JP2023024997A - 処理装置及び粉末の造粒のためのプロセス - Google Patents
処理装置及び粉末の造粒のためのプロセス Download PDFInfo
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- JP2023024997A JP2023024997A JP2022177855A JP2022177855A JP2023024997A JP 2023024997 A JP2023024997 A JP 2023024997A JP 2022177855 A JP2022177855 A JP 2022177855A JP 2022177855 A JP2022177855 A JP 2022177855A JP 2023024997 A JP2023024997 A JP 2023024997A
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- B29B7/80—Component parts, details or accessories; Auxiliary operations
- B29B7/84—Venting or degassing ; Removing liquids, e.g. by evaporating components
- B29B7/845—Venting, degassing or removing evaporated components in devices with rotary stirrers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B7/00—Mixing; Kneading
- B29B7/80—Component parts, details or accessories; Auxiliary operations
- B29B7/88—Adding charges, i.e. additives
- B29B7/94—Liquid charges
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B9/00—Making granules
- B29B9/16—Auxiliary treatment of granules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
- B29C48/04—Particle-shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/50—Details of extruders
- B29C48/505—Screws
- B29C48/625—Screws characterised by the ratio of the threaded length of the screw to its outside diameter [L/D ratio]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/50—Details of extruders
- B29C48/505—Screws
- B29C48/64—Screws with two or more threads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/78—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling
- B29C48/80—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling at the plasticising zone, e.g. by heating cylinders
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Abstract
Description
a)活性物質、結合剤、水、及び場合により添加剤を含む投入混合物を、フラクショナルローブ処理装置の吸入ゾーンに導入するステップと、
b)フラクショナル要素のみから構成されている造粒ゾーンに投入混合物を通すステップと、
c)搬送要素を備えている搬送ゾーンを通して細粒を搬送し、出口に向けるステップと、
d)湿った細粒を集めて、乾燥による損失が1.5%w/w未満になるまで乾燥させるステップと、
を含む。
a.直径の等しい2つの平行な互いに交差する穴を有する加熱手段及び冷却手段を有し、2つの穴の中心距離が穴の直径より小さいバレルと、
b.複数のスクリュー要素に連結されて、各穴の中にスクリューを形成するシャフトであって、スクリューが噛み合い、スクリューがバレル内に少なくとも3つのゾーンを形成するシャフトと、
