JP2023021276A5 - - Google Patents
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- Publication number
- JP2023021276A5 JP2023021276A5 JP2022198540A JP2022198540A JP2023021276A5 JP 2023021276 A5 JP2023021276 A5 JP 2023021276A5 JP 2022198540 A JP2022198540 A JP 2022198540A JP 2022198540 A JP2022198540 A JP 2022198540A JP 2023021276 A5 JP2023021276 A5 JP 2023021276A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridyl
- alkyl
- group
- pyridin
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 19
- -1 C 1 -C 3 alkoxy Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 9
- 238000006243 chemical reaction Methods 0.000 claims 9
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 5
- 239000002904 solvent Substances 0.000 claims 5
- 125000006677 (C1-C3) haloalkoxy group Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 claims 2
- CSRZQMIRAZTJOY-UHFFFAOYSA-N trimethylsilyl iodide Chemical compound C[Si](C)(C)I CSRZQMIRAZTJOY-UHFFFAOYSA-N 0.000 claims 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 125000004766 (C3-C6) cyclohaloalkyl group Chemical group 0.000 claims 1
- ONHSGOPTCOTAQD-UHFFFAOYSA-N 1,1-dimethyl-3-[4-[2-oxo-6-[2-(trifluoromethyl)phenyl]-1H-pyridin-4-yl]pyridin-2-yl]urea Chemical compound CN(C(=O)NC1=NC=CC(=C1)C1=CC(NC(=C1)C1=C(C=CC=C1)C(F)(F)F)=O)C ONHSGOPTCOTAQD-UHFFFAOYSA-N 0.000 claims 1
- WEUPTDZSLQUHHB-UHFFFAOYSA-N 4-(2-aminopyridin-4-yl)-6-(2-chlorophenyl)-1H-pyridin-2-one Chemical compound NC1=NC=CC(=C1)C1=CC(NC(=C1)C1=C(C=CC=C1)Cl)=O WEUPTDZSLQUHHB-UHFFFAOYSA-N 0.000 claims 1
- LRUDZBBEMDATJL-UHFFFAOYSA-N 4-(2-aminopyridin-4-yl)-6-pyridin-3-yl-1H-pyridin-2-one Chemical compound NC1=NC=CC(=C1)C1=CC(NC(=C1)C=1C=NC=CC=1)=O LRUDZBBEMDATJL-UHFFFAOYSA-N 0.000 claims 1
- ULRZATBBRNFUII-UHFFFAOYSA-N N-[4-[2-(2-chlorophenyl)-6-oxo-1H-pyridin-4-yl]pyridin-2-yl]-2-methoxyacetamide Chemical compound ClC1=C(C=CC=C1)C=1NC(C=C(C=1)C1=CC(=NC=C1)NC(COC)=O)=O ULRZATBBRNFUII-UHFFFAOYSA-N 0.000 claims 1
- GRXPRRPKOQULJV-UHFFFAOYSA-N N-[4-[2-(2-chlorophenyl)-6-oxo-1H-pyridin-4-yl]pyridin-2-yl]acetamide Chemical compound ClC1=C(C=CC=C1)C=1NC(C=C(C=1)C1=CC(=NC=C1)NC(C)=O)=O GRXPRRPKOQULJV-UHFFFAOYSA-N 0.000 claims 1
- GWHGMPUKIGJYGA-UHFFFAOYSA-N N-[4-[2-(2-methylpyridin-3-yl)-6-oxo-1H-pyridin-4-yl]pyridin-2-yl]acetamide Chemical compound CC1=NC=CC=C1C=1NC(C=C(C=1)C1=CC(=NC=C1)NC(C)=O)=O GWHGMPUKIGJYGA-UHFFFAOYSA-N 0.000 claims 1
- KYABMOVZHRXKDQ-UHFFFAOYSA-N N-[4-[2-(3-cyclopropylmorpholin-4-yl)-6-oxo-1H-pyridin-4-yl]pyridin-2-yl]acetamide Chemical compound C1(CC1)C1N(CCOC1)C=1NC(C=C(C=1)C1=CC(=NC=C1)NC(C)=O)=O KYABMOVZHRXKDQ-UHFFFAOYSA-N 0.000 claims 1
