JP2022547993A - 診断のための新規分子 - Google Patents

診断のための新規分子 Download PDF

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Publication number
JP2022547993A
JP2022547993A JP2022515903A JP2022515903A JP2022547993A JP 2022547993 A JP2022547993 A JP 2022547993A JP 2022515903 A JP2022515903 A JP 2022515903A JP 2022515903 A JP2022515903 A JP 2022515903A JP 2022547993 A JP2022547993 A JP 2022547993A
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JP
Japan
Prior art keywords
seq
amino acid
acid sequence
sequence
amyloid
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Pending
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JP2022515903A
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Japanese (ja)
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JP2022547993A5 (https=
Inventor
アドルフソン，オスカル
エヴァ ピオルコフスカ，カタジナ
Original Assignee
エイシー イミューン ソシエテ アノニム
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Publication of JP2022547993A publication Critical patent/JP2022547993A/ja
Publication of JP2022547993A5 publication Critical patent/JP2022547993A5/ja
Priority to JP2025135157A priority Critical patent/JP2025178565A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
JP2022515903A 2019-09-10 2020-09-10 診断のための新規分子 Pending JP2022547993A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025135157A JP2025178565A (ja) 2019-09-10 2025-08-14 診断のための新規分子

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP19196512.8 2019-09-10
EP19196512 2019-09-10
EP20184340.6 2020-07-06
EP20184340 2020-07-06
PCT/EP2020/075420 WO2021048324A1 (en) 2019-09-10 2020-09-10 Novel molecules for diagnosis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025135157A Division JP2025178565A (ja) 2019-09-10 2025-08-14 診断のための新規分子

Publications (2)

Publication Number Publication Date
JP2022547993A true JP2022547993A (ja) 2022-11-16
JP2022547993A5 JP2022547993A5 (https=) 2023-09-19

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JP2022515903A Pending JP2022547993A (ja) 2019-09-10 2020-09-10 診断のための新規分子
JP2025135157A Pending JP2025178565A (ja) 2019-09-10 2025-08-14 診断のための新規分子

Family Applications After (1)

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JP2025135157A Pending JP2025178565A (ja) 2019-09-10 2025-08-14 診断のための新規分子

Country Status (10)

Country Link
US (1) US20230034474A1 (https=)
EP (1) EP4028127A1 (https=)
JP (2) JP2022547993A (https=)
KR (1) KR20220087439A (https=)
CN (1) CN114650866B (https=)
AU (1) AU2020347483A1 (https=)
CA (1) CA3149837A1 (https=)
IL (1) IL291224A (https=)
MX (1) MX2022002873A (https=)
WO (1) WO2021048324A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN121002061A (zh) * 2023-01-12 2025-11-21 弗吉尼亚大学专利基金委员会 抗cith3抗体及其用途
WO2025134068A1 (en) 2023-12-22 2025-06-26 Ac Immune Sa Antibody drug conjugates targeting proteinopathies, and uses thereof
CN117567635B (zh) * 2024-01-16 2024-05-14 恺佧生物科技(上海)有限公司 抗Cas9酶的抗体及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006509721A (ja) * 2002-06-11 2006-03-23 ノースウエスタン ユニバーシティ 抗ａｄｄｌ抗体及びその使用
JP2008520553A (ja) * 2004-10-25 2008-06-19 メルク・アンド・カンパニー・インコーポレーテッド 抗ａｄｄｌ抗体およびこの使用
WO2009051220A1 (ja) * 2007-10-19 2009-04-23 Immunas Pharma, Inc. Aβオリゴマーに特異的に結合する抗体およびその利用
JP2013500940A (ja) * 2009-08-06 2013-01-10 イムナス・ファーマ株式会社 Ａβオリゴマーに特異的に結合する抗体およびその利用
JP2014503475A (ja) * 2010-10-26 2014-02-13 エーシー イミューン ソシエテ アノニム 疎水性部分によって修飾されたペプチドを含むリポソームベースの構築物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750324B1 (en) * 1997-12-02 2004-06-15 Neuralab Limited Humanized and chimeric N-terminal amyloid beta-antibodies
NZ581835A (en) * 2007-06-12 2012-09-28 Ac Immune Sa Monoclonal anti beta amyloid antibody
US20100074901A1 (en) * 2007-10-15 2010-03-25 Marc Hubert Mercken Human anti-amyloid antibodies, compositions, methods and uses

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006509721A (ja) * 2002-06-11 2006-03-23 ノースウエスタン ユニバーシティ 抗ａｄｄｌ抗体及びその使用
JP2008520553A (ja) * 2004-10-25 2008-06-19 メルク・アンド・カンパニー・インコーポレーテッド 抗ａｄｄｌ抗体およびこの使用
WO2009051220A1 (ja) * 2007-10-19 2009-04-23 Immunas Pharma, Inc. Aβオリゴマーに特異的に結合する抗体およびその利用
JP2013500940A (ja) * 2009-08-06 2013-01-10 イムナス・ファーマ株式会社 Ａβオリゴマーに特異的に結合する抗体およびその利用
JP2014503475A (ja) * 2010-10-26 2014-02-13 エーシー イミューン ソシエテ アノニム 疎水性部分によって修飾されたペプチドを含むリポソームベースの構築物

Also Published As

Publication number Publication date
KR20220087439A (ko) 2022-06-24
WO2021048324A1 (en) 2021-03-18
JP2025178565A (ja) 2025-12-08
CN114650866B (zh) 2025-08-01
EP4028127A1 (en) 2022-07-20
MX2022002873A (es) 2022-03-25
IL291224A (en) 2022-05-01
CN114650866A (zh) 2022-06-21
WO2021048324A9 (en) 2022-05-05
CA3149837A1 (en) 2021-03-18
US20230034474A1 (en) 2023-02-02
AU2020347483A1 (en) 2022-03-31

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