JP2023525555A5 - - Google Patents

Info

Publication number
JP2023525555A5
JP2023525555A5 JP2022568853A JP2022568853A JP2023525555A5 JP 2023525555 A5 JP2023525555 A5 JP 2023525555A5 JP 2022568853 A JP2022568853 A JP 2022568853A JP 2022568853 A JP2022568853 A JP 2022568853A JP 2023525555 A5 JP2023525555 A5 JP 2023525555A5
Authority
JP
Japan
Prior art keywords
agonist
therapeutic agent
agonist according
amino acid
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022568853A
Other languages
English (en)
Japanese (ja)
Other versions
JP7827640B2 (ja
JP2023525555A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/031806 external-priority patent/WO2021231447A1/en
Publication of JP2023525555A publication Critical patent/JP2023525555A/ja
Publication of JP2023525555A5 publication Critical patent/JP2023525555A5/ja
Priority to JP2025206113A priority Critical patent/JP2026048706A/ja
Application granted granted Critical
Publication of JP7827640B2 publication Critical patent/JP7827640B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022568853A 2020-05-12 2021-05-11 新規なil10アゴニストを含む治療剤 Active JP7827640B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025206113A JP2026048706A (ja) 2020-05-12 2025-11-27 新規なil10アゴニストおよびその使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063023703P 2020-05-12 2020-05-12
US63/023,703 2020-05-12
PCT/US2021/031806 WO2021231447A1 (en) 2020-05-12 2021-05-11 Novel il10 agonists and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025206113A Division JP2026048706A (ja) 2020-05-12 2025-11-27 新規なil10アゴニストおよびその使用方法

Publications (3)

Publication Number Publication Date
JP2023525555A JP2023525555A (ja) 2023-06-16
JP2023525555A5 true JP2023525555A5 (enExample) 2024-05-22
JP7827640B2 JP7827640B2 (ja) 2026-03-10

Family

ID=76181307

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022568853A Active JP7827640B2 (ja) 2020-05-12 2021-05-11 新規なil10アゴニストを含む治療剤
JP2025206113A Pending JP2026048706A (ja) 2020-05-12 2025-11-27 新規なil10アゴニストおよびその使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025206113A Pending JP2026048706A (ja) 2020-05-12 2025-11-27 新規なil10アゴニストおよびその使用方法

Country Status (12)

Country Link
US (3) US11673930B2 (enExample)
EP (1) EP4149963A1 (enExample)
JP (2) JP7827640B2 (enExample)
KR (1) KR20230009430A (enExample)
CN (1) CN115667290A (enExample)
AU (1) AU2021270563A1 (enExample)
BR (1) BR112022022899A2 (enExample)
CA (1) CA3183151A1 (enExample)
IL (1) IL298007A (enExample)
MX (1) MX2022014239A (enExample)
WO (1) WO2021231447A1 (enExample)
ZA (1) ZA202210918B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024249957A2 (en) * 2023-06-01 2024-12-05 Synthekine, Inc. Il10 inverted monomers