- JTUBLRKWQWLDGI-UHFFFAOYSA-N N-[4-[2-(4-methylpyridin-3-yl)-6-oxo-1H-pyridin-4-yl]pyridin-2-yl]acetamide Chemical compound CC1=C(C=NC=C1)C=1NC(C=C(C=1)C1=CC(=NC=C1)NC(C)=O)=O JTUBLRKWQWLDGI-UHFFFAOYSA-N 0.000 claims 1
- WHWGYPKJDYJZPK-UHFFFAOYSA-N N-[4-[2-[1-ethyl-3-(trifluoromethyl)pyrazol-4-yl]-6-oxo-1H-pyridin-4-yl]pyridin-2-yl]acetamide Chemical compound C(C)N1N=C(C(=C1)C=1NC(C=C(C=1)C1=CC(=NC=C1)NC(C)=O)=O)C(F)(F)F WHWGYPKJDYJZPK-UHFFFAOYSA-N 0.000 claims 1
- WMNIDEIOBLFDHX-UHFFFAOYSA-N N-[4-[2-[2-(2-methoxypropan-2-yl)pyrrolidin-1-yl]-6-oxo-1H-pyridin-4-yl]pyridin-2-yl]acetamide Chemical compound COC(C)(C)C1N(CCC1)C=1NC(C=C(C=1)C1=CC(=NC=C1)NC(C)=O)=O WMNIDEIOBLFDHX-UHFFFAOYSA-N 0.000 claims 1
- ZKBIQNBVDMYXCG-UHFFFAOYSA-N N-[4-[2-[4-ethylsulfonyl-2-(trifluoromethyl)piperazin-1-yl]-6-oxo-1H-pyridin-4-yl]pyridin-2-yl]acetamide Chemical compound C(C)S(=O)(=O)N1CC(N(CC1)C=1NC(C=C(C=1)C1=CC(=NC=C1)NC(C)=O)=O)C(F)(F)F ZKBIQNBVDMYXCG-UHFFFAOYSA-N 0.000 claims 1
- WYKJXFMXVUDREO-UHFFFAOYSA-N N-[4-[2-oxo-6-[2-(trifluoromethyl)phenyl]-1H-pyridin-4-yl]pyridin-2-yl]acetamide Chemical compound O=C1NC(=CC(=C1)C1=CC(=NC=C1)NC(C)=O)C1=C(C=CC=C1)C(F)(F)F WYKJXFMXVUDREO-UHFFFAOYSA-N 0.000 claims 1
- DEGTWMWMGZJAKR-UHFFFAOYSA-N N-[4-[2-oxo-6-[2-(trifluoromethyl)phenyl]-1H-pyridin-4-yl]pyridin-2-yl]pyrrolidine-1-carboxamide Chemical compound O=C1NC(=CC(=C1)C1=CC(=NC=C1)NC(=O)N1CCCC1)C1=C(C=CC=C1)C(F)(F)F DEGTWMWMGZJAKR-UHFFFAOYSA-N 0.000 claims 1
- WSZRNKMWOZHSEK-UHFFFAOYSA-N N-[4-[2-oxo-6-[2-(trifluoromethyl)piperidin-1-yl]-1H-pyridin-4-yl]pyridin-2-yl]acetamide Chemical compound O=C1NC(=CC(=C1)C1=CC(=NC=C1)NC(C)=O)N1C(CCCC1)C(F)(F)F WSZRNKMWOZHSEK-UHFFFAOYSA-N 0.000 claims 1
- SXTBJUQDFNIUBC-UHFFFAOYSA-N N-[4-[2-oxo-6-[2-(trifluoromethyl)piperidin-1-yl]-1H-pyridin-4-yl]pyridin-2-yl]cyclopropanecarboxamide Chemical compound O=C1NC(=CC(=C1)C1=CC(=NC=C1)NC(=O)C1CC1)N1C(CCCC1)C(F)(F)F SXTBJUQDFNIUBC-UHFFFAOYSA-N 0.000 claims 1
- FMUDKKVYHUYDHN-UHFFFAOYSA-N N-[4-[2-oxo-6-[2-(trifluoromethyl)pyridin-3-yl]-1H-pyridin-4-yl]pyridin-2-yl]acetamide Chemical compound O=C1NC(=CC(=C1)C1=CC(=NC=C1)NC(C)=O)C=1C(=NC=CC=1)C(F)(F)F FMUDKKVYHUYDHN-UHFFFAOYSA-N 0.000 claims 1
- MVNXIWSZHATYNO-UHFFFAOYSA-N N-[4-[2-oxo-6-[3-(trifluoromethyl)morpholin-4-yl]-1H-pyridin-4-yl]pyridin-2-yl]acetamide Chemical compound O=C1NC(=CC(=C1)C1=CC(=NC=C1)NC(C)=O)N1C(COCC1)C(F)(F)F MVNXIWSZHATYNO-UHFFFAOYSA-N 0.000 claims 1
- YHZOOIVUJYXALU-UHFFFAOYSA-N N-[4-[2-oxo-6-[4-(trifluoromethyl)thiophen-3-yl]-1H-pyridin-4-yl]pyridin-2-yl]acetamide Chemical compound O=C1NC(=CC(=C1)C1=CC(=NC=C1)NC(C)=O)C1=CSC=C1C(F)(F)F YHZOOIVUJYXALU-UHFFFAOYSA-N 0.000 claims 1
