JP2023506258A5 - - Google Patents
Info
- Publication number
- JP2023506258A5 JP2023506258A5 JP2022536726A JP2022536726A JP2023506258A5 JP 2023506258 A5 JP2023506258 A5 JP 2023506258A5 JP 2022536726 A JP2022536726 A JP 2022536726A JP 2022536726 A JP2022536726 A JP 2022536726A JP 2023506258 A5 JP2023506258 A5 JP 2023506258A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleotide
- dsrna agent
- nucleotides
- agent according
- modifications
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962948445P | 2019-12-16 | 2019-12-16 | |
| US62/948,445 | 2019-12-16 | ||
| US202063040602P | 2020-06-18 | 2020-06-18 | |
| US63/040,602 | 2020-06-18 | ||
| PCT/US2020/064776 WO2021126734A1 (en) | 2019-12-16 | 2020-12-14 | Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023506258A JP2023506258A (ja) | 2023-02-15 |
| JP2023506258A5 true JP2023506258A5 (https=) | 2023-12-18 |
| JP7797388B2 JP7797388B2 (ja) | 2026-01-13 |
Family
ID=76437193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022536726A Active JP7797388B2 (ja) | 2019-12-16 | 2020-12-14 | パタチン様ホスホリパーゼドメイン含有３（ＰＮＰＬＡ３）ｉＲＮＡ組成物およびその使用法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11149276B2 (https=) |
| EP (1) | EP4077666A1 (https=) |
| JP (1) | JP7797388B2 (https=) |
| KR (1) | KR20220116520A (https=) |
| CN (1) | CN115176007A (https=) |
| AU (1) | AU2020404905A1 (https=) |
| BR (1) | BR112022011412A2 (https=) |
| CA (1) | CA3164628A1 (https=) |
| CO (1) | CO2022008105A2 (https=) |
| IL (1) | IL293860A (https=) |
| MX (1) | MX2022007144A (https=) |
| PH (1) | PH12022551417A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2976445A1 (en) | 2015-02-13 | 2016-08-18 | Alnylam Pharmaceuticals, Inc. | Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof |
| EP4077666A1 (en) | 2019-12-16 | 2022-10-26 | Alnylam Pharmaceuticals, Inc. | Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof |
| AR121672A1 (es) * | 2020-03-26 | 2022-06-29 | Arrowhead Pharmaceuticals Inc | AGENTES DE ARNi PARA INHIBIR LA EXPRESIÓN DE PNPLA3, COMPOSICIONES FARMACÉUTICAS DE ESTA, Y MÉTODOS DE USO |
| WO2024120412A1 (en) * | 2022-12-07 | 2024-06-13 | Shanghai Argo Biopharmaceutical Co., Ltd. | Compositions and methods for inhibiting expression of patatin-like phospholipase domain-containing 3 (pnpla3) |
| WO2025098440A1 (zh) * | 2023-11-08 | 2025-05-15 | 浙江扬厉医药技术有限公司 | 抑制PNPLA3表达的双链siRNA以及其缀合物 |
| WO2025242147A1 (zh) * | 2024-05-21 | 2025-11-27 | 北京安龙生物医药有限公司 | 靶向外周髓鞘蛋白-22基因的寡核苷酸及其用途 |
| WO2025252063A1 (zh) * | 2024-06-04 | 2025-12-11 | 正大天晴药业集团股份有限公司 | 靶向pnpla3的双链核糖核酸 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003295600A1 (en) | 2002-11-14 | 2004-06-15 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| US7217807B2 (en) | 2002-11-26 | 2007-05-15 | Rosetta Genomics Ltd | Bioinformatically detectable group of novel HIV regulatory genes and uses thereof |
| WO2012177639A2 (en) | 2011-06-22 | 2012-12-27 | Alnylam Pharmaceuticals, Inc. | Bioprocessing and bioproduction using avian cell lines |
| EP3730618A1 (en) | 2011-11-18 | 2020-10-28 | Alnylam Pharmaceuticals, Inc. | Rnai agents, compositions and methods of use thereof for treating transthyretin (ttr) associated diseases |
| SI3366775T2 (sl) | 2011-11-18 | 2025-12-31 | Alnylam Pharmaceuticals, Inc. | Modificirana sredstva RNAI |
| EP2991136A1 (en) | 2014-08-29 | 2016-03-02 | Centre National De La Recherche Scientifique | Method for manufacturing a miniaturized electrochemical cell |
| CA2976445A1 (en) * | 2015-02-13 | 2016-08-18 | Alnylam Pharmaceuticals, Inc. | Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof |
| WO2017048620A1 (en) | 2015-09-14 | 2017-03-23 | Alnylam Pharmaceuticals, Inc. | Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (pnpla3) and methods of use thereof |
| US10036024B2 (en) | 2016-06-03 | 2018-07-31 | Purdue Research Foundation | siRNA compositions that specifically downregulate expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease or alcoholic liver disease (ALD) |
| UY38003A (es) | 2017-12-12 | 2019-06-28 | Amgen Inc | Construcciones de arni para inhibir la expresión de pnpla3 y métodos de uso de las mismas |
| CN110384796A (zh) * | 2019-07-11 | 2019-10-29 | 南京医科大学 | 马铃薯样磷脂酶7的应用 |
| WO2021126734A1 (en) | 2019-12-16 | 2021-06-24 | Alnylam Pharmaceuticals, Inc. | Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof |
| EP4077666A1 (en) | 2019-12-16 | 2022-10-26 | Alnylam Pharmaceuticals, Inc. | Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof |
| EP4347823A1 (en) | 2021-06-02 | 2024-04-10 | Alnylam Pharmaceuticals, Inc. | Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof |
-
2020
- 2020-12-14 EP EP20829496.7A patent/EP4077666A1/en active Pending
- 2020-12-14 JP JP2022536726A patent/JP7797388B2/ja active Active
- 2020-12-14 CN CN202080096559.2A patent/CN115176007A/zh active Pending
- 2020-12-14 MX MX2022007144A patent/MX2022007144A/es unknown
- 2020-12-14 PH PH1/2022/551417A patent/PH12022551417A1/en unknown
- 2020-12-14 AU AU2020404905A patent/AU2020404905A1/en active Pending
- 2020-12-14 KR KR1020227024693A patent/KR20220116520A/ko active Pending
- 2020-12-14 BR BR112022011412A patent/BR112022011412A2/pt unknown
- 2020-12-14 IL IL293860A patent/IL293860A/en unknown
- 2020-12-14 CA CA3164628A patent/CA3164628A1/en active Pending
-
2021
- 2021-02-23 US US17/182,348 patent/US11149276B2/en active Active
- 2021-04-27 US US17/241,227 patent/US12480125B2/en active Active
-
2022
- 2022-06-07 CO CONC2022/0008105A patent/CO2022008105A2/es unknown
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