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
JP3051145B2 (ja) 1990-08-28 2000-06-12 住友製薬株式会社 新規なポリエチレングリコール誘導体修飾ペプチド
US5582996A (en) 1990-12-04 1996-12-10 The Wistar Institute Of Anatomy & Biology Bifunctional antibodies and method of preparing same
US5932448A (en) 1991-11-29 1999-08-03 Protein Design Labs., Inc. Bispecific antibody heterodimers
CA2128511C (en) 1992-01-23 2006-11-07 Andreas Pluckthun Monomeric and dimeric antibody-fragment fusion proteins
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
US6410008B1 (en) 1994-12-12 2002-06-25 Beth Israel Hospital Association Chimeric IL-10 proteins and uses thereof
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
GB9625640D0 (en) 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
US20020062010A1 (en) 1997-05-02 2002-05-23 Genentech, Inc. Method for making multispecific antibodies having heteromultimeric and common components
GB9720054D0 (en) 1997-09-19 1997-11-19 Celltech Therapeutics Ltd Biological products
GB9824437D0 (en) 1998-11-06 1999-01-06 Ylo Herttuala Seppo Gene therapy
US6833441B2 (en) 2001-08-01 2004-12-21 Abmaxis, Inc. Compositions and methods for generating chimeric heteromultimers
NZ540194A (en) 2002-11-08 2008-07-31 Ablynx Nv Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
US7261882B2 (en) 2003-06-23 2007-08-28 Reagents Of The University Of Colorado Methods for treating neuropathic pain by administering IL-10 polypeptides
PT1644412E (pt) 2003-07-01 2015-12-23 Ucb Biopharma Sprl Fragmentos de anticorpos fab modificados
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
WO2005049094A1 (en) 2003-11-13 2005-06-02 Advantagene, Inc. A mixed complementary viral vector for gene therapy
WO2006028936A2 (en) 2004-09-02 2006-03-16 Genentech, Inc. Heteromultimeric molecules
KR101374454B1 (ko) 2005-03-31 2014-03-17 추가이 세이야쿠 가부시키가이샤 회합제어에 의한 폴리펩티드 제조방법
WO2007061657A2 (en) 2005-11-14 2007-05-31 The Brigham & Women's Hospital, Inc. Interleukin-10 compositions for the treatment of adenocarcinomas
US20070179094A1 (en) * 2006-01-31 2007-08-02 Bayer Schering Pharma Ag Modulation of MDL-1 activity for treatment of inflammatory disease
US20070269422A1 (en) 2006-05-17 2007-11-22 Ablynx N.V. Serum albumin binding proteins with long half-lives
US20100093076A1 (en) * 2006-08-25 2010-04-15 Moore Margaret D Soluble il-27 receptor
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
EP3663318A1 (en) 2008-01-07 2020-06-10 Amgen Inc. Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
TWI507525B (zh) 2009-06-26 2015-11-11 Regeneron Pharma 具天然免疫球蛋白形式之易分離的雙專一性抗體
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
WO2012045334A1 (en) * 2010-10-05 2012-04-12 Synthon Bv Biologically active il-10 fusion proteins
EA201892619A1 (ru) 2011-04-29 2019-04-30 Роше Гликарт Аг Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
US9346872B2 (en) 2012-08-08 2016-05-24 Roche Glycart Ag Interleukin-10 fusion proteins
MX385344B (es) 2012-11-28 2025-03-18 Zymeworks Bc Inc Pares de cadena pesada-cadena ligera de inmunoglobulina modificados genéticamente y usos de estos.
TWI682941B (zh) * 2013-02-01 2020-01-21 美商再生元醫藥公司 含嵌合恆定區之抗體
US10047167B2 (en) 2013-03-15 2018-08-14 Eli Lilly And Company Methods for producing fabs and bi-specific antibodies
EP2986306A4 (en) 2013-04-18 2016-12-07 Armo Biosciences Inc METHOD FOR USE OF INTERLEUKIN-10 FOR THE TREATMENT OF ILLNESSES AND SUFFERING
KR20160079114A (ko) 2013-11-11 2016-07-05 아르모 바이오사이언시스 인코포레이티드 질환 및 장애를 치료하기 위한 인터류킨-10을 사용하는 방법
BR112016016658A2 (pt) 2014-02-06 2018-01-23 F. Hoffmann-La Roche Ag proteína de fusão de um anticorpo, polinucleotídeo, vetor, célula hospedeira, composição farmacêutica, métodos para produzir uma proteína de fusão e de tratamento de uma doença em um indivíduo e uso da proteína de fusão
AU2015336101A1 (en) 2014-10-22 2017-04-20 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
CN104403004B (zh) 2014-11-24 2017-10-13 苏州丁孚靶点生物技术有限公司 抗体‑干扰素异二聚体的制备和用途
EP3233920B1 (en) 2014-12-19 2020-08-26 Alkermes, Inc. Single chain fc fusion proteins
DK3277725T3 (da) 2015-03-30 2021-01-11 Regeneron Pharma Konstante tungkædeområder med reduceret binding til FC-gammareceptorer
WO2016191587A1 (en) 2015-05-28 2016-12-01 Armo Biosciences, Inc. Pegylated interleukin-10 for use in treating cancer
WO2017087784A1 (en) 2015-11-18 2017-05-26 Duke University Tumor infiltrating lymphocytes for treatment of cancer
RU2725292C2 (ru) * 2016-04-27 2020-06-30 Иммьюномедикс, Инк. Эффективность конъюгатов антитела против trop-2 с лекарственным средством sn-38 для терапии рецидивирующих/рефрактерных к ингибиторам контрольной точки опухолей
WO2017210684A1 (en) 2016-06-03 2017-12-07 New York University Methods and reagents for modulating macrophage phenotype
WO2018005226A2 (en) 2016-06-22 2018-01-04 Alkermes, Inc. Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties
CN110234355B (zh) 2017-02-01 2021-11-09 浙江时迈药业有限公司 单体人IgG1 Fc和双特异性抗体
JP7795181B2 (ja) * 2017-09-06 2026-01-07 イェール ユニバーシティー インターロイキン-18バリアントとその利用法
CN111315398A (zh) * 2017-11-10 2020-06-19 阿尔莫生物科技股份有限公司 白介素-10与免疫检查点途径抑制剂的组合的组合物和使用方法
WO2019152344A1 (en) * 2018-01-30 2019-08-08 University Of Louisville Research Foundation, Inc. Compositions and methods for treating inflammation and cancer
EP3808376A4 (en) * 2018-06-17 2021-09-01 L&L Biopharma Co., Ltd. CLDN18.2 ANTIBODY, BISPECIFIC ANTIBODY, ADC AND CAR, AND APPLICATIONS THEREOF
WO2020097946A1 (zh) 2018-11-18 2020-05-22 杭州博虎生物科技有限公司 一种重组人白细胞介素10融合蛋白及其应用
CN113811549A (zh) * 2019-02-21 2021-12-17 Xencor股份有限公司 非靶向和靶向性il-10 fc融合蛋白
US20220227827A1 (en) * 2019-03-25 2022-07-21 Dingfu Biotarget Co., Ltd. Proteinaceous heterodimer and use thereof
JP7641912B2 (ja) * 2019-04-19 2025-03-07 シナーキン・ファーマ・ベスローテン・フエンノートシャップ Il13を含む融合タンパク質
EP3795583A1 (en) * 2019-09-19 2021-03-24 Ecole Polytechnique Federale de Lausanne (EPFL) Il10/fc fusion proteins useful as enhancers of immunotherapies
WO2021158938A1 (en) * 2020-02-06 2021-08-12 Bristol-Myers Squibb Company Il-10 and uses thereof

