JP2023024574A5 - - Google Patents
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- Publication number
- JP2023024574A5 JP2023024574A5 JP2022202809A JP2022202809A JP2023024574A5 JP 2023024574 A5 JP2023024574 A5 JP 2023024574A5 JP 2022202809 A JP2022202809 A JP 2022202809A JP 2022202809 A JP2022202809 A JP 2022202809A JP 2023024574 A5 JP2023024574 A5 JP 2023024574A5
- Authority
- JP
- Japan
- Prior art keywords
- varenicline
- pharmaceutically acceptable
- acceptable salt
- medicament
- micrograms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 31
- 150000003839 salts Chemical class 0.000 claims 18
- JQSHBVHOMNKWFT-DTORHVGOSA-N varenicline Chemical compound C12=CC3=NC=CN=C3C=C2[C@H]2C[C@@H]1CNC2 JQSHBVHOMNKWFT-DTORHVGOSA-N 0.000 claims 18
- 229960004751 varenicline Drugs 0.000 claims 18
- 210000003928 nasal cavity Anatomy 0.000 claims 3
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 2
- 206010052143 Ocular discomfort Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 238000002483 medication Methods 0.000 claims 2
- 239000007922 nasal spray Substances 0.000 claims 2
- 229940097496 nasal spray Drugs 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 230000004489 tear production Effects 0.000 claims 2
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
- 241000021559 Dicerandra Species 0.000 claims 1
- 206010065062 Meibomian gland dysfunction Diseases 0.000 claims 1
- 235000010654 Melissa officinalis Nutrition 0.000 claims 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 claims 1
- 206010034960 Photophobia Diseases 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 1
- 208000010217 blepharitis Diseases 0.000 claims 1
- 230000008499 blood brain barrier function Effects 0.000 claims 1
- 210000001218 blood-brain barrier Anatomy 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000000744 eyelid Anatomy 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 230000007794 irritation Effects 0.000 claims 1
- 230000007803 itching Effects 0.000 claims 1
- 239000000865 liniment Substances 0.000 claims 1
- 238000002690 local anesthesia Methods 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 230000036407 pain Effects 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000011514 reflex Effects 0.000 claims 1
- 230000035807 sensation Effects 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 210000003901 trigeminal nerve Anatomy 0.000 claims 1
- 239000006200 vaporizer Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462066280P | 2014-10-20 | 2014-10-20 | |
| US62/066,280 | 2014-10-20 | ||
| US201562100844P | 2015-01-07 | 2015-01-07 | |
| US62/100,844 | 2015-01-07 | ||
| JP2020193269A JP7257371B2 (ja) | 2014-10-20 | 2020-11-20 | 眼の病状の治療方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020193269A Division JP7257371B2 (ja) | 2014-10-20 | 2020-11-20 | 眼の病状の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023024574A JP2023024574A (ja) | 2023-02-16 |
| JP2023024574A5 true JP2023024574A5 (enExample) | 2023-09-25 |
| JP7502404B2 JP7502404B2 (ja) | 2024-06-18 |
Family
ID=55748136
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017539528A Active JP6873906B2 (ja) | 2014-10-20 | 2015-10-19 | 眼の病状の治療方法 |
| JP2020193269A Active JP7257371B2 (ja) | 2014-10-20 | 2020-11-20 | 眼の病状の治療方法 |
| JP2022202809A Active JP7502404B2 (ja) | 2014-10-20 | 2022-12-20 | 眼の病状の治療方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017539528A Active JP6873906B2 (ja) | 2014-10-20 | 2015-10-19 | 眼の病状の治療方法 |
