JP2023521180A - ハンチントン病の治療のためのブロモドメイン阻害剤の使用 - Google Patents

ハンチントン病の治療のためのブロモドメイン阻害剤の使用 Download PDF

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JP2023521180A
JP2023521180A JP2022562062A JP2022562062A JP2023521180A JP 2023521180 A JP2023521180 A JP 2023521180A JP 2022562062 A JP2022562062 A JP 2022562062A JP 2022562062 A JP2022562062 A JP 2022562062A JP 2023521180 A JP2023521180 A JP 2023521180A
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brd9
inhibitor
brd9 inhibitor
independently
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JP2023521180A5 (enExample
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セラス，カーロタ ペレダ
エトック，フレッド
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ルミ サイエンティフィック ホールディングス，インコーポレーテッド
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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JP2022562062A 2020-04-08 2021-04-07 ハンチントン病の治療のためのブロモドメイン阻害剤の使用 Pending JP2023521180A (ja)

Applications Claiming Priority (3)

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US202063007161P 2020-04-08 2020-04-08
US63/007,161 2020-04-08
PCT/US2021/026223 WO2021207387A1 (en) 2020-04-08 2021-04-07 Use of bromodomain inhibitors for treatment of huntington's disease

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JP2023521180A true JP2023521180A (ja) 2023-05-23
JP2023521180A5 JP2023521180A5 (enExample) 2024-04-11

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US (1) US20230149373A1 (enExample)
EP (1) EP4132520A1 (enExample)
JP (1) JP2023521180A (enExample)
KR (1) KR20230023615A (enExample)
CN (1) CN115666562B (enExample)
AU (1) AU2021254396A1 (enExample)
BR (1) BR112022020392A2 (enExample)
CA (1) CA3175916A1 (enExample)
IL (1) IL296984A (enExample)
MX (1) MX2022012632A (enExample)
WO (1) WO2021207387A1 (enExample)

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CN115300507B (zh) * 2022-08-23 2024-03-01 杭州天玑济世生物科技有限公司 I-brd9作为arih1激动剂的用途
CN116143787B (zh) * 2023-02-21 2024-11-29 烟台皓元生物医药科技有限公司 一种tp-472中间体及其制备方法和应用
CN116942818B (zh) * 2023-02-24 2025-09-02 中南大学 以brd7为靶点在制备肥胖相关精神疾病药物中的应用

Citations (2)

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JP2017511814A (ja) * 2014-02-24 2017-04-27 セルジーン コーポレイション 神経細胞増幅及び中枢神経系障害治療のためのセレブロンの活性化因子の使用方法
WO2017223452A1 (en) * 2016-06-23 2017-12-28 Dana-Farber Cancer Institute, Inc. Degradation of bromodomain-containing protein 9 (brd9) by conjugation of brd9 inhibitors with e3 ligase ligand and methods of use

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CA3013988A1 (en) * 2016-02-15 2017-08-24 Cemm-Forschungszentrum Fur Molekulare Medizin Gmbh Taf1 inhibitors for the therapy of cancer
WO2019023149A1 (en) * 2017-07-24 2019-01-31 Salk Institute For Biological Studies USE OF BROMODOMAIN-CONTAINING PROTEIN-9 ANTAGONISTS IN ASSOCIATION WITH VITAMIN D RECEPTOR AGONISTS IN THE TREATMENT OF DIABETES
CN109568307A (zh) * 2017-09-29 2019-04-05 中国科学院上海药物研究所 一类环状内酯类化合物在制备用于预防和/或治疗亨廷顿病的药物中的用途
US20210198629A1 (en) * 2018-08-20 2021-07-01 University Of Georgia Research Foundation, Inc. Compositions and methods for increasing beiging of white adipose tissue

Patent Citations (2)

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JP2017511814A (ja) * 2014-02-24 2017-04-27 セルジーン コーポレイション 神経細胞増幅及び中枢神経系障害治療のためのセレブロンの活性化因子の使用方法
WO2017223452A1 (en) * 2016-06-23 2017-12-28 Dana-Farber Cancer Institute, Inc. Degradation of bromodomain-containing protein 9 (brd9) by conjugation of brd9 inhibitors with e3 ligase ligand and methods of use

Non-Patent Citations (3)

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Title
CELL CHEMICAL BIOLOGY, vol. 24, JPN6025014111, 2017, pages 9 - 23, ISSN: 0005711781 *
EXPERT REV. MOL. MED., vol. 13, JPN6025014113, 2011, pages 29, ISSN: 0005711780 *
NAT BIOTECHNOL, vol. 37, JPN6025014112, 2019, pages 1198 - 1208, ISSN: 0005711779 *

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CA3175916A1 (en) 2021-10-14
US20230149373A1 (en) 2023-05-18
CN115666562A (zh) 2023-01-31
AU2021254396A1 (en) 2022-10-20
BR112022020392A2 (pt) 2022-11-29
IL296984A (en) 2022-12-01
WO2021207387A1 (en) 2021-10-14
CN115666562B (zh) 2026-03-27
KR20230023615A (ko) 2023-02-17
EP4132520A1 (en) 2023-02-15
MX2022012632A (es) 2023-02-22

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