JP2023156372A5 - - Google Patents
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- JP2023156372A5 JP2023156372A5 JP2023123302A JP2023123302A JP2023156372A5 JP 2023156372 A5 JP2023156372 A5 JP 2023156372A5 JP 2023123302 A JP2023123302 A JP 2023123302A JP 2023123302 A JP2023123302 A JP 2023123302A JP 2023156372 A5 JP2023156372 A5 JP 2023156372A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- compound
- medicament
- manufacture
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- FARXPFGGGGLENU-UHFFFAOYSA-N 3-(5-fluoro-1-benzofuran-3-yl)-4-(5-methyl-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione Chemical compound C12=CC=3OCOC=3C=C2N(C)C=C1C1=C(C=2C3=CC(F)=CC=C3OC=2)C(=O)NC1=O FARXPFGGGGLENU-UHFFFAOYSA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Claims (5)
- 化合物であって、前記化合物は、アモルファス３－（５－フルオロベンゾフラン－３－イル）－４－（５－メチル－５Ｈ－［１，３］ジオキソロ［４，５－ｆ］インドール－７－イル）ピロール－２，５－ジオンである、化合物。
- 請求項１記載の化合物および薬学的に許容な賦形剤を含む医薬組成物。
- 癌を治療するための薬剤の製造における、請求項１記載の化合物の治療有効量の使用。
- 請求項３記載の使用において、前記癌は、脳腫瘍、肺癌、乳癌、卵巣癌、膀胱癌、神経芽細胞腫、腎臓癌、または膵臓癌である、使用。
- 患者の外傷性脳損傷を治療するための薬剤の製造における、請求項１記載の化合物の治療有効量の使用。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762544277P | 2017-08-11 | 2017-08-11 | |
| US62/544,277 | 2017-08-11 | ||
| JP2020530441A JP7424639B2 (ja) | 2017-08-11 | 2018-08-10 | ３－（５－フルオロベンゾフラン－３－イル）－４－（５－メチル－５Ｈ－［１，３］ジオキソロ［４，５－ｆ］インドール－７－イル）ピロール－２，５－ジオンの固体形態 |
| PCT/US2018/046203 WO2019032958A1 (en) | 2017-08-11 | 2018-08-10 | SOLID FORMS OF 3- (5-FLUOROBENZOFURAN-3-YL) -4- (5-METHYL-5H [1,3] DIOXOLO [4,5-F] INDOL-7-YL) PYRROLE-2,5-DIONE |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020530441A Division JP7424639B2 (ja) | 2017-08-11 | 2018-08-10 | ３－（５－フルオロベンゾフラン－３－イル）－４－（５－メチル－５Ｈ－［１，３］ジオキソロ［４，５－ｆ］インドール－７－イル）ピロール－２，５－ジオンの固体形態 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023156372A JP2023156372A (ja) | 2023-10-24 |
| JP2023156372A5 true JP2023156372A5 (ja) | 2024-04-12 |
Family
ID=63405430
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020530441A Active JP7424639B2 (ja) | 2017-08-11 | 2018-08-10 | ３－（５－フルオロベンゾフラン－３－イル）－４－（５－メチル－５Ｈ－［１，３］ジオキソロ［４，５－ｆ］インドール－７－イル）ピロール－２，５－ジオンの固体形態 |
| JP2023123302A Pending JP2023156372A (ja) | 2017-08-11 | 2023-07-28 | ３－（５－フルオロベンゾフラン－３－イル）－４－（５－メチル－５Ｈ－［１，３］ジオキソロ［４，５－ｆ］インドール－７－イル）ピロール－２，５－ジオンの固体形態 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020530441A Active JP7424639B2 (ja) | 2017-08-11 | 2018-08-10 | ３－（５－フルオロベンゾフラン－３－イル）－４－（５－メチル－５Ｈ－［１，３］ジオキソロ［４，５－ｆ］インドール－７－イル）ピロール－２，５－ジオンの固体形態 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11136334B2 (ja) |
| EP (1) | EP3665176B1 (ja) |
| JP (2) | JP7424639B2 (ja) |
| KR (2) | KR20200040799A (ja) |
| CN (2) | CN111247153B (ja) |
| AU (2) | AU2018313259B2 (ja) |
| BR (1) | BR112020002892A2 (ja) |
| CA (1) | CA3072240A1 (ja) |
| DK (1) | DK3665176T3 (ja) |
| ES (1) | ES2974328T3 (ja) |
| FI (1) | FI3665176T3 (ja) |
| IL (1) | IL272556A (ja) |
| MX (2) | MX2020001547A (ja) |
| PL (1) | PL3665176T3 (ja) |
| PT (1) | PT3665176T (ja) |
| WO (1) | WO2019032958A1 (ja) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018352384B2 (en) | 2017-10-16 | 2023-12-21 | Actuate Therapeutics Inc. | Solid forms of 3-[5-Fluorobenzofuran-3-yl]-4-[5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl] pyrrole-2,5-dione |
| CN112437663A (zh) * | 2018-05-17 | 2021-03-02 | 开动疗法公司 | 用β型糖原合酶激酶3抑制剂治疗特发性肺纤维化 |
| WO2024006750A1 (en) | 2022-06-27 | 2024-01-04 | Actuate Therapeutics, Inc. | Oral dosage forms of elraglusib |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2446269T3 (es) | 2006-12-19 | 2014-03-06 | The Board Of Trustees Of The University Of Illinois | 3-Benzofuranil-4-indolil-maleimidas como potentes inhibidores de GSK-3 para trastornos neurodegenerativos |
| AU2010336533B9 (en) | 2009-12-23 | 2015-10-08 | Arqule, Inc. | Purified pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same |
-
2018
- 2018-08-10 EP EP18760168.7A patent/EP3665176B1/en active Active
- 2018-08-10 FI FIEP18760168.7T patent/FI3665176T3/fi active
- 2018-08-10 KR KR1020207006706A patent/KR20200040799A/ko active IP Right Grant
- 2018-08-10 US US16/638,303 patent/US11136334B2/en active Active
- 2018-08-10 PL PL18760168.7T patent/PL3665176T3/pl unknown
- 2018-08-10 MX MX2020001547A patent/MX2020001547A/es unknown
- 2018-08-10 AU AU2018313259A patent/AU2018313259B2/en active Active
- 2018-08-10 CN CN201880059690.4A patent/CN111247153B/zh active Active
- 2018-08-10 CA CA3072240A patent/CA3072240A1/en active Pending
- 2018-08-10 DK DK18760168.7T patent/DK3665176T3/da active
- 2018-08-10 PT PT187601687T patent/PT3665176T/pt unknown
- 2018-08-10 CN CN202311213594.XA patent/CN117362305A/zh active Pending
- 2018-08-10 KR KR1020247014386A patent/KR20240063198A/ko active Application Filing
- 2018-08-10 ES ES18760168T patent/ES2974328T3/es active Active
- 2018-08-10 JP JP2020530441A patent/JP7424639B2/ja active Active
- 2018-08-10 BR BR112020002892-4A patent/BR112020002892A2/pt unknown
- 2018-08-10 WO PCT/US2018/046203 patent/WO2019032958A1/en unknown
-
2020
- 2020-02-07 MX MX2023005875A patent/MX2023005875A/es unknown
- 2020-02-09 IL IL272556A patent/IL272556A/en unknown
-
2021
- 2021-09-24 US US17/484,025 patent/US20220009939A1/en active Pending
-
2023
- 2023-02-23 AU AU2023201059A patent/AU2023201059A1/en active Pending
- 2023-07-28 JP JP2023123302A patent/JP2023156372A/ja active Pending
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