutica, agente profilÁtico ou agente terapÊutico, agentes para melhorar a funÇço das cÉlulas b no pÂncreas, e para a reduÇço da razço da hemoglobina glicosilada, e, usos da 5-[4-(6-metàxi-1-metil-1h-benzimidazol-2-ilmetàxi)benzi l] tiazolidina-2,4-diona ou de um sal farmacologicamente aceitÁvel da mesma e de um inibidor de fbpase, e do 2-amino-5-isobutil-4-[2-[5-(n,n'-bis((s)-1etoxicarbonil)eti l) fosfonamido] furanil} tiazol ou de um sal farmacologicamente aceitÁvel do mesmo
|
|
US7759493B2
(en)
|
2005-01-31 |
2010-07-20 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
|
EP1889618A4
(en)
|
2005-05-27 |
2010-11-24 |
Daiichi Sankyo Co Ltd |
Combined drug for treating diabetes
|
|
TW200740802A
(en)
|
2005-07-08 |
2007-11-01 |
Sankyo Co |
Pharmaceutical composition containing thiazolidinedione compound
|
|
US7598273B2
(en)
|
2005-10-06 |
2009-10-06 |
Auspex Pharmaceuticals, Inc |
Inhibitors of the gastric H+, K+-ATPase with enhanced therapeutic properties
|
|
EP1982718A4
(en)
|
2006-02-09 |
2010-05-12 |
Daiichi Sankyo Co Ltd |
PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OF CANCER
|
|
US7750168B2
(en)
|
2006-02-10 |
2010-07-06 |
Sigma-Aldrich Co. |
Stabilized deuteroborane-tetrahydrofuran complex
|
|
TW200745099A
(en)
|
2006-03-02 |
2007-12-16 |
Sankyo Co |
Optically active thiazolidinedione derivatives
|
|
CA2646207C
(en)
|
2006-03-16 |
2016-01-19 |
Metabolic Solutions Development Company |
Thiazolidinedione analogues for the treatment of metabolic inflammation mediated disease
|
|
TWI407959B
(zh)
|
2006-05-23 |
2013-09-11 |
Takeda Pharmaceutical |
口服製劑
|
|
TW200838512A
(en)
|
2007-02-08 |
2008-10-01 |
Daiichi Sankyo Co Ltd |
Crystalline forms of a thiazolidinedione compound and manufacturing methods thereof
|
|
NZ597381A
(en)
|
2007-09-14 |
2013-03-28 |
Metabolic Solutions Dev Co Llc |
Thiazolidinedione analogues for the treatment of diabetes and inflammatory diseases
|
|
US20090076093A1
(en)
|
2007-09-14 |
2009-03-19 |
Protia, Llc |
Deuterium-enriched rosiglitazone
|
|
US8722710B2
(en)
*
|
2007-09-26 |
2014-05-13 |
Deuterx, Llc |
Deuterium-enriched pioglitazone
|
|
US8236786B2
(en)
|
2008-08-07 |
2012-08-07 |
Pulmagen Therapeutics (Inflammation) Limited |
Respiratory disease treatment
|
|
DK2222272T3
(da)
|
2008-08-07 |
2013-02-11 |
Pulmagen Therapeutics Inflammation Ltd |
Behandling af luftvejssygdom
|
|
WO2010150014A1
(en)
|
2009-06-24 |
2010-12-29 |
Pulmagen Therapeutics (Inflammation) Limited |
5r- 5 -deuterated glitazones for respiratory disease treatment
|
|
WO2011017244A1
(en)
|
2009-08-05 |
2011-02-10 |
Metabolic Solutions Development Company |
Polymorphs of 5-(4-(2-(5-ethylpyridin-2-yl)-2-oxoethoxy)benzyl)-1,3-thiazolidine-2,4-dione (mitoglitazone)
|
|
EP2505587A1
(en)
|
2009-11-26 |
2012-10-03 |
Daiichi Sankyo Company, Limited |
