JP2023507848A - 癌の治療のための療法 - Google Patents

癌の治療のための療法 Download PDF

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JP2023507848A
JP2023507848A JP2022538737A JP2022538737A JP2023507848A JP 2023507848 A JP2023507848 A JP 2023507848A JP 2022538737 A JP2022538737 A JP 2022538737A JP 2022538737 A JP2022538737 A JP 2022538737A JP 2023507848 A JP2023507848 A JP 2023507848A
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cancer
lag
domain
molecule
cdr
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JPWO2021133653A5 (https=
JP2023507848A5 (https=
Inventor
ブラッドレイ ジェームズ スムラウ
モット-モース ロス ラ
ジョン マーク ウィギントン
エツィオ ボンビニ
ポール エー. ムーア
スコット ケーニヒ
シャオユ ジャン
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マクロジェニクス,インコーポレーテッド
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    • C07K16/2818Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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JP2022538737A 2019-12-23 2020-12-18 癌の治療のための療法 Pending JP2023507848A (ja)

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JP2025154757A JP2026001028A (ja) 2019-12-23 2025-09-18 癌の治療のための療法

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201962952878P 2019-12-23 2019-12-23
US201962952859P 2019-12-23 2019-12-23
US62/952,878 2019-12-23
US62/952,859 2019-12-23
US202063019857P 2020-05-04 2020-05-04
US63/019,857 2020-05-04
US202063021556P 2020-05-07 2020-05-07
US63/021,556 2020-05-07
US202063031453P 2020-05-28 2020-05-28
US63/031,453 2020-05-28
US202063123581P 2020-12-10 2020-12-10
US63/123,581 2020-12-10
PCT/US2020/065873 WO2021133653A1 (en) 2019-12-23 2020-12-18 Therapy for the treatment of cancer

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JP2023507848A true JP2023507848A (ja) 2023-02-27
JPWO2021133653A5 JPWO2021133653A5 (https=) 2023-12-21
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JP2025154757A Pending JP2026001028A (ja) 2019-12-23 2025-09-18 癌の治療のための療法

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US (1) US20230056230A1 (https=)
EP (1) EP4081248A4 (https=)
JP (2) JP2023507848A (https=)
KR (1) KR20220119694A (https=)
CN (1) CN114901306A (https=)
AU (1) AU2020412595A1 (https=)
BR (1) BR112022012437A2 (https=)
CA (1) CA3165839A1 (https=)
IL (1) IL294207A (https=)
MX (1) MX2022007790A (https=)
TW (1) TW202138387A (https=)
WO (1) WO2021133653A1 (https=)
ZA (1) ZA202206743B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4106813A4 (en) * 2020-02-21 2024-03-27 MacroGenics, Inc. CD137 BINDING MOLECULES AND THEIR USES
WO2022087402A1 (en) * 2020-10-23 2022-04-28 Bristol-Myers Squibb Company Lag-3 antagonist therapy for lung cancer
EP4363449A2 (en) * 2021-07-02 2024-05-08 Genentech, Inc. Methods and compositions for treating cancer
AU2022317820A1 (en) * 2021-07-28 2023-12-14 F. Hoffmann-La Roche Ag Methods and compositions for treating cancer
CA3233205A1 (en) * 2021-09-29 2023-04-06 Yu Xia Anti-lag3 antibody, pharmaceutical composition and use
WO2023066322A1 (zh) * 2021-10-21 2023-04-27 杭州阿诺生物医药科技有限公司 一种融合多肽及其用途
WO2024051223A1 (zh) * 2022-09-09 2024-03-14 中山康方生物医药有限公司 药物组合及用途
WO2024163009A1 (en) * 2023-01-31 2024-08-08 Genentech, Inc. Methods and compositions for treating urothelial bladder cancer
TW202436339A (zh) * 2023-01-31 2024-09-16 瑞士商赫孚孟拉羅股份公司 治療選自非小細胞肺癌或三陰性乳癌的癌症之用途

