CN116507740A - 检测作为用于纤维化例如硬皮病的标志物的染色体构象 - Google Patents

检测作为用于纤维化例如硬皮病的标志物的染色体构象 Download PDF

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Publication number
CN116507740A
CN116507740A CN202180060427.9A CN202180060427A CN116507740A CN 116507740 A CN116507740 A CN 116507740A CN 202180060427 A CN202180060427 A CN 202180060427A CN 116507740 A CN116507740 A CN 116507740A
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China
Prior art keywords
chromosomal
interactions
fibrosis
markers
typed
Prior art date
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Pending
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CN202180060427.9A
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English (en)
Chinese (zh)
Inventor
A·S·拉马达斯
E·亨特
A·阿库利切夫
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Oxford Biodynamics PLC
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Oxford Biodynamics PLC
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Publication of CN116507740A publication Critical patent/CN116507740A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202180060427.9A 2020-06-02 2021-06-02 检测作为用于纤维化例如硬皮病的标志物的染色体构象 Pending CN116507740A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2008269.9 2020-06-02
GBGB2008269.9A GB202008269D0 (en) 2020-06-02 2020-06-02 Detecting a chromosome marker
PCT/GB2021/051356 WO2021245409A1 (en) 2020-06-02 2021-06-02 Detecting a chromosome conformation as marker for fibrosis, e.g. scleroderma

Publications (1)

Publication Number Publication Date
CN116507740A true CN116507740A (zh) 2023-07-28

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CN202180060427.9A Pending CN116507740A (zh) 2020-06-02 2021-06-02 检测作为用于纤维化例如硬皮病的标志物的染色体构象

Country Status (12)

Country Link
US (1) US20230193390A1 (enExample)
EP (1) EP4158066A1 (enExample)
JP (1) JP2023528621A (enExample)
KR (1) KR20230019939A (enExample)
CN (1) CN116507740A (enExample)
AU (1) AU2021283746B2 (enExample)
CA (1) CA3178914A1 (enExample)
GB (2) GB202008269D0 (enExample)
IL (1) IL298266A (enExample)
TW (1) TW202210635A (enExample)
WO (1) WO2021245409A1 (enExample)
ZA (1) ZA202212301B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202314402D0 (en) * 2023-09-20 2023-11-01 Oxford BioDynamics PLC Chromosome detection assay

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1981052A (zh) * 2004-05-05 2007-06-13 生物概念股份有限公司 检测染色体病
CN110234769A (zh) * 2016-12-01 2019-09-13 牛津生物动力有限公司 表观遗传染色体相互作用在癌症诊断中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003259877A (ja) * 2002-03-11 2003-09-16 Sumitomo Pharmaceut Co Ltd 肝線維症疾患マーカーおよびその利用
WO2005111241A2 (en) * 2004-05-07 2005-11-24 Applera Corporation Genetic polymorphisms associated with liver fibrosis methods of detection and uses thereof
AU2006264564B2 (en) * 2005-07-04 2012-04-19 Erasmus University Medical Center Chromosome conformation capture-on-chip (4c) assay
CN108624668B (zh) * 2013-02-01 2022-12-02 加利福尼亚大学董事会 用于基因组组装及单体型定相的方法
JP2018527016A (ja) * 2015-06-24 2018-09-20 オックスフォード バイオダイナミックス リミテッド 染色体相互作用の検出
CN111511930B (zh) * 2017-11-03 2024-11-22 牛津生物动力有限责任公司 通过染色体相互作用遗传调节免疫响应
US20230054595A1 (en) * 2019-12-18 2023-02-23 The Children's Hospital Of Philadelphia Novel druggable targets for the treatment of inflammatory diseases such as systemic lupus erythematosus (sle) and methods for diagnosis and treatment using the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1981052A (zh) * 2004-05-05 2007-06-13 生物概念股份有限公司 检测染色体病
CN110234769A (zh) * 2016-12-01 2019-09-13 牛津生物动力有限公司 表观遗传染色体相互作用在癌症诊断中的应用

Also Published As

Publication number Publication date
GB202219352D0 (en) 2023-02-01
AU2021283746B2 (en) 2023-06-15
WO2021245409A1 (en) 2021-12-09
GB202008269D0 (en) 2020-07-15
US20230193390A1 (en) 2023-06-22
ZA202212301B (en) 2023-07-26
CA3178914A1 (en) 2021-12-09
GB2611903B (en) 2025-08-06
TW202210635A (zh) 2022-03-16
AU2021283746A1 (en) 2022-12-22
EP4158066A1 (en) 2023-04-05
IL298266A (en) 2023-01-01
GB2611903A (en) 2023-04-19
JP2023528621A (ja) 2023-07-05
KR20230019939A (ko) 2023-02-09

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