JP2023052777A5 - - Google Patents
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- JP2023052777A5 JP2023052777A5 JP2023012476A JP2023012476A JP2023052777A5 JP 2023052777 A5 JP2023052777 A5 JP 2023052777A5 JP 2023012476 A JP2023012476 A JP 2023012476A JP 2023012476 A JP2023012476 A JP 2023012476A JP 2023052777 A5 JP2023052777 A5 JP 2023052777A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- lymphocytes
- polynucleotide
- contacting
- encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 21
- 210000004698 lymphocyte Anatomy 0.000 claims 17
- 210000001744 T-lymphocyte Anatomy 0.000 claims 9
- 102000040430 polynucleotide Human genes 0.000 claims 9
- 108091033319 polynucleotide Proteins 0.000 claims 9
- 239000002157 polynucleotide Substances 0.000 claims 9
- 230000004913 activation Effects 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 102400000552 Notch 1 intracellular domain Human genes 0.000 claims 6
- 101800001628 Notch 1 intracellular domain Proteins 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 102000005650 Notch Receptors Human genes 0.000 claims 3
- 108010070047 Notch Receptors Proteins 0.000 claims 3
- 230000000735 allogeneic effect Effects 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 3
- 230000035755 proliferation Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025017444A JP2025069383A (ja) | 2011-04-06 | 2025-02-05 | 末梢免疫機能を調節するための方法及び組成物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161516637P | 2011-04-06 | 2011-04-06 | |
| US61/516,637 | 2011-04-06 | ||
| US201161541248P | 2011-09-30 | 2011-09-30 | |
| US61/541,248 | 2011-09-30 | ||
| JP2020150411A JP7267976B2 (ja) | 2011-04-06 | 2020-09-08 | 末梢免疫機能を調節するための方法及び組成物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020150411A Division JP7267976B2 (ja) | 2011-04-06 | 2020-09-08 | 末梢免疫機能を調節するための方法及び組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025017444A Division JP2025069383A (ja) | 2011-04-06 | 2025-02-05 | 末梢免疫機能を調節するための方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023052777A JP2023052777A (ja) | 2023-04-12 |
| JP2023052777A5 true JP2023052777A5 (enExample) | 2023-06-16 |
| JP7631387B2 JP7631387B2 (ja) | 2025-02-18 |
Family
ID=47139503
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014504019A Active JP5932970B2 (ja) | 2011-04-06 | 2012-04-06 | 末梢免疫機能を調節するための方法及び組成物 |
| JP2016089159A Active JP6134032B2 (ja) | 2011-04-06 | 2016-04-27 | 末梢免疫機能を調節するための方法及び組成物 |
| JP2017083713A Active JP6392926B2 (ja) | 2011-04-06 | 2017-04-20 | 末梢免疫機能を調節するための方法及び組成物 |
| JP2018153539A Active JP6981934B2 (ja) | 2011-04-06 | 2018-08-17 | 末梢免疫機能を調節するための方法及び組成物 |
| JP2020150411A Active JP7267976B2 (ja) | 2011-04-06 | 2020-09-08 | 末梢免疫機能を調節するための方法及び組成物 |
| JP2023012476A Active JP7631387B2 (ja) | 2011-04-06 | 2023-01-31 | 末梢免疫機能を調節するための方法及び組成物 |
| JP2025017444A Pending JP2025069383A (ja) | 2011-04-06 | 2025-02-05 | 末梢免疫機能を調節するための方法及び組成物 |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014504019A Active JP5932970B2 (ja) | 2011-04-06 | 2012-04-06 | 末梢免疫機能を調節するための方法及び組成物 |
| JP2016089159A Active JP6134032B2 (ja) | 2011-04-06 | 2016-04-27 | 末梢免疫機能を調節するための方法及び組成物 |
| JP2017083713A Active JP6392926B2 (ja) | 2011-04-06 | 2017-04-20 | 末梢免疫機能を調節するための方法及び組成物 |
| JP2018153539A Active JP6981934B2 (ja) | 2011-04-06 | 2018-08-17 | 末梢免疫機能を調節するための方法及び組成物 |
| JP2020150411A Active JP7267976B2 (ja) | 2011-04-06 | 2020-09-08 | 末梢免疫機能を調節するための方法及び組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025017444A Pending JP2025069383A (ja) | 2011-04-06 | 2025-02-05 | 末梢免疫機能を調節するための方法及び組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (6) | US8785190B2 (enExample) |
