JP2023512833A - 新型コロナウイルス感染症に対するmRNAワクチンの組成物及び方法 - Google Patents

新型コロナウイルス感染症に対するmRNAワクチンの組成物及び方法 Download PDF

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JP2023512833A
JP2023512833A JP2022548143A JP2022548143A JP2023512833A JP 2023512833 A JP2023512833 A JP 2023512833A JP 2022548143 A JP2022548143 A JP 2022548143A JP 2022548143 A JP2022548143 A JP 2022548143A JP 2023512833 A JP2023512833 A JP 2023512833A
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タン、ションカオ
シェン、トン
ルー、チュン
ホー、ツーヤン
ホー、チアシー
ルー、パトリック、ワイ.
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RNAimmune Inc
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JP2022548143A 2020-02-07 2021-02-08 新型コロナウイルス感染症に対するmRNAワクチンの組成物及び方法 Pending JP2023512833A (ja)

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US202062971834P 2020-02-07 2020-02-07
US62/971,834 2020-02-07
US202063058463P 2020-07-29 2020-07-29
US63/058,463 2020-07-29
US202063130581P 2020-12-24 2020-12-24
US63/130,581 2020-12-24
PCT/US2021/017149 WO2021159118A2 (en) 2020-02-07 2021-02-08 Composition and method of mrna vaccines against novel coronavirus infection

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JP2023512833A true JP2023512833A (ja) 2023-03-29
JP2023512833A5 JP2023512833A5 (https=) 2024-02-19

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US (2) US12029786B2 (https=)
EP (1) EP4100066A4 (https=)
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KR (1) KR20220143684A (https=)
CN (1) CN115297892A (https=)
AU (1) AU2021216443A1 (https=)
BR (1) BR112022015626A2 (https=)
CA (1) CA3167257A1 (https=)
IL (1) IL295360A (https=)
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Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12029786B2 (en) 2020-02-07 2024-07-09 RNAimmune, Inc. Composition and method of mRNA vaccines against novel coronavirus infection
WO2021160887A1 (en) * 2020-02-14 2021-08-19 Immunor As Corona virus vaccine
JPWO2021181994A1 (https=) * 2020-03-10 2021-09-16
US20230313323A1 (en) * 2020-03-26 2023-10-05 Ionian Technologies, Llc Assays for detecting coronavirus disease 2019 (covid-19)
IL297419B2 (en) 2020-04-22 2025-02-01 BioNTech SE Coronavirus vaccine
WO2021229270A1 (es) 2020-05-13 2021-11-18 Laboratorio Avi-Mex, S.A. De C.V. Vacuna recombinante contra covid-19 en vector viral
EP4334479A4 (en) * 2021-05-06 2025-02-19 Lu, Shi-Long DETECTION OF VIRAL VARIANTS
JP2024530672A (ja) 2021-08-11 2024-08-23 アールエヌエーイミューン、インコーポレイテッド 新規なコロナウイルス感染症に対するmRNAワクチンの組成物および方法
WO2023020939A1 (en) * 2021-08-17 2023-02-23 Janssen Pharmaceuticals, Inc. Sars-cov-2 vaccines
CN118475371A (zh) * 2021-09-22 2024-08-09 圣诺制药公司 基于组氨酸-赖氨酸共聚物形成的改善的纳米颗粒制剂
WO2023049814A2 (en) * 2021-09-22 2023-03-30 Sirnaomics, Inc. Nanoparticle pharmaceutical compositions with reduced nanoparticle size and improved polydispersity index
CN113881806A (zh) * 2021-09-23 2022-01-04 华南理工大学 基于CRISPR/Cas12a技术检测新冠病毒和69/70突变株的方法及试剂盒
EP4183409A1 (en) * 2021-11-17 2023-05-24 Charité - Universitätsmedizin Berlin Vaccine with improved immunogenicity against mutant coronaviruses
WO2023091766A2 (en) * 2021-11-19 2023-05-25 RNAimmune, Inc. Compositions and methods of ribonucleic acid respiratory syncytial virus (rsv) vaccines
AU2022398292A1 (en) * 2021-11-29 2024-06-13 BioNTech SE Coronavirus vaccine
US12186387B2 (en) 2021-11-29 2025-01-07 BioNTech SE Coronavirus vaccine
CN118556131A (zh) 2022-01-27 2024-08-27 爱思开生物科技有限公司 用于蛋白质表达的mRNA及其模板
US20250228929A1 (en) * 2022-04-03 2025-07-17 Icahn School Of Medicine At Mount Sinai Recombinant newcastle disease viruses and immunogenic compositions for use in immunizing against sars-cov-2 omicron variant
US20240207389A1 (en) * 2022-04-27 2024-06-27 Northwestern University Methods for improving covid vaccine immunogenicity
DE102023002588A1 (de) * 2022-06-26 2024-01-25 BioNTech SE Coronavirus-Impfstoff
WO2024002985A1 (en) * 2022-06-26 2024-01-04 BioNTech SE Coronavirus vaccine
US12280104B2 (en) 2022-11-01 2025-04-22 RNAimmune, Inc. Composition and methods for MRNA vaccines against novel omicron coronavirus infections
KR102832944B1 (ko) * 2024-12-27 2025-07-15 대한민국 제2형 중증급성호흡기증후군 코로나바이러스 변이들의 공통 서열을 포함하는 코로나바이러스감염증-19 범용 백신 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004536598A (ja) * 2001-06-21 2004-12-09 エヌ.ヴイ.アントワープ イノベーティーセントラム 電気穿孔による真核細胞への線形ポリヌクレオチドの改良された形質移入
JP2009509516A (ja) * 2005-09-28 2009-03-12 ヨハネス・グーテンベルク−ウニヴェルジテート・マインツ 転写産物の安定性と転写効率の向上をもたらすrnaの修飾
JP2015513897A (ja) * 2012-03-27 2015-05-18 キュアバック ゲーエムベーハーCurevac Gmbh 人工核酸分子
US20190240317A1 (en) * 2015-10-22 2019-08-08 Modernatx, Inc. Hpiv3 rna vaccines
WO2019226940A1 (en) * 2018-05-24 2019-11-28 Sirnaomics, Inc. Composition and methods of controllable co-coupling polypeptide nanoparticle delivery system for nucleic acid therapeutics

