CN115843299A - 寡核苷酸的合成和相关化合物 - Google Patents

寡核苷酸的合成和相关化合物 Download PDF

Info

Publication number
CN115843299A
CN115843299A CN202180039628.0A CN202180039628A CN115843299A CN 115843299 A CN115843299 A CN 115843299A CN 202180039628 A CN202180039628 A CN 202180039628A CN 115843299 A CN115843299 A CN 115843299A
Authority
CN
China
Prior art keywords
group
compound
formula
optionally substituted
independently selected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180039628.0A
Other languages
English (en)
Chinese (zh)
Inventor
钟明宏
Y·金
D·加拉
M·普哈维克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jensen Biopharmaceutical Co ltd
Original Assignee
Jensen Biopharmaceutical Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jensen Biopharmaceutical Co ltd filed Critical Jensen Biopharmaceutical Co ltd
Publication of CN115843299A publication Critical patent/CN115843299A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
CN202180039628.0A 2020-03-31 2021-03-30 寡核苷酸的合成和相关化合物 Pending CN115843299A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063003067P 2020-03-31 2020-03-31
US63/003067 2020-03-31
PCT/IB2021/052595 WO2021198883A1 (en) 2020-03-31 2021-03-30 Synthesis of oligonucleotides and related compounds

Publications (1)

Publication Number Publication Date
CN115843299A true CN115843299A (zh) 2023-03-24

Family

ID=75340013

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180039628.0A Pending CN115843299A (zh) 2020-03-31 2021-03-30 寡核苷酸的合成和相关化合物

Country Status (11)

Country Link
US (1) US12649761B2 (enExample)
EP (1) EP4126894A1 (enExample)
JP (1) JP2023520201A (enExample)
KR (1) KR20220161436A (enExample)
CN (1) CN115843299A (enExample)
AU (1) AU2021247043A1 (enExample)
BR (1) BR112022019752A2 (enExample)
CA (1) CA3178892A1 (enExample)
IL (1) IL296862A (enExample)
MX (1) MX2022012255A (enExample)
WO (1) WO2021198883A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12649761B2 (en) 2020-03-31 2026-06-09 Janssen Biopharma, Inc. Synthesis of oligonucleotides and related compounds
CN116888136A (zh) 2021-02-12 2023-10-13 味之素株式会社 寡核苷酸的制备方法
EP4601656A1 (en) * 2022-10-12 2025-08-20 Pharmorage Pty Limited Modified oligonucleotides
EP4755898A1 (en) 2023-08-02 2026-06-10 Nitto Denko Corporation Method for producing oligonucleotide
WO2025235761A1 (en) * 2024-05-09 2025-11-13 Biogen Ma Inc. Reagents and processes for preparing oligonucleotides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000247940A (ja) * 1999-02-26 2000-09-12 Sankyo Co Ltd 新規ベンジルアジド化合物
CN101684136A (zh) * 2008-09-23 2010-03-31 苏州瑞博生物技术有限公司 一种寡核苷酸的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001704A1 (en) 1990-07-26 1992-02-06 Koichi Shudo Oligodeoxyribonucleotides
US6972330B2 (en) * 1996-02-13 2005-12-06 Sirna Therapeutics, Inc. Chemical synthesis of methoxy nucleosides
US5753789A (en) 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
ES2192672T3 (es) 1996-11-18 2003-10-16 Takeshi Imanishi Nuevos analogos de nucleotidos.
US6770748B2 (en) 1997-03-07 2004-08-03 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogue
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6251666B1 (en) 1997-03-31 2001-06-26 Ribozyme Pharmaceuticals, Inc. Nucleic acid catalysts comprising L-nucleotide analogs
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
EP1015469B2 (en) 1997-09-12 2015-11-18 Exiqon A/S Bi- and tri-cyclic nucleoside, nucleotide and oligonucleoide analogues
BRPI0008131B8 (pt) 1999-02-12 2021-05-25 Daiichi Sankyo Co Ltd composto ou um sal deste, análogo de oligonucleotídeo, composição farmacêutica, sonda para um gene,iniciador para começar a amplificação, uso de um análogo de oligonucleotídeo ou de um sal deste farmacologicamente aceitável, agente antisentido, e, agente antígeno
US7084125B2 (en) 1999-03-18 2006-08-01 Exiqon A/S Xylo-LNA analogues
ATE356824T1 (de) 1999-05-04 2007-04-15 Santaris Pharma As L-ribo-lna analoge
US6525191B1 (en) 1999-05-11 2003-02-25 Kanda S. Ramasamy Conformationally constrained L-nucleosides
JP4151751B2 (ja) 1999-07-22 2008-09-17 第一三共株式会社 新規ビシクロヌクレオシド類縁体
US7569575B2 (en) 2002-05-08 2009-08-04 Santaris Pharma A/S Synthesis of locked nucleic acid derivatives
CA2504694C (en) 2002-11-05 2013-10-01 Isis Pharmaceuticals, Inc. Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
WO2013179412A1 (ja) 2012-05-30 2013-12-05 北海道システム・サイエンス株式会社 高分散性液相支持体を用いたオリゴヌクレオチド合成法
US10214555B2 (en) 2012-11-14 2019-02-26 Takeda Pharmaceutical Company Limitjed Method for liquid-phase synthesis of nucleic acid
EP3398955B1 (en) 2015-12-16 2026-06-03 Ajinomoto Co., Inc. Oligonucleotide production method, and nucleoside, nucleotide, or oligonucleotide
JPWO2017111137A1 (ja) 2015-12-22 2018-10-18 味の素株式会社 オリゴヌクレオチドの製造方法
JP7306263B2 (ja) 2017-05-02 2023-07-11 日産化学株式会社 オリゴヌクレオチドの製造方法
US12649761B2 (en) 2020-03-31 2026-06-09 Janssen Biopharma, Inc. Synthesis of oligonucleotides and related compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000247940A (ja) * 1999-02-26 2000-09-12 Sankyo Co Ltd 新規ベンジルアジド化合物
CN101684136A (zh) * 2008-09-23 2010-03-31 苏州瑞博生物技术有限公司 一种寡核苷酸的制备方法
CN101868473A (zh) * 2008-09-23 2010-10-20 苏州瑞博生物技术有限公司 一种寡核苷酸的制备方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HARRI LÖNNBERG: "Synthesis of oligonucleotides on a soluble support", 《BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY》, vol. 13, 12 July 2017 (2017-07-12), pages 1368 - 1387, XP055798685, DOI: 10.3762/bjoc.13.134 *
TAKESHI WADA ET AL.: "2-(Azidomethyl)benzoyl as a new protecting group in nucleosides", 《TETRAHEDRON LETTERS》, vol. 42, 30 December 2001 (2001-12-30), pages 1069 - 1072, XP085040739, DOI: 10.1016/S0040-4039(00)02183-3 *
赵兴绪编著: "《转基因食品生物技术及其安全评价》", 30 July 2009, 北京：中国轻工业出版社, pages: 69 *