を備え、ゾーンが、
i.活性物質及び添加剤を含む投入混合物を受けるための、少なくとも1つの深型フライトショベル要素を噛み合う各スクリューに備えている吸入ゾーンと、
ii.水分又は結合剤溶液を導入し、活性物質及び添加剤を造粒するための手段を有する、フラクショナルローブ要素のみから構成されている造粒ゾーンと、
iii.湿った細粒を乾燥させるための任意選択的な乾燥ゾーンと、
iv.細粒を排出するための排出ゾーンと、
を含み、造粒ゾーンが排出ゾーンの前及び吸入ゾーンの後に位置し、乾燥ゾーンが各シャフトに1つ又は複数のフラクショナルローブ要素を有し、造粒ゾーンが各シャフトに複数のフラクショナルローブ要素を有する、フラクショナルローブ処理装置に関する。
a.直径の等しい2つの平行な互いに交差する穴を有する加熱手段及び冷却手段を有し、2つの穴の中心距離が穴の直径より小さいバレルと、
b.複数のスクリュー要素に連結されて、各穴の中にスクリューを形成するシャフトであって、スクリューが噛み合い、スクリューがバレル内に少なくとも3つのゾーンを形成するシャフトと、
を備え、ゾーンが、
i.活性物質及び添加剤を含む投入混合物を受けるための、少なくとも1つの深型フライトショベル要素を噛み合う各スクリューに備えている吸入ゾーンと、
ii.水分又は結合剤溶液を導入し、活性物質及び添加剤を造粒するための手段を有する、フラクショナルローブ要素のみから構成されている造粒ゾーンと、
iii.湿った細粒を乾燥させるための任意選択的な乾燥ゾーンと、
iv.細粒を排出するための排出ゾーンと、
を含み、造粒ゾーンが排出ゾーンの前及び吸入ゾーンの後に位置し、乾燥ゾーンが各シャフトに1つ又は複数のフラクショナルローブ要素を有し、造粒ゾーンが各シャフトに複数のフラクショナルローブ要素を有する、フラクショナルローブ処理装置に関する。
a)活性物質及び/又は添加剤を含む投入混合物を、上記実施形態によるフラクショナルローブ処理装置の吸入ゾーンに導入するステップと、
b)フラクショナルローブ要素のみから構成されている造粒ゾーンに投入混合物を通し、フラクショナルローブ要素を用いて混合物を処理しながら、投入混合物の毎分20%w/w以下の水分を混合物に導入して、湿った塊を形成するステップと、
c)バレル温度が造粒ゾーンのバレル温度の少なくとも2倍の温度に設定される乾燥ゾーンに、湿った塊を通すステップと、
d)細粒を排出ゾーンに通して、バレルの出口に向けるステップと、
e)細粒を集めるステップと、
を含む造粒方法に関する。
a)活性物質、結合剤、水、及び場合により添加剤を含む投入混合物を、フラクショナルローブ処理装置の吸入ゾーンに導入するステップと、
b)フラクショナルローブ要素のみから構成されている造粒ゾーンに投入混合物を通すステップと、
c)搬送要素を備えている搬送ゾーンを通して細粒を搬送し、出口に向けるステップと、
d)湿った細粒を集めて、乾燥による損失が1.5%w/w未満になるまで乾燥させるステップと、
を含む造粒方法に関する。
500 V1.09-MICROMERITICS)を用いて判定される。
)、並びに化粧品、家畜、及び植物に使用するための成分が挙げられる。
#30(17.71)、#40(29.63)、#60(54.94)、#80(72.
88)、#100(81.68)、中央径=300ミクロン
アスペクト比は、最小径と最大径の比である。アスペクト比は、物体の真円度を定める。アスペクト比1は円を表す。
#30(20.34)、#40(33.52)、#60(59.77)、#80(73.58)、#100(80.80)、中央径=330ミクロン
RSE-右回りスクリュー要素、RFV-レギュラーフライトショベル要素、RFN-レギュラーフライトショベル要素-ノーマル、NRF-ノーマル-RFV(推移要素)、RKB-右回りニーディングブロック、FKB-フラクショナルニーディングブロック
供給速度:150g/分、スクリュー速度:500rpm、流体取込み:4.5ml/分
1.細粒の粒度分布(ふるい番号、保持された累積重量%):
#20=25.40、#40=48.0.8、#60=60.97、#80=67.90、#100=74.23
2.細粒特性:かさ密度(g/cc)=0.402、タップ密度(g/cc)=0.566、圧縮性指数(%)=28.986、ハウスナー比=1.408、KFによる水分量=0.9%
1.粒度分布(ふるい番号、保持された累積重量%):
#20=16.12、#40=49.77、#60=66.00、#100=76.27、
中央径 430ミクロン
2.細粒特性:
かさ密度(g/cc)=0.500、タップ密度(g/cc)=0.625、圧縮性指数(%)=20.00、ハウスナー比=1.25、乾燥による損失(%w/w)=1.06
