CN115297892A - 抗新型冠状病毒感染的mRNA疫苗的组合物和方法 - Google Patents
抗新型冠状病毒感染的mRNA疫苗的组合物和方法 Download PDFInfo
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- CN115297892A CN115297892A CN202180024212.1A CN202180024212A CN115297892A CN 115297892 A CN115297892 A CN 115297892A CN 202180024212 A CN202180024212 A CN 202180024212A CN 115297892 A CN115297892 A CN 115297892A
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/544—Mucosal route to the airways
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20071—Demonstrated in vivo effect
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Dermatology (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062971834P | 2020-02-07 | 2020-02-07 | |
| US62/971,834 | 2020-02-07 | ||
| US202063058463P | 2020-07-29 | 2020-07-29 | |
| US63/058,463 | 2020-07-29 | ||
| US202063130581P | 2020-12-24 | 2020-12-24 | |
| US63/130,581 | 2020-12-24 | ||
| PCT/US2021/017149 WO2021159118A2 (en) | 2020-02-07 | 2021-02-08 | Composition and method of mrna vaccines against novel coronavirus infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115297892A true CN115297892A (zh) | 2022-11-04 |
Family
ID=77200778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180024212.1A Pending CN115297892A (zh) | 2020-02-07 | 2021-02-08 | 抗新型冠状病毒感染的mRNA疫苗的组合物和方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12029786B2 (https=) |
| EP (1) | EP4100066A4 (https=) |
| JP (1) | JP2023512833A (https=) |
| KR (1) | KR20220143684A (https=) |
| CN (1) | CN115297892A (https=) |
| AU (1) | AU2021216443A1 (https=) |
| BR (1) | BR112022015626A2 (https=) |
| CA (1) | CA3167257A1 (https=) |
| IL (1) | IL295360A (https=) |
| MX (1) | MX2022009688A (https=) |
| WO (1) | WO2021159118A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US12029786B2 (en) | 2020-02-07 | 2024-07-09 | RNAimmune, Inc. | Composition and method of mRNA vaccines against novel coronavirus infection |
| WO2021160887A1 (en) * | 2020-02-14 | 2021-08-19 | Immunor As | Corona virus vaccine |
| JPWO2021181994A1 (https=) * | 2020-03-10 | 2021-09-16 | ||
| US20230313323A1 (en) * | 2020-03-26 | 2023-10-05 | Ionian Technologies, Llc | Assays for detecting coronavirus disease 2019 (covid-19) |
| IL297419B2 (en) | 2020-04-22 | 2025-02-01 | BioNTech SE | Coronavirus vaccine |
| WO2021229270A1 (es) | 2020-05-13 | 2021-11-18 | Laboratorio Avi-Mex, S.A. De C.V. | Vacuna recombinante contra covid-19 en vector viral |
| EP4334479A4 (en) * | 2021-05-06 | 2025-02-19 | Lu, Shi-Long | DETECTION OF VIRAL VARIANTS |
| JP2024530672A (ja) | 2021-08-11 | 2024-08-23 | アールエヌエーイミューン、インコーポレイテッド | 新規なコロナウイルス感染症に対するmRNAワクチンの組成物および方法 |
| WO2023020939A1 (en) * | 2021-08-17 | 2023-02-23 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
| CN118475371A (zh) * | 2021-09-22 | 2024-08-09 | 圣诺制药公司 | 基于组氨酸-赖氨酸共聚物形成的改善的纳米颗粒制剂 |
| WO2023049814A2 (en) * | 2021-09-22 | 2023-03-30 | Sirnaomics, Inc. | Nanoparticle pharmaceutical compositions with reduced nanoparticle size and improved polydispersity index |
| CN113881806A (zh) * | 2021-09-23 | 2022-01-04 | 华南理工大学 | 基于CRISPR/Cas12a技术检测新冠病毒和69/70突变株的方法及试剂盒 |
