JP2023529026A - Mhc-i発現を調節するための方法及びその免疫療法の使用 - Google Patents
Mhc-i発現を調節するための方法及びその免疫療法の使用 Download PDFInfo
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- JP2023529026A JP2023529026A JP2023517825A JP2023517825A JP2023529026A JP 2023529026 A JP2023529026 A JP 2023529026A JP 2023517825 A JP2023517825 A JP 2023517825A JP 2023517825 A JP2023517825 A JP 2023517825A JP 2023529026 A JP2023529026 A JP 2023529026A
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/19—Omega peptidases (3.4.19)
- C12Y304/19012—Ubiquitinyl hydrolase 1 (3.4.19.12)
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- General Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063032956P | 2020-06-01 | 2020-06-01 | |
| US63/032,956 | 2020-06-01 | ||
| US202063039211P | 2020-06-15 | 2020-06-15 | |
| US63/039,211 | 2020-06-15 | ||
| PCT/US2021/035205 WO2021247540A1 (en) | 2020-06-01 | 2021-06-01 | Methods for modulating mhc-i expression and immunotherapy uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023529026A true JP2023529026A (ja) | 2023-07-06 |
| JP2023529026A5 JP2023529026A5 (https=) | 2024-06-11 |
| JPWO2021247540A5 JPWO2021247540A5 (https=) | 2024-06-11 |
Family
ID=78829900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023517825A Pending JP2023529026A (ja) | 2020-06-01 | 2021-06-01 | Mhc-i発現を調節するための方法及びその免疫療法の使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20230203485A1 (https=) |
| EP (1) | EP4161658A4 (https=) |
| JP (1) | JP2023529026A (https=) |
| WO (1) | WO2021247540A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020237294A1 (en) * | 2019-05-27 | 2020-12-03 | Murdoch University | Novel retinitis pigmentosa treatment |
| CN113249382B (zh) * | 2021-04-12 | 2023-05-12 | 右江民族医学院 | 下调TRIM56基因表达的siRNA及其应用 |
| CN114694748B (zh) * | 2022-02-22 | 2022-10-28 | 中国人民解放军军事科学院军事医学研究院 | 一种基于预后信息与强化学习的蛋白质组学分子分型方法 |
| CN114805553B (zh) * | 2022-04-13 | 2024-06-18 | 武汉大学 | 蛋白ZYG11B在制备用于促进cGAS的酶活性的药物中的应用 |
| CN116179543B (zh) * | 2022-07-06 | 2024-08-13 | 四川农业大学 | 基于CRISPR特异性靶向猪Cavin-1基因的sgRNA及应用 |
| WO2024025832A2 (en) * | 2022-07-25 | 2024-02-01 | Nant Holdings Ip, Llc | Treatment of mhc-i negative tumors with nk and t cells |
| CN120359417A (zh) * | 2022-12-23 | 2025-07-22 | 文塔纳医疗系统公司 | 用于评估抗原呈递机制组分的材料和方法及其用途 |
| CN117069838B (zh) * | 2023-10-13 | 2023-12-08 | 广东赛尔生物科技有限公司 | Aoh1160和抗体联合治疗癌症的用途 |
| CN117538544A (zh) * | 2023-11-22 | 2024-02-09 | 湛江中心人民医院 | 检测基因Ccdc181表达量的试剂在制备精子异常诊断产品中的应用 |
| WO2025171164A1 (en) * | 2024-02-07 | 2025-08-14 | Board Of Regents, The University Of Texas System | Gene signatures predictive of cancer cell response to immunomodulatory therapy |
| CN118186089B (zh) * | 2024-04-02 | 2024-11-12 | 中山大学附属第一医院 | Nit2在胃癌化疗增敏中的应用 |
| WO2025212419A1 (en) * | 2024-04-05 | 2025-10-09 | Genecentric Therapeutics, Inc. | Method for assessing microsatellite instability and homologous recombination repair deficiency in cancer |
