JP2023522166A5 - - Google Patents

Info

Publication number
JP2023522166A5
JP2023522166A5 JP2022561040A JP2022561040A JP2023522166A5 JP 2023522166 A5 JP2023522166 A5 JP 2023522166A5 JP 2022561040 A JP2022561040 A JP 2022561040A JP 2022561040 A JP2022561040 A JP 2022561040A JP 2023522166 A5 JP2023522166 A5 JP 2023522166A5
Authority
JP
Japan
Application number
JP2022561040A
Other languages
Japanese (ja)
Other versions
JPWO2021207335A5 (https=
JP2023522166A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/026141 external-priority patent/WO2021207335A1/en
Publication of JP2023522166A publication Critical patent/JP2023522166A/ja
Publication of JP2023522166A5 publication Critical patent/JP2023522166A5/ja
Publication of JPWO2021207335A5 publication Critical patent/JPWO2021207335A5/ja
Pending legal-status Critical Current

Links

JP2022561040A 2020-04-07 2021-04-07 メニン阻害剤とcyp3a4阻害剤との組合せ、およびその使用方法 Pending JP2023522166A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063006574P 2020-04-07 2020-04-07
US63/006,574 2020-04-07
PCT/US2021/026141 WO2021207335A1 (en) 2020-04-07 2021-04-07 Combinations of menin inhibitors and cyp3a4 inhibitors and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2023522166A JP2023522166A (ja) 2023-05-29
JP2023522166A5 true JP2023522166A5 (https=) 2024-04-16
JPWO2021207335A5 JPWO2021207335A5 (https=) 2024-04-16

Family

ID=78023861

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022561040A Pending JP2023522166A (ja) 2020-04-07 2021-04-07 メニン阻害剤とcyp3a4阻害剤との組合せ、およびその使用方法

Country Status (10)

Country Link
US (1) US12564590B2 (https=)
EP (1) EP4132932A4 (https=)
JP (1) JP2023522166A (https=)
KR (1) KR20230007359A (https=)
CN (3) CN120393026A (https=)
AU (1) AU2021252552A1 (https=)
CA (1) CA3178691A1 (https=)
IL (1) IL297039A (https=)
MX (1) MX2022012471A (https=)
WO (1) WO2021207335A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3805215A1 (en) 2016-06-10 2021-04-14 Vitae Pharmaceuticals, LLC Inhibitors of the menin-mll interaction
JP7554829B2 (ja) 2019-12-19 2024-09-20 ヤンセン ファーマシューティカ エヌ.ベー. 置換直鎖スピロ誘導体
MX2022012471A (es) 2020-04-07 2022-11-30 Syndax Pharmaceuticals Inc Combinaciones de inhibidores de menina e inhibidores de cyp3a4 y métodos de uso de las mismas.
TW202311262A (zh) 2021-05-14 2023-03-16 美商錫達斯醫藥股份有限公司 Menin-mll交互作用之抑制劑
WO2023150635A1 (en) * 2022-02-04 2023-08-10 Kura Oncology, Inc. Treatment of hematological malignancies with menin inhibitors and p-glycoprotein inhibitors
JP2025516558A (ja) * 2022-05-09 2025-05-30 シンダックス ファーマシューティカルズ, インコーポレイテッド 癌治療のためのメニン-mll阻害剤
CN120456907A (zh) * 2022-11-02 2025-08-08 库拉肿瘤学公司 急性白血病的治疗方法
CN120529900A (zh) 2022-11-24 2025-08-22 奥莱松基因组股份有限公司 用于治疗癌症的LSD1抑制剂和Menin抑制剂的组合
WO2025106862A1 (en) * 2023-11-17 2025-05-22 Kura Oncology, Inc. Methods of treating kit positive cancers with a menin inhibitor