| JP2020193269A Active JP7257371B2 (ja) | 2014-10-20 | 2020-11-20 | 眼の病状の治療方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (14) | US9504645B2 (enExample) |
| EP (3) | EP3209295B2 (enExample) |
| JP (3) | JP6873906B2 (enExample) |
| KR (2) | KR102601505B1 (enExample) |
| CN (3) | CN107106542B (enExample) |
| AU (2) | AU2015336216B2 (enExample) |
| BR (2) | BR112017008097B1 (enExample) |
| CA (1) | CA2965129C (enExample) |
| DK (2) | DK3209295T4 (enExample) |
| EA (1) | EA035335B1 (enExample) |
| ES (2) | ES2848977T5 (enExample) |
| FI (1) | FI3848028T3 (enExample) |
| IL (3) | IL251769B (enExample) |
| MX (2) | MX392383B (enExample) |
| MY (1) | MY186870A (enExample) |
| PH (1) | PH12017500602A1 (enExample) |
| PL (1) | PL3848028T3 (enExample) |
| PT (2) | PT3209295T (enExample) |
| SG (2) | SG11201703135XA (enExample) |
| WO (1) | WO2016064759A1 (enExample) |
| ZA (1) | ZA201703467B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9504645B2 (en) * | 2014-10-20 | 2016-11-29 | Oyster Point Pharma, Inc. | Pharmaceutical formulations for treating ocular conditions |
| US10709707B2 (en) * | 2016-04-07 | 2020-07-14 | Oyster Point Pharma, Inc. | Methods of treating ocular conditions |
| EP3820443A1 (en) | 2018-07-10 | 2021-05-19 | Oyster Point Pharma, Inc. | Combinations of positive allosteric modulators and nicotinic acetylcholine receptor agonists for treating ocular conditions |
| WO2020014217A1 (en) * | 2018-07-10 | 2020-01-16 | Oyster Point Pharma, Inc. | Methods of treating ocular conditions |
| EP4142734B1 (en) | 2020-04-28 | 2025-08-20 | Oyster Point Pharma, Inc. | Local administration of nicotinic acetylcholine receptor agonists for the inhibition of coronavirus infections |
| WO2025037323A1 (en) * | 2023-08-12 | 2025-02-20 | Pavan Kumar Kothapuvari | Pharmaceutical compositions for treatment of dry eye disease and associated disorders |
| DE102023208057A1 (de) * | 2023-08-23 | 2025-02-27 | Ursapharm Arzneimittel Gmbh | Ophthalmologische zusammensetzung enthaltend mindestens einen nikotinischen acetylcholinrezeptor-agonist zur topischen applikation am auge bei der prävention oder behandlung von entzündungen am auge |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6277855B1 (en) | 2000-04-21 | 2001-08-21 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with nicotinic acetylcholine receptor agonists |
| US20030008892A1 (en) | 2001-07-09 | 2003-01-09 | Pfizer Inc. | Pharmaceutical composition and method of modulating cholinergic function in a mammal |
| ES2258652T3 (es) | 2001-11-29 | 2006-09-01 | Pfizer Products Inc. | Sales de succinato de 5,8,14-triazatetraciclo(10.3.1.02,11.04,9)-hexadeca-2(11),3,5,7,9-pentaeno y composiciones farmaceuticas de los mismos. |
| AU2003269413A1 (en) * | 2002-11-01 | 2004-05-25 | Pharmacia & Upjohn Company Llc | Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy |
| US20060270592A1 (en) * | 2004-03-19 | 2006-11-30 | Ophthalmic Research Associates, Inc. | Use of neurotransmitters and neuropeptides for the treatment of dry eye diseases and related conditions |
| EP1802276A1 (en) | 2004-10-15 | 2007-07-04 | Pfizer Products Inc. | Compositions and methods for intranasal, buccal, sublingual and pulmonary delivery of varenicline |
| EP1809237B1 (en) * | 2004-11-09 | 2008-12-31 | Novagali Pharma SA | Ophthalmic oil-in-water type emulsion with stable positive zeta potential |
| AU2006226509A1 (en) * | 2005-03-22 | 2006-09-28 | Niconovum Ab | Use of an artificial sweetener to enhance absorption of nicotine |
| US20110086086A1 (en) | 2005-07-26 | 2011-04-14 | Pfizer Inc | Transdermal system for varenicline |
