BR112022018436A2 - Formas cristalinas de 4-[(7-cloro-2-metoxibenzo[b][1,5]naftiridin-10-il)amino]-2,6-bis(pirrolidin-1-ilmetil)fenol e seus sais - Google Patents
Formas cristalinas de 4-[(7-cloro-2-metoxibenzo[b][1,5]naftiridin-10-il)amino]-2,6-bis(pirrolidin-1-ilmetil)fenol e seus saisInfo
- Publication number
- BR112022018436A2 BR112022018436A2 BR112022018436A BR112022018436A BR112022018436A2 BR 112022018436 A2 BR112022018436 A2 BR 112022018436A2 BR 112022018436 A BR112022018436 A BR 112022018436A BR 112022018436 A BR112022018436 A BR 112022018436A BR 112022018436 A2 BR112022018436 A2 BR 112022018436A2
- Authority
- BR
- Brazil
- Prior art keywords
- methoxybenzo
- naphthyridin
- pyrrolidin
- chloro
- phenol
- Prior art date
Links
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 title abstract 2
- 208000030852 Parasitic disease Diseases 0.000 abstract 1
- 201000004792 malaria Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- DJUFPMUQJKWIJB-UHFFFAOYSA-N pyronaridine Chemical compound C12=NC(OC)=CC=C2N=C2C=C(Cl)C=CC2=C1NC(C=C(CN1CCCC1)C=1O)=CC=1CN1CCCC1 DJUFPMUQJKWIJB-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20170197 | 2020-04-17 | ||
| PCT/EP2021/059604 WO2021209477A1 (en) | 2020-04-17 | 2021-04-14 | Crystalline forms of 4-[(7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol and salts thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022018436A2 true BR112022018436A2 (pt) | 2022-11-01 |
Family
ID=70333787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022018436A BR112022018436A2 (pt) | 2020-04-17 | 2021-04-14 | Formas cristalinas de 4-[(7-cloro-2-metoxibenzo[b][1,5]naftiridin-10-il)amino]-2,6-bis(pirrolidin-1-ilmetil)fenol e seus sais |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230295156A1 (https=) |
| EP (1) | EP4136087A1 (https=) |
| JP (1) | JP2023522023A (https=) |
| CN (1) | CN115515955A (https=) |
| BR (1) | BR112022018436A2 (https=) |
| CA (1) | CA3175552A1 (https=) |
| PH (1) | PH12022552366A1 (https=) |
| WO (1) | WO2021209477A1 (https=) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100975895B1 (ko) * | 2008-04-29 | 2010-08-18 | 강민석 | 피로나리딘의 제조방법 및 이를 위한 중간체 |
| CN101544638B (zh) * | 2009-05-12 | 2012-05-30 | 重庆通天药业有限公司 | 乳酸咯萘啶及其药物组合物 |
| CN103373995B (zh) * | 2012-04-28 | 2016-04-27 | 上海迪赛诺药业有限公司 | 一种制备咯萘啶的方法 |
| ES2902143T3 (es) * | 2014-07-04 | 2022-03-25 | Merck Patent Gmbh | Derivados de azepanilo y composiciones farmacéuticas que los comprenden con actividad antiparasitaria |
| CN105461713A (zh) | 2014-09-25 | 2016-04-06 | 刘力 | 苯并萘啶类的新化合物及其组合物和用途 |
| JP2019530712A (ja) * | 2016-10-13 | 2019-10-24 | エムエムヴィ メディシンズ フォア マラリア ヴェンチャーＭｍｖ Ｍｅｄｉｃｉｎｅｓ Ｆｏｒ Ｍａｌａｒｉａ Ｖｅｎｔｕｒｅ | 新規抗マラリア薬 |
| HUE069225T2 (hu) * | 2018-04-11 | 2025-02-28 | Merck Patent Gmbh | Kinolin-4-karboxamidok és benzonaftiridin származékok kombinációja maláriaellenes gyógyszer-kombinációként |
| CN112209926A (zh) * | 2019-07-12 | 2021-01-12 | 中国中医科学院中药研究所 | 磷酸咯萘啶的多晶型物及其制备方法、应用 |
| CA3182616A1 (en) * | 2020-06-15 | 2021-12-23 | Lukas Shinji OKITSU | Tlr7/8 antagonists and uses thereof |
-
2021
- 2021-04-14 EP EP21717119.8A patent/EP4136087A1/en active Pending
- 2021-04-14 JP JP2022562632A patent/JP2023522023A/ja active Pending
- 2021-04-14 CA CA3175552A patent/CA3175552A1/en active Pending
- 2021-04-14 CN CN202180028991.2A patent/CN115515955A/zh active Pending
- 2021-04-14 PH PH1/2022/552366A patent/PH12022552366A1/en unknown
- 2021-04-14 WO PCT/EP2021/059604 patent/WO2021209477A1/en not_active Ceased
- 2021-04-14 BR BR112022018436A patent/BR112022018436A2/pt unknown
- 2021-04-14 US US17/995,388 patent/US20230295156A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021209477A1 (en) | 2021-10-21 |
| JP2023522023A (ja) | 2023-05-26 |
| PH12022552366A1 (en) | 2024-03-18 |
| CA3175552A1 (en) | 2021-10-21 |
| US20230295156A1 (en) | 2023-09-21 |
| CN115515955A (zh) | 2022-12-23 |
| EP4136087A1 (en) | 2023-02-22 |
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