Similar Documents

Publication Publication Date Title
EP3638700B1 (en) Proteinaceous heterodimer and use thereof
CN112534052B (zh) 全新il-21前药及使用方法
AU2026200173A1 (en) Activatable Cytokine Constructs And Related Compositions And Methods
US11905322B2 (en) Engineered PD-1 variants
JP2023518518A5 (enExample)
CA2948346C (en) Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo
CN111527109A (zh) 以抗体Fc区为骨架的融合蛋白二聚体及其应用
EP4017594A1 (en) Novel il-21 prodrugs and methods of use thereof
JP2023534636A5 (enExample)
US20200277350A1 (en) Proteinaceous heterodimer and use thereof
WO1996010089A1 (en) Modification of peptide and protein
JP2023123649A5 (enExample)
JP2006006339A (ja) サイトカインの免疫複合体
HRP20030192A2 (en) Fusion protein from antibody cytokine-cytokine inhibitor (selectokine) for use as target specific prodrug
EP4019536A1 (en) Immunocytokine, preparation for same, and uses thereof
WO2022165443A1 (en) Chimeric molecules comprising an il-10 or tgf-beta agonist polypeptide
ZA200308430B (en) Reducing the immunogenicity of fusion proteins.
JPH04504363A (ja) 組換え抗体―毒素融合タンパク質
JP2026048706A5 (enExample)
JP2022530742A5 (enExample)
WO2024193705A1 (en) Tnf superfamily member immunocytokine and uses thereof
CN107226866A (zh) 一种抗cd24人源化抗体融合蛋白
CN120590542A (zh) 基于clec9a的嵌合蛋白复合物
WO2024094119A1 (zh) 融合蛋白及其应用
WO2024078479A1 (zh) 一种异源二聚体融合蛋白及其应用