JP2022545542A5 - - Google Patents
Info
- Publication number
- JP2022545542A5 JP2022545542A5 JP2022513277A JP2022513277A JP2022545542A5 JP 2022545542 A5 JP2022545542 A5 JP 2022545542A5 JP 2022513277 A JP2022513277 A JP 2022513277A JP 2022513277 A JP2022513277 A JP 2022513277A JP 2022545542 A5 JP2022545542 A5 JP 2022545542A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazole
- ethoxycyclohexyl
- difluoropyridine
- thiazole
- carbamoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025203023A JP2026053335A (ja) | 2019-08-30 | 2025-11-25 | ピラゾール化合物、その製剤並びに化合物及び/又は製剤を使用する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962894547P | 2019-08-30 | 2019-08-30 | |
| US62/894,547 | 2019-08-30 | ||
| PCT/US2020/048528 WO2021041898A1 (en) | 2019-08-30 | 2020-08-28 | Pyrazole compounds, formulations thereof, and a method for using the compounds and/or formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025203023A Division JP2026053335A (ja) | 2019-08-30 | 2025-11-25 | ピラゾール化合物、その製剤並びに化合物及び/又は製剤を使用する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022545542A JP2022545542A (ja) | 2022-10-27 |
| JP2022545542A5 true JP2022545542A5 (cg-RX-API-DMAC10.html) | 2023-09-04 |
Family
ID=72473975
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022513277A Pending JP2022545542A (ja) | 2019-08-30 | 2020-08-28 | ピラゾール化合物、その製剤並びに化合物及び/又は製剤を使用する方法 |
| JP2025203023A Pending JP2026053335A (ja) | 2019-08-30 | 2025-11-25 | ピラゾール化合物、その製剤並びに化合物及び/又は製剤を使用する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025203023A Pending JP2026053335A (ja) | 2019-08-30 | 2025-11-25 | ピラゾール化合物、その製剤並びに化合物及び/又は製剤を使用する方法 |
Country Status (21)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022545542A (ja) | 2019-08-30 | 2022-10-27 | ライジェル ファーマシューティカルズ, インコーポレイテッド | ピラゾール化合物、その製剤並びに化合物及び/又は製剤を使用する方法 |
| WO2022187303A1 (en) * | 2021-03-03 | 2022-09-09 | Rigel Pharmaceuticals, Inc. | A method for treating a disease or condition using a pyrazole compound or formulation thereof |
| EP4399208A4 (en) * | 2021-09-08 | 2025-07-16 | Rigel Pharmaceuticals Inc | IRAK INHIBITOR FOR TREATING CYTOKINE RELEASE CONDITIONS ASSOCIATED WITH RESPIRATORY VIRUS INFECTION |
| ES3075943T3 (en) * | 2022-03-23 | 2026-08-10 | Rigel Pharmaceuticals Inc | Pyrimid-2-yl-pyrazole compounds as irak inhibitors |
| WO2026122888A1 (en) * | 2024-12-06 | 2026-06-11 | Rigel Pharmaceuticals, Inc. | Pharmaceutical compositions comprising 1-(4-(4-((3-(3,6-difluoropyridin-2-yl)-1-((1r,4r)-4-ethoxycyclohexyl)-1h-pyrazol -4-yl)carbamoyl)thiazol-2-yl)-1h-pyrazol-1-yl)ethyl phosphate or its salts |
| US20260159538A1 (en) * | 2024-12-06 | 2026-06-11 | Rigel Pharmaceuticals, Inc. | Solid forms of 1-(4-(4-((3-(3,6-difluoropyridin-2-yl)-1-((1r,4r)-4-ethoxycyclohexyl)-1h-pyrazol-4-yl)carbamoyl)thiazol-2-yl)-1h-pyrazol-1-yl)ethyl phosphate and salts thereof, and their pharmaceutical compositions and uses |
| US20260158048A1 (en) | 2024-12-06 | 2026-06-11 | Rigel Pharmaceuticals, Inc. | Methods of treatment |
| CN119950825B (zh) * | 2025-03-13 | 2025-07-22 | 北京工业大学 | 基于压电驱动的自适应释药电纺覆膜气管支架的制备方法 |
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| US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
| US5087240A (en) | 1983-08-18 | 1992-02-11 | Drug Delivery Systems Inc. | Transdermal drug patch with conductive fibers |
| US4738851A (en) | 1985-09-27 | 1988-04-19 | University Of Iowa Research Foundation, Inc. | Controlled release ophthalmic gel formulation |