| EP (1) | EP2694080B1 (enExample) |
| JP (7) | JP5932970B2 (enExample) |
| CN (2) | CN103547275B (enExample) |
| CA (1) | CA2832356C (enExample) |
| WO (1) | WO2012154344A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8785190B2 (en) | 2011-04-06 | 2014-07-22 | Sanbio, Inc. | Methods and compositions for modulating peripheral immune function |
| JP6023218B2 (ja) | 2012-01-27 | 2016-11-09 | サンバイオ，インコーポレイティド | 血管新生及び血管発生を調節するための方法及び組成物 |
| EP2849766B1 (en) | 2012-05-16 | 2019-03-06 | SanBio, Inc. | Cells for use in the treatment of brain injury |
| CA2885414C (en) | 2012-10-09 | 2018-05-01 | Sanbio, Inc. | Methods and compositions for treatment of retinal degeneration |
| CA2901653C (en) * | 2013-03-01 | 2019-01-08 | Gunther Eissner | Protection of the vascular endothelium from immunologically mediated cytotoxic reactions with human cd34-negative progenitor cells |
| AU2014230014B2 (en) | 2013-03-15 | 2019-11-14 | Tigenix, S.A.U. | Lymphocyte biomarkers for determining the clinical response to therapy with mesenschymal stromal cells(MSC) |
| US20160095885A1 (en) | 2014-10-01 | 2016-04-07 | WibiWorks Therapeutics, Inc. | Induction Medium & Methods for Stem Cell Culture & Therapy |
| CN105985928A (zh) * | 2015-02-10 | 2016-10-05 | 睿尔（天津）生物科技有限公司 | 一种增强间充质干细胞免疫调节能力的预处理培养方法 |
| EP3261651B1 (en) * | 2015-02-27 | 2022-05-04 | iCell Gene Therapeutics LLC | Chimeric antigen receptors (cars) targeting hematologic malignancies, compositions and methods of use thereof |
| CN106148276A (zh) * | 2015-04-16 | 2016-11-23 | 中国科学院上海生命科学研究院 | 间充质干细胞在制备治疗神经退行性疾病的药物中的应用 |
| EP3307346A4 (en) * | 2015-06-15 | 2019-01-02 | Vital Therapies, Inc. | Composition and method for inducing anti-inflammatory response |
| US11655452B2 (en) | 2015-06-25 | 2023-05-23 | Icell Gene Therapeutics Inc. | Chimeric antigen receptors (CARs), compositions and methods of use thereof |
| US11173179B2 (en) | 2015-06-25 | 2021-11-16 | Icell Gene Therapeutics Llc | Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof |
| US10383895B2 (en) * | 2016-02-18 | 2019-08-20 | Viera Bioscience, Inc. | Stimulation of therapeutic angiogenesis by T regulatory cells |
| EP3463482B1 (en) | 2016-06-07 | 2021-10-06 | The Brigham and Women's Hospital, Inc. | Methods relating to t peripheral helper cells in autoantibody-associated conditions |
| EP4353750A3 (en) | 2016-06-24 | 2024-07-24 | iCell Gene Therapeutics LLC | Chimeric antigen receptors (cars), compositions and methods thereof |
| CN110382020A (zh) | 2016-12-28 | 2019-10-25 | 桑比欧公司 | 细胞递送系统及操作细胞递送系统的方法 |
| SG11202000555UA (en) | 2017-06-21 | 2020-02-27 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (cars), compositions and methods thereof |
| JP7664169B2 (ja) | 2019-10-17 | 2025-04-17 | テルモ株式会社 | 炎症性疾患を処置するための細胞培養物 |
| CN111979186B (zh) * | 2020-08-21 | 2022-04-08 | 遵义医科大学附属医院 | 一种快速高效体外扩增人间充质干细胞的方法及应用 |
| CN116376828B (zh) * | 2023-06-02 | 2023-08-11 | 成都云测医学生物技术有限公司 | 一种诱导CD4+T细胞生成Treg细胞的方法及应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5932970Y2 (ja) | 1979-09-29 | 1984-09-14 | トキナ−光学株式会社 | ズ−ム式交換レンズにおける焦点距離の表示装置 |
| JPS5993639U (ja) | 1982-12-11 | 1984-06-25 | 愛知電機株式会社 | 撹拌装置における内容物の自動排出，投入装置 |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| CA2271248C (en) * | 1996-11-07 | 2009-08-11 | Jonathan Robert Lamb | Use of a notch ligand in immunotherapy |
| US6280718B1 (en) | 1999-11-08 | 2001-08-28 | Wisconsin Alumni Reasearch Foundation | Hematopoietic differentiation of human pluripotent embryonic stem cells |
