JP2023508071A5 - - Google Patents
Info
- Publication number
- JP2023508071A5 JP2023508071A5 JP2022538939A JP2022538939A JP2023508071A5 JP 2023508071 A5 JP2023508071 A5 JP 2023508071A5 JP 2022538939 A JP2022538939 A JP 2022538939A JP 2022538939 A JP2022538939 A JP 2022538939A JP 2023508071 A5 JP2023508071 A5 JP 2023508071A5
- Authority
- JP
- Japan
- Prior art keywords
- protecting group
- formula
- amino protecting
- hydrogen
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102019000025348A IT201900025348A1 (it) | 2019-12-23 | 2019-12-23 | Procedimento per la sintesi di melfalan |
| IT102019000025348 | 2019-12-23 | ||
| PCT/EP2020/087443 WO2021130163A1 (en) | 2019-12-23 | 2020-12-21 | A process for the synthesis of melphalan |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023508071A JP2023508071A (ja) | 2023-02-28 |
| JP2023508071A5 true JP2023508071A5 (enExample) | 2023-12-18 |
| JP7748948B2 JP7748948B2 (ja) | 2025-10-03 |
Family
ID=70009318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022538939A Active JP7748948B2 (ja) | 2019-12-23 | 2020-12-21 | メルファランの合成方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11787761B2 (enExample) |
| EP (1) | EP4081503B1 (enExample) |
| JP (1) | JP7748948B2 (enExample) |
| CN (1) | CN114845991B (enExample) |
| ES (1) | ES3040894T3 (enExample) |
| HU (1) | HUE073252T2 (enExample) |
| IT (1) | IT201900025348A1 (enExample) |
| WO (1) | WO2021130163A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114315618A (zh) * | 2021-12-04 | 2022-04-12 | 浙江恒腾福生物科技集团有限公司 | 一种合成美法仑的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB750155A (en) | 1953-03-17 | 1956-06-13 | Nat Res Dev | Substituted alanines |
| US3032585A (en) | 1954-12-03 | 1962-05-01 | Nat Res Dev | Process for the production of p-bis-(2-chloroethyl)-aminophenylalanine |
| US4255326A (en) * | 1979-03-30 | 1981-03-10 | Eastman Kodak Company | Nitrogen and/or sulfur containing heterocyclic azo dyes with aniline, tetrahydroquinoline and benzomorpholine couplers having sulfate group |
| US4267104A (en) * | 1979-06-14 | 1981-05-12 | Eastman Kodak Company | Dyes from selected substituted aniline diazo components and aniline couplers containing sulfate ester groups |
| DE4026115A1 (de) * | 1990-08-17 | 1992-02-20 | Consortium Elektrochem Ind | Verfahren zur herstellung von 1-alkylisochinolinderivaten |
| CN100491339C (zh) | 2007-04-20 | 2009-05-27 | 苏州市立德化学有限公司 | 一种抗肿瘤药物美法仑的合成工艺 |
| US8575385B2 (en) | 2008-03-20 | 2013-11-05 | Navinta Llc | Process of making optically pure melphalan |
| ITMI20130896A1 (it) * | 2013-05-31 | 2014-12-01 | Farmabios Spa | Processo di purificazione di melphalan |
| CN107935875B (zh) * | 2017-12-27 | 2020-07-24 | 兆科（广州）肿瘤药物有限公司 | 一种美法仑的合成方法 |
-
2019
- 2019-12-23 IT IT102019000025348A patent/IT201900025348A1/it unknown
-
2020
- 2020-12-21 JP JP2022538939A patent/JP7748948B2/ja active Active
- 2020-12-21 HU HUE20838517A patent/HUE073252T2/hu unknown
- 2020-12-21 EP EP20838517.9A patent/EP4081503B1/en active Active
- 2020-12-21 US US17/757,830 patent/US11787761B2/en active Active
- 2020-12-21 WO PCT/EP2020/087443 patent/WO2021130163A1/en not_active Ceased
- 2020-12-21 ES ES20838517T patent/ES3040894T3/es active Active
- 2020-12-21 CN CN202080089455.9A patent/CN114845991B/zh active Active
-
2023
- 2023-05-19 US US18/320,326 patent/US12077484B2/en active Active
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