JP2023515664A5 - - Google Patents
Info
- Publication number
- JP2023515664A5 JP2023515664A5 JP2022552538A JP2022552538A JP2023515664A5 JP 2023515664 A5 JP2023515664 A5 JP 2023515664A5 JP 2022552538 A JP2022552538 A JP 2022552538A JP 2022552538 A JP2022552538 A JP 2022552538A JP 2023515664 A5 JP2023515664 A5 JP 2023515664A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleotides
- double
- nucleotide sequence
- seq
- stranded
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062986150P | 2020-03-06 | 2020-03-06 | |
| US62/986,150 | 2020-03-06 | ||
| US202063109196P | 2020-11-03 | 2020-11-03 | |
| US63/109,196 | 2020-11-03 | ||
| PCT/US2021/021199 WO2021178885A1 (en) | 2020-03-06 | 2021-03-05 | Modified short interfering nucleic acid (sina) molecules and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023515664A JP2023515664A (ja) | 2023-04-13 |
| JP2023515664A5 true JP2023515664A5 (OSRAM) | 2024-03-14 |
Family
ID=75278356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022552538A Pending JP2023515664A (ja) | 2020-03-06 | 2021-03-05 | 修飾された短い干渉核酸（ｓｉＮＡ）分子およびそれらの使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US20220364096A1 (OSRAM) |
| EP (1) | EP4121533A1 (OSRAM) |
| JP (1) | JP2023515664A (OSRAM) |
| KR (1) | KR20220163960A (OSRAM) |
| CN (1) | CN115485384A (OSRAM) |
| AU (1) | AU2021230601A1 (OSRAM) |
| BR (1) | BR112022017287A2 (OSRAM) |
| CA (1) | CA3170466A1 (OSRAM) |
| CL (1) | CL2022002379A1 (OSRAM) |
| CO (1) | CO2022014258A2 (OSRAM) |
| GE (2) | GEP20257742B (OSRAM) |
| IL (1) | IL296045A (OSRAM) |
| MX (1) | MX2022011012A (OSRAM) |
| PE (1) | PE20221578A1 (OSRAM) |
| PH (1) | PH12022552163A1 (OSRAM) |
| TW (1) | TW202208625A (OSRAM) |
| WO (1) | WO2021178885A1 (OSRAM) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202002149XA (en) * | 2017-09-14 | 2020-04-29 | Janssen Biopharma Inc | Galnac derivatives |
| GEP20257742B (en) * | 2020-03-06 | 2025-03-10 | Aligos Therapeutics Inc | Modified short interfering nucleic acid (sina) molecules and uses thereof |
| CA3197470A1 (en) | 2020-10-21 | 2022-04-28 | Aligos Therapeutics, Inc. | Bicyclic compounds |
| WO2022184852A1 (en) * | 2021-03-03 | 2022-09-09 | Silence Therapeutics Gmbh | Conjugated nucleic acids comprising a phosphorodithioate for inhibiting gene expression in a cell |
| US11957683B2 (en) | 2021-06-18 | 2024-04-16 | Aligos Therapeutics, Inc. | Bicyclic compounds |
| WO2023088227A1 (zh) | 2021-11-16 | 2023-05-25 | 上海舶望制药有限公司 | 抑制血管紧张素原(agt)蛋白表达的组合物和方法 |
| WO2023122317A2 (en) * | 2021-12-23 | 2023-06-29 | Aligos Therapeutics, Inc. | SHORT INTERFERING NUCLEIC ACID (SINA) MOLECULES FOR TARGETING β-CATENIN AND USES THEREOF |
| US20230399645A1 (en) * | 2022-05-16 | 2023-12-14 | University Of Massachusetts | Optimized sirna scaffolds |
| EP4541804A1 (en) * | 2022-06-14 | 2025-04-23 | Rona Bioscience, Limited | Cyclic phosphonate-modified nucleotide |
| WO2024033374A1 (en) | 2022-08-11 | 2024-02-15 | Syngenta Crop Protection Ag | Novel arylcarboxamide or arylthioamide compounds |