| US20070054843A1 (en) | 2005-08-26 | 2007-03-08 | Yeomans David C | Methods for treatment of headaches by administration of oxytocin |
| JP5505760B2 (ja) | 2005-09-27 | 2014-05-28 | ティッシュテク・インコーポレーテッド | 羊膜調製物及び精製組成物及びその使用方法 |
| TWI405763B (zh) * | 2006-11-02 | 2013-08-21 | Targacept Inc | 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺 |
| US20080132475A1 (en) * | 2006-12-05 | 2008-06-05 | Charles Gerald Connor | Treatment for dry eye |
| KR101107949B1 (ko) * | 2007-02-02 | 2012-02-08 | 화이자 프로덕츠 인코포레이티드 | 트라이사이클릭 화합물 및 글루코코르티코이드 수용체 조절자로서의 이들의 용도 |
| EP2322168A1 (en) * | 2007-04-02 | 2011-05-18 | Parkinson's Institute | Methods and Compositions for Reduction of Side Effects of Therapeutic Treatments |
| US20090093446A1 (en) | 2007-10-05 | 2009-04-09 | Winston Laboratories, Inc. | Method for alleviating keratoconjunctivitis sicca |
| CL2008003507A1 (es) * | 2007-11-26 | 2009-11-27 | Neuroderm Ltd | Composicion farmaceutica que comprende nicotina y un inhibidor de la desensibilizacion del receptor de acetilcolina nicotinico (nachr) opipramol; kit farmaceutico; dispositivo medico; y uso para tratar una enfermedad o trastorno del sistema nervioso central o periferico. |
| US20090215787A1 (en) | 2008-02-22 | 2009-08-27 | Mai De Ltd. | Preparations of new polymorphic forms of varenicline tartrate |
| JP2011513421A (ja) | 2008-03-05 | 2011-04-28 | ターガセプト，インコーポレイテッド | サブタイプ選択的なジアザビシクロアルカンのアミド |
| US20110263629A1 (en) * | 2008-09-05 | 2011-10-27 | Targacept, Inc. | Amides of diazabicyclooctanes and uses thereof |
| WO2010028011A1 (en) | 2008-09-05 | 2010-03-11 | Targacept, Inc. | Amides of diazabicyclononanes and uses thereof |
| DK3279195T3 (en) | 2008-12-01 | 2020-08-17 | Oyster Point Pharma Inc | Synthesis and novel salt forms of (R)-5-((E)-2-(pyrrolidin-3-ylvinyl)pyrimidine |
| US9145396B2 (en) | 2008-12-01 | 2015-09-29 | Targacept, Inc. | Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine |
| US20110274628A1 (en) | 2010-05-07 | 2011-11-10 | Borschke August J | Nicotine-containing pharmaceutical compositions |
| US8821457B2 (en) * | 2010-09-08 | 2014-09-02 | Johnson & Johnson Vision Care, Inc. | Punctal plug containing drug formulation |
| CA2841416A1 (en) * | 2011-06-15 | 2012-12-20 | Glaxosmithkline Intellectual Property (No.2) Limited | Method of selecting therapeutic indications |
| AU2012276651A1 (en) * | 2011-06-30 | 2014-02-06 | Toray Industries, Inc. | Antipruritic agent |
| AU2012324458B2 (en) * | 2011-10-20 | 2016-05-19 | Novartis Ag | Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment |
| EP3029463A1 (en) * | 2011-11-30 | 2016-06-08 | DiagnosTear Ltd | Dry eye diagnostic |
| ES2426517B1 (es) * | 2012-04-20 | 2014-05-14 | Genetracer Biotech S.L | Método para predecir la seguridad de un tratamiento farmacológico |
| CA2909490C (en) | 2013-03-15 | 2021-07-13 | Glia, Llc | Cranial delivery of pharmaceuticals |
| HK1220934A1 (zh) | 2013-04-19 | 2017-05-19 | Oculeve, Inc. | 鼻刺激装置和方法 |
| US9504645B2 (en) | 2014-10-20 | 2016-11-29 | Oyster Point Pharma, Inc. | Pharmaceutical formulations for treating ocular conditions |
| US10709707B2 (en) | 2016-04-07 | 2020-07-14 | Oyster Point Pharma, Inc. | Methods of treating ocular conditions |
| WO2020014217A1 (en) | 2018-07-10 | 2020-01-16 | Oyster Point Pharma, Inc. | Methods of treating ocular conditions |
| EP3820443A1 (en) | 2018-07-10 | 2021-05-19 | Oyster Point Pharma, Inc. | Combinations of positive allosteric modulators and nicotinic acetylcholine receptor agonists for treating ocular conditions |
