JP2023500263A5 - - Google Patents
Info
- Publication number
- JP2023500263A5 JP2023500263A5 JP2022525189A JP2022525189A JP2023500263A5 JP 2023500263 A5 JP2023500263 A5 JP 2023500263A5 JP 2022525189 A JP2022525189 A JP 2022525189A JP 2022525189 A JP2022525189 A JP 2022525189A JP 2023500263 A5 JP2023500263 A5 JP 2023500263A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- fluorine
- alkyl
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19207536.4 | 2019-11-06 | ||
| EP19207536 | 2019-11-06 | ||
| PCT/EP2020/081097 WO2021089683A1 (en) | 2019-11-06 | 2020-11-05 | Inhibitors of adrenoreceptor adrac2 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023500263A JP2023500263A (ja) | 2023-01-05 |
| JP2023500263A5 true JP2023500263A5 (https=) | 2024-08-29 |
| JP7748938B2 JP7748938B2 (ja) | 2025-10-03 |
Family
ID=68531352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022525189A Active JP7748938B2 (ja) | 2019-11-06 | 2020-11-05 | アドレナリン受容体ａｄｒａｃ２の阻害剤 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US12540134B2 (https=) |
| EP (1) | EP4021905A1 (https=) |
| JP (1) | JP7748938B2 (https=) |
| KR (1) | KR20220098160A (https=) |
| CN (4) | CN120025328A (https=) |
| AR (1) | AR120404A1 (https=) |
| AU (1) | AU2020377470A1 (https=) |
| BR (1) | BR112022008146A2 (https=) |
| CA (1) | CA3160035A1 (https=) |
| CO (1) | CO2022005783A2 (https=) |
| CR (1) | CR20220195A (https=) |
| DO (1) | DOP2022000093A (https=) |
| EC (1) | ECSP22035103A (https=) |
| GE (2) | GEAP202415966A (https=) |
| IL (1) | IL292656A (https=) |
| JO (1) | JOP20220102A1 (https=) |
| MX (1) | MX2022005414A (https=) |
| PE (1) | PE20221025A1 (https=) |
| PH (1) | PH12022551097A1 (https=) |
| SA (1) | SA522432419B1 (https=) |
| TW (1) | TWI867088B (https=) |
| WO (1) | WO2021089683A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022008426A1 (en) * | 2020-07-06 | 2022-01-13 | Bayer Aktiengesellschaft | Combination of an alpha2-adrenoceptor subtype c (alpha-2c) antagonist with a task1/3 channel blocker for the treatment of sleep apnea |
| WO2022155264A1 (en) * | 2021-01-12 | 2022-07-21 | University Of Virginia Patent Foundation | Adrenergic mechanisms of audiogenic seizure-induced death in mouse model of scn8a encephalopathy |
| KR20240124995A (ko) | 2021-12-22 | 2024-08-19 | 바이엘 악티엔게젤샤프트 | 수면 무호흡의 치료를 위한 a2-아드레날린수용체 하위유형 c (알파-2c) 길항제와 노르에피네프린 재흡수 억제제의 조합물 |
| CA3259602A1 (en) | 2021-12-22 | 2023-06-29 | Bayer Aktiengesellschaft | Combination of an .alpha.2-adrenoceptor subtype c (alpha-2c) antagonists with a muscarinic receptor antagonist for the treatment of sleep apnea |
| WO2025068514A1 (en) | 2023-09-28 | 2025-04-03 | Bayer Aktiengesellschaft | Substituted heterocyclic carboxamindes and use thereof |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3966781A (en) | 1970-12-17 | 1976-06-29 | Merck Sharp & Dohme (I.A.) Corporation | Deuteration of functional group-containing hydrocarbons |
| US5082665A (en) | 1990-03-15 | 1992-01-21 | Tom Verny | Anti-snoring formulations using yohimbine |
| US5902807A (en) | 1997-05-12 | 1999-05-11 | Antti Haapalinna | Method for the treatment of mental illness in mammals and a composition therefor |
| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| DE19943639A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften |
| DE19943634A1 (de) | 1999-09-13 | 2001-04-12 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943636A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| AR031176A1 (es) | 2000-11-22 | 2003-09-10 | Bayer Ag | Nuevos derivados de pirazolpiridina sustituidos con piridina |
| DE10110749A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte Aminodicarbonsäurederivate |
| DE10110750A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
| TW200825058A (en) | 2006-10-30 | 2008-06-16 | Glaxo Group Ltd | Cysteine protease inhibitors |
| WO2008060568A2 (en) * | 2006-11-15 | 2008-05-22 | Neurogen Corporation | Amide-substituted aryl piperidines |