| WO2024089216A1 (en) | 2022-10-27 | 2024-05-02 | Syngenta Crop Protection Ag | Novel sulfur-containing heteroaryl carboxamide compounds |
| EP4634152A1 (en) | 2022-12-15 | 2025-10-22 | Syngenta Crop Protection AG | Novel bicyclic-carboxamide compounds useful as pesticides |
| AR131541A1 (es) | 2023-01-07 | 2025-04-09 | Syngenta Crop Protection Ag | Compuestos de carboxamida novedosos |
| AU2024212652A1 (en) * | 2023-01-26 | 2025-07-10 | Aligos Therapeutics, Inc. | Hepatitis b combination therapies |
| WO2024173593A1 (en) * | 2023-02-14 | 2024-08-22 | Basecure Therapeutics | Modified double stranded rna agents |
| WO2024254091A1 (en) * | 2023-06-05 | 2024-12-12 | Empirico Inc. | Treatment of fgg related diseases and disorders |
| WO2025032129A1 (en) | 2023-08-08 | 2025-02-13 | Syngenta Crop Protection Ag | Novel aminoindane and aminotetraline compounds |
| CN117024485B (zh) * | 2023-08-11 | 2026-02-13 | 江苏申基生物科技有限公司 | 一种2’-OMe腺苷的合成方法 |
| IL327476A (en) * | 2023-11-03 | 2026-05-01 | Basecure Therapeutics Llc | Modified oligonucleotides and methods for using them |
| WO2025104032A1 (en) | 2023-11-14 | 2025-05-22 | Syngenta Crop Protection Ag | Novel carboxamide compounds |
| WO2025109114A1 (en) | 2023-11-24 | 2025-05-30 | Syngenta Crop Protection Ag | Novel carboxamide compounds |
| CN117534717A (zh) * | 2024-01-09 | 2024-02-09 | 凯莱英生命科学技术(天津)有限公司 | 5′-(e)-乙烯基磷酸酯的合成方法 |
| PY2501648A (es) | 2024-01-12 | 2025-10-31 | Syngenta Crop Protection Ag | Nuevos compuestos de carboxamida |
| WO2025149637A1 (en) | 2024-01-12 | 2025-07-17 | Syngenta Crop Protection Ag | Novel carboxamide compounds |
| WO2025201529A1 (en) * | 2024-03-29 | 2025-10-02 | Ractigen Therapeutics | Compounds for synthesizing modified small activating rna molecules, modified small activating rna molecules and uses thereof |
| WO2025240506A1 (en) | 2024-05-14 | 2025-11-20 | Aligos Therapeutics, Inc. | Modified antisense oligonucleotides for treating hepatitis b virus |
| WO2025242321A1 (en) | 2024-05-24 | 2025-11-27 | Glaxosmithkline Intellectual Property (No.3) Limited | Novel use |
| WO2026008750A1 (en) | 2024-07-05 | 2026-01-08 | Syngenta Crop Protection Ag | Novel carboxamide compounds |
| CN120796266A (zh) * | 2024-07-08 | 2025-10-17 | 北京悦康科创医药科技股份有限公司 | 一种降低hbv基因表达的反义寡核苷酸及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009002944A1 (en) * | 2007-06-22 | 2008-12-31 | Isis Pharmaceuticals, Inc. | Double strand compositions comprising differentially modified strands for use in gene modulation |
| EP2437752A2 (en) * | 2009-06-03 | 2012-04-11 | Dicerna Pharmaceuticals, Inc. | Peptide dicer substrate agents and methods for their specific inhibition of gene expression |
| EP2601204B1 (en) | 2010-04-28 | 2016-09-07 | Ionis Pharmaceuticals, Inc. | Modified nucleosides and oligomeric compounds prepared therefrom |
| JP6165723B2 (ja) * | 2011-06-30 | 2017-07-19 | アローヘッド ファーマシューティカルズ インコーポレイテッド | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
| IL303831A (en) * | 2011-11-18 | 2023-08-01 | Alnylam Pharmaceuticals Inc | Adapted RNAI factors |
