JP7626774B2 - HER2阻害薬としての[1,3]ジアジノ[5,4-d]ピリミジン - Google Patents

HER2阻害薬としての[1,3]ジアジノ[5,4-d]ピリミジン Download PDF

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JP7626774B2
JP7626774B2 JP2022542952A JP2022542952A JP7626774B2 JP 7626774 B2 JP7626774 B2 JP 7626774B2 JP 2022542952 A JP2022542952 A JP 2022542952A JP 2022542952 A JP2022542952 A JP 2022542952A JP 7626774 B2 JP7626774 B2 JP 7626774B2
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compound
cancer
salt
her2
pharma
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JP2023512175A5 (https=
JP2023512175A (ja
JPWO2021156180A5 (https=
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ビルギット ワイルディング
ディートリッヒ ベーゼ
ハーラルト エンゲルハルト
ユリアン フックス
ラルフ ノイミュラー
マルク ペトロンスキ
ディルク シャルン
マティアス トロイ
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2022542952A 2020-02-03 2021-02-01 HER2阻害薬としての[1,3]ジアジノ[5,4-d]ピリミジン Active JP7626774B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20155161 2020-02-03
EP20155161.1 2020-02-03
PCT/EP2021/052263 WO2021156180A1 (en) 2020-02-03 2021-02-01 [1,3]diazino[5,4-d]pyrimidines as her2 inhibitors

Publications (4)

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JP2023512175A JP2023512175A (ja) 2023-03-24
JP2023512175A5 JP2023512175A5 (https=) 2024-02-08
JPWO2021156180A5 JPWO2021156180A5 (https=) 2024-02-08
JP7626774B2 true JP7626774B2 (ja) 2025-02-04

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JP2022542952A Active JP7626774B2 (ja) 2020-02-03 2021-02-01 HER2阻害薬としての[1,3]ジアジノ[5,4-d]ピリミジン

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US (1) US20230131720A1 (https=)
EP (1) EP4100412A1 (https=)
JP (1) JP7626774B2 (https=)
CN (1) CN115052881B (https=)
WO (1) WO2021156180A1 (https=)

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EP4323356A1 (en) 2021-04-13 2024-02-21 Nuvalent, Inc. Amino-substituted heterocycles for treating cancers with egfr mutations
PE20250118A1 (es) 2021-06-26 2025-01-16 Array Biopharma Inc Inhibidores de mutacion de her2
WO2023081637A1 (en) * 2021-11-02 2023-05-11 Enliven Therapeutics, Inc. Fused tetracyclic quinazoline derivatives as inhibitors of erbb2
CN114031619A (zh) * 2021-12-17 2022-02-11 山东汇海医药化工有限公司 一种图卡替尼中间体的制备方法
CN114621221B (zh) * 2022-03-12 2022-10-11 陕西海辰风扬医药科技有限公司 妥卡替尼关键中间体及其制备方法
JP2025509995A (ja) 2022-03-28 2025-04-11 江蘇恒瑞医薬股▲ふん▼有限公司 含窒素複素環系化合物、その調製方法及びその医薬的使用
CN117384162A (zh) * 2022-05-17 2024-01-12 浙江文达医药科技有限公司 选择性her2抑制剂
WO2024027695A1 (zh) * 2022-08-04 2024-02-08 微境生物医药科技(上海)有限公司 作为her2抑制剂的化合物
US20240132521A1 (en) 2022-08-22 2024-04-25 Iambic Therapeutics, Inc. Compounds and methods for modulating her2
EP4687905A1 (en) 2023-03-30 2026-02-11 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
WO2024229019A1 (en) * 2023-05-01 2024-11-07 Enliven Inc. Polymorphic forms of (e)-l-((10s)-4-((4-([l,2,4]triazolo[l,5-a]pyridin- 7-yloxy)-2-fluoro-5-methylphenyl)amino)-7,8,10,ll-tetrahydro- 9h-6,10-methanopyrimido[4',5':5,6]pyrido[3,2-b][l,4,7]oxadiazonin-9- yl)-4-(dimethylamino)but-2-en-l-one
AU2024265078A1 (en) 2023-05-04 2025-12-11 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
CN116903615A (zh) * 2023-06-21 2023-10-20 江苏丽源医药有限公司 一种妥卡替尼及其中间体的制备方法
IL326136A (en) 2023-08-07 2026-03-01 Revolution Medicines Inc RMC-6291 for use in the treatment of a disease or disorder associated with the RAS protein
WO2025034912A2 (en) 2023-08-07 2025-02-13 Cogent Biosciences, Inc. Compounds for fgfr inhibition
US20250154171A1 (en) 2023-10-12 2025-05-15 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026007878A1 (zh) * 2024-07-01 2026-01-08 北京鞍石生物科技股份有限公司 稠环化合物及其制备方法和应用
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer

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JP2009515988A (ja) 2005-11-15 2009-04-16 アレイ バイオファーマ、インコーポレイテッド 過剰増殖性疾患の処置のためのErbBI型受容体チロシンキナーゼ阻害剤としてのN4−フェニルキナゾリン−4−アミン誘導体および関連化合物
JP2019507170A (ja) 2016-03-01 2019-03-14 シャンハイ ファーマシューティカルズ ホールディング カンパニー,リミティド 含窒素ヘテロ環化合物、製造方法、中間体、組成物及び応用
JP2020531553A (ja) 2017-09-01 2020-11-05 シャンハイ ファーマシューティカルズ ホールディング カンパニー,リミティド 窒素含有複素環化合物、製造方法、中間体、組成物および使用

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JP6863901B2 (ja) * 2015-05-13 2021-04-28 アリアド ファーマシューティカルズ, インコーポレイテッド キナーゼ阻害のためのヘテロアリール化合物
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JP2009515988A (ja) 2005-11-15 2009-04-16 アレイ バイオファーマ、インコーポレイテッド 過剰増殖性疾患の処置のためのErbBI型受容体チロシンキナーゼ阻害剤としてのN4−フェニルキナゾリン−4−アミン誘導体および関連化合物
JP2019507170A (ja) 2016-03-01 2019-03-14 シャンハイ ファーマシューティカルズ ホールディング カンパニー,リミティド 含窒素ヘテロ環化合物、製造方法、中間体、組成物及び応用
JP2020531553A (ja) 2017-09-01 2020-11-05 シャンハイ ファーマシューティカルズ ホールディング カンパニー,リミティド 窒素含有複素環化合物、製造方法、中間体、組成物および使用

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WO2021156180A1 (en) 2021-08-12
EP4100412A1 (en) 2022-12-14
US20230131720A1 (en) 2023-04-27
JP2023512175A (ja) 2023-03-24
CN115052881A (zh) 2022-09-13
CN115052881B (zh) 2024-07-09

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