各実験により得られた湿った塊を、乾燥による損失が1.5%w/w未満になるまで熱風炉において50℃で乾燥させた。乾燥した細粒を粒径、形状、破砕性、流動性、及び多孔率について特徴付けした。
一連のふるい(150、180、250、420、600、及び850μm)を使用して、細粒を2mmの振幅で5分間、ふるい振とう機に入れた。各ふるいによって保持された細粒の量を判定した。ふるい振とう機(Electrolab、インド)を使用してふるい分析を行った。
破砕性試験装置(Electrolab、インド)を使用して細粒の破砕性試験を行い、試験の前後に比較ふるい分析を行うことにより、細粒の引張強度を判定した。20ステンレス鋼ビーズ(平均直径4mm)を用いて10グラムの細粒に落下衝撃を与えることにより、破砕性試験装置を25rpmで10分間作動させた。その後、ビーズを除去し、細粒のふるい分析を行った。
多孔率を判定するために、BLP1実験及びFLP1実験による細粒を選択した。これら2つのバッチは、同様の粒度分布を有していた。各バッチの細粒を、#40ふるいを通して分粒し、#60ふるいに保持された分について、高圧水銀多孔率メータ(AutoPore IV 9500 V1.09、Micromeritics Instrument Corporation)を用いて多孔率評価を行った。
錠剤を、重量偏差、硬度、破砕性、及び崩壊時間について評価した。
トルク評価:アナログトルク取得システムを用いて、各実験中のトルクを0.5秒ごとにオンラインで測定し分析した。
計算領域を形成する数値的調査について、10mm厚さの2ローブ輪郭及びフラクショナルローブ輪郭を考慮した。これらのローブを、モデリング加工において固定壁を形成する2つの互いに交差する円筒穴の中心で旋回させた。これらのローブは、旋回点の周りで同じ方向に動く境界を形成する(共回転)。ローブ同士の向きを45°及び90°にして、定常状態の分析を行った。
BLP実験及びFLP実験についてのトルクパラメータ及び細粒特性の比較は、以下の通りである。
1)FLPは、はるかに広範囲の処理量にわたって、均一なトルクを示す定常状態をもたらす。
2)より均一な加工が行われることにより、FLPにより対称形状の粒子が得られた。
3)粒子のより良好な対称性により、流動性及び破砕性などの望ましい特性が得られた。
4)より低い平均トルクが、より低い比力学的エネルギー(SME)に変わることにより、特に多孔構造が得られた。
5)数理モデリングは、BLPの一貫性のないトルクがホットスポットの存在を示す高い壁圧力によるものであることを示す。
Claims (17)
- a.直径の等しい2つの平行な互いに交差する穴を有する加熱手段及び冷却手段を有し、前記2つの穴の中心距離が前記直径より小さいバレルと、
b.複数のスクリュー要素に連結されて、前記穴の各々の中にスクリューを形成するシャフトであって、前記スクリューが噛み合い、前記スクリューが前記バレル内に少なくとも3つのゾーンを形成するシャフトと、
を備えるフラクショナルローブ処理装置であって、
前記ゾーンが、
i.活性物質及び添加剤を含む投入混合物を受けるための、少なくとも1つの深型フライトショベル要素を、互いに噛み合う前記スクリューの各々に備えている吸入ゾーンと、
ii.水分又は結合剤溶液を導入し、前記活性物質及び前記添加剤を造粒するための手段を有する、フラクショナルローブ要素のみから構成されている造粒ゾーンと、
iii.湿った細粒を乾燥させるための任意選択的な乾燥ゾーンと、
iv.前記細粒を排出するための排出ゾーンと、
を含み、
前記造粒ゾーンが前記排出ゾーンの前及び前記吸入ゾーンの後に位置し、
前記乾燥ゾーンが前記シャフトの各々に1つ又は複数のフラクショナルローブ要素を有し、
前記造粒ゾーンが前記シャフトの各々に複数のフラクショナルローブ要素を有する、フラクショナルローブ処理装置。 - 互いに噛み合う前記スクリューの各々の少なくとも4分の1が、前記造粒ゾーンから前記排出ゾーンまでフラクショナルローブ要素を備えている、請求項1に記載のフラクショナルローブ処理装置。
- 互いに噛み合う前記スクリューの各々の前記造粒ゾーンから前記排出ゾーンまでが、フラクショナルローブ要素のみを備えている、請求項1に記載のフラクショナルローブ処理装置。
- 互いに噛み合う前記スクリューの各々の前記造粒ゾーンから前記排出ゾーンまでが、複数の少なくとも2つの異なるフラクショナルローブ要素を備えている、請求項1に記載のフラクショナルローブ処理装置。
- 前記造粒ゾーンの前記フラクショナルローブ要素の少なくとも1つが、第1の先端角度を規定する第1のローブと、第2の先端角度を規定する第2のローブと、前記第1の先端角度及び第2の先端角度とは異なる第3の先端角度を規定する第3のローブとを有する、請求項1に記載のフラクショナルローブ処理装置。