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018115527A2 (en) 2016-12-23 2018-06-28 Curevac Ag Mers coronavirus vaccine
CN110520155A (zh) * 2017-02-28 2019-11-29 广州纳泰生物医药技术有限公司 预防和治疗寨卡病毒感染的rna药物制剂
PH12022551788A1 (en) * 2020-01-28 2024-02-26 Codagenix Inc DEOPTIMIZED SARS-CoV-2 AND METHODS AND USES THEREOF
JP2023512519A (ja) 2020-01-31 2023-03-27 ベス イスラエル ディーコネス メディカル センター インコーポレイテッド コロナウイルス感染症を予防および処置するための組成物および方法-sars-cov-2ワクチン
US12029786B2 (en) 2020-02-07 2024-07-09 RNAimmune, Inc. Composition and method of mRNA vaccines against novel coronavirus infection
GB202004974D0 (en) 2020-04-03 2020-05-20 Treos Bio Ltd Coronavirus vaccine
US20210316002A1 (en) 2020-04-14 2021-10-14 Ut-Battelle, Llc Compositions and methods for drug delivery and treating viral infections
BR112022024662A2 (pt) 2020-06-03 2023-04-04 Regeneron Pharma Métodos para tratamento ou prevenção de infecções por sars-cov-2 e covid-19 com anticorpos de glicoproteína spike anti-sars-cov-2
EP4204015A4 (en) 2020-08-31 2025-01-01 The Board of Trustees of the Leland Stanford Junior University Systems and methods for producing rna constructs with increased translation and stability
US20250213679A1 (en) 2020-10-02 2025-07-03 Celsion Corporation Polynucleotide vaccines and methods of using the same
CN115160413B (zh) 2021-04-06 2023-11-14 清华大学 一种新型冠状病毒疫苗

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004536598A (ja) * 2001-06-21 2004-12-09 エヌ.ヴイ.アントワープ イノベーティーセントラム 電気穿孔による真核細胞への線形ポリヌクレオチドの改良された形質移入
JP2009509516A (ja) * 2005-09-28 2009-03-12 ヨハネス・グーテンベルク−ウニヴェルジテート・マインツ 転写産物の安定性と転写効率の向上をもたらすrnaの修飾
JP2015513897A (ja) * 2012-03-27 2015-05-18 キュアバック ゲーエムベーハーCurevac Gmbh 人工核酸分子
US20190240317A1 (en) * 2015-10-22 2019-08-08 Modernatx, Inc. Hpiv3 rna vaccines
WO2019226940A1 (en) * 2018-05-24 2019-11-28 Sirnaomics, Inc. Composition and methods of controllable co-coupling polypeptide nanoparticle delivery system for nucleic acid therapeutics

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LANCET, vol. 395, JPN6025003673, January 2020 (2020-01-01), pages 565 - 574, ISSN: 0005671816 *
ZHANG, YZ. ET AL.: "Definition: Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome", DATABASE DDBJ/EMBL/GENBANK [ONLINE], JPN6025003672, 14 January 2020 (2020-01-14), ISSN: 0005671815 *

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WO2021159118A3 (en) 2021-10-28
IL295360A (en) 2022-10-01
EP4100066A4 (en) 2024-05-01
KR20220143684A (ko) 2022-10-25
CA3167257A1 (en) 2021-08-12
US12029786B2 (en) 2024-07-09
WO2021159118A2 (en) 2021-08-12
MX2022009688A (es) 2022-12-15
CN115297892A (zh) 2022-11-04
US20230108926A1 (en) 2023-04-06
US20220040292A1 (en) 2022-02-10
EP4100066A2 (en) 2022-12-14
BR112022015626A2 (pt) 2022-10-11
AU2021216443A1 (en) 2022-09-08
WO2021159118A8 (en) 2022-09-22

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