JP2023512175A5 - - Google Patents

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Publication number
JP2023512175A5
JP2023512175A5 JP2022542952A JP2022542952A JP2023512175A5 JP 2023512175 A5 JP2023512175 A5 JP 2023512175A5 JP 2022542952 A JP2022542952 A JP 2022542952A JP 2022542952 A JP2022542952 A JP 2022542952A JP 2023512175 A5 JP2023512175 A5 JP 2023512175A5
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JP
Japan
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JP2022542952A
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Japanese (ja)
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JP7626774B2 (ja
JP2023512175A (ja
JPWO2021156180A5 (https=
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Publication of JPWO2021156180A5 publication Critical patent/JPWO2021156180A5/ja
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JP2022542952A 2020-02-03 2021-02-01 HER2阻害薬としての[1,3]ジアジノ[5,4-d]ピリミジン Active JP7626774B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20155161 2020-02-03
EP20155161.1 2020-02-03
PCT/EP2021/052263 WO2021156180A1 (en) 2020-02-03 2021-02-01 [1,3]diazino[5,4-d]pyrimidines as her2 inhibitors

Publications (4)

Publication Number Publication Date
JP2023512175A JP2023512175A (ja) 2023-03-24
JP2023512175A5 true JP2023512175A5 (https=) 2024-02-08
JPWO2021156180A5 JPWO2021156180A5 (https=) 2024-02-08
JP7626774B2 JP7626774B2 (ja) 2025-02-04

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JP2022542952A Active JP7626774B2 (ja) 2020-02-03 2021-02-01 HER2阻害薬としての[1,3]ジアジノ[5,4-d]ピリミジン

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Country Link
US (1) US20230131720A1 (https=)
EP (1) EP4100412A1 (https=)
JP (1) JP7626774B2 (https=)
CN (1) CN115052881B (https=)
WO (1) WO2021156180A1 (https=)

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TW202214641A (zh) 2020-06-30 2022-04-16 美商艾瑞生藥股份有限公司 Her2突變抑制劑
EP4323356A1 (en) 2021-04-13 2024-02-21 Nuvalent, Inc. Amino-substituted heterocycles for treating cancers with egfr mutations
PE20250118A1 (es) 2021-06-26 2025-01-16 Array Biopharma Inc Inhibidores de mutacion de her2
WO2023081637A1 (en) * 2021-11-02 2023-05-11 Enliven Therapeutics, Inc. Fused tetracyclic quinazoline derivatives as inhibitors of erbb2
CN114031619A (zh) * 2021-12-17 2022-02-11 山东汇海医药化工有限公司 一种图卡替尼中间体的制备方法
CN114621221B (zh) * 2022-03-12 2022-10-11 陕西海辰风扬医药科技有限公司 妥卡替尼关键中间体及其制备方法
JP2025509995A (ja) 2022-03-28 2025-04-11 江蘇恒瑞医薬股▲ふん▼有限公司 含窒素複素環系化合物、その調製方法及びその医薬的使用
CN117384162A (zh) * 2022-05-17 2024-01-12 浙江文达医药科技有限公司 选择性her2抑制剂
WO2024027695A1 (zh) * 2022-08-04 2024-02-08 微境生物医药科技(上海)有限公司 作为her2抑制剂的化合物
US20240132521A1 (en) 2022-08-22 2024-04-25 Iambic Therapeutics, Inc. Compounds and methods for modulating her2
EP4687905A1 (en) 2023-03-30 2026-02-11 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
WO2024229019A1 (en) * 2023-05-01 2024-11-07 Enliven Inc. Polymorphic forms of (e)-l-((10s)-4-((4-([l,2,4]triazolo[l,5-a]pyridin- 7-yloxy)-2-fluoro-5-methylphenyl)amino)-7,8,10,ll-tetrahydro- 9h-6,10-methanopyrimido[4',5':5,6]pyrido[3,2-b][l,4,7]oxadiazonin-9- yl)-4-(dimethylamino)but-2-en-l-one
AU2024265078A1 (en) 2023-05-04 2025-12-11 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
CN116903615A (zh) * 2023-06-21 2023-10-20 江苏丽源医药有限公司 一种妥卡替尼及其中间体的制备方法
IL326136A (en) 2023-08-07 2026-03-01 Revolution Medicines Inc RMC-6291 for use in the treatment of a disease or disorder associated with the RAS protein
WO2025034912A2 (en) 2023-08-07 2025-02-13 Cogent Biosciences, Inc. Compounds for fgfr inhibition
US20250154171A1 (en) 2023-10-12 2025-05-15 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
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WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026007878A1 (zh) * 2024-07-01 2026-01-08 北京鞍石生物科技股份有限公司 稠环化合物及其制备方法和应用
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
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