JP2023520201A - オリゴヌクレオチド及び関連化合物の合成 - Google Patents

オリゴヌクレオチド及び関連化合物の合成 Download PDF

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Publication number
JP2023520201A
JP2023520201A JP2022559478A JP2022559478A JP2023520201A JP 2023520201 A JP2023520201 A JP 2023520201A JP 2022559478 A JP2022559478 A JP 2022559478A JP 2022559478 A JP2022559478 A JP 2022559478A JP 2023520201 A JP2023520201 A JP 2023520201A
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JP2023520201A5 (enExample
Inventor
ジョン，ミンホン
ジン，イ
ガラ，ディネシュ
プラハブ，マリジャ
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ヤンセン バイオファーマ インク．
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Publication of JP2023520201A publication Critical patent/JP2023520201A/ja
Publication of JP2023520201A5 publication Critical patent/JP2023520201A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
JP2022559478A 2020-03-31 2021-03-30 オリゴヌクレオチド及び関連化合物の合成 Pending JP2023520201A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063003067P 2020-03-31 2020-03-31
US63/003,067 2020-03-31
PCT/IB2021/052595 WO2021198883A1 (en) 2020-03-31 2021-03-30 Synthesis of oligonucleotides and related compounds

Publications (2)

Publication Number Publication Date
JP2023520201A true JP2023520201A (ja) 2023-05-16
JP2023520201A5 JP2023520201A5 (enExample) 2024-04-02

Family

ID=75340013

Family Applications (1)

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JP2022559478A Pending JP2023520201A (ja) 2020-03-31 2021-03-30 オリゴヌクレオチド及び関連化合物の合成

Country Status (11)

Country Link
US (1) US12649761B2 (enExample)
EP (1) EP4126894A1 (enExample)
JP (1) JP2023520201A (enExample)
KR (1) KR20220161436A (enExample)
CN (1) CN115843299A (enExample)
AU (1) AU2021247043A1 (enExample)
BR (1) BR112022019752A2 (enExample)
CA (1) CA3178892A1 (enExample)
IL (1) IL296862A (enExample)
MX (1) MX2022012255A (enExample)
WO (1) WO2021198883A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12649761B2 (en) 2020-03-31 2026-06-09 Janssen Biopharma, Inc. Synthesis of oligonucleotides and related compounds
CN116888136A (zh) 2021-02-12 2023-10-13 味之素株式会社 寡核苷酸的制备方法
EP4601656A1 (en) * 2022-10-12 2025-08-20 Pharmorage Pty Limited Modified oligonucleotides
EP4755898A1 (en) 2023-08-02 2026-06-10 Nitto Denko Corporation Method for producing oligonucleotide
WO2025235761A1 (en) * 2024-05-09 2025-11-13 Biogen Ma Inc. Reagents and processes for preparing oligonucleotides

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012502935A (ja) * 2008-09-23 2012-02-02 蘇州瑞博生物技術有限公司 オリゴヌクレオチドの合成方法

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WO1992001704A1 (en) 1990-07-26 1992-02-06 Koichi Shudo Oligodeoxyribonucleotides
US6972330B2 (en) * 1996-02-13 2005-12-06 Sirna Therapeutics, Inc. Chemical synthesis of methoxy nucleosides
US5753789A (en) 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
ES2192672T3 (es) 1996-11-18 2003-10-16 Takeshi Imanishi Nuevos analogos de nucleotidos.
US6770748B2 (en) 1997-03-07 2004-08-03 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogue
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6251666B1 (en) 1997-03-31 2001-06-26 Ribozyme Pharmaceuticals, Inc. Nucleic acid catalysts comprising L-nucleotide analogs
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
EP1015469B2 (en) 1997-09-12 2015-11-18 Exiqon A/S Bi- and tri-cyclic nucleoside, nucleotide and oligonucleoide analogues
BRPI0008131B8 (pt) 1999-02-12 2021-05-25 Daiichi Sankyo Co Ltd composto ou um sal deste, análogo de oligonucleotídeo, composição farmacêutica, sonda para um gene,iniciador para começar a amplificação, uso de um análogo de oligonucleotídeo ou de um sal deste farmacologicamente aceitável, agente antisentido, e, agente antígeno
JP2000247940A (ja) * 1999-02-26 2000-09-12 Sankyo Co Ltd 新規ベンジルアジド化合物
US7084125B2 (en) 1999-03-18 2006-08-01 Exiqon A/S Xylo-LNA analogues
ATE356824T1 (de) 1999-05-04 2007-04-15 Santaris Pharma As L-ribo-lna analoge
US6525191B1 (en) 1999-05-11 2003-02-25 Kanda S. Ramasamy Conformationally constrained L-nucleosides
JP4151751B2 (ja) 1999-07-22 2008-09-17 第一三共株式会社 新規ビシクロヌクレオシド類縁体
US7569575B2 (en) 2002-05-08 2009-08-04 Santaris Pharma A/S Synthesis of locked nucleic acid derivatives
CA2504694C (en) 2002-11-05 2013-10-01 Isis Pharmaceuticals, Inc. Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
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US10214555B2 (en) 2012-11-14 2019-02-26 Takeda Pharmaceutical Company Limitjed Method for liquid-phase synthesis of nucleic acid
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JPWO2017111137A1 (ja) 2015-12-22 2018-10-18 味の素株式会社 オリゴヌクレオチドの製造方法
JP7306263B2 (ja) 2017-05-02 2023-07-11 日産化学株式会社 オリゴヌクレオチドの製造方法
US12649761B2 (en) 2020-03-31 2026-06-09 Janssen Biopharma, Inc. Synthesis of oligonucleotides and related compounds

Patent Citations (1)

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JP2012502935A (ja) * 2008-09-23 2012-02-02 蘇州瑞博生物技術有限公司 オリゴヌクレオチドの合成方法

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HUANG, J. ET AL.: "Chemical synthesis of bioactive siRNA in solution phase by using 2-(azidomethyl)benzoyl as 3'-hydrox", TETRAHEDRON LETTERS, vol. 53, no. 28, JPN6025005692, 2012, pages 3654 - 3657, XP028522086, ISSN: 0005665621, DOI: 10.1016/j.tetlet.2012.05.027 *
KAWANAKA, T. ET AL.: "Synthesis of dinucleoside phosphates and their analogs by the boranophosphotriester method using azi", TETRAHEDRON LETTERS, vol. 48, no. 11, JPN6025005691, 2007, pages 1973 - 1976, XP005890695, ISSN: 0005665620, DOI: 10.1016/j.tetlet.2007.01.064 *

Also Published As

Publication number Publication date
KR20220161436A (ko) 2022-12-06
AU2021247043A1 (en) 2022-10-27
US12649761B2 (en) 2026-06-09
MX2022012255A (es) 2023-01-11
CN115843299A (zh) 2023-03-24
EP4126894A1 (en) 2023-02-08
IL296862A (en) 2022-11-01
CA3178892A1 (en) 2021-10-07
BR112022019752A2 (pt) 2022-11-16
US20240092821A1 (en) 2024-03-21
WO2021198883A1 (en) 2021-10-07

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