- 238000005903 acid hydrolysis reaction Methods 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
- DQKMSARXLJYZJQ-UHFFFAOYSA-N methyl N-[4-[2-(2-chlorophenyl)-6-oxo-1H-pyridin-4-yl]pyridin-2-yl]carbamate Chemical compound ClC1=C(C=CC=C1)C=1NC(C=C(C=1)C1=CC(=NC=C1)NC(OC)=O)=O DQKMSARXLJYZJQ-UHFFFAOYSA-N 0.000 claims 1
- HQUNJFIESNSZTF-UHFFFAOYSA-N methyl N-[4-[2-[1-ethyl-3-(trifluoromethyl)pyrazol-4-yl]-6-oxo-1H-pyridin-4-yl]pyridin-2-yl]carbamate Chemical compound C(C)N1N=C(C(=C1)C=1NC(C=C(C=1)C1=CC(=NC=C1)NC(OC)=O)=O)C(F)(F)F HQUNJFIESNSZTF-UHFFFAOYSA-N 0.000 claims 1
- BFXQCYNFXBAUJV-UHFFFAOYSA-N methyl N-[4-[2-oxo-6-[2-(trifluoromethyl)phenyl]-1H-pyridin-4-yl]pyridin-2-yl]carbamate Chemical compound O=C1NC(=CC(=C1)C1=CC(=NC=C1)NC(OC)=O)C1=C(C=CC=C1)C(F)(F)F BFXQCYNFXBAUJV-UHFFFAOYSA-N 0.000 claims 1
- YEHAXKAYTZMYNC-UHFFFAOYSA-N methyl N-[4-[2-oxo-6-[2-(trifluoromethyl)piperidin-1-yl]-1H-pyridin-4-yl]pyridin-2-yl]carbamate Chemical compound O=C1NC(=CC(=C1)C1=CC(=NC=C1)NC(OC)=O)N1C(CCCC1)C(F)(F)F YEHAXKAYTZMYNC-UHFFFAOYSA-N 0.000 claims 1
- UYCPAINACUBWSG-UHFFFAOYSA-N methyl N-[4-[2-oxo-6-[2-(trifluoromethyl)pyridin-3-yl]-1H-pyridin-4-yl]pyridin-2-yl]carbamate Chemical compound O=C1NC(=CC(=C1)C1=CC(=NC=C1)NC(OC)=O)C=1C(=NC=CC=1)C(F)(F)F UYCPAINACUBWSG-UHFFFAOYSA-N 0.000 claims 1
- JPDYKOOKVQBXPO-UHFFFAOYSA-N methyl N-[4-[2-oxo-6-[3-(trifluoromethyl)morpholin-4-yl]-1H-pyridin-4-yl]pyridin-2-yl]carbamate Chemical compound O=C1NC(=CC(=C1)C1=CC(=NC=C1)NC(OC)=O)N1C(COCC1)C(F)(F)F JPDYKOOKVQBXPO-UHFFFAOYSA-N 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17187544 | 2017-08-23 | ||
| EP17187544.6 | 2017-08-23 | ||
| JP2020510096A JP7199737B2 (ja) | 2017-08-23 | 2018-08-23 | ピリジルピリドン化合物 |
| PCT/EP2018/072788 WO2019038387A1 (en) | 2017-08-23 | 2018-08-23 | PYRIDYLPYRIDONE COMPOUNDS |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020510096A Division JP7199737B2 (ja) | 2017-08-23 | 2018-08-23 | ピリジルピリドン化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023021276A JP2023021276A (ja) | 2023-02-10 |
| JP2023021276A5 true JP2023021276A5 (https=) | 2023-08-25 |
Family
ID=59686881
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020510096A Active JP7199737B2 (ja) | 2017-08-23 | 2018-08-23 | ピリジルピリドン化合物 |
| JP2022198540A Pending JP2023021276A (ja) | 2017-08-23 | 2022-12-13 | ピリジルピリドン化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020510096A Active JP7199737B2 (ja) | 2017-08-23 | 2018-08-23 | ピリジルピリドン化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11219618B2 (https=) |
