JP2023528621A - 線維症、例えば強皮症のためのマーカーとしての染色体コンフォメーションの検出 - Google Patents

線維症、例えば強皮症のためのマーカーとしての染色体コンフォメーションの検出 Download PDF

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JP2023528621A
JP2023528621A JP2022574303A JP2022574303A JP2023528621A JP 2023528621 A JP2023528621 A JP 2023528621A JP 2022574303 A JP2022574303 A JP 2022574303A JP 2022574303 A JP2022574303 A JP 2022574303A JP 2023528621 A JP2023528621 A JP 2023528621A
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chromosomal
tables
markers
interactions
fibrosis
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JP2022574303A
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JP2023528621A5 (enExample
Inventor
セルバム ラマダス、アロウル
ハンター、ユアン
アクーリチェフ、アレクサンドル
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Oxford Biodynamics PLC
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Oxford Biodynamics PLC
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022574303A 2020-06-02 2021-06-02 線維症、例えば強皮症のためのマーカーとしての染色体コンフォメーションの検出 Pending JP2023528621A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2008269.9 2020-06-02
GBGB2008269.9A GB202008269D0 (en) 2020-06-02 2020-06-02 Detecting a chromosome marker
PCT/GB2021/051356 WO2021245409A1 (en) 2020-06-02 2021-06-02 Detecting a chromosome conformation as marker for fibrosis, e.g. scleroderma

Publications (2)

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JP2023528621A true JP2023528621A (ja) 2023-07-05
JP2023528621A5 JP2023528621A5 (enExample) 2024-06-10

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JP2022574303A Pending JP2023528621A (ja) 2020-06-02 2021-06-02 線維症、例えば強皮症のためのマーカーとしての染色体コンフォメーションの検出

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Country Link
US (1) US20230193390A1 (enExample)
EP (1) EP4158066A1 (enExample)
JP (1) JP2023528621A (enExample)
KR (1) KR20230019939A (enExample)
CN (1) CN116507740A (enExample)
AU (1) AU2021283746B2 (enExample)
CA (1) CA3178914A1 (enExample)
GB (2) GB202008269D0 (enExample)
IL (1) IL298266A (enExample)
TW (1) TW202210635A (enExample)
WO (1) WO2021245409A1 (enExample)
ZA (1) ZA202212301B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202314402D0 (en) * 2023-09-20 2023-11-01 Oxford BioDynamics PLC Chromosome detection assay

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003259877A (ja) * 2002-03-11 2003-09-16 Sumitomo Pharmaceut Co Ltd 肝線維症疾患マーカーおよびその利用
JP2009523005A (ja) * 2004-05-07 2009-06-18 アプレラ コーポレイション 肝線維症に関連する遺伝的多型、その検出方法および使用
US20180274015A1 (en) * 2015-06-24 2018-09-27 Oxford Biodynamics Limited Detection processes using sites of chromosome interaction
WO2019086898A2 (en) * 2017-11-03 2019-05-09 Oxford Biodynamics Limited Genetic regulation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7468249B2 (en) * 2004-05-05 2008-12-23 Biocept, Inc. Detection of chromosomal disorders
AU2006264564B2 (en) * 2005-07-04 2012-04-19 Erasmus University Medical Center Chromosome conformation capture-on-chip (4c) assay
CN108624668B (zh) * 2013-02-01 2022-12-02 加利福尼亚大学董事会 用于基因组组装及单体型定相的方法
ES2971286T3 (es) * 2016-12-01 2024-06-04 Oxford BioDynamics PLC Aplicación de interacciones cromosómicas epigenéticas en diagnóstico de cáncer
US20230054595A1 (en) * 2019-12-18 2023-02-23 The Children's Hospital Of Philadelphia Novel druggable targets for the treatment of inflammatory diseases such as systemic lupus erythematosus (sle) and methods for diagnosis and treatment using the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003259877A (ja) * 2002-03-11 2003-09-16 Sumitomo Pharmaceut Co Ltd 肝線維症疾患マーカーおよびその利用
JP2009523005A (ja) * 2004-05-07 2009-06-18 アプレラ コーポレイション 肝線維症に関連する遺伝的多型、その検出方法および使用
US20180274015A1 (en) * 2015-06-24 2018-09-27 Oxford Biodynamics Limited Detection processes using sites of chromosome interaction
WO2019086898A2 (en) * 2017-11-03 2019-05-09 Oxford Biodynamics Limited Genetic regulation

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Publication number Publication date
GB202219352D0 (en) 2023-02-01
AU2021283746B2 (en) 2023-06-15
WO2021245409A1 (en) 2021-12-09
GB202008269D0 (en) 2020-07-15
US20230193390A1 (en) 2023-06-22
ZA202212301B (en) 2023-07-26
CA3178914A1 (en) 2021-12-09
CN116507740A (zh) 2023-07-28
GB2611903B (en) 2025-08-06
TW202210635A (zh) 2022-03-16
AU2021283746A1 (en) 2022-12-22
EP4158066A1 (en) 2023-04-05
IL298266A (en) 2023-01-01
GB2611903A (en) 2023-04-19
KR20230019939A (ko) 2023-02-09

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