JP2022544564A5 - - Google Patents
Info
- Publication number
- JP2022544564A5 JP2022544564A5 JP2022509137A JP2022509137A JP2022544564A5 JP 2022544564 A5 JP2022544564 A5 JP 2022544564A5 JP 2022509137 A JP2022509137 A JP 2022509137A JP 2022509137 A JP2022509137 A JP 2022509137A JP 2022544564 A5 JP2022544564 A5 JP 2022544564A5
- Authority
- JP
- Japan
- Prior art keywords
- opioid
- hexadienoneate
- methylhexadienoneate
- composition according
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962885311P | 2019-08-11 | 2019-08-11 | |
| US62/885,311 | 2019-08-11 | ||
| US16/540,058 | 2019-08-14 | ||
| US16/540,058 US11186585B2 (en) | 2018-08-17 | 2019-08-14 | Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates |
| PCT/US2020/021599 WO2021029914A1 (en) | 2019-08-11 | 2020-03-07 | Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022544564A JP2022544564A (ja) | 2022-10-19 |
| JP2022544564A5 true JP2022544564A5 (enExample) | 2023-03-15 |
| JP7535569B2 JP7535569B2 (ja) | 2024-08-16 |
Family
ID=74571142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022509137A Active JP7535569B2 (ja) | 2019-08-11 | 2020-03-07 | オピオイドヘキサジエノエート及び選択的に置換されたヘキサジエノエートによってオピオイド受容体の結合を改善する組成物並びに方法 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP4010078A4 (enExample) |
| JP (1) | JP7535569B2 (enExample) |
| CN (1) | CN114828961B (enExample) |
| CA (1) | CA3149152A1 (enExample) |
| MX (1) | MX2022001520A (enExample) |
| WO (1) | WO2021029914A1 (enExample) |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4668685A (en) | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| EP0615756B1 (en) * | 1993-03-15 | 2001-06-27 | National Science Council | Nalbuphine esters and long-acting pharmaceutical compositions containing them |
| CN1050130C (zh) | 1997-07-04 | 2000-03-08 | 卢正堂 | 纳洛酮酸脂和纳屈酮酸脂及系列物和制备方法 |
| EP1149836B1 (en) | 2000-04-27 | 2003-02-26 | Oliver Yoa-Pu Hu | Polynalbuphine derivatives |
| TWI226239B (en) | 2000-05-15 | 2005-01-11 | You-Pu Hu | Novel oral pharmaceutical composition containing nalbuphine ester prodrug |
| CA2771263A1 (en) | 2000-07-27 | 2002-02-07 | Rutgers, The State University | Therapeutic polyesters and polyamides |
| US6569449B1 (en) * | 2000-11-13 | 2003-05-27 | University Of Kentucky Research Foundation | Transdermal delivery of opioid antagonist prodrugs |
| US20040033253A1 (en) | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
| WO2005009377A2 (en) | 2003-07-23 | 2005-02-03 | University Of Kentucky Research Foundation | Novel oral bioavailable prodrugs |
| US20050137141A1 (en) | 2003-10-24 | 2005-06-23 | John Hilfinger | Prodrug composition |
| WO2007022535A2 (en) | 2005-08-19 | 2007-02-22 | Pharmacofore, Inc. | Prodrugs of active agents |
| WO2009092071A2 (en) | 2008-01-18 | 2009-07-23 | Shire Llc | Amino acid and peptide pro-drugs of phenolic analgesics and uses thereof |
| KR20110134510A (ko) | 2009-04-02 | 2011-12-14 | 샤이어 엘엘씨 | 오피오이드의 신규한 디카르복실산 연결 아미노산 및 펩티드 프로드러그와 그 용도 |
| WO2011007247A1 (en) | 2009-07-17 | 2011-01-20 | Llc Shire | Novel carbamate amino acid and peptide prodrugs of opioids and uses thereof |
| CA2768392C (en) | 2009-07-21 | 2018-04-17 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
| US20110190267A1 (en) * | 2010-01-05 | 2011-08-04 | Shire Pharmaceuticals, Inc. | Prodrugs of opioids and uses thereof |
| US8461171B2 (en) | 2010-02-09 | 2013-06-11 | QRxPharma Ltd. | Hybrid opioid compounds and compositions |
| JP5941038B2 (ja) * | 2010-04-02 | 2016-06-29 | ジネルバ ファーマシューティカルズ， インコーポレイティド | 経皮送達可能なオピオイドプロドラッグ、乱用抵抗性組成物及びオピオイドプロドラッグを使用する方法 |
| JP5864606B2 (ja) | 2010-12-28 | 2016-02-17 | ユーロ−セルティーク エス．エイ． | パーキンソン病の治療におけるオピオイド作動薬とオピオイド拮抗薬との組合せ |
| US9987269B2 (en) | 2015-04-27 | 2018-06-05 | 3St Research Llc | Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of oxymorphone and uses thereof |
| US10449190B2 (en) * | 2015-04-27 | 2019-10-22 | John K. Thottathil | Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of opioids and uses thereof |
| US10017519B2 (en) * | 2015-04-27 | 2018-07-10 | 3St Research Llc | Alpha-hydroxy carboxylic acid and derivatives and other GRAS based prodrugs of oxycodone and uses thereof |
| WO2017037813A1 (ja) * | 2015-08-29 | 2017-03-09 | 株式会社メドレックス | 塩基性薬物とソルビン酸とを含有する経皮吸収組成物 |
| US12590065B2 (en) | 2017-04-14 | 2026-03-31 | Zevra Therapeutics, Inc. | Levorphanol prodrugs and processes for making and using them |
| US11186585B2 (en) * | 2018-08-17 | 2021-11-30 | Kappa-Pharma LLC | Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates |
-
2020
- 2020-03-07 EP EP20852037.9A patent/EP4010078A4/en active Pending
- 2020-03-07 JP JP2022509137A patent/JP7535569B2/ja active Active
- 2020-03-07 MX MX2022001520A patent/MX2022001520A/es unknown
- 2020-03-07 WO PCT/US2020/021599 patent/WO2021029914A1/en not_active Ceased
- 2020-03-07 CN CN202080071185.9A patent/CN114828961B/zh active Active
- 2020-03-07 CA CA3149152A patent/CA3149152A1/en active Pending
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