JP2022546964A - Ｐｂｐ結合二環式ペプチドリガンド - Google Patents

Ｐｂｐ結合二環式ペプチドリガンド Download PDF

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Publication number
JP2022546964A
JP2022546964A JP2022513188A JP2022513188A JP2022546964A JP 2022546964 A JP2022546964 A JP 2022546964A JP 2022513188 A JP2022513188 A JP 2022513188A JP 2022513188 A JP2022513188 A JP 2022513188A JP 2022546964 A JP2022546964 A JP 2022546964A
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Japan
Prior art keywords
seq
pbp
peptide
acid
peptide ligand
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Ceased
Application number
JP2022513188A
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English (en)
Japanese (ja)
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JP2022546964A5 (https=
Inventor
ヴァン リーツチョーテン カテリーヌ
ベスウィック ポール
ドーソン マイク
バームフォース マシュー
スカイナー マイケル
チェン リューホン
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BicycleTx Ltd
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BicycleTx Ltd
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Publication date
Application filed by BicycleTx Ltd filed Critical BicycleTx Ltd
Publication of JP2022546964A publication Critical patent/JP2022546964A/ja
Publication of JP2022546964A5 publication Critical patent/JP2022546964A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2022513188A 2019-08-28 2020-08-28 Ｐｂｐ結合二環式ペプチドリガンド Ceased JP2022546964A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1912320.7A GB201912320D0 (en) 2019-08-28 2019-08-28 PBP Binding Bicyclic Peptide Ligands
GB1912320.7 2019-08-28
PCT/GB2020/052058 WO2021038232A1 (en) 2019-08-28 2020-08-28 Pbp binding bicyclic peptide ligands

Publications (2)

Publication Number Publication Date
JP2022546964A true JP2022546964A (ja) 2022-11-10
JP2022546964A5 JP2022546964A5 (https=) 2023-09-05

Family

ID=68108985

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022513188A Ceased JP2022546964A (ja) 2019-08-28 2020-08-28 Ｐｂｐ結合二環式ペプチドリガンド

Country Status (6)

Country Link
US (1) US20220281918A1 (https=)
EP (1) EP4021922A1 (https=)
JP (1) JP2022546964A (https=)
CN (1) CN114829374B (https=)
GB (1) GB201912320D0 (https=)
WO (1) WO2021038232A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023515567A (ja) * 2020-02-26 2023-04-13 バイスクルテクス・リミテッド Ｐｂｐ３結合二環式ペプチドリガンド

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107148425B (zh) 2014-10-29 2021-08-03 拜斯科阿迪有限公司 对mt1-mmp特异性的双环肽配体
EP3645549A1 (en) 2017-06-26 2020-05-06 BicycleRD Limited Bicyclic peptide ligands with detectable moieties and uses thereof
JP7670481B2 (ja) 2017-08-04 2025-04-30 バイスクルテクス・リミテッド Ｃｄ１３７に対して特異的な二環式ペプチドリガンド
CN111902429A (zh) 2018-02-23 2020-11-06 拜斯科技术开发有限公司 多聚体双环肽配体
IL279489B2 (en) 2018-06-22 2025-10-01 Bicycletx Ltd Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
WO2020128527A1 (en) 2018-12-21 2020-06-25 Bicyclerd Limited Bicyclic peptide ligands specific for pd-l1
US12492224B2 (en) 2018-12-21 2025-12-09 Bicycletx Limited Bicyclic peptide ligands specific for PD-L1
GB201900529D0 (en) 2019-01-15 2019-03-06 Bicycletx Ltd Bicyclic peptide ligands specific for CD38
TWI860386B (zh) 2019-07-30 2024-11-01 英商拜西可泰克斯有限公司 異質雙環肽複合物
AU2021322934A1 (en) 2020-08-03 2023-03-30 Bicycletx Limited Peptide-based linkers
KR20230107589A (ko) * 2020-11-13 2023-07-17 바이사이클티엑스 리미티드 트랜스페린 수용체 1 (TfR1)에 특이적인 비시클릭 펩티드 리간드

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
WO2006078161A1 (en) 2005-01-24 2006-07-27 Pepscan Systems B.V. Binding compounds, immunogenic compounds and peptidomimetics
EP2653545A1 (en) 2008-02-05 2013-10-23 Bicycle Therapeutics Limited Methods and compositions
CN107148425B (zh) * 2014-10-29 2021-08-03 拜斯科阿迪有限公司 对mt1-mmp特异性的双环肽配体
GB201706477D0 (en) * 2017-04-24 2017-06-07 Bicycle Therapeutics Ltd Modification of polypeptides
EP3645549A1 (en) * 2017-06-26 2020-05-06 BicycleRD Limited Bicyclic peptide ligands with detectable moieties and uses thereof
WO2020084305A1 (en) * 2018-10-23 2020-04-30 Bicycletx Limited Bicyclic peptide ligands and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DEYLE, K. ET AL: "Phage Selection of Cyclic Peptides for Application in Research and Drug Development", ACC. CHEM. RES., vol. 50, JPN6024031671, 2017, pages 1866 - 1874, ISSN: 0005391084 *
LI, S. ET AL: "A Novel Strategy for In Vitro Selection of Peptide-Drug Conjugates", CHEMISTRY & BIOLOGY, vol. 10, JPN6024031670, 2003, pages 233 - 239, ISSN: 0005391085 *
RUDGERS, G. W. ET AL: "Binding Properties of a Peptide Derived from β-Lactamase Inhibitory Protein", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 45, no. 12, JPN6024031673, 2001, pages 3279 - 3286, ISSN: 0005391087 *
ZAPUN, A. ET AL: "Penicillin-binding proteins and β-lactam resistance", FEMS MICROBIOL REV, vol. 32, JPN6024031672, 2008, pages 361 - 385, ISSN: 0005391086 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023515567A (ja) * 2020-02-26 2023-04-13 バイスクルテクス・リミテッド Ｐｂｐ３結合二環式ペプチドリガンド

Also Published As

Publication number Publication date
CN114829374A (zh) 2022-07-29
WO2021038232A1 (en) 2021-03-04
GB201912320D0 (en) 2019-10-09
CN114829374B (zh) 2025-04-04
EP4021922A1 (en) 2022-07-06
US20220281918A1 (en) 2022-09-08

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