JP2023522023A - ４－［（７－クロロ－２－メトキシベンゾ［ｂ］［１，５］ナフチリジン－１０－イル）アミノ］－２，６－ビス（ピロリジン－１－イルメチル）フェノールおよびそれらの塩の結晶形態 - Google Patents

４－［（７－クロロ－２－メトキシベンゾ［ｂ］［１，５］ナフチリジン－１０－イル）アミノ］－２，６－ビス（ピロリジン－１－イルメチル）フェノールおよびそれらの塩の結晶形態 Download PDF

Info

Publication number
JP2023522023A
JP2023522023A JP2022562632A JP2022562632A JP2023522023A JP 2023522023 A JP2023522023 A JP 2023522023A JP 2022562632 A JP2022562632 A JP 2022562632A JP 2022562632 A JP2022562632 A JP 2022562632A JP 2023522023 A JP2023522023 A JP 2023522023A
Authority
JP
Japan
Prior art keywords
ylmethyl
methoxybenzo
chloro
pyrrolidin
bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022562632A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023522023A5 (https=
Inventor
ベッカー，アクセル
グルイア，デリア－マリア
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of JP2023522023A publication Critical patent/JP2023522023A/ja
Publication of JP2023522023A5 publication Critical patent/JP2023522023A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2022562632A 2020-04-17 2021-04-14 ４－［（７－クロロ－２－メトキシベンゾ［ｂ］［１，５］ナフチリジン－１０－イル）アミノ］－２，６－ビス（ピロリジン－１－イルメチル）フェノールおよびそれらの塩の結晶形態 Pending JP2023522023A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20170197.6 2020-04-17
EP20170197 2020-04-17
PCT/EP2021/059604 WO2021209477A1 (en) 2020-04-17 2021-04-14 Crystalline forms of 4-[(7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol and salts thereof

Publications (2)

Publication Number Publication Date
JP2023522023A true JP2023522023A (ja) 2023-05-26
JP2023522023A5 JP2023522023A5 (https=) 2025-07-16

Family

ID=70333787

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022562632A Pending JP2023522023A (ja) 2020-04-17 2021-04-14 ４－［（７－クロロ－２－メトキシベンゾ［ｂ］［１，５］ナフチリジン－１０－イル）アミノ］－２，６－ビス（ピロリジン－１－イルメチル）フェノールおよびそれらの塩の結晶形態

Country Status (8)

Country Link
US (1) US20230295156A1 (https=)
EP (1) EP4136087A1 (https=)
JP (1) JP2023522023A (https=)
CN (1) CN115515955A (https=)
BR (1) BR112022018436A2 (https=)
CA (1) CA3175552A1 (https=)
PH (1) PH12022552366A1 (https=)
WO (1) WO2021209477A1 (https=)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090114029A (ko) * 2008-04-29 2009-11-03 강민석 피로나리딘의 제조방법 및 이를 위한 중간체

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101544638B (zh) * 2009-05-12 2012-05-30 重庆通天药业有限公司 乳酸咯萘啶及其药物组合物
CN103373995B (zh) * 2012-04-28 2016-04-27 上海迪赛诺药业有限公司 一种制备咯萘啶的方法
ES2902143T3 (es) * 2014-07-04 2022-03-25 Merck Patent Gmbh Derivados de azepanilo y composiciones farmacéuticas que los comprenden con actividad antiparasitaria
CN105461713A (zh) 2014-09-25 2016-04-06 刘力 苯并萘啶类的新化合物及其组合物和用途
JP2019530712A (ja) * 2016-10-13 2019-10-24 エムエムヴィ メディシンズ フォア マラリア ヴェンチャーＭｍｖ Ｍｅｄｉｃｉｎｅｓ Ｆｏｒ Ｍａｌａｒｉａ Ｖｅｎｔｕｒｅ 新規抗マラリア薬
HUE069225T2 (hu) * 2018-04-11 2025-02-28 Merck Patent Gmbh Kinolin-4-karboxamidok és benzonaftiridin származékok kombinációja maláriaellenes gyógyszer-kombinációként
CN112209926A (zh) * 2019-07-12 2021-01-12 中国中医科学院中药研究所 磷酸咯萘啶的多晶型物及其制备方法、应用
CA3182616A1 (en) * 2020-06-15 2021-12-23 Lukas Shinji OKITSU Tlr7/8 antagonists and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090114029A (ko) * 2008-04-29 2009-11-03 강민석 피로나리딘의 제조방법 및 이를 위한 중간체