| US6602711B1 (en) | 2000-02-21 | 2003-08-05 | Wisconsin Alumni Research Foundation | Method of making embryoid bodies from primate embryonic stem cells |
| US7005252B1 (en) | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
| US20030003090A1 (en) | 2001-05-31 | 2003-01-02 | Prockop Darwin J. | Directed in vitro differentiation of marrow stromal cells into neural cell progenitors |
| EP1410018A1 (en) | 2001-07-25 | 2004-04-21 | Lorantis Limited | Method for detecting modultators of notch signalling |
| US6887706B2 (en) | 2001-10-03 | 2005-05-03 | Wisconsin Alumni Research Foundation | Method of in vitro differentiation of transplantable neural precursor cells from primate embryonic stem cells |
| EP2270146A1 (en) | 2002-02-06 | 2011-01-05 | Sanbio, Inc. | Method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene |
| JP2007532112A (ja) | 2004-04-12 | 2007-11-15 | サンバイオ，インコーポレイティド | ニューロン始原細胞特性を示す細胞 |
| US20060216276A1 (en) | 2005-03-07 | 2006-09-28 | Mari Dezawa | Use of materials for treatment of central nervous system lesions |
| WO2008102460A1 (en) | 2007-02-23 | 2008-08-28 | Sanbio Inc. | Transplantation of bone marrow stromal cell-induced neural stem cells for promoting fuctional recovery after spinal cord injury |
| EP2175868B1 (en) * | 2007-08-15 | 2017-12-20 | SanBio, Inc. | Bone marrow derived cells for use in treating neural degeneration |
| US10702554B2 (en) | 2007-12-03 | 2020-07-07 | Sanbio, Inc. | Extracellular matrix from pluripotent cells |
| PL2274430T3 (pl) * | 2008-04-30 | 2017-09-29 | Sanbio Inc | Komórki regenerujące nerwy ze zmianami w metylacji DNA |
| GB0814249D0 (en) * | 2008-08-04 | 2008-09-10 | Cellerix Sa | Uses of mesenchymal stem cells |
| US8518397B2 (en) * | 2009-08-14 | 2013-08-27 | Case Western Reserve University | Notch induced natural killer cell generation and therapeutic uses |
| US8785190B2 (en) | 2011-04-06 | 2014-07-22 | Sanbio, Inc. | Methods and compositions for modulating peripheral immune function |
| US20120263681A1 (en) * | 2011-04-12 | 2012-10-18 | Fujifilm Corporation | Composition comprising cell and biocompatible polymer |
-
2012
- 2012-04-06 US US13/441,311 patent/US8785190B2/en not_active Ceased
- 2012-04-06 CN CN201280024630.1A patent/CN103547275B/zh active Active
- 2012-04-06 WO PCT/US2012/032504 patent/WO2012154344A1/en not_active Ceased
- 2012-04-06 JP JP2014504019A patent/JP5932970B2/ja active Active
- 2012-04-06 CA CA2832356A patent/CA2832356C/en active Active
- 2012-04-06 CN CN201611001568.0A patent/CN106692193B/zh active Active
- 2012-04-06 EP EP12782502.4A patent/EP2694080B1/en active Active
-
2014
- 2014-06-06 US US14/298,001 patent/US9655927B2/en active Active
-
2015
- 2015-10-02 US US14/874,249 patent/USRE46382E1/en active Active
-
2016
- 2016-04-27 JP JP2016089159A patent/JP6134032B2/ja active Active
-
2017
- 2017-04-20 JP JP2017083713A patent/JP6392926B2/ja active Active
- 2017-04-21 US US15/494,208 patent/US10543234B2/en active Active
-
2018
- 2018-08-17 JP JP2018153539A patent/JP6981934B2/ja active Active
-
2019
- 2019-12-12 US US16/712,863 patent/US11903972B2/en active Active
-
2020
- 2020-09-08 JP JP2020150411A patent/JP7267976B2/ja active Active
-
2023
- 2023-01-31 JP JP2023012476A patent/JP7631387B2/ja active Active
-
2024
- 2024-01-09 US US18/408,002 patent/US20240139255A1/en active Pending
-
2025
- 2025-02-05 JP JP2025017444A patent/JP2025069383A/ja active Pending
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