| US5163899A (en) | 1987-03-20 | 1992-11-17 | Drug Delivery Systems Inc. | Transdermal drug delivery system |
| US5312325A (en) | 1987-05-28 | 1994-05-17 | Drug Delivery Systems Inc | Pulsating transdermal drug delivery system |
| GB8804164D0 (en) | 1988-02-23 | 1988-03-23 | Tucker J M | Bandage for administering physiologically active compound |
| US4882150A (en) | 1988-06-03 | 1989-11-21 | Kaufman Herbert E | Drug delivery system |
| US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
| US5088977A (en) | 1988-12-21 | 1992-02-18 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator with counteractor and method of drug delivery |
| US5521222A (en) | 1989-09-28 | 1996-05-28 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
| CA2031376A1 (en) | 1989-12-04 | 1991-06-05 | Bahram Farhadieh | Single layer transdermal drug administration system |
| US5077033A (en) | 1990-08-07 | 1991-12-31 | Mediventures Inc. | Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide |
| DK0495421T3 (da) | 1991-01-15 | 1996-12-09 | Alcon Lab Inc | Anvendelse af carragenaner i topiske ophthalmiske sammensætninger |
| US5352456A (en) | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
| CA2123809A1 (en) | 1991-12-18 | 1993-06-24 | Debra L. Wilfong | Multilayered barrier structures |
| ATE132381T1 (de) | 1992-01-29 | 1996-01-15 | Voelkl Franz Ski | Ballspielschläger, insbesondere tennisschläger |
| IL114193A (en) | 1994-06-20 | 2000-02-29 | Teva Pharma | Ophthalmic pharmaceutical compositions based on sodium alginate |
| ES2094688B1 (es) | 1994-08-08 | 1997-08-01 | Cusi Lab | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. |
| IT1283911B1 (it) | 1996-02-05 | 1998-05-07 | Farmigea Spa | Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo |
| US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
| US6261547B1 (en) | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
| US6197934B1 (en) | 1998-05-22 | 2001-03-06 | Collagenesis, Inc. | Compound delivery using rapidly dissolving collagen film |
| AU2003287965A1 (en) | 2002-10-24 | 2004-05-13 | Carex Sa | Modulation of peroxisome proliferator activated receptors activity |
| TWI372050B (en) | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| EP1836188A1 (en) | 2004-12-30 | 2007-09-26 | Astex Therapeutics Limited | Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases |
| WO2006070202A1 (en) | 2004-12-30 | 2006-07-06 | Astex Therapeutics Limited | Pyrazole derivatives having kinase modulating activity |
| SI2206707T1 (sl) | 2007-10-24 | 2014-11-28 | Astellas Pharma Inc. | Azolkarboksamidna spojina ali njena sol |
| EP2070925A1 (de) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Neue 2-substituierte Tiazol-4-carbonsäureamid-Derivative deren Herstellung und Verwendung als Arzneimittel |
| US8987309B2 (en) | 2009-04-17 | 2015-03-24 | The Translational Genomics Research Institute | Compounds, pharmaceutical compositions and methods of use of 2-aryl pyridylazoles |
| EP2243481A1 (en) | 2009-04-24 | 2010-10-27 | PamGene B.V. | Irak kinase family as novel drug target for Alzheimer |
| JP2012254939A (ja) | 2009-10-07 | 2012-12-27 | Astellas Pharma Inc | オキサゾール化合物 |
| CA2794801C (en) | 2010-04-07 | 2019-01-15 | F. Hoffmann-La Roche Ag | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| RU2632900C2 (ru) | 2010-11-19 | 2017-10-11 | Лиганд Фармасьютикалс Инкорпорейтед | Гетероциклические амины и их применение |
