JP2023036663A5 - - Google Patents
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- Publication number
- JP2023036663A5 JP2023036663A5 JP2022196699A JP2022196699A JP2023036663A5 JP 2023036663 A5 JP2023036663 A5 JP 2023036663A5 JP 2022196699 A JP2022196699 A JP 2022196699A JP 2022196699 A JP2022196699 A JP 2022196699A JP 2023036663 A5 JP2023036663 A5 JP 2023036663A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- gastroparesis
- formulation
- polyethylene glycol
- disorder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- -1 poly(ethylene oxide) Polymers 0.000 claims 8
- 206010021518 Impaired gastric emptying Diseases 0.000 claims 6
- 208000001288 gastroparesis Diseases 0.000 claims 6
- 239000002202 Polyethylene glycol Substances 0.000 claims 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 229960001253 domperidone Drugs 0.000 claims 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims 2
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 2
- 206010028813 Nausea Diseases 0.000 claims 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims 2
- 206010047700 Vomiting Diseases 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- 235000006708 antioxidants Nutrition 0.000 claims 2
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims 2
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims 2
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 2
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims 2
- FGXWKSZFVQUSTL-UHFFFAOYSA-N domperidone Chemical compound C12=CC=CC=C2NC(=O)N1CCCN(CC1)CCC1N1C2=CC=C(Cl)C=C2NC1=O FGXWKSZFVQUSTL-UHFFFAOYSA-N 0.000 claims 2
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 2
- 230000006651 lactation Effects 0.000 claims 2
- 230000008693 nausea Effects 0.000 claims 2
- 230000008673 vomiting Effects 0.000 claims 2
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims 1
- 229930003427 Vitamin E Natural products 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- RWPGFSMJFRPDDP-UHFFFAOYSA-L potassium metabisulfite Chemical compound [K+].[K+].[O-]S(=O)S([O-])(=O)=O RWPGFSMJFRPDDP-UHFFFAOYSA-L 0.000 claims 1
- 229940043349 potassium metabisulfite Drugs 0.000 claims 1
- 235000010263 potassium metabisulphite Nutrition 0.000 claims 1
- 235000010388 propyl gallate Nutrition 0.000 claims 1
- 239000000473 propyl gallate Substances 0.000 claims 1
- 229940075579 propyl gallate Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims 1
- 229940001584 sodium metabisulfite Drugs 0.000 claims 1
- 235000010262 sodium metabisulphite Nutrition 0.000 claims 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 claims 1
- 229940001474 sodium thiosulfate Drugs 0.000 claims 1
- 235000019345 sodium thiosulphate Nutrition 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 235000019165 vitamin E Nutrition 0.000 claims 1
- 229940046009 vitamin E Drugs 0.000 claims 1
- 239000011709 vitamin E Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862750491P | 2018-10-25 | 2018-10-25 | |
| US62/750,491 | 2018-10-25 | ||
| JP2021547550A JP7583728B2 (ja) | 2018-10-25 | 2019-10-25 | 重水素化ドンペリドンを含む製剤 |
| PCT/US2019/058033 WO2020086947A1 (en) | 2018-10-25 | 2019-10-25 | Formulations containing deuterated domperidone |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021547550A Division JP7583728B2 (ja) | 2018-10-25 | 2019-10-25 | 重水素化ドンペリドンを含む製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023036663A JP2023036663A (ja) | 2023-03-14 |
| JP2023036663A5 true JP2023036663A5 (https=) | 2023-08-08 |
| JP7652751B2 JP7652751B2 (ja) | 2025-03-27 |
Family
ID=68582416
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021547550A Active JP7583728B2 (ja) | 2018-10-25 | 2019-10-25 | 重水素化ドンペリドンを含む製剤 |
