BR112017017500A2 - derivado de quinolina para uso no tratamento e prevenção de infecções virais - Google Patents

derivado de quinolina para uso no tratamento e prevenção de infecções virais

Info

Publication number
BR112017017500A2
BR112017017500A2 BR112017017500-2A BR112017017500A BR112017017500A2 BR 112017017500 A2 BR112017017500 A2 BR 112017017500A2 BR 112017017500 A BR112017017500 A BR 112017017500A BR 112017017500 A2 BR112017017500 A2 BR 112017017500A2
Authority
BR
Brazil
Prior art keywords
quinoline derivative
prevention
treatment
viral infections
present
Prior art date
Application number
BR112017017500-2A
Other languages
English (en)
Other versions
BR112017017500B1 (pt
Inventor
Scherrer Didier
Garcel Aude
Campos Noëlie
Tazi Jamal
VAUTRIN Audrey
Mahuteau Florence
Najman Romain
FORNARELLI Pauline
Original Assignee
Abivax
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abivax filed Critical Abivax
Publication of BR112017017500A2 publication Critical patent/BR112017017500A2/pt
Publication of BR112017017500B1 publication Critical patent/BR112017017500B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

a presente invenção se refere a um derivado de quinolina de fórmula (1) ou um dos seus sais farmaceuticamente aceitáveis. a presente invenção diz ainda respeito ao referido derivado de quinolina para utilização como um medicamento e para utilização no tratamento ou prevenção de uma infecção viral ou retroviral e, em particular, aids ou de uma condição relacionada com a aids ou com o vírus da imunodeficiência humana (hiv). a presente invenção também se refere a uma composição farmacêutica compreendendo o referido derivado de quinolina e a um processo para sua preparação compreendendo um novo composto intermediário.
BR112017017500-2A 2015-02-23 2016-02-19 Derivado de quinolina para uso no tratamento e prevenção de infecções virais, composição farmacêutica, medicamento,processo para a preparação dos derivados e composto BR112017017500B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15305274.1A EP3059236A1 (en) 2015-02-23 2015-02-23 A new quinoline derivative for use in the treatment and prevention of viral infections
EP15305274.1 2015-02-23
PCT/EP2016/053532 WO2016135052A1 (en) 2015-02-23 2016-02-19 A new quinoline derivative for use in the treatment and prevention of viral infections

Publications (2)

Publication Number Publication Date
BR112017017500A2 true BR112017017500A2 (pt) 2018-04-17
BR112017017500B1 BR112017017500B1 (pt) 2023-04-04

Family

ID=52629497

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017017500-2A BR112017017500B1 (pt) 2015-02-23 2016-02-19 Derivado de quinolina para uso no tratamento e prevenção de infecções virais, composição farmacêutica, medicamento,processo para a preparação dos derivados e composto

Country Status (22)