| EP (2) | EP4056556A1 (https=) |
| JP (2) | JP7199737B2 (https=) |
| KR (1) | KR102730718B1 (https=) |
| CN (3) | CN111094244B (https=) |
| AU (2) | AU2018320416B2 (https=) |
| CY (1) | CY1125138T1 (https=) |
| DK (1) | DK3672941T3 (https=) |
| ES (1) | ES2910839T3 (https=) |
| HR (1) | HRP20220571T1 (https=) |
| HU (1) | HUE058977T2 (https=) |
| IL (3) | IL302356A (https=) |
| LT (1) | LT3672941T (https=) |
| PL (1) | PL3672941T3 (https=) |
| PT (1) | PT3672941T (https=) |
| RS (1) | RS63161B1 (https=) |
| SI (1) | SI3672941T1 (https=) |
| SM (1) | SMT202200183T1 (https=) |
| TW (2) | TW202308996A (https=) |
| WO (1) | WO2019038387A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11919902B2 (en) | 2017-12-22 | 2024-03-05 | Hibercell, Inc. | Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| CA3199999A1 (en) | 2020-11-25 | 2022-06-02 | Deciphera Pharmaceuticals, Llc | Morpholino derivatives as vsp34 inhibitors for use in the treatment of a viral infection |
| US11801238B2 (en) | 2020-11-25 | 2023-10-31 | Deciphera Pharmaceuticals, Llc | Anti-viral activity of VPS34 inhibitors |
| WO2023019259A1 (en) * | 2021-08-13 | 2023-02-16 | Deciphera Pharmaceuticals, Llc | Combination therapy of vps34 inhibitors and sting agonist for use in the treatment of cancer |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4606161B2 (ja) * | 2002-05-21 | 2011-01-05 | アムジエン・インコーポレーテツド | 置換複素環式化合物および使用方法 |
| TW200908984A (en) * | 2007-08-07 | 2009-03-01 | Piramal Life Sciences Ltd | Pyridyl derivatives, their preparation and use |
| WO2012085815A1 (en) | 2010-12-21 | 2012-06-28 | Novartis Ag | Bi-heteroaryl compounds as vps34 inhibitors |
| DK2655375T3 (en) | 2010-12-23 | 2015-03-09 | Sanofi Sa | PYRIMIDINON DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF |
| GB201120317D0 (en) | 2011-11-24 | 2012-01-04 | Queen Mary & Westfield College | Screening method |
| DK2820009T3 (en) * | 2012-03-01 | 2018-04-16 | Array Biopharma Inc | Serine / threonine kinase inhibitors |
| AU2012382373A1 (en) * | 2012-06-12 | 2014-12-11 | Abbvie Inc. | Pyridinone and pyridazinone derivatives |
| FR2992314B1 (fr) | 2012-06-22 | 2015-10-16 | Sanofi Sa | Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one et 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one comportant une morpholine substituee, leur preparation et leur utilisation pharmaceutique |
| WO2015108881A1 (en) | 2014-01-14 | 2015-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| WO2015108861A1 (en) | 2014-01-14 | 2015-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| MA39823A (fr) | 2014-04-03 | 2018-01-09 | Janssen Pharmaceutica Nv | Dérivés de pyridine macrocyclique |