- 前記造粒ゾーンの前記フラクショナルローブ要素の少なくとも1つが、リード「L」を有するらせん状に形成された連続的なフライトを有し、
前記フライトが前記リード「L」の何分の1かの間に整数ローブフライトから非整数ローブフライトに少なくとも一度変形し、前記リード「L」の何分の1かの間に整数ローブフライトに戻るように変形するか、又は、前記フライトが前記リード「L」の何分の1かの間に非整数ローブフライトから整数ローブフライトに少なくとも一度変形し、前記リード「L」の何分の1かの間に非整数ローブフライトに戻るように変形する、請求項1に記載のフラクショナルローブ処理装置。 - 前記造粒ゾーンの前記フラクショナルローブ要素の少なくとも1つが、リード「L」及びらせん状に形成された少なくとも1つの連続的なフライトを有し、
前記フライトが前記リード「L」の何分の1かの間に第1の非整数ローブフライトから第2の非整数ローブフライトに少なくとも一度変形し、前記リード「L」の何分の1かの間に前記第1の非整数ローブフライトに戻るように変形する、請求項1に記載のフラクショナルローブ処理装置。 - a)活性物質及び/又は添加剤を含む投入混合物を、請求項1に記載のフラクショナルローブ処理装置の吸入ゾーンに導入するステップと、
b)フラクショナルローブ要素のみから構成されている造粒ゾーンに前記投入混合物を通し、前記フラクショナルローブ要素を用いて前記混合物を処理しながら、投入混合物の毎分20%w/w以下の水分を前記混合物に導入して、湿った塊を形成するステップと、
c)バレル温度が前記造粒ゾーンのバレル温度の少なくとも2倍の温度に設定される乾燥ゾーンに、前記湿った塊を通すステップと、
d)細粒を排出ゾーンに通して、バレルの出口に向けるステップと、
e)前記細粒を集めるステップと、
を含む造粒方法。 - 前記フラクショナルローブ処理装置は、前記吸入ゾーンが特別ショベル型要素及び特別ショベル型要素-3ローブ右回りスクリュー要素からなる群から選択された1つ又は複数の要素を備え、前記造粒ゾーンが3ローブ動的撹拌要素及びフラクショナルニーディングブロックからなる群から選択された1つ又は複数の要素を備えているスクリュー構成を有する、請求項8に記載の方法。
- 前記細粒のアスペクト比が0.8~1の範囲にある、請求項8に記載の方法。
- a)活性物質、結合剤、水、及び場合により添加剤を含む投入混合物を、フラクショナルローブ処理装置の吸入ゾーンに導入するステップと、
b)フラクショナルローブ要素のみから構成されている造粒ゾーンに前記投入混合物を通すステップと、
c)搬送要素を備えている搬送ゾーンを通して細粒を搬送し、出口に向けるステップと、
d)湿った前記細粒を集めて、乾燥による損失が1.5%w/w未満になるまで乾燥させるステップと、
を含む造粒方法。 - 得られる乾燥細粒の平均粒径が、供給速度の4倍の変化によっては大きく影響されない、請求項11に記載の方法。
- 乾燥細粒の平均粒径が、破砕性試験が続くふるい分析の後において、破砕性試験が続くふるい分析の前の細粒の平均粒径と比べて大きくは影響されない、請求項11に記載の方法。
- 乾燥細粒の中央孔径(面積)が、フラクショナルジオメトリを持つ要素のないスクリュー構成を有するツインスクリュー処理装置を使用して同様の処理条件下で作られた細粒の中央孔径(面積)の少なくとも6倍であり、
前記中央孔径(面積)が、高圧水銀多孔率メータ(Auto Pore IV 9500 V1.09-MICROMERITICS)を用いて判定される、請求項11に記載の方法。 - 乾燥細粒の平均孔径が、フラクショナルジオメトリを持つ要素のないスクリュー構成を有するツインスクリュー処理装置を使用して同様の処理条件下で作られた細粒の平均孔径の少なくとも1.5倍であり、
前記平均孔径が、高圧水銀多孔率メータ(Auto Pore IV 9500 V1.09-MICROMERITICS)を用いて判定される、請求項11に記載の方法。 - 乾燥細粒の見かけの骨格密度が、フラクショナルジオメトリを持つ要素のないスクリュー構成を有するツインスクリュー処理装置を使用して同様の処理条件下で作られた細粒の見かけの骨格密度より大きく、
前記見かけの骨格密度が、高圧水銀多孔率メータ(Auto Pore IV 9500 V1.09-MICROMERITICS)を用いて判定される、請求項11に記載の方法。 - 乾燥細粒のパーセント多孔率が、フラクショナルジオメトリを持つ要素のないスクリュー構成を有するツインスクリュー処理装置を使用して同様の処理条件下で作られた細粒のパーセント多孔率より大きく、
前記パーセント多孔率が、高圧水銀多孔率メータ(Auto Pore IV 9500 V1.09-MICROMERITICS)を用いて判定される、請求項11に記載の方法。
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