| EP4183409A1 (en) * | 2021-11-17 | 2023-05-24 | Charité - Universitätsmedizin Berlin | Vaccine with improved immunogenicity against mutant coronaviruses |
| WO2023091766A2 (en) * | 2021-11-19 | 2023-05-25 | RNAimmune, Inc. | Compositions and methods of ribonucleic acid respiratory syncytial virus (rsv) vaccines |
| AU2022398292A1 (en) * | 2021-11-29 | 2024-06-13 | BioNTech SE | Coronavirus vaccine |
| US12186387B2 (en) | 2021-11-29 | 2025-01-07 | BioNTech SE | Coronavirus vaccine |
| CN118556131A (zh) | 2022-01-27 | 2024-08-27 | 爱思开生物科技有限公司 | 用于蛋白质表达的mRNA及其模板 |
| US20250228929A1 (en) * | 2022-04-03 | 2025-07-17 | Icahn School Of Medicine At Mount Sinai | Recombinant newcastle disease viruses and immunogenic compositions for use in immunizing against sars-cov-2 omicron variant |
| US20240207389A1 (en) * | 2022-04-27 | 2024-06-27 | Northwestern University | Methods for improving covid vaccine immunogenicity |
| DE102023002588A1 (de) * | 2022-06-26 | 2024-01-25 | BioNTech SE | Coronavirus-Impfstoff |
| WO2024002985A1 (en) * | 2022-06-26 | 2024-01-04 | BioNTech SE | Coronavirus vaccine |
| US12280104B2 (en) | 2022-11-01 | 2025-04-22 | RNAimmune, Inc. | Composition and methods for MRNA vaccines against novel omicron coronavirus infections |
| KR102832944B1 (ko) * | 2024-12-27 | 2025-07-15 | 대한민국 | 제2형 중증급성호흡기증후군 코로나바이러스 변이들의 공통 서열을 포함하는 코로나바이러스감염증-19 범용 백신 조성물 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190240317A1 (en) * | 2015-10-22 | 2019-08-08 | Modernatx, Inc. | Hpiv3 rna vaccines |
| US20190351048A1 (en) * | 2016-12-23 | 2019-11-21 | Curevac Ag | Mers coronavirus vaccine |
| CN110520155A (zh) * | 2017-02-28 | 2019-11-29 | 广州纳泰生物医药技术有限公司 | 预防和治疗寨卡病毒感染的rna药物制剂 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1270732A1 (en) * | 2001-06-21 | 2003-01-02 | Schuler, Gerold | Improved transfection of eukaryontic cells with linear polynucleotides by electroporation |
| DE102005046490A1 (de) * | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
| SG11201405542UA (en) * | 2012-03-27 | 2014-10-30 | Curevac Gmbh | Artificial nucleic acid molecules |
| AU2019275071B2 (en) * | 2018-05-24 | 2022-12-15 | Sirnaomics, Inc. | Composition and methods of controllable co-coupling polypeptide nanoparticle delivery system for nucleic acid therapeutics |
| PH12022551788A1 (en) * | 2020-01-28 | 2024-02-26 | Codagenix Inc | DEOPTIMIZED SARS-CoV-2 AND METHODS AND USES THEREOF |
| JP2023512519A (ja) | 2020-01-31 | 2023-03-27 | ベス イスラエル ディーコネス メディカル センター インコーポレイテッド | コロナウイルス感染症を予防および処置するための組成物および方法-sars-cov-2ワクチン |
| US12029786B2 (en) | 2020-02-07 | 2024-07-09 | RNAimmune, Inc. | Composition and method of mRNA vaccines against novel coronavirus infection |
| GB202004974D0 (en) | 2020-04-03 | 2020-05-20 | Treos Bio Ltd | Coronavirus vaccine |
| US20210316002A1 (en) | 2020-04-14 | 2021-10-14 | Ut-Battelle, Llc | Compositions and methods for drug delivery and treating viral infections |
| BR112022024662A2 (pt) | 2020-06-03 | 2023-04-04 | Regeneron Pharma | Métodos para tratamento ou prevenção de infecções por sars-cov-2 e covid-19 com anticorpos de glicoproteína spike anti-sars-cov-2 |
