AU2021247043A1 - Synthesis of oligonucleotides and related compounds - Google Patents

Synthesis of oligonucleotides and related compounds Download PDF

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Publication number
AU2021247043A1
AU2021247043A1 AU2021247043A AU2021247043A AU2021247043A1 AU 2021247043 A1 AU2021247043 A1 AU 2021247043A1 AU 2021247043 A AU2021247043 A AU 2021247043A AU 2021247043 A AU2021247043 A AU 2021247043A AU 2021247043 A1 AU2021247043 A1 AU 2021247043A1
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AU
Australia
Prior art keywords
compound
optionally substituted
group
moiety
independently selected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2021247043A
Other languages
English (en)
Inventor
Dinesh Gala
Yi Jin
Marija Prhavc
Minghong Zhong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Biopharma Inc
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Janssen Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biopharma Inc filed Critical Janssen Biopharma Inc
Publication of AU2021247043A1 publication Critical patent/AU2021247043A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
AU2021247043A 2020-03-31 2021-03-30 Synthesis of oligonucleotides and related compounds Abandoned AU2021247043A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063003067P 2020-03-31 2020-03-31
US63/003,067 2020-03-31
PCT/IB2021/052595 WO2021198883A1 (en) 2020-03-31 2021-03-30 Synthesis of oligonucleotides and related compounds

Publications (1)

Publication Number Publication Date
AU2021247043A1 true AU2021247043A1 (en) 2022-10-27

Family

ID=75340013

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021247043A Abandoned AU2021247043A1 (en) 2020-03-31 2021-03-30 Synthesis of oligonucleotides and related compounds

Country Status (11)

Country Link
US (1) US12649761B2 (enExample)
EP (1) EP4126894A1 (enExample)
JP (1) JP2023520201A (enExample)
KR (1) KR20220161436A (enExample)
CN (1) CN115843299A (enExample)
AU (1) AU2021247043A1 (enExample)
BR (1) BR112022019752A2 (enExample)
CA (1) CA3178892A1 (enExample)
IL (1) IL296862A (enExample)
MX (1) MX2022012255A (enExample)
WO (1) WO2021198883A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12649761B2 (en) 2020-03-31 2026-06-09 Janssen Biopharma, Inc. Synthesis of oligonucleotides and related compounds
CN116888136A (zh) 2021-02-12 2023-10-13 味之素株式会社 寡核苷酸的制备方法
EP4601656A1 (en) * 2022-10-12 2025-08-20 Pharmorage Pty Limited Modified oligonucleotides
EP4755898A1 (en) 2023-08-02 2026-06-10 Nitto Denko Corporation Method for producing oligonucleotide
WO2025235761A1 (en) * 2024-05-09 2025-11-13 Biogen Ma Inc. Reagents and processes for preparing oligonucleotides

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001704A1 (en) 1990-07-26 1992-02-06 Koichi Shudo Oligodeoxyribonucleotides
US6972330B2 (en) * 1996-02-13 2005-12-06 Sirna Therapeutics, Inc. Chemical synthesis of methoxy nucleosides
US5753789A (en) 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
ES2192672T3 (es) 1996-11-18 2003-10-16 Takeshi Imanishi Nuevos analogos de nucleotidos.
US6770748B2 (en) 1997-03-07 2004-08-03 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogue
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6251666B1 (en) 1997-03-31 2001-06-26 Ribozyme Pharmaceuticals, Inc. Nucleic acid catalysts comprising L-nucleotide analogs
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
EP1015469B2 (en) 1997-09-12 2015-11-18 Exiqon A/S Bi- and tri-cyclic nucleoside, nucleotide and oligonucleoide analogues
BRPI0008131B8 (pt) 1999-02-12 2021-05-25 Daiichi Sankyo Co Ltd composto ou um sal deste, análogo de oligonucleotídeo, composição farmacêutica, sonda para um gene,iniciador para começar a amplificação, uso de um análogo de oligonucleotídeo ou de um sal deste farmacologicamente aceitável, agente antisentido, e, agente antígeno
JP2000247940A (ja) * 1999-02-26 2000-09-12 Sankyo Co Ltd 新規ベンジルアジド化合物
US7084125B2 (en) 1999-03-18 2006-08-01 Exiqon A/S Xylo-LNA analogues
ATE356824T1 (de) 1999-05-04 2007-04-15 Santaris Pharma As L-ribo-lna analoge
US6525191B1 (en) 1999-05-11 2003-02-25 Kanda S. Ramasamy Conformationally constrained L-nucleosides
JP4151751B2 (ja) 1999-07-22 2008-09-17 第一三共株式会社 新規ビシクロヌクレオシド類縁体
US7569575B2 (en) 2002-05-08 2009-08-04 Santaris Pharma A/S Synthesis of locked nucleic acid derivatives
CA2504694C (en) 2002-11-05 2013-10-01 Isis Pharmaceuticals, Inc. Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
CN101684136A (zh) * 2008-09-23 2010-03-31 苏州瑞博生物技术有限公司 一种寡核苷酸的制备方法
WO2013179412A1 (ja) 2012-05-30 2013-12-05 北海道システム・サイエンス株式会社 高分散性液相支持体を用いたオリゴヌクレオチド合成法
US10214555B2 (en) 2012-11-14 2019-02-26 Takeda Pharmaceutical Company Limitjed Method for liquid-phase synthesis of nucleic acid
EP3398955B1 (en) 2015-12-16 2026-06-03 Ajinomoto Co., Inc. Oligonucleotide production method, and nucleoside, nucleotide, or oligonucleotide
JPWO2017111137A1 (ja) 2015-12-22 2018-10-18 味の素株式会社 オリゴヌクレオチドの製造方法
JP7306263B2 (ja) 2017-05-02 2023-07-11 日産化学株式会社 オリゴヌクレオチドの製造方法
US12649761B2 (en) 2020-03-31 2026-06-09 Janssen Biopharma, Inc. Synthesis of oligonucleotides and related compounds

Also Published As

Publication number Publication date
KR20220161436A (ko) 2022-12-06
US12649761B2 (en) 2026-06-09
MX2022012255A (es) 2023-01-11
CN115843299A (zh) 2023-03-24
EP4126894A1 (en) 2023-02-08
IL296862A (en) 2022-11-01
CA3178892A1 (en) 2021-10-07
BR112022019752A2 (pt) 2022-11-16
JP2023520201A (ja) 2023-05-16
US20240092821A1 (en) 2024-03-21
WO2021198883A1 (en) 2021-10-07

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Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period