JP2022549102A - 創傷治癒および／または瘢痕修復の促進の有効性を有する皮膚局所用組成物 - Google Patents
創傷治癒および／または瘢痕修復の促進の有効性を有する皮膚局所用組成物 Download PDFInfo
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| CN201911189594.4A CN110876760B (zh) | 2019-11-28 | 2019-11-28 | 具有促进伤口愈合和/或疤痕修复功效的皮肤外用组合物 |
| PCT/CN2020/102452 WO2021103581A1 (zh) | 2019-11-28 | 2020-07-16 | 具有促进伤口愈合和/或疤痕修复功效的皮肤外用组合物 |
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| CN110731925A (zh) * | 2019-07-30 | 2020-01-31 | 浙江养生堂天然药物研究所有限公司 | 美白化妆品组合物 |
| CN110731974B (zh) * | 2019-07-30 | 2022-09-02 | 浙江养生堂天然药物研究所有限公司 | 具有增强的抗炎功效的皮肤外用组合物 |
| CN110731922B (zh) * | 2019-07-30 | 2022-08-02 | 浙江养生堂天然药物研究所有限公司 | 增强的防脱生发组合物 |
| CN110876760B (zh) * | 2019-11-28 | 2022-09-30 | 浙江养生堂天然药物研究所有限公司 | 具有促进伤口愈合和/或疤痕修复功效的皮肤外用组合物 |
| CN111281940B (zh) * | 2020-04-14 | 2021-08-03 | 浙江沃野神生物科技有限公司 | 祛疤痕组合物及其制备方法与应用 |
| CN113456733A (zh) * | 2021-07-29 | 2021-10-01 | 福建百想生物科技有限公司 | 一种具有促进伤口愈合的护理软膏及制备方法 |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000119156A (ja) * | 1998-10-14 | 2000-04-25 | Kose Corp | 皮膚外用剤 |
| JP2007320921A (ja) * | 2006-06-01 | 2007-12-13 | Nitta Gelatin Inc | 樹液配合化粧料 |
| CN102784299A (zh) * | 2012-08-16 | 2012-11-21 | 武汉东保科技开发有限责任公司 | 促进伤口愈合不留瘢痕色素的外用膏及其制备方法 |
| JP2013542970A (ja) * | 2010-11-17 | 2013-11-28 | ロレアル | 顔および目をケアおよび／またはメイクアップするための化粧用組成物 |
| CN106490439A (zh) * | 2016-10-03 | 2017-03-15 | 嘉荫丰实绿色食品有限责任公司 | 一种桦树浓缩液的保鲜方法 |
| JP2018527881A (ja) * | 2015-09-17 | 2018-09-27 | ノルディック コイヴ オイ | 樹液を採取する方法及び装置 |
| JP2019519549A (ja) * | 2017-04-27 | 2019-07-11 | ヤン シェン タン（シャンハイ） コスメティック アールアンドデー カンパニー リミテッド | 保湿化粧品組成物 |
| JP2019520406A (ja) * | 2017-04-27 | 2019-07-18 | ヤン シェン タン（シャンハイ） コスメティック アールアンドデー カンパニー リミテッド | スキンケア化粧品組成物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE1009114A3 (nl) * | 1995-02-10 | 1996-11-05 | Jadoulle Domien | Haargroeimiddel en gebruik van dit haargroeimiddel. |
| US20140154374A1 (en) * | 2012-11-30 | 2014-06-05 | Feronia Holdings, Llc | Birch Sap Beverage |
| CN107837224A (zh) * | 2017-12-22 | 2018-03-27 | 珍尔姿（广州）化妆品有限公司 | 一种含白桦提取物的功效性外用组合物 |
| CN110731976B (zh) * | 2019-07-30 | 2024-02-06 | 浙江养生堂天然药物研究所有限公司 | 防脱生发组合物 |
| CN110731921A (zh) * | 2019-07-30 | 2020-01-31 | 浙江养生堂天然药物研究所有限公司 | 具有祛痘功效的皮肤外用组合物 |
| CN110731973A (zh) * | 2019-07-30 | 2020-01-31 | 浙江养生堂天然药物研究所有限公司 | 具有抗炎功效的皮肤外用组合物 |
| CN110731928A (zh) * | 2019-07-30 | 2020-01-31 | 浙江养生堂天然药物研究所有限公司 | 抗衰老化妆品组合物 |
| CN110731926A (zh) * | 2019-07-30 | 2020-01-31 | 浙江养生堂天然药物研究所有限公司 | 保湿化妆品组合物 |
| CN110731925A (zh) * | 2019-07-30 | 2020-01-31 | 浙江养生堂天然药物研究所有限公司 | 美白化妆品组合物 |
| CN110731975A (zh) * | 2019-07-30 | 2020-01-31 | 浙江养生堂天然药物研究所有限公司 | 具有抗湿疹功效的皮肤外用组合物 |
| CN110731929A (zh) * | 2019-08-21 | 2020-01-31 | 浙江养生堂天然药物研究所有限公司 | 混合的桦树汁及其在护肤化妆品组合物中的应用 |
| CN110876760B (zh) * | 2019-11-28 | 2022-09-30 | 浙江养生堂天然药物研究所有限公司 | 具有促进伤口愈合和/或疤痕修复功效的皮肤外用组合物 |
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- 2020-07-16 JP JP2022516746A patent/JP2022549102A/ja active Pending
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Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000119156A (ja) * | 1998-10-14 | 2000-04-25 | Kose Corp | 皮膚外用剤 |
| JP2007320921A (ja) * | 2006-06-01 | 2007-12-13 | Nitta Gelatin Inc | 樹液配合化粧料 |
| JP2013542970A (ja) * | 2010-11-17 | 2013-11-28 | ロレアル | 顔および目をケアおよび／またはメイクアップするための化粧用組成物 |
| CN102784299A (zh) * | 2012-08-16 | 2012-11-21 | 武汉东保科技开发有限责任公司 | 促进伤口愈合不留瘢痕色素的外用膏及其制备方法 |
| JP2018527881A (ja) * | 2015-09-17 | 2018-09-27 | ノルディック コイヴ オイ | 樹液を採取する方法及び装置 |
| CN106490439A (zh) * | 2016-10-03 | 2017-03-15 | 嘉荫丰实绿色食品有限责任公司 | 一种桦树浓缩液的保鲜方法 |
| JP2019519549A (ja) * | 2017-04-27 | 2019-07-11 | ヤン シェン タン（シャンハイ） コスメティック アールアンドデー カンパニー リミテッド | 保湿化粧品組成物 |
| JP2019520406A (ja) * | 2017-04-27 | 2019-07-18 | ヤン シェン タン（シャンハイ） コスメティック アールアンドデー カンパニー リミテッド | スキンケア化粧品組成物 |
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| WO2021103581A1 (zh) | 2021-06-03 |
| CN110876760A (zh) | 2020-03-13 |
| CN110876760B (zh) | 2022-09-30 |
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