JP2023525039A - Ｓａｒｓ－ｃｏｖ－２に対する抗体 - Google Patents
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- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1002—Coronaviridae
- C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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- Medicinal Preparation (AREA)
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| US202163170368P | 2021-04-02 | 2021-04-02 | |
| US63/170,368 | 2021-04-02 | ||
| PCT/US2021/031442 WO2021226560A1 (fr) | 2020-05-08 | 2021-05-07 | Anticorps contre sars-cov-2 |
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| IL (1) | IL297988A (fr) |
| MX (1) | MX2022013886A (fr) |
| WO (1) | WO2021226560A1 (fr) |
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| PL3872091T3 (pl) * | 2020-02-26 | 2023-12-27 | Vir Biotechnology, Inc. | Przeciwciała przeciw sars-cov-2 |
| SG11202103404PA (en) | 2020-04-02 | 2021-04-29 | Regeneron Pharma | Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments |
| WO2021247779A1 (fr) | 2020-06-03 | 2021-12-09 | Regeneron Pharmaceuticals, Inc. | Méthodes de traitement ou de prévention d'infections au sars-cov-2 et de la covid-19 à l'aide d'anticorps de glycoprotéine de spicule anti-sars-cov-2 |
| JP2023534923A (ja) | 2020-07-06 | 2023-08-15 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | ＳＡＲＳ－ＣｏＶ－２を標的にする抗原結合分子 |
| IL300720A (en) | 2020-08-26 | 2023-04-01 | Flagship Pioneering Innovations Vi Llc | Antigen binding molecules targeting Sars-cov-2 |
| WO2022263638A1 (fr) * | 2021-06-17 | 2022-12-22 | Centre Hospitalier Universitaire Vaudois (C.H.U.V.) | Anticorps anti-sars-cov-2 et leur utilisation dans le traitement d'une infection par le sars-cov-2 |
| WO2023287875A1 (fr) * | 2021-07-14 | 2023-01-19 | Regeneron Pharmaceuticals, Inc. | Anticorps anti-glycoprotéine de spicule du sars-cov-2 et fragments de liaison à l'antigène |
| WO2023201256A1 (fr) * | 2022-04-12 | 2023-10-19 | Vir Biotechnology, Inc. | Thérapies par anticorps à haute dose contre une infection par le sars-cov-2 |
| WO2023215910A1 (fr) | 2022-05-06 | 2023-11-09 | Generate Biomedicines, Inc. | Molécules de liaison à l'antigène ciblant le sars-cov-2 |
| US20230365658A1 (en) * | 2022-05-16 | 2023-11-16 | Lawrence Livermore National Security, Llc | REPAIRED THERAPEUTIC AND PROPHYLACTIC ANTIBODIES AGAINST SARS-CoV-2 VARIANTS |
| WO2023235827A2 (fr) * | 2022-06-03 | 2023-12-07 | The Rockefeller University | Anticorps inhibant les coronavirus |
| WO2024006472A1 (fr) | 2022-06-30 | 2024-01-04 | Vir Biotechnology, Inc. | Anticorps qui se lient à de multiples sarbecovirus |
| WO2024081269A1 (fr) * | 2022-10-10 | 2024-04-18 | Dixit Rohan | Combinaisons thérapeutiques et méthodes de traitement de covid longue |
| WO2024102674A1 (fr) | 2022-11-13 | 2024-05-16 | Generate Biomedicines, Inc. | Molécules de liaison à l'antigène ciblant sars-cov-2 |
| CN117362421A (zh) * | 2022-12-02 | 2024-01-09 | 中国科学院微生物研究所 | 一种针对新冠病毒rbd的广谱单克隆抗体、其制备方法及应用 |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US7018809B1 (en) | 1991-09-19 | 2006-03-28 | Genentech, Inc. | Expression of functional antibody fragments |
| US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
| US6833268B1 (en) | 1999-06-10 | 2004-12-21 | Abgenix, Inc. | Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions |
| NZ517906A (en) | 1999-10-04 | 2003-01-31 | Medicago Inc | Cloning of genomic sequences encoding nitrite reductase (NiR) for use in regulated expression of foreign genes in host plants |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| AU2004215125B2 (en) | 2003-02-26 | 2011-01-06 | Institute For Research In Biomedicine | Monoclonal antibody production by EBV transformation of B cells |
| ATE492562T1 (de) | 2003-09-24 | 2011-01-15 | Kyowa Hakko Kirin Co Ltd | Rekombinanter antikörper gegen humanen insulin- like growth factor |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| WO2008042814A2 (fr) | 2006-09-29 | 2008-04-10 | California Institute Of Technology | Récepteurs mart-1 des lymphocytes t |
| EP4071177A1 (fr) | 2013-12-30 | 2022-10-12 | Epimab Biotherapeutics, Inc. | Immunoglobuline fabs-in-tandem et ses utilisations |
| US11267899B2 (en) | 2015-05-13 | 2022-03-08 | Zumutor Biologics Inc. | Afucosylated protein, cell expressing said protein and associated methods |
| WO2019024979A1 (fr) | 2017-07-31 | 2019-02-07 | Institute For Research In Biomedicine | Anticorps à domaines fonctionnels dans la région de coude |
| IL310960A (en) | 2017-09-22 | 2024-04-01 | Wuxi Biologics Ireland Ltd | New bispecific polypeptide complexes |
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| CL2022003085A1 (es) | 2023-09-01 |
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| IL297988A (en) | 2023-01-01 |
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