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017035086A (ja) * 2010-03-04 2017-02-16 マクロジェニクス,インコーポレーテッド B7−h3と反応性のある抗体、その免疫学的に活性なフラグメントおよびその使用
JP2017526632A (ja) * 2014-06-26 2017-09-14 マクロジェニクス,インコーポレーテッド Pd‐1及びlag‐3との免疫反応性を有する共有結合ダイアボディ並びにその使用方法
JP2018523686A (ja) * 2015-08-17 2018-08-23 マクロジェニクス,インコーポレーテッド B7‐h3及びcd3に結合できる二重特異性1価ダイアボディ並びにその使用
JP2018524394A (ja) * 2015-07-30 2018-08-30 マクロジェニクス,インコーポレーテッド Pd‐1結合分子及びその使用方法
WO2018178122A1 (en) * 2017-03-29 2018-10-04 Glycotope Gmbh Pd-l1 and ta-muc1 antibodies
JP2019520308A (ja) * 2016-04-15 2019-07-18 マクロジェニクス,インコーポレーテッド 新規のb7‐h3結合分子、その抗体薬物コンジュゲート、及びその使用方法
WO2019152642A1 (en) * 2018-02-01 2019-08-08 Merck Sharp & Dohme Corp. Anti-pd-1/lag3 bispecific antibodies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201601763SA (en) * 2013-09-20 2016-04-28 Bristol Myers Squibb Co Combination of anti-lag-3 antibodies and anti-pd-1 antibodies to treat tumors
TWI773646B (zh) * 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 結合lag-3的分子和其使用方法
US10954301B2 (en) * 2015-12-14 2021-03-23 Macrogenics, Inc. Bispecific molecules having immunoreactivity with PD-1 and CTLA-4, and methods of use thereof
MX2018014950A (es) * 2016-06-07 2019-04-25 Macrogenics Inc Terapia de combinacion.
KR102664891B1 (ko) * 2016-06-20 2024-05-13 에프-스타 테라퓨틱스 리미티드 Pd-l1 및 lag-3에 결합하는 결합 분자
TWI690538B (zh) * 2017-04-05 2020-04-11 瑞士商赫孚孟拉羅股份公司 特異性結合至pd1至lag3的雙特異性抗體
EP3630179A2 (en) * 2017-05-30 2020-04-08 Bristol-Myers Squibb Company Compositions comprising an anti-lag-3 antibody or an anti-lag-3 antibody and an anti-pd-1 or anti-pd-l1 antibody
WO2019179422A1 (en) * 2018-03-20 2019-09-26 Wuxi Biologics (Shanghai) Co., Ltd. Novel bispecific pd-1/lag-3 antibody molecules

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017035086A (ja) * 2010-03-04 2017-02-16 マクロジェニクス,インコーポレーテッド B7−h3と反応性のある抗体、その免疫学的に活性なフラグメントおよびその使用
JP2017526632A (ja) * 2014-06-26 2017-09-14 マクロジェニクス,インコーポレーテッド Pd‐1及びlag‐3との免疫反応性を有する共有結合ダイアボディ並びにその使用方法
JP2018524394A (ja) * 2015-07-30 2018-08-30 マクロジェニクス,インコーポレーテッド Pd‐1結合分子及びその使用方法
JP2018523686A (ja) * 2015-08-17 2018-08-23 マクロジェニクス,インコーポレーテッド B7‐h3及びcd3に結合できる二重特異性1価ダイアボディ並びにその使用
JP2019520308A (ja) * 2016-04-15 2019-07-18 マクロジェニクス,インコーポレーテッド 新規のb7‐h3結合分子、その抗体薬物コンジュゲート、及びその使用方法
WO2018178122A1 (en) * 2017-03-29 2018-10-04 Glycotope Gmbh Pd-l1 and ta-muc1 antibodies
WO2019152642A1 (en) * 2018-02-01 2019-08-08 Merck Sharp & Dohme Corp. Anti-pd-1/lag3 bispecific antibodies

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. Vol. 5, Supp.2, JPN6024048858, 2017, pages 87 - 337, ISSN: 0005747370 *
JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. Vol. 5, Supp.2, JPN6024048859, 2017, pages 87 - 244, ISSN: 0005747369 *
JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. Vol. 7, Supp.1, JPN6024048860, November 2019 (2019-11-01), pages 282 - 375, ISSN: 0005747368 *

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