| EP4204015A4 (en) | 2020-08-31 | 2025-01-01 | The Board of Trustees of the Leland Stanford Junior University | Systems and methods for producing rna constructs with increased translation and stability |
| US20250213679A1 (en) | 2020-10-02 | 2025-07-03 | Celsion Corporation | Polynucleotide vaccines and methods of using the same |
| CN115160413B (zh) | 2021-04-06 | 2023-11-14 | 清华大学 | 一种新型冠状病毒疫苗 |
-
2021
- 2021-02-08 US US17/170,876 patent/US12029786B2/en active Active
- 2021-02-08 BR BR112022015626A patent/BR112022015626A2/pt not_active Application Discontinuation
- 2021-02-08 US US17/798,051 patent/US20230108926A1/en not_active Abandoned
- 2021-02-08 EP EP21750867.0A patent/EP4100066A4/en not_active Withdrawn
- 2021-02-08 CN CN202180024212.1A patent/CN115297892A/zh active Pending
- 2021-02-08 WO PCT/US2021/017149 patent/WO2021159118A2/en not_active Ceased
- 2021-02-08 IL IL295360A patent/IL295360A/en unknown
- 2021-02-08 KR KR1020227030556A patent/KR20220143684A/ko not_active Withdrawn
- 2021-02-08 CA CA3167257A patent/CA3167257A1/en active Pending
- 2021-02-08 MX MX2022009688A patent/MX2022009688A/es unknown
- 2021-02-08 JP JP2022548143A patent/JP2023512833A/ja active Pending
- 2021-02-08 AU AU2021216443A patent/AU2021216443A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190240317A1 (en) * | 2015-10-22 | 2019-08-08 | Modernatx, Inc. | Hpiv3 rna vaccines |
| US20190351048A1 (en) * | 2016-12-23 | 2019-11-21 | Curevac Ag | Mers coronavirus vaccine |
| CN110520155A (zh) * | 2017-02-28 | 2019-11-29 | 广州纳泰生物医药技术有限公司 | 预防和治疗寨卡病毒感染的rna药物制剂 |
Non-Patent Citations (3)
| Title |
|---|
| JIAXI HE ET AL.: "Location of a single histidine within peptide carriers increases mRNA delivery", J GENE MED., vol. 23, no. 2, 21 December 2020 (2020-12-21), pages 1 - 11 * |
| LENG ET AL.: "Histidine-Lysine Peptides as Carriers of Nucleic Acids", DRUG NEWS PERSPECT, vol. 20, no. 2, 31 March 2007 (2007-03-31), pages 77 - 86, XP001526414, DOI: 10.1358/dnp.2007.20.2.1083026 * |
| LU ET AL.: "Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding", LANCET, 29 January 2020 (2020-01-29) * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021159118A3 (en) | 2021-10-28 |
| IL295360A (en) | 2022-10-01 |
| EP4100066A4 (en) | 2024-05-01 |
| JP2023512833A (ja) | 2023-03-29 |
| KR20220143684A (ko) | 2022-10-25 |
| CA3167257A1 (en) | 2021-08-12 |
| US12029786B2 (en) | 2024-07-09 |
| WO2021159118A2 (en) | 2021-08-12 |
| MX2022009688A (es) | 2022-12-15 |
| US20230108926A1 (en) | 2023-04-06 |
| US20220040292A1 (en) | 2022-02-10 |
| EP4100066A2 (en) | 2022-12-14 |
| BR112022015626A2 (pt) | 2022-10-11 |
| AU2021216443A1 (en) | 2022-09-08 |
| WO2021159118A8 (en) | 2022-09-22 |
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| CB03 | Change of inventor or designer information |
Inventor after: Tang Shenggao Inventor after: Shen Dong Inventor after: Lu Chun Inventor after: He Ziyang Inventor after: He Jiaxi Inventor after: Patrick Y. Lu Inventor before: Tang Shenggao Inventor before: Shen Dong Inventor before: Lu Chun Inventor before: He Ziyang Inventor before: He Jiaxi Inventor before: Patrick Y. Lu |
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