JP2022552008A5 - - Google Patents

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Publication number
JP2022552008A5
JP2022552008A5 JP2022523023A JP2022523023A JP2022552008A5 JP 2022552008 A5 JP2022552008 A5 JP 2022552008A5 JP 2022523023 A JP2022523023 A JP 2022523023A JP 2022523023 A JP2022523023 A JP 2022523023A JP 2022552008 A5 JP2022552008 A5 JP 2022552008A5
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JP
Japan
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lnp
substituted
composition
tissue
group
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JP2022523023A
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English (en)
Japanese (ja)
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JP2022552008A (ja
JP7744687B2 (ja
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Priority claimed from PCT/US2020/056255 external-priority patent/WO2021077067A1/en
Publication of JP2022552008A publication Critical patent/JP2022552008A/ja
Publication of JP2022552008A5 publication Critical patent/JP2022552008A5/ja
Priority to JP2025147778A priority Critical patent/JP2025175052A/ja
Application granted granted Critical
Publication of JP7744687B2 publication Critical patent/JP7744687B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2022523023A 2019-10-18 2020-10-19 CAR mRNA送達のための脂質ナノ粒子とその製剤 Active JP7744687B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025147778A JP2025175052A (ja) 2019-10-18 2025-09-05 CAR mRNA送達のための脂質ナノ粒子とその製剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962916942P 2019-10-18 2019-10-18
US62/916,942 2019-10-18
PCT/US2020/056255 WO2021077067A1 (en) 2019-10-18 2020-10-19 Lipid nanoparticles and formulations thereof for car mrna delivery

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025147778A Division JP2025175052A (ja) 2019-10-18 2025-09-05 CAR mRNA送達のための脂質ナノ粒子とその製剤

Publications (3)

Publication Number Publication Date
JP2022552008A JP2022552008A (ja) 2022-12-14
JP2022552008A5 true JP2022552008A5 (enExample) 2023-10-25
JP7744687B2 JP7744687B2 (ja) 2025-09-26

Family

ID=75538674

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022523023A Active JP7744687B2 (ja) 2019-10-18 2020-10-19 CAR mRNA送達のための脂質ナノ粒子とその製剤
JP2025147778A Pending JP2025175052A (ja) 2019-10-18 2025-09-05 CAR mRNA送達のための脂質ナノ粒子とその製剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025147778A Pending JP2025175052A (ja) 2019-10-18 2025-09-05 CAR mRNA送達のための脂質ナノ粒子とその製剤

Country Status (8)

Country Link
US (1) US20220378700A1 (enExample)
EP (1) EP4045021A4 (enExample)
JP (2) JP7744687B2 (enExample)
KR (1) KR20220084366A (enExample)
CN (1) CN114828837A (enExample)
AU (1) AU2020366519A1 (enExample)
CA (1) CA3155075A1 (enExample)
WO (1) WO2021077067A1 (enExample)

