IT201900025348A1 - Procedimento per la sintesi di melfalan - Google Patents
Procedimento per la sintesi di melfalanInfo
- Publication number
- IT201900025348A1 IT201900025348A1 IT102019000025348A IT201900025348A IT201900025348A1 IT 201900025348 A1 IT201900025348 A1 IT 201900025348A1 IT 102019000025348 A IT102019000025348 A IT 102019000025348A IT 201900025348 A IT201900025348 A IT 201900025348A IT 201900025348 A1 IT201900025348 A1 IT 201900025348A1
- Authority
- IT
- Italy
- Prior art keywords
- melfalan
- synthesis
- procedure
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 title 1
- 229960001924 melphalan Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102019000025348A IT201900025348A1 (it) | 2019-12-23 | 2019-12-23 | Procedimento per la sintesi di melfalan |
| JP2022538939A JP7748948B2 (ja) | 2019-12-23 | 2020-12-21 | メルファランの合成方法 |
| HUE20838517A HUE073252T2 (hu) | 2019-12-23 | 2020-12-21 | Eljárás melfalán szintézisére |
| CN202080089455.9A CN114845991B (zh) | 2019-12-23 | 2020-12-21 | 合成美法仑的方法 |
| US17/757,830 US11787761B2 (en) | 2019-12-23 | 2020-12-21 | Process for the synthesis of Melphalan |
| EP20838517.9A EP4081503B1 (en) | 2019-12-23 | 2020-12-21 | A process for the synthesis of melphalan |
| ES20838517T ES3040894T3 (en) | 2019-12-23 | 2020-12-21 | A process for the synthesis of melphalan |
| PCT/EP2020/087443 WO2021130163A1 (en) | 2019-12-23 | 2020-12-21 | A process for the synthesis of melphalan |
| US18/320,326 US12077484B2 (en) | 2019-12-23 | 2023-05-19 | Process for the synthesis of melphalan |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102019000025348A IT201900025348A1 (it) | 2019-12-23 | 2019-12-23 | Procedimento per la sintesi di melfalan |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IT201900025348A1 true IT201900025348A1 (it) | 2021-06-23 |
Family
ID=70009318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT102019000025348A IT201900025348A1 (it) | 2019-12-23 | 2019-12-23 | Procedimento per la sintesi di melfalan |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11787761B2 (enExample) |
| EP (1) | EP4081503B1 (enExample) |
| JP (1) | JP7748948B2 (enExample) |
| CN (1) | CN114845991B (enExample) |
| ES (1) | ES3040894T3 (enExample) |
| HU (1) | HUE073252T2 (enExample) |
| IT (1) | IT201900025348A1 (enExample) |
| WO (1) | WO2021130163A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114315618A (zh) * | 2021-12-04 | 2022-04-12 | 浙江恒腾福生物科技集团有限公司 | 一种合成美法仑的制备方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3032584A (en) | 1953-03-17 | 1962-05-01 | Nat Res Dev | p-bis-(2-chloroethyl) aminophenylalanine and the process for the production thereof |
| US3032585A (en) | 1954-12-03 | 1962-05-01 | Nat Res Dev | Process for the production of p-bis-(2-chloroethyl)-aminophenylalanine |
| CN101100440A (zh) | 2007-04-20 | 2008-01-09 | 苏州市立德化学有限公司 | 一种抗肿瘤药物美法仑的合成工艺 |
| WO2009117164A1 (en) | 2008-03-20 | 2009-09-24 | Navinta Llc | Process of making optically pure melphalan |
| WO2014191426A1 (en) * | 2013-05-31 | 2014-12-04 | Farmabios S.P.A. | Process for the purification of melphalan |
| CN107935875A (zh) * | 2017-12-27 | 2018-04-20 | 兆科药业（广州）有限公司 | 一种美法仑的合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4255326A (en) * | 1979-03-30 | 1981-03-10 | Eastman Kodak Company | Nitrogen and/or sulfur containing heterocyclic azo dyes with aniline, tetrahydroquinoline and benzomorpholine couplers having sulfate group |
| US4267104A (en) * | 1979-06-14 | 1981-05-12 | Eastman Kodak Company | Dyes from selected substituted aniline diazo components and aniline couplers containing sulfate ester groups |
| DE4026115A1 (de) * | 1990-08-17 | 1992-02-20 | Consortium Elektrochem Ind | Verfahren zur herstellung von 1-alkylisochinolinderivaten |
-
2019
- 2019-12-23 IT IT102019000025348A patent/IT201900025348A1/it unknown
-
2020
- 2020-12-21 JP JP2022538939A patent/JP7748948B2/ja active Active
- 2020-12-21 HU HUE20838517A patent/HUE073252T2/hu unknown
- 2020-12-21 EP EP20838517.9A patent/EP4081503B1/en active Active
- 2020-12-21 US US17/757,830 patent/US11787761B2/en active Active
- 2020-12-21 WO PCT/EP2020/087443 patent/WO2021130163A1/en not_active Ceased
- 2020-12-21 ES ES20838517T patent/ES3040894T3/es active Active
- 2020-12-21 CN CN202080089455.9A patent/CN114845991B/zh active Active
-
2023
- 2023-05-19 US US18/320,326 patent/US12077484B2/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3032584A (en) | 1953-03-17 | 1962-05-01 | Nat Res Dev | p-bis-(2-chloroethyl) aminophenylalanine and the process for the production thereof |
| US3032585A (en) | 1954-12-03 | 1962-05-01 | Nat Res Dev | Process for the production of p-bis-(2-chloroethyl)-aminophenylalanine |
| CN101100440A (zh) | 2007-04-20 | 2008-01-09 | 苏州市立德化学有限公司 | 一种抗肿瘤药物美法仑的合成工艺 |
| WO2009117164A1 (en) | 2008-03-20 | 2009-09-24 | Navinta Llc | Process of making optically pure melphalan |
| WO2014191426A1 (en) * | 2013-05-31 | 2014-12-04 | Farmabios S.P.A. | Process for the purification of melphalan |
| CN107935875A (zh) * | 2017-12-27 | 2018-04-20 | 兆科药业（广州）有限公司 | 一种美法仑的合成方法 |
Non-Patent Citations (3)
| Title |
|---|
| BIXUE XUC., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, 2009, pages 3118 - 3125 |
| D.A. TOMALIA, ET AL.: "The synthesis and reactions of beta-substituted ethyl sulfates", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 9, no. 4, August 1972 (1972-08-01), Wiley Periodicals, Hoboken, NJ, US, pages 891 - 894, XP002243544, ISSN: 0022-152X, DOI: 10.1002/jhet.5570090424 * |
| TETRAHEDRON ASYMMETRY, vol. 22, no. 2, 2011, pages 185 - 189 |
Also Published As
| Publication number | Publication date |
|---|---|
| US12077484B2 (en) | 2024-09-03 |
| US20230094970A1 (en) | 2023-03-30 |
| EP4081503C0 (en) | 2025-07-30 |
| ES3040894T3 (en) | 2025-11-05 |
| WO2021130163A1 (en) | 2021-07-01 |
| CN114845991B (zh) | 2024-05-07 |
| US20230286901A1 (en) | 2023-09-14 |
| JP7748948B2 (ja) | 2025-10-03 |
| HUE073252T2 (hu) | 2026-01-28 |
| EP4081503B1 (en) | 2025-07-30 |
| JP2023508071A (ja) | 2023-02-28 |
| US11787761B2 (en) | 2023-10-17 |
| CN114845991A (zh) | 2022-08-02 |
| EP4081503A1 (en) | 2022-11-02 |
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