| HRP20151052T1 (xx) * | 2007-07-19 | 2015-11-06 | H. Lundbeck A/S | Peteroäślani heterocikliäśki amidi i srodne tvari |
| DE102010021637A1 (de) | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
| EA201390060A1 (ru) | 2010-07-09 | 2013-07-30 | Байер Интеллектуэль Проперти Гмбх | Аннелированные пиримидины и триазины и их применение для лечения и/или профилактики сердечно-сосудистых заболеваний |
| DE102010040233A1 (de) | 2010-09-03 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Bicyclische Aza-Heterocyclen und ihre Verwendung |
| DE102010043379A1 (de) | 2010-11-04 | 2012-05-10 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung |
| US8791162B2 (en) | 2011-02-14 | 2014-07-29 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| WO2015017305A1 (en) | 2013-07-31 | 2015-02-05 | Merck Sharp & Dohme Corp | Inhibitors of the renal outer medullary potassium channel |
| US20160318866A1 (en) * | 2013-12-19 | 2016-11-03 | Bayer Pharma Aktiengesellschaft | Substituted bipiperidinyl derivatives |
| EP3083610A1 (de) * | 2013-12-19 | 2016-10-26 | Bayer Pharma Aktiengesellschaft | Substituierte bipiperidinyl-derivate als adrenrezeptor alpha 2c antagonisten |
| CN104771398B (zh) | 2014-01-09 | 2017-01-18 | 湖南大学 | N‑[5‑（2‑硝基乙基）噻唑‑2‑基]苯甲酰胺及其医药用途 |
| WO2017097671A1 (de) | 2015-12-10 | 2017-06-15 | Bayer Pharma Aktiengesellschaft | Substituierte perhydropyrrolo[3,4-c]pyrrol-derivate und ihre verwendung |
| JP2018536693A (ja) | 2015-12-10 | 2018-12-13 | バイエル・ファルマ・アクティエンゲゼルシャフト | 睡眠関連呼吸障害を治療するためのＴＡＳＫ−１およびＴＡＳＫ−２チャネルの遮断薬としての２−フェニル−３−（ピペラジノメチル）イミダゾ［１，２−ａ］ピリジン誘導体 |
| JOP20190005A1 (ar) | 2016-07-20 | 2019-01-20 | Bayer Ag | مركبات ديازاهيترو ثنائية الحلقة مستبدلة واستخداماتها |
| JOP20190284A1 (ar) | 2017-06-14 | 2019-12-11 | Bayer Pharma AG | مركبات إيميدازوبيريميدين مستبدلة بديازا ثنائي الحلقة واستخدامها للمعالجة من اضطرابات التنفس |
| WO2018227427A1 (en) | 2017-06-14 | 2018-12-20 | Bayer Aktiengesellschaft | Substituted bridged diazepane derivatives and use thereof |
| CA3137472A1 (en) * | 2019-04-25 | 2020-10-29 | Bayer Aktiengesellschaft | Acyl sulfonamides for treating cancer |
-
2020
- 2020-11-05 PE PE2022000716A patent/PE20221025A1/es unknown
- 2020-11-05 EP EP20800159.4A patent/EP4021905A1/en active Pending
- 2020-11-05 PH PH1/2022/551097A patent/PH12022551097A1/en unknown
- 2020-11-05 US US17/774,459 patent/US12540134B2/en active Active
- 2020-11-05 AR ARP200103077A patent/AR120404A1/es unknown
- 2020-11-05 CN CN202510047627.0A patent/CN120025328A/zh active Pending
- 2020-11-05 KR KR1020227018406A patent/KR20220098160A/ko active Pending
- 2020-11-05 JP JP2022525189A patent/JP7748938B2/ja active Active
- 2020-11-05 JO JOP/2022/0102A patent/JOP20220102A1/ar unknown
- 2020-11-05 CN CN202510047620.9A patent/CN120025327A/zh active Pending
- 2020-11-05 IL IL292656A patent/IL292656A/en unknown
- 2020-11-05 CA CA3160035A patent/CA3160035A1/en active Pending
- 2020-11-05 GE GEAP202415966A patent/GEAP202415966A/en unknown
- 2020-11-05 GE GEAP202015966A patent/GEP20247644B/en unknown
- 2020-11-05 BR BR112022008146A patent/BR112022008146A2/pt unknown
- 2020-11-05 MX MX2022005414A patent/MX2022005414A/es unknown
- 2020-11-05 TW TW109138601A patent/TWI867088B/zh active
- 2020-11-05 WO PCT/EP2020/081097 patent/WO2021089683A1/en not_active Ceased
- 2020-11-05 CN CN202080091881.6A patent/CN114929694B/zh active Active
- 2020-11-05 AU AU2020377470A patent/AU2020377470A1/en active Pending
- 2020-11-05 CR CR20220195A patent/CR20220195A/es unknown
- 2020-11-05 CN CN202510047624.7A patent/CN120136863A/zh active Pending
-
2022
- 2022-04-28 SA SA522432419A patent/SA522432419B1/ar unknown
- 2022-04-29 DO DO2022000093A patent/DOP2022000093A/es unknown
- 2022-05-03 CO CONC2022/0005783A patent/CO2022005783A2/es unknown
- 2022-05-03 EC ECSENADI202235103A patent/ECSP22035103A/es unknown
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