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CN115724806B (zh) * 2021-08-25 2025-07-01 广州谷森制药有限公司 阳离子脂质化合物
CN118317944A (zh) 2021-09-14 2024-07-09 雷纳嘉德医疗管理公司 非环状脂质及其使用方法
TW202328067A (zh) 2021-09-14 2023-07-16 美商雷納嘉德醫療管理公司 環狀脂質及其使用方法
CA3255883A1 (en) * 2021-10-01 2023-04-06 The Trustees Of The University Of Pennsylvania LIPID NANOPARTICLE (LNP) COMPOSITIONS AND THEIR METHODS OF USE
CA3237482A1 (en) 2021-11-03 2023-05-11 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Precise genome editing using retrons
EP4452928A1 (en) 2021-12-23 2024-10-30 Renagade Therapeutics Management Inc. Constrained lipids and methods of use thereof
WO2023141602A2 (en) 2022-01-21 2023-07-27 Renagade Therapeutics Management Inc. Engineered retrons and methods of use
WO2023183300A1 (en) * 2022-03-22 2023-09-28 The Children's Medical Center Corporation Compositions and methods for prevention and treatment of genetic disease
AU2023251104A1 (en) 2022-04-07 2024-10-17 Renagade Therapeutics Management Inc. Cyclic lipids and lipid nanoparticles (lnp) for the delivery of nucleic acids or peptides for use in vaccinating against infectious agents
US20250295788A1 (en) * 2022-05-04 2025-09-25 The Trustees Of The University Of Pennsylvania Siloxane-based lipids, lipid nanoparticle compositions comprising the same, and methods of use thereof for targeted delivery
CA3256897A1 (en) 2022-05-25 2023-11-30 Akagera Medicines, Inc. Lipid nanoparticles for the administration of nucleic acids and their methods of use
JP2025525569A (ja) 2022-07-18 2025-08-05 レナゲード セラピューティクス マネージメント インコーポレイテッド 遺伝子編集成分、システム、及び使用方法
EP4561537A2 (en) * 2022-07-27 2025-06-04 Trustees Of Tufts College Lipid nanoparticles for immunotherapy
WO2024044723A1 (en) 2022-08-25 2024-02-29 Renagade Therapeutics Management Inc. Engineered retrons and methods of use
AU2024234874A1 (en) 2023-03-15 2025-10-09 Renagade Therapeutics Management Inc. Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
AU2024236558A1 (en) 2023-03-15 2025-10-09 Renagade Therapeutics Management Inc. Delivery of gene editing systems and methods of use thereof
EP4680728A1 (en) 2023-03-17 2026-01-21 Quell Therapeutics Limited Treg therapy
WO2024206230A1 (en) * 2023-03-24 2024-10-03 Trustees Of Tufts College Tissue targeting lipids and lipid nanoparticles
WO2024220609A1 (en) * 2023-04-18 2024-10-24 The Trustees Of The University Of Pennsylvania Ionizable lipid compounds, lipid nanoparticles (lnps) comprising the same, and methods of use thereof for cell engineering
WO2025007148A1 (en) 2023-06-30 2025-01-02 Orna Therapeutics, Inc. Polymer lipid nanoparticle compositions for delivering circular polynucleotides
TW202517616A (zh) * 2023-07-06 2025-05-01 比利時商eTheRNA免疫治療公司 可離子化脂質
IT202300015003A1 (it) * 2023-07-18 2025-01-18 Univ Degli Studi Di Salerno Composizione e procedimento per la realizzazione di nano-carriers lipidici ed i relativi nano-carriers lipidici di uso biomedico
WO2025038494A1 (en) 2023-08-11 2025-02-20 Tune Therapeutics, Inc. Compositions, systems, and methods for lymphoid cell differentiation using targeted gene activation
AU2024335327A1 (en) 2023-09-01 2026-03-26 Renagade Therapeutics Management Inc. Gene editing systems, compositions, and methods for treatment of vexas syndrome
WO2025072623A1 (en) * 2023-09-28 2025-04-03 The Trustees Of The University Of Pennsylvania Compositions and methods for targeting immune cells
WO2025075396A1 (ko) * 2023-10-06 2025-04-10 한국과학기술연구원 타겟 핵산 검출물질이 담지된 지질 나노입자 및 이를 이용한 막융합 기반의 타겟 핵산 검출 방법
AU2024357861A1 (en) 2023-10-12 2026-04-23 Renagade Therapeutics Management Inc. Nickase-retron template-based precision editing system and methods of use
WO2025090525A1 (en) * 2023-10-22 2025-05-01 Tessera Therapeutics, Inc. Lipid nanoparticles for delivery of therapeutic payloads to t cells
WO2025128871A2 (en) 2023-12-13 2025-06-19 Renagade Therapeutics Management Inc. Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
WO2025129333A1 (en) * 2023-12-18 2025-06-26 Nanovation Therapeutics Inc. Lipid nanoparticles having non-polar lipids for nucleic acid delivery to the liver
WO2025144938A1 (en) 2023-12-26 2025-07-03 Emmune, Inc. Systems for nucleic acid transfer
WO2025155753A2 (en) 2024-01-17 2025-07-24 Renagade Therapeutics Management Inc. Improved gene editing system, guides, and methods
WO2025166238A1 (en) 2024-01-31 2025-08-07 Orna Therapeutics, Inc. Fast-shedding polyethylene glycol lipids
WO2025174765A1 (en) 2024-02-12 2025-08-21 Renagade Therapeutics Management Inc. Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
WO2025184476A1 (en) * 2024-02-29 2025-09-04 The Trustees Of The University Of Pennsylvania Cationic degradable lipid compositions, lipid nanoparticles (lnps) comprising same, and methods of use thereof
WO2025252759A1 (en) 2024-06-03 2025-12-11 Bio-Sourcing Transient expression by lipid nanoparticle formulations
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WO2026015458A1 (en) * 2024-07-08 2026-01-15 Memorial Sloan-Kettering Cancer Center Cells comprising non-hla restricted t cell receptors

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US9126966B2 (en) * 2011-08-31 2015-09-08 Protiva Biotherapeutics, Inc. Cationic lipids and methods of use thereof
JP2018509387A (ja) * 2015-01-21 2018-04-05 フェーズアールエックス インコーポレイテッド 細胞に治療および診断剤を送達するための方法、組成物、ならびにシステム
LT3394030T (lt) 2015-12-22 2022-04-11 Modernatx, Inc. Junginiai ir kompozicijos terapinei medžiagai teikti intraceliuliniu būdu
MA43587A (fr) * 2016-01-10 2018-11-14 Modernatx Inc Arnm thérapeutiques codant pour des anticorps anti-ctla-4
WO2018064611A1 (en) * 2016-09-30 2018-04-05 Baylor College Of Medicine Antibody based gene therapy with tissue-directed expression
US20190314291A1 (en) 2018-01-30 2019-10-17 Modernatx, Inc. Compositions and methods for delivery of agents to immune cells

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