CN120393025A - Menin抑制剂和cyp3a4抑制剂的组合及其使用方法 - Google Patents

Menin抑制剂和cyp3a4抑制剂的组合及其使用方法

Info

Publication number
CN120393025A
CN120393025A CN202510541621.9A CN202510541621A CN120393025A CN 120393025 A CN120393025 A CN 120393025A CN 202510541621 A CN202510541621 A CN 202510541621A CN 120393025 A CN120393025 A CN 120393025A
Authority
CN
China
Prior art keywords
inhibitor
men
cyp3a4
administered
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202510541621.9A
Other languages
English (en)
Chinese (zh)
Inventor
G·M·麦克吉汉
P·欧尔德恩特里奇
G·罗森
S·A·史密斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syndax Pharmaceuticals Inc
Original Assignee
Syndax Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syndax Pharmaceuticals Inc filed Critical Syndax Pharmaceuticals Inc
Publication of CN120393025A publication Critical patent/CN120393025A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202510541621.9A 2020-04-07 2021-04-07 Menin抑制剂和cyp3a4抑制剂的组合及其使用方法 Pending CN120393025A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063006574P 2020-04-07 2020-04-07
US63/006,574 2020-04-07
PCT/US2021/026141 WO2021207335A1 (en) 2020-04-07 2021-04-07 Combinations of menin inhibitors and cyp3a4 inhibitors and methods of use thereof
CN202180040679.5A CN115698013B (zh) 2020-04-07 2021-04-07 Menin抑制剂和cyp3a4抑制剂的组合及其使用方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN202180040679.5A Division CN115698013B (zh) 2020-04-07 2021-04-07 Menin抑制剂和cyp3a4抑制剂的组合及其使用方法

Publications (1)

Publication Number Publication Date
CN120393025A true CN120393025A (zh) 2025-08-01

Family

ID=78023861

Family Applications (3)

Application Number Title Priority Date Filing Date
CN202510541621.9A Pending CN120393025A (zh) 2020-04-07 2021-04-07 Menin抑制剂和cyp3a4抑制剂的组合及其使用方法
CN202510541711.8A Pending CN120393026A (zh) 2020-04-07 2021-04-07 Menin抑制剂和cyp3a4抑制剂的组合及其使用方法
CN202180040679.5A Active CN115698013B (zh) 2020-04-07 2021-04-07 Menin抑制剂和cyp3a4抑制剂的组合及其使用方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202510541711.8A Pending CN120393026A (zh) 2020-04-07 2021-04-07 Menin抑制剂和cyp3a4抑制剂的组合及其使用方法
CN202180040679.5A Active CN115698013B (zh) 2020-04-07 2021-04-07 Menin抑制剂和cyp3a4抑制剂的组合及其使用方法

Country Status (10)

Country Link
US (1) US12564590B2 (https=)
EP (1) EP4132932A4 (https=)
JP (1) JP2023522166A (https=)
KR (1) KR20230007359A (https=)
CN (3) CN120393025A (https=)
AU (1) AU2021252552A1 (https=)
CA (1) CA3178691A1 (https=)
IL (1) IL297039A (https=)
MX (1) MX2022012471A (https=)
WO (1) WO2021207335A1 (https=)

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US20250152591A1 (en) * 2022-02-04 2025-05-15 Kura Oncology, Inc. Treatment of hematological malignancies with menin inhibitors and p-glycoprotein inhibitors
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CN120456907A (zh) * 2022-11-02 2025-08-08 库拉肿瘤学公司 急性白血病的治疗方法
CN120529900A (zh) 2022-11-24 2025-08-22 奥莱松基因组股份有限公司 用于治疗癌症的LSD1抑制剂和Menin抑制剂的组合
WO2025106862A1 (en) * 2023-11-17 2025-05-22 Kura Oncology, Inc. Methods of treating kit positive cancers with a menin inhibitor

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Also Published As

Publication number Publication date
US12564590B2 (en) 2026-03-03
CN115698013B (zh) 2026-01-02
MX2022012471A (es) 2022-11-30
EP4132932A1 (en) 2023-02-15
KR20230007359A (ko) 2023-01-12
IL297039A (en) 2022-12-01
CA3178691A1 (en) 2021-10-14
US20230165858A1 (en) 2023-06-01
EP4132932A4 (en) 2024-04-17
WO2021207335A1 (en) 2021-10-14
JP2023522166A (ja) 2023-05-29
CN120393026A (zh) 2025-08-01
AU2021252552A1 (en) 2022-10-27
CN115698013A (zh) 2023-02-03

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