Method for manufacturing a 6-substituted-1-methyl-1h-benzimidazole derivative, and manufacturing intermediate from said method
|
|
WO2011098746A1
(en)
*
|
2010-02-09 |
2011-08-18 |
Pulmagen Therapeutics (Inflammation) Limited |
Crystalline acid addition salts of ( 5r) -enanti0mer of pioglitazone
|
|
GB201002224D0
(en)
|
2010-02-10 |
2010-03-31 |
Argenta Therapeutics Ltd |
Respiratory disease treatment
|
|
GB201002243D0
(en)
|
2010-02-10 |
2010-03-31 |
Argenta Therapeutics Ltd |
Respiratory disease treatment
|
|
WO2011100685A2
(en)
|
2010-02-12 |
2011-08-18 |
Case Western Reserve University |
Methods of generating hyper inos expressing cells and uses thereof
|
|
AU2011242955A1
(en)
|
2010-04-19 |
2012-11-01 |
Metabolic Solutions Development Company, Llc |
Novel synthesis for thiazolidinedione compounds
|
|
CA2841757A1
(en)
|
2011-07-15 |
2013-01-24 |
Etzer Darout |
Gpr 119 modulators
|
|
JP2014528486A
(ja)
|
2011-10-13 |
2014-10-27 |
ケース ウエスタン リザーブ ユニバーシティ |
Rxrアゴニスト化合物および方法
|
|
US20150018396A1
(en)
|
2012-03-08 |
2015-01-15 |
President And Fellows Of Harvard College |
Prevention and treatment of respiratory infection with peroxisome proliferator activator receptor delta agonist
|
|
US20140221369A1
(en)
|
2013-02-01 |
2014-08-07 |
Deuterx, Llc |
5-deutero-2,4-thiazolidinedione and 5-deutero-2,4-oxazolidinedione derivatives and compositions comprising and methods of using the same
|
|
JP6800013B2
(ja)
|
2013-03-14 |
2020-12-16 |
ポクセル・ソシエテ・アノニムPoxel SA |
重水素化2,4−チアゾリジンジオン及び治療方法
|
|
US10188639B2
(en)
|
2014-01-15 |
2019-01-29 |
Deuterx, Llc |
Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone
|
|
US9123444B2
(en)
|
2014-02-03 |
2015-09-01 |
Freescale Semiconductor, Inc. |
Method of testing coherency of data storage in multi-processor shared memory system
|
|
SG11201608218QA
(en)
|
2014-04-02 |
2016-10-28 |
Minoryx Therapeutics S L |
2,4-thiazolidinedione derivatives in the treatment of central nervous system disorders
|
|
WO2016153952A1
(en)
|
2015-03-20 |
2016-09-29 |
Deuterx, Llc |
Methods of treating bacterial infections and fungal infections using enantiopure deuterium-enriched pioglitazone
|
|
WO2016153948A1
(en)
|
2015-03-20 |
2016-09-29 |
Deuterx, Llc |
Combination therapy using enantiopure, oxy-substituted, deuterium-enriched 5-(benzyl)-5-deutero-thiazolidine-2, 4-diones for treatment of medical disorders
|
|
WO2016153951A1
(en)
|
2015-03-20 |
2016-09-29 |
Deuterx, Llc |
5-deutero-thiazolidinyldione compounds and methods of treating medical disorders using same
|
|
WO2016153949A1
(en)
|
2015-03-20 |
2016-09-29 |
Deuterx, Llc |
5-deutero-thiazolidine-2,4-dione compounds and methods of treating medical disorders using same
|
|
IL266530B2
(en)
*
|
2016-11-10 |
2024-09-01 |
Galmed Res And Development Ltd |
Aramchol for use in fibrosis treatment
|
|
CN110357871A
(zh)
*
|
2019-07-03 |
2019-10-22 |
天津大学 |
二甲双胍-吡格列酮盐及其制备方法和应用
|