| WO2012072685A1 (en) | 2010-12-02 | 2012-06-07 | Katholieke Universiteit Leuven, K.U.Leuven R&D | Irak-related interventions and diagnosis |
| HUE029617T2 (en) | 2010-12-20 | 2017-03-28 | Merck Serono Sa | Indazolyl triazole derivatives as IRAK inhibitors |
| EP3239154A1 (en) | 2011-01-10 | 2017-11-01 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| CN103347873A (zh) | 2011-02-09 | 2013-10-09 | 日产化学工业株式会社 | 吡唑衍生物和有害生物防除剂 |
| US8575336B2 (en) | 2011-07-27 | 2013-11-05 | Pfizer Limited | Indazoles |
| EP2760857A1 (en) | 2011-09-27 | 2014-08-06 | F.Hoffmann-La Roche Ag | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| TW201728592A (zh) | 2012-01-10 | 2017-08-16 | 林伯士艾瑞斯公司 | Irak抑制劑及其用途 |
| WO2014048939A1 (en) | 2012-09-26 | 2014-04-03 | F. Hoffmann-La Roche Ag | Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| WO2014058691A1 (en) | 2012-10-08 | 2014-04-17 | Merck Sharp & Dohme Corp. | Inhibitors of irak4 activity |
| JP6483624B2 (ja) | 2013-02-07 | 2019-03-13 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | ピリダジノン−アミド誘導体 |
| ES2639717T3 (es) | 2013-02-07 | 2017-10-30 | Merck Patent Gmbh | Derivados de piridazinona macrocíclicos |
| ES2728403T3 (es) | 2014-01-09 | 2019-10-24 | Merck Patent Gmbh | Derivados de pirimidin pirazolilo y su uso como inhibidores de IRAK |
| LT3221306T (lt) | 2014-11-20 | 2020-03-10 | Merck Patent Gmbh | Heteroarilo junginiai, kaip irak inhibitoriai ir jų panaudojimas |
| DK3286181T3 (da) * | 2015-04-22 | 2021-04-06 | Rigel Pharmaceuticals Inc | Pyrazolforbindelser og fremgangsmåde til fremstilling og anvendelse af forbindelserne |
| CN110099899B (zh) * | 2016-10-26 | 2024-01-02 | 里格尔药品股份有限公司 | 用作irak抑制剂的噁唑衍生物及其制备方法 |
| JP2022545542A (ja) * | 2019-08-30 | 2022-10-27 | ライジェル ファーマシューティカルズ, インコーポレイテッド | ピラゾール化合物、その製剤並びに化合物及び/又は製剤を使用する方法 |
-
2020
- 2020-08-28 JP JP2022513277A patent/JP2022545542A/ja active Pending
- 2020-08-28 BR BR112022003564A patent/BR112022003564A2/pt unknown
- 2020-08-28 EP EP20771685.3A patent/EP4003990A1/en active Pending
- 2020-08-28 PH PH1/2022/550466A patent/PH12022550466A1/en unknown
- 2020-08-28 CR CR20220085A patent/CR20220085A/es unknown
- 2020-08-28 AU AU2020335903A patent/AU2020335903B2/en active Active
- 2020-08-28 MX MX2022002292A patent/MX2022002292A/es unknown
- 2020-08-28 IL IL290882A patent/IL290882B2/en unknown
- 2020-08-28 CA CA3152264A patent/CA3152264A1/en active Pending
- 2020-08-28 TW TW109129543A patent/TWI870449B/zh active
- 2020-08-28 CN CN202511306178.3A patent/CN121159524A/zh active Pending
- 2020-08-28 AR ARP200102424A patent/AR119857A1/es unknown
- 2020-08-28 PY PY202002049213A patent/PY2049213A/es unknown
- 2020-08-28 US US17/006,150 patent/US11370787B2/en active Active
- 2020-08-28 CN CN202080061311.2A patent/CN114364674B/zh active Active
- 2020-08-28 PE PE2022000318A patent/PE20220970A1/es unknown
- 2020-08-28 WO PCT/US2020/048528 patent/WO2021041898A1/en not_active Ceased
-
2022
- 2022-02-23 EC ECSENADI202214379A patent/ECSP22014379A/es unknown
- 2022-02-25 DO DO2022000047A patent/DOP2022000047A/es unknown
- 2022-02-27 JO JOP/2022/0050A patent/JOP20220050A1/ar unknown
- 2022-02-28 SA SA522431791A patent/SA522431791B1/ar unknown
- 2022-03-15 CO CONC2022/0002993A patent/CO2022002993A2/es unknown
- 2022-05-18 US US17/747,384 patent/US20220306620A1/en not_active Abandoned
-
2023
- 2023-08-24 US US18/237,824 patent/US12441723B2/en active Active
-
2025
- 2025-11-25 JP JP2025203023A patent/JP2026053335A/ja active Pending
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