JP2022537140A5 - - Google Patents
Info
- Publication number
- JP2022537140A5 JP2022537140A5 JP2021573446A JP2021573446A JP2022537140A5 JP 2022537140 A5 JP2022537140 A5 JP 2022537140A5 JP 2021573446 A JP2021573446 A JP 2021573446A JP 2021573446 A JP2021573446 A JP 2021573446A JP 2022537140 A5 JP2022537140 A5 JP 2022537140A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- membered
- cycloalkyl
- optionally substituted
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962861902P | 2019-06-14 | 2019-06-14 | |
| US62/861,902 | 2019-06-14 | ||
| PCT/US2020/037591 WO2020252383A2 (en) | 2019-06-14 | 2020-06-12 | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (pcsk9) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022537140A JP2022537140A (ja) | 2022-08-24 |
| JP2022537140A5 true JP2022537140A5 (enExample) | 2023-06-19 |
Family
ID=73780709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021573446A Pending JP2022537140A (ja) | 2019-06-14 | 2020-06-12 | プロタンパク質転換酵素サブチリシン／ケキシン９型（ｐｃｓｋ９）の調節のための化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220267269A1 (enExample) |
| EP (1) | EP3983392A4 (enExample) |
| JP (1) | JP2022537140A (enExample) |
| CN (1) | CN114206843A (enExample) |
| AU (1) | AU2020291468A1 (enExample) |
| CA (1) | CA3142890A1 (enExample) |
| IL (1) | IL288848A (enExample) |
| WO (1) | WO2020252383A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3337497B1 (en) | 2015-08-21 | 2023-07-12 | SRX Cardio, LLC | Composition and methods of use of novel phenylalanine small organic compounds to directly modulate pcsk9 protein activity |
| EP3337564A4 (en) | 2015-08-21 | 2019-01-23 | Portola Pharmaceuticals, Inc. | COMPOSITION AND METHOD FOR THE USE OF TETRAHYDROISOCHINOLINE SMALL MOLECULES FOR THE BINDING AND MODULATION OF PCSK9 PROTEIN ACTIVITY |
| HK1257102A1 (zh) | 2015-08-21 | 2019-10-11 | Portola Pharmaceuticals, Inc. | 苯基哌嗪前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)调节剂及其应用 |
| WO2017147328A1 (en) | 2016-02-23 | 2017-08-31 | Portola Pharmaceuticals, Inc. | Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9) |
| US12115154B2 (en) | 2020-12-16 | 2024-10-15 | Srx Cardio, Llc | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) |
| TW202506682A (zh) * | 2023-07-27 | 2025-02-16 | 大陸商上海拓界生物醫藥科技有限公司 | 二胺基環戊基取代的雜芳基衍生物及其用途和製備方法 |
| WO2025034510A1 (en) | 2023-08-04 | 2025-02-13 | University Of Rochester | Adrenergic antagonists for use in a method for treating cerebral edema or a brain injury |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5556990A (en) * | 1994-12-16 | 1996-09-17 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Polyarylcarbamoylaza- and -carbamoylalkanedioic acids |
| HN1997000027A (es) * | 1996-12-06 | 1997-06-05 | Pfizer Prod Inc | Derivados de 6-fenil piridil - 2 amina |
| TR200103351T2 (tr) * | 1999-05-21 | 2002-06-21 | Pfizer Products Inc. | Nos inhibitörleri için yeni farmasötik kombinasyonlar. |
| WO2005016910A1 (ja) * | 2003-08-18 | 2005-02-24 | Sankio Chemical Co., Ltd. | ピリジルテトラヒドロピリジン類およびピリジルピペリジン類とそれらの製造方法 |
| JP5227796B2 (ja) * | 2005-09-29 | 2013-07-03 | アボット・ラボラトリーズ | ２位においてフェニルによって置換された１ｈ−ベンズイミダゾール−４−カルボキサミドは強力なｐａｒｐ阻害薬である |
| US7834178B2 (en) * | 2006-03-01 | 2010-11-16 | Bristol-Myers Squibb Company | Triazine 11-beta hydroxysteroid dehydrogenase type 1 inhibitors |
| ES2392553T3 (es) * | 2006-07-10 | 2012-12-11 | H. Lundbeck A/S | Derivados (3-aril-piperazina-1-ilo) de 6,7-dialcoxiquinazolina, 6,7-dialcoxiftalazina y 6,7-dialcoxiisoquinolina |
| HK1257102A1 (zh) * | 2015-08-21 | 2019-10-11 | Portola Pharmaceuticals, Inc. | 苯基哌嗪前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)调节剂及其应用 |
| CN106995413A (zh) * | 2016-01-25 | 2017-08-01 | 中国科学院大连化学物理研究所 | 一种铱催化氢化不对称合成哌嗪衍生物的方法 |
| WO2018165718A1 (en) * | 2017-03-17 | 2018-09-20 | Cardio Therapeutics Pty Ltd | Heterocyclic inhibitors of pcsk9 |
| CN110546149B (zh) * | 2017-04-21 | 2022-11-11 | 深圳信立泰药业股份有限公司 | 作为pcsk9抑制剂的哌啶类化合物 |
-
2020
- 2020-06-12 AU AU2020291468A patent/AU2020291468A1/en not_active Abandoned
- 2020-06-12 JP JP2021573446A patent/JP2022537140A/ja active Pending
- 2020-06-12 EP EP20823039.1A patent/EP3983392A4/en not_active Withdrawn
- 2020-06-12 US US17/618,873 patent/US20220267269A1/en not_active Abandoned
- 2020-06-12 CN CN202080050808.4A patent/CN114206843A/zh active Pending
- 2020-06-12 WO PCT/US2020/037591 patent/WO2020252383A2/en not_active Ceased
- 2020-06-12 CA CA3142890A patent/CA3142890A1/en active Pending
-
2021
- 2021-12-09 IL IL288848A patent/IL288848A/en unknown
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