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
平山令明, 有機化合物結晶作製ハンドブック, JPN6024053124, 25 July 2008 (2008-07-25), pages 37 - 44, ISSN: 0005714149 *
芦澤一英, 医薬品の多形現象と晶析の化学, JPN6015027444, 2002, pages 273 - 278, ISSN: 0005714148 *

Also Published As

Publication number Publication date
WO2021209477A1 (en) 2021-10-21
PH12022552366A1 (en) 2024-03-18
CA3175552A1 (en) 2021-10-21
BR112022018436A2 (pt) 2022-11-01
US20230295156A1 (en) 2023-09-21
CN115515955A (zh) 2022-12-23
EP4136087A1 (en) 2023-02-22

Similar Documents

Publication Publication Date Title
JP7035108B2 (ja) プリドピジンの類似体、それらの製造および使用
JP7710223B2 (ja) 置換ピロロトリアジン系化合物およびその医薬組成物並びにそれらの使用
JP2022517396A (ja) Ｅｇｆｒ阻害剤の塩、結晶形及びその製造方法
WO2024067744A1 (zh) 杂环取代喹唑啉及其制备方法和应用
CN114853750A (zh) 占诺美林的帕莫酸盐、晶型及其制备方法和用途
WO2022144002A1 (zh) 2,5-二酮哌嗪类化合物衍生物、其制备方法、药物组合物及其用途
TWI830884B (zh) 磷酸二酯酶抑制劑的晶型、其製備方法及其用途
KR20240154068A (ko) P2x3 억제제 화합물 및 이의 염, 다형체 및 용도
CN114044776A (zh) 化合物的盐及其晶型
JP2023522023A (ja) ４－［（７－クロロ－２－メトキシベンゾ［ｂ］［１，５］ナフチリジン－１０－イル）アミノ］－２，６－ビス（ピロリジン－１－イルメチル）フェノールおよびそれらの塩の結晶形態
KR20240115849A (ko) 라벡시모드 화합물
CN118574823A (zh) Arv-110的晶型及其制备方法和用途
ES2970232T3 (es) Modificaciones cristalinas de clorhidrato de N-(4,5-bismetansulfonil-2-metilbenzoil)guanidina y sales de N-(4,5-bismetansulfonil-2-metilbenzoil)guanidina
TWI915082B (zh) 用於egfr蛋白降解的化合物及其用途
WO2016206097A1 (zh) 新的5型磷酸二酯酶抑制剂及其应用
CN113149998B (zh) 2-吲哚啉螺环酮类化合物或其盐、溶剂合物的无定形形式或结晶形式
WO2012003413A1 (en) Novel solid forms of tacedinaline
CN115677698B (zh) 一种高效抗病毒化合物及其用途
WO2025113494A1 (zh) 多环类化合物及其应用
TW202539674A (zh) 用作cdk4蛋白激酶抑制劑的化合物及其應用
HK40120019A (zh) 一种选择性钾通道调节剂的固态结晶形式
WO2026052020A1 (zh) 用作cdk4蛋白激酶抑制剂的化合物及其应用
CN115707702A (zh) Rad51抑制剂化合物的晶型及其应用
WO2026051971A1 (zh) 用作cdk4蛋白激酶抑制剂的化合物及其应用
WO2026021588A1 (zh) Oga抑制剂及其应用

Legal Events

Date Code Title Description
RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20240410

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20240410

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240412

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250106

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20250404

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250707

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20250707

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20251023