MX2022012255A - Sintesis de oligonucleotidos y compuestos relacionados. - Google Patents
Sintesis de oligonucleotidos y compuestos relacionados.Info
- Publication number
- MX2022012255A MX2022012255A MX2022012255A MX2022012255A MX2022012255A MX 2022012255 A MX2022012255 A MX 2022012255A MX 2022012255 A MX2022012255 A MX 2022012255A MX 2022012255 A MX2022012255 A MX 2022012255A MX 2022012255 A MX2022012255 A MX 2022012255A
- Authority
- MX
- Mexico
- Prior art keywords
- support
- azidomethyl
- moiety
- synthesis
- oligonucleotide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063003067P | 2020-03-31 | 2020-03-31 | |
| PCT/IB2021/052595 WO2021198883A1 (en) | 2020-03-31 | 2021-03-30 | Synthesis of oligonucleotides and related compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022012255A true MX2022012255A (es) | 2023-01-11 |
Family
ID=75340013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022012255A MX2022012255A (es) | 2020-03-31 | 2021-03-30 | Sintesis de oligonucleotidos y compuestos relacionados. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12649761B2 (enExample) |
| EP (1) | EP4126894A1 (enExample) |
| JP (1) | JP2023520201A (enExample) |
| KR (1) | KR20220161436A (enExample) |
| CN (1) | CN115843299A (enExample) |
| AU (1) | AU2021247043A1 (enExample) |
| BR (1) | BR112022019752A2 (enExample) |
| CA (1) | CA3178892A1 (enExample) |
| IL (1) | IL296862A (enExample) |
| MX (1) | MX2022012255A (enExample) |
| WO (1) | WO2021198883A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12649761B2 (en) | 2020-03-31 | 2026-06-09 | Janssen Biopharma, Inc. | Synthesis of oligonucleotides and related compounds |
| CN116888136A (zh) | 2021-02-12 | 2023-10-13 | 味之素株式会社 | 寡核苷酸的制备方法 |
| EP4601656A1 (en) * | 2022-10-12 | 2025-08-20 | Pharmorage Pty Limited | Modified oligonucleotides |
| EP4755898A1 (en) | 2023-08-02 | 2026-06-10 | Nitto Denko Corporation | Method for producing oligonucleotide |
| WO2025235761A1 (en) * | 2024-05-09 | 2025-11-13 | Biogen Ma Inc. | Reagents and processes for preparing oligonucleotides |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992001704A1 (en) | 1990-07-26 | 1992-02-06 | Koichi Shudo | Oligodeoxyribonucleotides |
| US6972330B2 (en) * | 1996-02-13 | 2005-12-06 | Sirna Therapeutics, Inc. | Chemical synthesis of methoxy nucleosides |
| US5753789A (en) | 1996-07-26 | 1998-05-19 | Yale University | Oligonucleotides containing L-nucleosides |
| ES2192672T3 (es) | 1996-11-18 | 2003-10-16 | Takeshi Imanishi | Nuevos analogos de nucleotidos. |
| US6770748B2 (en) | 1997-03-07 | 2004-08-03 | Takeshi Imanishi | Bicyclonucleoside and oligonucleotide analogue |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| US6251666B1 (en) | 1997-03-31 | 2001-06-26 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid catalysts comprising L-nucleotide analogs |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| EP1015469B2 (en) | 1997-09-12 | 2015-11-18 | Exiqon A/S | Bi- and tri-cyclic nucleoside, nucleotide and oligonucleoide analogues |
| BRPI0008131B8 (pt) | 1999-02-12 | 2021-05-25 | Daiichi Sankyo Co Ltd | composto ou um sal deste, análogo de oligonucleotídeo, composição farmacêutica, sonda para um gene,iniciador para começar a amplificação, uso de um análogo de oligonucleotídeo ou de um sal deste farmacologicamente aceitável, agente antisentido, e, agente antígeno |
| JP2000247940A (ja) * | 1999-02-26 | 2000-09-12 | Sankyo Co Ltd | 新規ベンジルアジド化合物 |
| US7084125B2 (en) | 1999-03-18 | 2006-08-01 | Exiqon A/S | Xylo-LNA analogues |
| ATE356824T1 (de) | 1999-05-04 | 2007-04-15 | Santaris Pharma As | L-ribo-lna analoge |
| US6525191B1 (en) | 1999-05-11 | 2003-02-25 | Kanda S. Ramasamy | Conformationally constrained L-nucleosides |
| JP4151751B2 (ja) | 1999-07-22 | 2008-09-17 | 第一三共株式会社 | 新規ビシクロヌクレオシド類縁体 |
| US7569575B2 (en) | 2002-05-08 | 2009-08-04 | Santaris Pharma A/S | Synthesis of locked nucleic acid derivatives |
| CA2504694C (en) | 2002-11-05 | 2013-10-01 | Isis Pharmaceuticals, Inc. | Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation |
| CN101684136A (zh) * | 2008-09-23 | 2010-03-31 | 苏州瑞博生物技术有限公司 | 一种寡核苷酸的制备方法 |
| WO2013179412A1 (ja) | 2012-05-30 | 2013-12-05 | 北海道システム・サイエンス株式会社 | 高分散性液相支持体を用いたオリゴヌクレオチド合成法 |
| US10214555B2 (en) | 2012-11-14 | 2019-02-26 | Takeda Pharmaceutical Company Limitjed | Method for liquid-phase synthesis of nucleic acid |
| EP3398955B1 (en) | 2015-12-16 | 2026-06-03 | Ajinomoto Co., Inc. | Oligonucleotide production method, and nucleoside, nucleotide, or oligonucleotide |
| JPWO2017111137A1 (ja) | 2015-12-22 | 2018-10-18 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| JP7306263B2 (ja) | 2017-05-02 | 2023-07-11 | 日産化学株式会社 | オリゴヌクレオチドの製造方法 |
| US12649761B2 (en) | 2020-03-31 | 2026-06-09 | Janssen Biopharma, Inc. | Synthesis of oligonucleotides and related compounds |
-
2021
- 2021-03-30 US US17/916,064 patent/US12649761B2/en active Active
- 2021-03-30 CN CN202180039628.0A patent/CN115843299A/zh active Pending
- 2021-03-30 KR KR1020227037806A patent/KR20220161436A/ko active Pending
- 2021-03-30 BR BR112022019752A patent/BR112022019752A2/pt not_active IP Right Cessation
- 2021-03-30 CA CA3178892A patent/CA3178892A1/en active Pending
- 2021-03-30 WO PCT/IB2021/052595 patent/WO2021198883A1/en not_active Ceased
- 2021-03-30 MX MX2022012255A patent/MX2022012255A/es unknown
- 2021-03-30 IL IL296862A patent/IL296862A/en unknown
- 2021-03-30 EP EP21715980.5A patent/EP4126894A1/en active Pending
- 2021-03-30 JP JP2022559478A patent/JP2023520201A/ja active Pending
- 2021-03-30 AU AU2021247043A patent/AU2021247043A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20220161436A (ko) | 2022-12-06 |
| AU2021247043A1 (en) | 2022-10-27 |
| US12649761B2 (en) | 2026-06-09 |
| CN115843299A (zh) | 2023-03-24 |
| EP4126894A1 (en) | 2023-02-08 |
| IL296862A (en) | 2022-11-01 |
| CA3178892A1 (en) | 2021-10-07 |
| BR112022019752A2 (pt) | 2022-11-16 |
| JP2023520201A (ja) | 2023-05-16 |
| US20240092821A1 (en) | 2024-03-21 |
| WO2021198883A1 (en) | 2021-10-07 |
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