Country Link
US (1) US10329317B2 (pt)
EP (2) EP3059236A1 (pt)
JP (1) JP6797126B2 (pt)
KR (1) KR102583506B1 (pt)
CN (1) CN107531681B (pt)
AU (1) AU2016223687B2 (pt)
BR (1) BR112017017500B1 (pt)
CA (1) CA2975577C (pt)
CU (1) CU24525B1 (pt)
DK (1) DK3262037T3 (pt)
ES (1) ES2785374T3 (pt)
HR (1) HRP20200649T1 (pt)
HU (1) HUE048577T2 (pt)
LT (1) LT3262037T (pt)
MX (1) MX2017010506A (pt)
PL (1) PL3262037T3 (pt)
PT (1) PT3262037T (pt)
RS (1) RS60369B1 (pt)
RU (1) RU2723013C2 (pt)
SI (1) SI3262037T1 (pt)
WO (1) WO2016135052A1 (pt)
ZA (1) ZA201705633B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2757161A1 (en) 2013-01-17 2014-07-23 Splicos miRNA-124 as a biomarker of viral infection
EP2974729A1 (en) 2014-07-17 2016-01-20 Abivax Quinoline derivatives for use in the treatment of inflammatory diseases
EP3059591A1 (en) 2015-02-23 2016-08-24 Abivax Methods for screening compounds for treating or preventing a viral infection or a virus-related condition
US20190034990A1 (en) * 2017-07-26 2019-01-31 International Business Machines Corporation Information insight system for providers of products or services
EP3669874A1 (en) * 2018-12-20 2020-06-24 Abivax Quinoline derivatives for use in the treatment or prevention of cancer
EP3669873A1 (en) * 2018-12-20 2020-06-24 Abivax Quinoline derivatives for use ine the traeatment of inflammation diseases
CN115605205A (zh) * 2020-03-20 2023-01-13 Abivax公司（Fr） 用于治疗或预防冠状病毒科感染的化合物以及用于评估冠状病毒科感染的发生的方法和用途
EP3881844A1 (en) * 2020-03-20 2021-09-22 Abivax Compounds for treating or preventing a coronaviridae infection & methods and uses for assessing the occurrence of a coronaviridae infection
EP3884946A1 (en) * 2020-03-25 2021-09-29 Abivax Compounds for treating or preventing a coronaviridae infection & methods and uses for assessing the occurrence of a coronaviridae infection
CA3219657A1 (en) * 2021-05-27 2022-12-01 Fanglong Yang Quinolinamine compound, preparation method therefor and application thereof in pharmaceuticals
EP4201948A1 (en) 2021-12-21 2023-06-28 Abivax Method of preparation of 1-(n-(quinolin-2-yl)-(phenylamino)-1-deoxy-beta-d-glucopyranuronic acid derivatives
EP4212156A1 (en) 2022-01-13 2023-07-19 Abivax Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator
EP4215196A1 (en) * 2022-01-24 2023-07-26 Abivax Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a jak inhibitor
CN116617226A (zh) * 2023-06-21 2023-08-22 湖北工业大学 新型吲哚喹啉衍生物作为肠道病毒71型抑制剂的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2436786A1 (fr) 1978-09-21 1980-04-18 Anvar Nouveaux derives des pyrido (4,3-b) carbazoles (ellipticines), substitues en position 1 par une chaine polyaminee, leur obtention et leur application a titre de medicaments
FR2627493B1 (fr) 1988-02-23 1991-10-31 Sanofi Sa Procede de preparation de derives d'isoquinoleine
FR2645861A1 (fr) 1989-04-17 1990-10-19 Inst Nat Sante Rech Med Utilisation de dipyrido (4,3-b) (3,4-f) indoles pour la preparation de medicaments utiles pour le traitement du sida
US5354853A (en) * 1993-03-12 1994-10-11 Genzyme Corporation Phospholipid-saccharide conjugates
FR2859474B1 (fr) 2003-09-04 2006-01-13 Centre Nat Rech Scient Utilisation de composes derives d'indole pour la preparation d'un medicament utile pour le traitement de maladies genetiques resultant de l'alteration des processus d'epissage
TR201910781T4 (tr) 2009-06-12 2019-08-21 Abivax Kanser tedavisi için yararlı bileşikler.
EP2465502A1 (en) 2010-12-15 2012-06-20 Société Splicos Compounds useful for treating AIDS
HRP20211839T1 (hr) * 2013-07-05 2022-03-04 Abivax Biciklički spojevi korisni za liječenje bolesti uzrokovanih retrovirusima
EP2974729A1 (en) 2014-07-17 2016-01-20 Abivax Quinoline derivatives for use in the treatment of inflammatory diseases
EP2975034A1 (en) 2014-07-17 2016-01-20 Abivax A quinoline derivative for the treatment of inflammatory diseases and AIDS

Also Published As

Publication number Publication date
JP6797126B2 (ja) 2020-12-09
HUE048577T2 (hu) 2020-07-28
KR20170129698A (ko) 2017-11-27
RS60369B1 (sr) 2020-07-31
DK3262037T3 (da) 2020-05-04
SI3262037T1 (sl) 2020-09-30
HRP20200649T1 (hr) 2020-10-16
MX2017010506A (es) 2017-11-13
BR112017017500B1 (pt) 2023-04-04
PT3262037T (pt) 2020-04-09
CU24525B1 (es) 2021-06-08
CU20170109A7 (es) 2018-02-08
ZA201705633B (en) 2018-12-19
US10329317B2 (en) 2019-06-25
US20180030078A1 (en) 2018-02-01
RU2017128643A (ru) 2019-03-25
PL3262037T3 (pl) 2020-10-19
RU2017128643A3 (pt) 2019-04-15
EP3262037A1 (en) 2018-01-03
CA2975577C (en) 2020-04-07
CN107531681A (zh) 2018-01-02
EP3059236A1 (en) 2016-08-24
EP3262037B1 (en) 2020-02-12
RU2723013C2 (ru) 2020-06-08
KR102583506B1 (ko) 2023-09-26
CN107531681B (zh) 2020-11-24
WO2016135052A1 (en) 2016-09-01
AU2016223687A1 (en) 2017-08-31
CA2975577A1 (en) 2016-09-01
AU2016223687B2 (en) 2020-03-19
JP2018507215A (ja) 2018-03-15
ES2785374T3 (es) 2020-10-06
LT3262037T (lt) 2020-07-10

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 405/12

Ipc: C07D 405/12 (2006.01), A61P 31/12 (2006.01), A61P

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 19/02/2016, OBSERVADAS AS CONDICOES LEGAIS