JP2023519925A - フォルスコリン誘導性プロモーター及び低酸素誘導性プロモーター - Google Patents

フォルスコリン誘導性プロモーター及び低酸素誘導性プロモーター Download PDF

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JP2023519925A
JP2023519925A JP2022558590A JP2022558590A JP2023519925A JP 2023519925 A JP2023519925 A JP 2023519925A JP 2022558590 A JP2022558590 A JP 2022558590A JP 2022558590 A JP2022558590 A JP 2022558590A JP 2023519925 A JP2023519925 A JP 2023519925A
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sequence
campre
cells
vector
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JP2023519925A5 (enExample
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グラハム・ホワイトサイド
ヴィクトリア・フィオナ・トーランス
マイケル・エル・ロバーツ
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アスクレピオス バイオファーマシューティカル， インコーポレイテッド
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Priority claimed from GBGB2005473.0A external-priority patent/GB202005473D0/en
Priority claimed from GBGB2005475.5A external-priority patent/GB202005475D0/en
Priority claimed from GBGB2101969.0A external-priority patent/GB202101969D0/en
Priority claimed from GBGB2101972.4A external-priority patent/GB202101972D0/en
Application filed by アスクレピオス バイオファーマシューティカル， インコーポレイテッド filed Critical アスクレピオス バイオファーマシューティカル， インコーポレイテッド
Publication of JP2023519925A publication Critical patent/JP2023519925A/ja
Publication of JP2023519925A5 publication Critical patent/JP2023519925A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor

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  • Health & Medical Sciences (AREA)
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  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2022558590A 2020-03-26 2021-03-26 フォルスコリン誘導性プロモーター及び低酸素誘導性プロモーター Pending JP2023519925A (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US202063000155P 2020-03-26 2020-03-26
US63/000,155 2020-03-26
US202063010330P 2020-04-15 2020-04-15
GB2005475.5 2020-04-15
GBGB2005473.0A GB202005473D0 (en) 2020-04-15 2020-04-15 Forskolin-inducible promoters
GBGB2005475.5A GB202005475D0 (en) 2020-04-15 2020-04-15 Hypoxia-inducible promoters
GB2005473.0 2020-04-15
US63/010,330 2020-04-15
GB2101972.4 2021-02-12
GBGB2101969.0A GB202101969D0 (en) 2021-02-12 2021-02-12 Hypoxia inducible promoters
GBGB2101972.4A GB202101972D0 (en) 2021-02-12 2021-02-12 Forskolin inducible promoters
GB2101969.0 2021-02-12
PCT/GB2021/050743 WO2021191628A1 (en) 2020-03-26 2021-03-26 Forskolin-inducible promoters and hypoxia-inducible promoters

Publications (2)

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JP2023519925A true JP2023519925A (ja) 2023-05-15
JP2023519925A5 JP2023519925A5 (enExample) 2024-03-22

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US (1) US20230374526A1 (enExample)
EP (1) EP4127180A1 (enExample)
JP (1) JP2023519925A (enExample)
CN (1) CN115698300A (enExample)
AU (1) AU2021240417A1 (enExample)
CA (1) CA3171636A1 (enExample)
WO (1) WO2021191628A1 (enExample)

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WO2025015211A1 (en) * 2023-07-12 2025-01-16 Georgia Tech Research Corporation Synthetic genetic constructs that induce gene expression in response to tumor-specific metabolic alterations
WO2025090555A1 (en) * 2023-10-23 2025-05-01 University Of Southern California Ultrasound-controlled car t with sensitive evolved promoter and feedback integration and uses thereof

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US20060127371A1 (en) * 2002-11-25 2006-06-15 Peppelenbosch Maikel P ASB transcription repressor proteins and nucleic acids and their application in expansion of stem cells
US20100273865A1 (en) * 2007-11-02 2010-10-28 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg Polypeptides involved in neuronal regeneration-associated gene expression
US20110065100A1 (en) * 2009-09-16 2011-03-17 SwitchGear Genomics, Inc., a Delaware Corporation Transcription biomarkers of biological responses and methods

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MY172311A (en) * 2012-08-02 2019-11-21 Univ Putra Malaysia Hypoxia inducible factor (hif) activity reporter cell line
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WO2003038118A1 (fr) * 2001-10-31 2003-05-08 Fujisawa Pharmaceutical Co., Ltd. Methode d'evaluation d'inhibiteurs de la phosphatase
US20060127371A1 (en) * 2002-11-25 2006-06-15 Peppelenbosch Maikel P ASB transcription repressor proteins and nucleic acids and their application in expansion of stem cells
US20100273865A1 (en) * 2007-11-02 2010-10-28 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg Polypeptides involved in neuronal regeneration-associated gene expression
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CA3171636A1 (en) 2021-09-30
EP4127180A1 (en) 2023-02-08
CN115698300A (zh) 2023-02-03
WO2021191628A1 (en) 2021-09-30
AU2021240417A1 (en) 2022-10-20
US20230374526A1 (en) 2023-11-23

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