| MA39822A (fr) | 2014-04-03 | 2018-02-06 | Janssen Pharmaceutica Nv | Dérivés de pyrimidine bicycle |
| WO2016001789A1 (en) | 2014-06-30 | 2016-01-07 | Pfizer Inc. | Pyrimidine derivatives as pi3k inhibitors for use in the treatment of cancer |
| TWI721104B (zh) * | 2016-02-19 | 2021-03-11 | 瑞典商斯普林特生物科技公司 | 6‐芳基或6‐雜芳基‐4‐嗎啉‐4‐芳基‐吡啶‐2‐酮化合物 |
| ES2821400T3 (es) | 2016-02-19 | 2021-04-26 | Sprint Bioscience Ab | Compuestos de 6-heterociclil-4-morfolin-4-ilpiridin-2-ona útiles para el tratamiento del cáncer y la diabetes |
-
2018
- 2018-08-23 JP JP2020510096A patent/JP7199737B2/ja active Active
- 2018-08-23 ES ES18759308T patent/ES2910839T3/es active Active
- 2018-08-23 DK DK18759308.2T patent/DK3672941T3/da active
- 2018-08-23 LT LTEPPCT/EP2018/072788T patent/LT3672941T/lt unknown
- 2018-08-23 SI SI201830631T patent/SI3672941T1/sl unknown
- 2018-08-23 TW TW111144233A patent/TW202308996A/zh unknown
- 2018-08-23 HU HUE18759308A patent/HUE058977T2/hu unknown
- 2018-08-23 PL PL18759308T patent/PL3672941T3/pl unknown
- 2018-08-23 RS RS20220398A patent/RS63161B1/sr unknown
- 2018-08-23 EP EP22155562.6A patent/EP4056556A1/en not_active Withdrawn
- 2018-08-23 AU AU2018320416A patent/AU2018320416B2/en not_active Ceased
- 2018-08-23 US US16/639,895 patent/US11219618B2/en active Active
- 2018-08-23 SM SM20220183T patent/SMT202200183T1/it unknown
- 2018-08-23 PT PT187593082T patent/PT3672941T/pt unknown
- 2018-08-23 CN CN201880059987.0A patent/CN111094244B/zh active Active
- 2018-08-23 CN CN202310818724.6A patent/CN116903526A/zh active Pending
- 2018-08-23 WO PCT/EP2018/072788 patent/WO2019038387A1/en not_active Ceased
- 2018-08-23 KR KR1020207006936A patent/KR102730718B1/ko active Active
- 2018-08-23 EP EP18759308.2A patent/EP3672941B1/en active Active
- 2018-08-23 HR HRP20220571TT patent/HRP20220571T1/hr unknown
- 2018-08-23 CN CN202310818638.5A patent/CN116891431A/zh active Pending
- 2018-08-23 TW TW107129492A patent/TWI787335B/zh not_active IP Right Cessation
- 2018-08-23 IL IL302356A patent/IL302356A/en unknown
-
2020
- 2020-02-20 IL IL272805A patent/IL272805B/en unknown
-
2021
- 2021-12-15 US US17/644,486 patent/US20220218688A1/en not_active Abandoned
-
2022
- 2022-04-25 IL IL292485A patent/IL292485B2/en unknown
- 2022-04-27 CY CY20221100305T patent/CY1125138T1/el unknown
- 2022-12-13 JP JP2022198540A patent/JP2023021276A/ja active Pending
-
2023
- 2023-10-31 AU AU2023258375A patent/AU2023258375A1/en not_active Abandoned
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