| CN118021995B (zh) * | 2024-04-11 | 2024-06-11 | 南昌大学第一附属医院 | 多肽在制备用于预防和/或治疗骨肉瘤的药物中的应用 |
| CN118759189B (zh) * | 2024-07-11 | 2025-07-04 | 浙江省肿瘤医院 | 用于诊断宫颈癌淋巴转移的生物标记物及其应用 |
| CN118955595A (zh) * | 2024-07-29 | 2024-11-15 | 四川大学 | 一种治疗i型超敏反应的药物 |
| CN118566508B (zh) * | 2024-08-02 | 2025-04-08 | 德州市红拳医疗器械有限公司 | 一种用于检测胃癌标志物的试剂盒及其应用 |
| CN119955928B (zh) * | 2025-02-11 | 2025-11-07 | 中山大学中山眼科中心 | Serpind1抑制剂在制备用于治疗湿性年龄相关性黄斑变性药物中的应用 |
| CN120594834B (zh) * | 2025-08-08 | 2025-10-28 | 山东大学 | 一种针对echs1 k115位点的胰腺癌治疗靶点及应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9717717B1 (en) * | 2015-07-31 | 2017-08-01 | Progenra, Inc. | Methods of treating cancer through the inhibition of USP7 and immune system modulation |
| WO2018160944A1 (en) * | 2017-03-03 | 2018-09-07 | Progenra, Inc. | Azole compounds as ubiquitin-specific protease usp7 inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0917457D0 (en) * | 2009-10-06 | 2009-11-18 | Glaxosmithkline Biolog Sa | Method |
| KR102389677B1 (ko) * | 2013-03-15 | 2022-04-21 | 제넨테크, 인크. | Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법 |
| WO2015058780A1 (en) * | 2013-10-25 | 2015-04-30 | Biontech Ag | Method and kit for determining whether a subject shows an immune response |
| WO2018132825A2 (en) * | 2017-01-16 | 2018-07-19 | Memorial Sloan Kettering Cancer Center | Treatment of sarcoma |
| CA3096287A1 (en) * | 2018-01-22 | 2019-07-25 | Pascal Biosciences Inc. | Cannabinoids and derivatives for promoting immunogenicity of tumor and infected cells |
-
2021
- 2021-06-01 EP EP21818753.2A patent/EP4161658A4/en active Pending
- 2021-06-01 JP JP2023517825A patent/JP2023529026A/ja active Pending
- 2021-06-01 US US17/928,444 patent/US20230203485A1/en active Pending
- 2021-06-01 WO PCT/US2021/035205 patent/WO2021247540A1/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9717717B1 (en) * | 2015-07-31 | 2017-08-01 | Progenra, Inc. | Methods of treating cancer through the inhibition of USP7 and immune system modulation |
| WO2018160944A1 (en) * | 2017-03-03 | 2018-09-07 | Progenra, Inc. | Azole compounds as ubiquitin-specific protease usp7 inhibitors |
Non-Patent Citations (6)
| Title |
|---|
| CELL DEATH AND DISEASE, vol. 4, JPN6026005253, 2013, ISSN: 0005791907 * |
| FRONTIERS IN PHARMACOLOGY, vol. 10, JPN6026005251, 2019, ISSN: 0005791909 * |
| JOURNAL OF EXPERIMENTAL MEDICINE, vol. 215, no. 8, JPN6026005254, 2018, pages 2137 - 2155, ISSN: 0005791906 * |
| MOLECULAR CANCER THERAPEUTICS, vol. 19, JPN6026005252, 2018, pages 17 - 1, ISSN: 0005791908 * |
| ONCO TARGETS THER., vol. 12, JPN6025034606, 2019, pages 609 - 617, ISSN: 0005791910 * |
| SCIENTIFIC REPORTS, vol. 10, JPN6026005255, 24 March 2020 (2020-03-24), ISSN: 0005791905 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4161658A4 (en) | 2024-10-02 |
| EP4161658A1 (en) | 2023-04-12 |
| US20230203485A1 (en) | 2023-06-29 |
| WO2021247540A1 (en) | 2021-12-09 |
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