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2086544C1 (ru) 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
US5820915A (en) 1996-06-27 1998-10-13 Bioavailability Systems, L.L.C. Method for the preparation of a first-pass effective citrus-derived substance and product thereof
US6124477A (en) 1996-06-27 2000-09-26 Bioavailability Systems, Llc Anti-first-pass effect compounds
US5990154A (en) 1997-05-30 1999-11-23 Bioavailability Systems, L.L.C. Anti-first-pass effect compounds and citrus extract
US6063809A (en) 1997-08-26 2000-05-16 Bioavailability Systems, Llc Anti-first-pass effect compounds
US6248776B1 (en) 1997-08-26 2001-06-19 Bioavailability Systems, L.L.C. Anti-first-pass effect compounds
US20040058982A1 (en) 1999-02-17 2004-03-25 Bioavailability System, Llc Pharmaceutical compositions
US5993887A (en) 1998-06-29 1999-11-30 Bioavailability Systems, L.L.C. Safe citrus juice and process for preparation
WO2004037827A1 (en) 2000-10-20 2004-05-06 Bioavailability Systems, Llc Synthesis of spiro ortho esters, spiro ortho carbonates, and intermediates
US7968569B2 (en) 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
EP1732891A4 (en) 2004-03-11 2009-05-06 Sequoia Pharmaceuticals Inc RESISTANT PREVENTIVE INHIBITORS FOR RETROVIRAL PROTEASES
EP2422781A1 (en) 2004-05-07 2012-02-29 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
US20090281114A1 (en) 2008-05-08 2009-11-12 Fabre-Kramer Pharmaceuticals, Inc. Indolylalkyl derivatives of pyrimidinylpiperazine and metabolites thereof for treatment of anxiety, depression, and sexual dysfunction
AR071717A1 (es) 2008-05-13 2010-07-07 Array Biopharma Inc Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer.
KR20180084153A (ko) 2011-06-10 2018-07-24 메르크 파텐트 게엠베하 Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물의 조성물 및 제조방법
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
TWI599356B (zh) 2012-09-26 2017-09-21 安羅格製藥有限責任公司 抑制突變型c-kit的方法
ES2750523T3 (es) 2012-12-18 2020-03-26 Almirall Sa Derivados de ciclohexil y quinuclidinil carbamato que tienen actividades de agonista beta2 adrenérgicos y antagonistas muscarínicos M3
US9458124B2 (en) 2013-02-06 2016-10-04 Wayne State University Substituted pyran derivatives
KR20150130389A (ko) 2013-03-13 2015-11-23 더 리젠츠 오브 더 유니버시티 오브 미시간 티에노피리미딘 및 티에노피리딘 화합물을 포함하는 조성물 및 이의 사용 방법
WO2015108940A2 (en) 2014-01-14 2015-07-23 The Trustees Of The University Of Pennsylvania Tailored combinatorial epigenetic therapies for p53 gain-of-function tumors
US20170119769A1 (en) 2014-06-10 2017-05-04 The Trustees Of The University Of Pennsylvania Scaffolds for inhibitors of menin-mll interactions
WO2016025635A2 (en) * 2014-08-13 2016-02-18 Epizyme, Inc. Combination therapy for treating cancer
CN105732636B (zh) 2014-12-30 2020-04-21 广东东阳光药业有限公司 杂芳化合物及其在药物中的应用
WO2016197027A1 (en) 2015-06-04 2016-12-08 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with mll proteins
AU2016378579A1 (en) 2015-12-22 2018-06-14 Vitae Pharmaceuticals, Inc. Inhibitors of the menin-MLL interaction
EP4643952A3 (en) 2016-01-26 2026-01-14 Memorial Sloan Kettering Cancer Center Targeting chromatin regulators for inhibiting leukemogenic gene expression in npm1
CN109640987B (zh) 2016-03-16 2022-12-02 库拉肿瘤学公司 Menin-mll的桥联双环抑制剂及使用方法
WO2017192543A1 (en) 2016-05-02 2017-11-09 Regents Of The University Of Michigan Piperidines as menin inhibitors
EP3454862B1 (en) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
EP3805215A1 (en) * 2016-06-10 2021-04-14 Vitae Pharmaceuticals, LLC Inhibitors of the menin-mll interaction
US10899758B2 (en) 2016-09-16 2021-01-26 Vitae Pharmaceuticals, Llc Inhibitors of the menin-MLL interaction
CN110691779B (zh) 2017-03-24 2023-10-10 库拉肿瘤学公司 治疗血液系统恶性肿瘤和尤因肉瘤的方法
KR20200101389A (ko) 2017-12-20 2020-08-27 얀센 파마슈티카 엔.브이. 메닌-mll 상호작용의 엑소-아자 스피로 억제제
EP3740491A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
JP2021519785A (ja) 2018-03-30 2021-08-12 ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン 共有結合性メニン阻害剤としてのピペリジン化合物
AU2019337547A1 (en) 2018-09-13 2021-03-18 Merck Sharp & Dohme Llc Combination of PD-1 antagonist and LAG3 antagonist for treating non-microsatellite instablity-high/proficient mismatch repair colorectal cancer
EP3856173A4 (en) 2018-09-26 2022-07-06 Kura Oncology, Inc. TREATMENT OF HEMATOLOGICAL MALIGNITIES WITH MENIN INHIBITORS
EP3906026A4 (en) 2018-12-31 2022-10-19 Biomea Fusion, LLC IRREVERSIBLE INHIBITORS OF MENIN-MLL INTERACTION
MX2022012471A (es) 2020-04-07 2022-11-30 Syndax Pharmaceuticals Inc Combinaciones de inhibidores de menina e inhibidores de cyp3a4 y métodos de uso de las mismas.
AU2022271791A1 (en) 2021-05-12 2024-01-04 Board Of Regents, The University Of Texas System Combinations for treatment of cancer
TW202311262A (zh) 2021-05-14 2023-03-16 美商錫達斯醫藥股份有限公司 Menin-mll交互作用之抑制劑
AU2022325861A1 (en) 2021-08-11 2024-02-29 Biomea Fusion, Inc. Covalent inhibitors of menin-mll interaction for diabetes mellitus
CN118234497A (zh) 2021-12-15 2024-06-21 丹娜-法伯癌症研究所 通过破坏menin-mll表观遗传复合体靶向治疗胃肠道间质瘤(gist)
TW202525797A (zh) 2023-08-28 2025-07-01 美商錫達斯醫藥股份有限公司 作為menin-mll交互作用之抑制劑的芳基醚類似物

Similar Documents

Publication Publication Date Title
JP2023522166A5 (https=)
BR112023011738A2 (https=)
CN305762206S (https=)
CN305528915S (https=)
CN305528446S (https=)
CN305528266S (https=)
CN305528163S (https=)
CN305527691S (https=)
CN305527627S (https=)
CN306025248S (https=)
CN306024252S (https=)
CN306015938S (https=)
CN306014862S (https=)
CN306011334S (https=)
CN305895221S (https=)
CN305894826S (https=)
CN305890276S (https=)
CN305875756S (https=)
CN305861373S (https=)
CN305852207S (https=)
CN305838550S (https=)
CN305834484S (https=)
CN305587463S (https=)
CN305827867S (https=)
CN305818797S (https=)