| JP2022196699A Active JP7652751B2 (ja) | 2018-10-25 | 2022-12-09 | 重水素化ドンペリドンを含む製剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021547550A Active JP7583728B2 (ja) | 2018-10-25 | 2019-10-25 | 重水素化ドンペリドンを含む製剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US12514852B2 (https=) |
| EP (1) | EP3668510B1 (https=) |
| JP (2) | JP7583728B2 (https=) |
| KR (3) | KR20240068762A (https=) |
| CN (1) | CN113164463B (https=) |
| AU (1) | AU2019366993B2 (https=) |
| CA (1) | CA3117682A1 (https=) |
| ES (1) | ES2852623T3 (https=) |
| IL (1) | IL282575B (https=) |
| SG (1) | SG11202103284QA (https=) |
| WO (1) | WO2020086947A1 (https=) |
| ZA (1) | ZA202102115B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017136617A1 (en) * | 2016-02-04 | 2017-08-10 | Cinrx Pharma, Llc | Deuterated domperidone compositions and methods for therapy of disorders |
| KR20240068762A (ko) | 2018-10-25 | 2024-05-17 | 신돔 파마, 인크. | 중수소화 돔페리돈을 함유하는 제제 |
| EP4525868A1 (en) * | 2022-04-20 | 2025-03-26 | CinDome Pharma, Inc. | Deuterated domperidone for treating gastroparesis |
| CN120813355A (zh) * | 2023-03-23 | 2025-10-17 | 辛多美制药有限公司 | 用于治疗糖尿病性胃轻瘫的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9702392D0 (en) | 1997-02-06 | 1997-03-26 | Boots Co Plc | Therapeutic agents |
| US6383471B1 (en) | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
| US20050220825A1 (en) | 2004-03-10 | 2005-10-06 | Adrian Funke | Molecular dispersions of drospirenone |
| CN1686128A (zh) * | 2005-04-19 | 2005-10-26 | 北京正大绿洲医药科技有限公司 | 多潘立酮滴丸及其制备方法 |
| AU2008245580A1 (en) | 2007-04-26 | 2008-11-06 | Craig A. Aronchick | Compositions and methods for transmucosal delivery of domperidone |
| CN102125528A (zh) | 2010-01-12 | 2011-07-20 | 上海中邦斯瑞生物药业技术有限公司 | 多潘立酮口崩片 |
| DE102010015143A1 (de) * | 2010-04-16 | 2011-10-20 | Cts Chemical Industries Ltd. | Stabile flüssige ölige gebrauchsfertige Formulierungen, Herstellung davon und Verwendung davon |
| US9034858B2 (en) * | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US9943513B1 (en) | 2015-10-07 | 2018-04-17 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
| WO2017136617A1 (en) * | 2016-02-04 | 2017-08-10 | Cinrx Pharma, Llc | Deuterated domperidone compositions and methods for therapy of disorders |
| KR20240068762A (ko) | 2018-10-25 | 2024-05-17 | 신돔 파마, 인크. | 중수소화 돔페리돈을 함유하는 제제 |
| WO2020086950A1 (en) | 2018-10-25 | 2020-04-30 | Cindome Pharma, Inc. | Formulations containing domperidone |
-
2019
- 2019-10-25 KR KR1020247014648A patent/KR20240068762A/ko active Pending
- 2019-10-25 EP EP19804996.7A patent/EP3668510B1/en active Active
- 2019-10-25 JP JP2021547550A patent/JP7583728B2/ja active Active
- 2019-10-25 KR KR1020217015511A patent/KR20210080495A/ko not_active Ceased
- 2019-10-25 CA CA3117682A patent/CA3117682A1/en active Pending
- 2019-10-25 AU AU2019366993A patent/AU2019366993B2/en active Active
- 2019-10-25 CN CN201980069226.8A patent/CN113164463B/zh active Active
- 2019-10-25 WO PCT/US2019/058033 patent/WO2020086947A1/en not_active Ceased
- 2019-10-25 US US17/287,571 patent/US12514852B2/en active Active
- 2019-10-25 KR KR1020237041657A patent/KR102667995B1/ko active Active
- 2019-10-25 SG SG11202103284QA patent/SG11202103284QA/en unknown
- 2019-10-25 ES ES19804996T patent/ES2852623T3/es active Active
-
2021
- 2021-03-29 ZA ZA2021/02115A patent/ZA202102115B/en unknown
- 2021-04-22 IL IL282575A patent/IL282575B/en unknown
-
2022
- 2022-12-09 JP JP2022196699A patent/JP7652751B2/ja active Active
-
2025
- 2025-12-03 US US19/407,389 patent/US20260083717A1/en active Pending
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