Also Published As

Publication number Publication date
KR20220161436A (ko) 2022-12-06
AU2021247043A1 (en) 2022-10-27
US12649761B2 (en) 2026-06-09
MX2022012255A (es) 2023-01-11
EP4126894A1 (en) 2023-02-08
IL296862A (en) 2022-11-01
CA3178892A1 (en) 2021-10-07
BR112022019752A2 (pt) 2022-11-16
JP2023520201A (ja) 2023-05-16
US20240092821A1 (en) 2024-03-21
WO2021198883A1 (en) 2021-10-07

Similar Documents

Publication Publication Date Title
JP2023520201A (ja) オリゴヌクレオチド及び関連化合物の合成
RU2572826C2 (ru) Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
AU2026202225A1 (en) Technologies useful for oligonucleotide preparation
CN102766630B (zh) 6-修饰的双环核酸类似物
Langkjær et al. UNA (unlocked nucleic acid): a flexible RNA mimic that allows engineering of nucleic acid duplex stability
JP5677716B2 (ja) オリゴヌクレオチド類似体を含むキット及び方法並びにオリゴヌクレオチド類似体の使用
CA2368135C (en) Xylo-lna analogues
CN102180924A (zh) L-核糖-lna类似物
KR102190852B1 (ko) 변형된 커플링 프로토콜을 이용하는 올리고머 화합물의 제조 방법
KR20190065341A (ko) 올리고머 화합물들의 접합 방법
WO2018156056A1 (ru) Модифицированные олигонуклеотиды, активирующие рнказу н
JP7640461B2 (ja) 核酸オリゴマーの製造方法
US10634679B2 (en) Compounds and methods for the synthesis of 5-(N-protected-tryptaminocarboxyamide)-2′-deoxyuridine phosphoramidite for incorporation into a nucleic acid
JP7719788B2 (ja) 核酸オリゴマーの製造方法
US20200317685A1 (en) Photoresponsive nucleotide analog capable of photocrosslinking in visible light region
CN110914278B (zh) 在可见光区能进行光交联的光响应性核苷酸类似物
Pfundheller et al. Locked nucleic acid synthesis
JPH11506107A (ja) 求核試薬および一酸化炭素を用いるパラジウム触媒ヌクレオシド修飾方法
BR112021016460A2 (pt) Oligonucleotídeo gapmer antissenso de fita simples, sal farmaceuticamente aceitável de um oligonucleotídeo, conjugado, composição farmacêutica e invenção
Parel et al. Synthesis and Pairing Properties of Oligodeoxynucleotides Containing N7‐(Purin‐2‐amine Deoxynucleosides)
WO2004048376A1 (ja) 二環性ナフチリジンヌクレオシド
RU2258708C2 (ru) Аналоги l-рибо-знк
TW202542308A (zh) 用於增加蛋白質表現之經修飾rna
BR112021018492B1 (pt) Método para preparar um oligonucleotídeo e oligonucleotídeo
WO2005085270A1 (ja) ピリジン環５位にピロリル基を導入した核酸誘導体

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20230324

WD01 Invention patent application deemed withdrawn after publication