| CA2939822C (en) * | 2014-02-18 | 2018-09-25 | Osaka University | Crosslinked nucleoside and nucleotide |
| KR20180038465A (ko) * | 2015-08-07 | 2018-04-16 | 애로우헤드 파마슈티컬스 인코포레이티드 | Ｂ형 간염 바이러스 감염에 대한 ｒｎａｉ 치료법 |
| SG11201804729RA (en) * | 2015-12-07 | 2018-07-30 | Genzyme Corp | Methods and compositions for treating a serpinc1-associated disorder |
| JP2018536689A (ja) * | 2015-12-10 | 2018-12-13 | アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ステロール調節エレメント結合タンパク質（ＳＲＥＢＰ）シャペロン（ＳＣＡＰ）ｉＲＮＡ組成物およびその使用方法 |
| JP6989521B2 (ja) | 2016-09-02 | 2022-01-05 | アローヘッド ファーマシューティカルズ インコーポレイテッド | 標的化リガンド |
| WO2018045317A1 (en) | 2016-09-02 | 2018-03-08 | Dicerna Pharmaceuticals, Inc. | 4'-phosphate analogs and oligonucleotides comprising the same |
| RS63836B1 (sr) * | 2017-04-05 | 2023-01-31 | Silence Therapeutics Gmbh | Proizvodi i sastavi |
| CN110997919B (zh) * | 2017-12-01 | 2024-04-02 | 苏州瑞博生物技术股份有限公司 | 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途 |
| CN118638788A (zh) * | 2017-12-06 | 2024-09-13 | 艾维迪提生物科学公司 | 治疗肌萎缩和强直性肌营养不良的组合物和方法 |
| EP3790970A1 (en) * | 2018-05-07 | 2021-03-17 | Alnylam Pharmaceuticals Inc. | Extrahepatic delivery |
| WO2019217397A2 (en) * | 2018-05-07 | 2019-11-14 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for improving strand biased |
| MX2021005357A (es) | 2018-11-08 | 2021-06-30 | Aligos Therapeutics Inc | Polimeros oligonucleotidos que inhiben el transporte de antigeno s y metodos. |
| GEP20257742B (en) * | 2020-03-06 | 2025-03-10 | Aligos Therapeutics Inc | Modified short interfering nucleic acid (sina) molecules and uses thereof |
-
2021
- 2021-03-05 GE GEAP202116053A patent/GEP20257742B/en unknown
- 2021-03-05 EP EP21715377.4A patent/EP4121533A1/en active Pending
- 2021-03-05 US US17/194,079 patent/US20220364096A1/en active Pending
- 2021-03-05 GE GEAP202416053A patent/GEAP202416053A/en unknown
- 2021-03-05 TW TW110108015A patent/TW202208625A/zh unknown
- 2021-03-05 AU AU2021230601A patent/AU2021230601A1/en active Pending
- 2021-03-05 IL IL296045A patent/IL296045A/en unknown
- 2021-03-05 BR BR112022017287A patent/BR112022017287A2/pt unknown
- 2021-03-05 PH PH1/2022/552163A patent/PH12022552163A1/en unknown
- 2021-03-05 CN CN202180032666.3A patent/CN115485384A/zh active Pending
- 2021-03-05 JP JP2022552538A patent/JP2023515664A/ja active Pending
- 2021-03-05 MX MX2022011012A patent/MX2022011012A/es unknown
- 2021-03-05 KR KR1020227034100A patent/KR20220163960A/ko active Pending
- 2021-03-05 CA CA3170466A patent/CA3170466A1/en active Pending
- 2021-03-05 PE PE2022001900A patent/PE20221578A1/es unknown
- 2021-03-05 WO PCT/US2021/021199 patent/WO2021178885A1/en not_active Ceased
-
2022
- 2022-02-15 US US17/672,268 patent/US11549110B2/en active Active
- 2022-09-01 CL CL2022002379A patent/CL2022002379A1/es unknown
- 2022-10-05 CO CONC2022/0014258A patent/CO2022014258A2/es unknown
- 2022-11-29 US US18/059,561 patent/US20230332153A1/en active Pending
-
2023
- 2023-07-28 US US18/361,363 patent/US12129469B2/en active Active
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