-
2015
- 2015-10-19 US US14/887,259 patent/US9504645B2/en active Active
- 2015-10-19 AU AU2015336216A patent/AU2015336216B2/en active Active
- 2015-10-19 DK DK15852340.7T patent/DK3209295T4/da active
- 2015-10-19 BR BR112017008097-4A patent/BR112017008097B1/pt active IP Right Grant
- 2015-10-19 CN CN201580067940.5A patent/CN107106542B/zh active Active
- 2015-10-19 SG SG11201703135XA patent/SG11201703135XA/en unknown
- 2015-10-19 DK DK20212556.3T patent/DK3848028T5/da active
- 2015-10-19 ES ES15852340T patent/ES2848977T5/es active Active
- 2015-10-19 IL IL251769A patent/IL251769B/en unknown
- 2015-10-19 KR KR1020237009057A patent/KR102601505B1/ko active Active
- 2015-10-19 KR KR1020177013534A patent/KR102511955B1/ko active Active
- 2015-10-19 PT PT158523407T patent/PT3209295T/pt unknown
- 2015-10-19 MY MYPI2017701382A patent/MY186870A/en unknown
- 2015-10-19 EP EP15852340.7A patent/EP3209295B2/en active Active
- 2015-10-19 FI FIEP20212556.3T patent/FI3848028T3/fi active
- 2015-10-19 EP EP20212556.3A patent/EP3848028B9/en active Active
- 2015-10-19 MX MX2017005064A patent/MX392383B/es unknown
- 2015-10-19 WO PCT/US2015/056273 patent/WO2016064759A1/en not_active Ceased
- 2015-10-19 PL PL20212556.3T patent/PL3848028T3/pl unknown
- 2015-10-19 ES ES20212556T patent/ES2986830T3/es active Active
- 2015-10-19 EP EP24171017.7A patent/EP4413974A3/en active Pending
- 2015-10-19 JP JP2017539528A patent/JP6873906B2/ja active Active
- 2015-10-19 US US14/887,253 patent/US9532944B2/en active Active
- 2015-10-19 CN CN202010304809.9A patent/CN111956650B/zh active Active
- 2015-10-19 PT PT202125563T patent/PT3848028T/pt unknown
- 2015-10-19 IL IL293188A patent/IL293188B2/en unknown
- 2015-10-19 BR BR122022025737-2A patent/BR122022025737B1/pt active IP Right Grant
- 2015-10-19 IL IL318427A patent/IL318427A/en unknown
- 2015-10-19 SG SG10202011669PA patent/SG10202011669PA/en unknown
- 2015-10-19 US US14/887,248 patent/US9597284B2/en active Active
- 2015-10-19 EA EA201790893A patent/EA035335B1/ru unknown
- 2015-10-19 CA CA2965129A patent/CA2965129C/en active Active
- 2015-10-19 CN CN202010304375.2A patent/CN111956803B/zh active Active
- 2015-10-19 US US14/887,243 patent/US9504644B2/en active Active
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2017
- 2017-02-01 US US15/422,382 patent/US10456396B2/en active Active
- 2017-03-31 PH PH12017500602A patent/PH12017500602A1/en unknown
- 2017-04-19 MX MX2022005888A patent/MX2022005888A/es unknown
- 2017-05-19 ZA ZA2017/03467A patent/ZA201703467B/en unknown
-
2019
- 2019-09-10 US US16/566,237 patent/US11224598B2/en active Active
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2020
- 2020-08-06 AU AU2020213351A patent/AU2020213351B2/en active Active
- 2020-11-20 JP JP2020193269A patent/JP7257371B2/ja active Active
-
2021
- 2021-12-06 US US17/543,505 patent/US11903941B2/en active Active
-
2022
- 2022-12-20 JP JP2022202809A patent/JP7502404B2/ja active Active
-
2023
- 2023-03-23 US US18/125,551 patent/US11911380B2/en active Active
- 2023-03-23 US US18/125,517 patent/US11903942B2/en active Active
- 2023-03-23 US US18/125,562 patent/US11903943B2/en active Active
-
2024
- 2024-01-26 US US18/423,908 patent/US20240173318A1/en not_active Abandoned
-
2025
- 2025-04-03 US US19/169,843 patent/US20250255865A1/en active Pending
- 2025-04-03 US US19/169,836 patent/US20250275963A1/en active Pending
- 2025-04-03 US US19/169,817 patent/US20250235449A1/en active Pending
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