JP2022546040A - Ｐｃｓｋ９を阻害するための組成物および方法 - Google Patents

Ｐｃｓｋ９を阻害するための組成物および方法 Download PDF

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JP2022546040A
JP2022546040A JP2022513127A JP2022513127A JP2022546040A JP 2022546040 A JP2022546040 A JP 2022546040A JP 2022513127 A JP2022513127 A JP 2022513127A JP 2022513127 A JP2022513127 A JP 2022513127A JP 2022546040 A JP2022546040 A JP 2022546040A
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dsrna
seq
nucleotides
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pcsk9
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JP2022546040A5 (https=
JPWO2021037972A5 (https=
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ボードー・ブルナー
ケルスティーン・ヤーン－ホフマン
ザビーネ・シャイドラー
ピエリック・リヴァル
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Sanofi SA
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/00—Structure or type of the nucleic acid
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JP2022513127A 2019-08-27 2020-08-27 Ｐｃｓｋ９を阻害するための組成物および方法 Pending JP2022546040A (ja)

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JP2024180454A JP2025013845A (ja) 2019-08-27 2024-10-16 Ｐｃｓｋ９を阻害するための組成物および方法

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EP19306036.5 2019-08-27
EP19306036 2019-08-27
PCT/EP2020/073961 WO2021037972A1 (en) 2019-08-27 2020-08-27 Compositions and methods for inhibiting pcsk9

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US (1) US20220290156A1 (https=)
EP (1) EP4022061A1 (https=)
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CN (1) CN115176011B (https=)
WO (1) WO2021037972A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022547888A (ja) * 2019-09-05 2022-11-16 サノフイ ヌクレオチド類似体を含有するオリゴヌクレオチド

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WO2019006455A1 (en) 2017-06-30 2019-01-03 Solstice Biologics, Ltd. AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF
EP3884051A2 (en) 2018-11-23 2021-09-29 Sanofi Novel rna compositions and methods for inhibiting angptl8
WO2024002006A1 (zh) * 2022-06-27 2024-01-04 大睿生物医药科技(上海)有限公司 具有增强的稳定性的核苷酸替代物
JP2025532985A (ja) 2022-09-30 2025-10-03 アルナイラム ファーマシューティカルズ， インコーポレイテッド 修飾二本鎖ｒｎａ剤
WO2024228030A2 (en) * 2023-05-04 2024-11-07 Argonaute RNA Limited Dual silencing
CN121866332A (zh) * 2023-06-21 2026-04-14 美国圣因生物股份有限公司 靶向前蛋白转化酶枯草杆菌蛋白酶kexin 9（pcsk9）的双链rna及其使用方法
WO2025077949A1 (zh) * 2023-11-06 2025-04-17 杭州天龙药业有限公司 提升双链寡核苷酸靶基因抑制效果的修饰模板及其组合与应用

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022547888A (ja) * 2019-09-05 2022-11-16 サノフイ ヌクレオチド類似体を含有するオリゴヌクレオチド
JP7667775B2 (ja) 2019-09-05 2025-04-23 サノフイ ヌクレオチド類似体を含有するオリゴヌクレオチド

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CN115176011B (zh) 2025-11-11
EP4022061A1 (en) 2022-07-06
US20220290156A1 (en) 2022-09-15
JP2025013845A (ja) 2025-01-28
CN115176011A (zh) 2022-10-11
WO2021037972A1 (en) 2021-03-04

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