JP2023512828A - クロマカリムプロドラッグ療法のための改善された方法及び組成物 - Google Patents

クロマカリムプロドラッグ療法のための改善された方法及び組成物 Download PDF

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Publication number
JP2023512828A
JP2023512828A JP2022548125A JP2022548125A JP2023512828A JP 2023512828 A JP2023512828 A JP 2023512828A JP 2022548125 A JP2022548125 A JP 2022548125A JP 2022548125 A JP2022548125 A JP 2022548125A JP 2023512828 A JP2023512828 A JP 2023512828A
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Japan
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formula
pharmaceutically acceptable
cklp1
acceptable salt
effective amount
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Pending
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JP2022548125A
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Japanese (ja)
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JP2023512828A5 (https=
Inventor
トゥレイン エム． トゥー
バーバラ エム． ヴィロストコ
マイケル ピー． フォーシュ
Original Assignee
クラリス バイオ インコーポレイテッド
メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ
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Publication of JP2023512828A publication Critical patent/JP2023512828A/ja
Publication of JP2023512828A5 publication Critical patent/JP2023512828A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
JP2022548125A 2020-02-07 2021-02-05 クロマカリムプロドラッグ療法のための改善された方法及び組成物 Pending JP2023512828A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202062971752P 2020-02-07 2020-02-07
US62/971,752 2020-02-07
US202063120604P 2020-12-02 2020-12-02
US63/120,604 2020-12-02
US202163134042P 2021-01-05 2021-01-05
US63/134,042 2021-01-05
PCT/US2021/016920 WO2021158992A1 (en) 2020-02-07 2021-02-05 Improved methods and compositions for cromakalim prodrug therapy

Publications (2)

Publication Number Publication Date
JP2023512828A true JP2023512828A (ja) 2023-03-29
JP2023512828A5 JP2023512828A5 (https=) 2024-02-14

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JP2022548125A Pending JP2023512828A (ja) 2020-02-07 2021-02-05 クロマカリムプロドラッグ療法のための改善された方法及び組成物

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Country Link
US (1) US20220387457A1 (https=)
EP (1) EP4100003A4 (https=)
JP (1) JP2023512828A (https=)
CN (1) CN115768419A (https=)
AU (1) AU2021215932A1 (https=)
CA (1) CA3166579A1 (https=)
WO (1) WO2021158992A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10981951B2 (en) * 2014-01-31 2021-04-20 Mayo Foundation For Medical Education And Research Therapeutics for the treatment of glaucoma
CA3159771A1 (en) 2019-12-12 2021-06-17 Thurein M. Htoo Controlled-delivery cromakalim prodrugs
EP4384162A4 (en) * 2021-08-12 2025-06-04 Qlaris Bio, Inc. Compositions and methods for extended-release bromo-kallim therapy
CN115058440B (zh) * 2022-06-08 2023-08-15 郑州轻工业大学 催化合成天然蔗糖酯的工程菌及其构建方法和应用
GB202211936D0 (en) * 2022-08-16 2022-09-28 Royal Veterinary College Method and treatment for diabetes
IL320428A (en) * 2022-11-04 2025-06-01 Qlaris Bio Inc Topical ophthalmic administration of cromolyns
CN119548509B (zh) * 2024-11-21 2025-11-14 中山大学中山眼科中心 一种小分子化合物组合物及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59176282A (ja) * 1983-03-24 1984-10-05 ビーチヤム・グループ・ピーエルシー 薬理活性を有する化合物の異性体、その製法及びそれを含む製薬組成物
WO1989010757A1 (en) * 1988-05-10 1989-11-16 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis New ophthalmic preparation for treating glaucoma
US20170002040A1 (en) * 2014-01-31 2017-01-05 Mayo Foundation For Medical Education And Research Novel therapeutics for the treatment of glaucoma

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565560A (en) * 1991-05-13 1996-10-15 Merck & Co., Inc. O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
CN101327325A (zh) * 2002-07-30 2008-12-24 奥默罗斯公司 眼科冲洗液及方法
DK2838533T3 (da) * 2012-04-16 2017-11-27 Univ Case Western Reserve Sammensætninger og fremgangsmåder til at modulere 15-pgdh-aktivitet
MA41252A (fr) * 2014-12-23 2017-10-31 Gilead Sciences Inc Formes solides d'un inhibiteur d'ask 1
WO2018047175A1 (en) * 2016-09-08 2018-03-15 Regenera Pharma Ltd. Compositions comprising triterpenoids and uses thereof for treating optic neuropathy
CA3159771A1 (en) * 2019-12-12 2021-06-17 Thurein M. Htoo Controlled-delivery cromakalim prodrugs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59176282A (ja) * 1983-03-24 1984-10-05 ビーチヤム・グループ・ピーエルシー 薬理活性を有する化合物の異性体、その製法及びそれを含む製薬組成物
WO1989010757A1 (en) * 1988-05-10 1989-11-16 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis New ophthalmic preparation for treating glaucoma
US20170002040A1 (en) * 2014-01-31 2017-01-05 Mayo Foundation For Medical Education And Research Novel therapeutics for the treatment of glaucoma

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"ATP sensitive potassium channel openers: A new class of ocular hypotensive agents", EXPERIMENTAL EYE RESEARCH, vol. 158, JPN6025003927, pages 85 - 93, ISSN: 0005651302 *
"Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Ther", IOVS, vol. 58, JPN6025003926, 2017, pages 5731 - 5742, ISSN: 0005651301 *

Also Published As

Publication number Publication date
WO2021158992A1 (en) 2021-08-12
CA3166579A1 (en) 2021-08-12
US20220387457A1 (en) 2022-12-08
AU2021215932A1 (en) 2022-09-15
EP4100003A1 (en) 2022-12-14
EP4100003A4 (en) 2024-04-24
CN115768419A (zh) 2023-03-07

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