JP2022537140A5 - - Google Patents
Info
- Publication number
- JP2022537140A5 JP2022537140A5 JP2021573446A JP2021573446A JP2022537140A5 JP 2022537140 A5 JP2022537140 A5 JP 2022537140A5 JP 2021573446 A JP2021573446 A JP 2021573446A JP 2021573446 A JP2021573446 A JP 2021573446A JP 2022537140 A5 JP2022537140 A5 JP 2022537140A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- membered
- cycloalkyl
- optionally substituted
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962861902P | 2019-06-14 | 2019-06-14 | |
| US62/861,902 | 2019-06-14 | ||
| PCT/US2020/037591 WO2020252383A2 (en) | 2019-06-14 | 2020-06-12 | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (pcsk9) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022537140A JP2022537140A (ja) | 2022-08-24 |
| JP2022537140A5 true JP2022537140A5 (enExample) | 2023-06-19 |
Family
ID=73780709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021573446A Pending JP2022537140A (ja) | 2019-06-14 | 2020-06-12 | プロタンパク質転換酵素サブチリシン／ケキシン９型（ｐｃｓｋ９）の調節のための化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220267269A1 (enExample) |
| EP (1) | EP3983392A4 (enExample) |
| JP (1) | JP2022537140A (enExample) |
| CN (1) | CN114206843A (enExample) |
| AU (1) | AU2020291468A1 (enExample) |
| CA (1) | CA3142890A1 (enExample) |
| IL (1) | IL288848A (enExample) |
| WO (1) | WO2020252383A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3337788A4 (en) | 2015-08-21 | 2019-03-27 | Portola Pharmaceuticals, Inc. | PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN / -KEXIN TYPE 9 P (CSK9) MODULATORS AND THEIR USE |
| HK1260897A1 (zh) | 2015-08-21 | 2019-12-27 | Portola Pharmaceuticals, Inc. | 使用四氢异喹啉小分子来结合并调节pcsk9的蛋白活性的组合物和方法 |
| WO2017034994A1 (en) | 2015-08-21 | 2017-03-02 | Portola Pharmaceuticals, Inc. | Composition and methods of use of novel phenylalanine small organic compounds to directly modulate pcsk9 protein activity |
| WO2017147328A1 (en) | 2016-02-23 | 2017-08-31 | Portola Pharmaceuticals, Inc. | Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9) |
| US12115154B2 (en) | 2020-12-16 | 2024-10-15 | Srx Cardio, Llc | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) |
| CN121443616A (zh) * | 2023-07-27 | 2026-01-30 | 上海拓界生物医药科技有限公司 | 二氨基环戊基取代的杂芳基衍生物及其用途和制备方法 |
| EP4753687A1 (en) | 2023-08-04 | 2026-06-10 | University of Rochester | Adrenergic antagonists for use in a method for treating cerebral edema or a brain injury |
| CN122213067A (zh) * | 2024-12-13 | 2026-06-16 | 中国药科大学 | 异色满酮类化合物及其药物组合物和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5556990A (en) * | 1994-12-16 | 1996-09-17 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Polyarylcarbamoylaza- and -carbamoylalkanedioic acids |
| HN1997000027A (es) * | 1996-12-06 | 1997-06-05 | Pfizer Prod Inc | Derivados de 6-fenil piridil - 2 amina |
| PL358538A1 (en) * | 1999-05-21 | 2004-08-09 | Pfizer Products Inc. | New pharmaceutical combinations for nos inhibitors |
| EP1657240A4 (en) * | 2003-08-18 | 2009-04-08 | Fujifilm Finechemicals Co Ltd | PYRIDYLTETRAHYDROPYRIDINE, PYRIDYLPIPERIDINE AND METHOD FOR THE PRODUCTION THEREOF |
| CN101316834A (zh) * | 2005-09-29 | 2008-12-03 | 艾博特公司 | 在2位取代有苯基的1h-苯并咪唑-4-甲酰胺是强效parp抑制剂 |
| US7834178B2 (en) * | 2006-03-01 | 2010-11-16 | Bristol-Myers Squibb Company | Triazine 11-beta hydroxysteroid dehydrogenase type 1 inhibitors |
| US8492394B2 (en) * | 2006-07-10 | 2013-07-23 | H. Lundbeck A/S | (3-aryl-piperazin-1-yl), (2-aryl-morpholin-4-yl) and (2-aryl-thiomorpholin-4-yl) derivatives of 6,7-dialkoxy-quinazoline, 6,7-dialkoxyphtalazine and 6,7-dialkoxyisoquinoline as PDE10A enzyme inhibitors |
| EP3337788A4 (en) * | 2015-08-21 | 2019-03-27 | Portola Pharmaceuticals, Inc. | PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN / -KEXIN TYPE 9 P (CSK9) MODULATORS AND THEIR USE |
| CN106995413A (zh) * | 2016-01-25 | 2017-08-01 | 中国科学院大连化学物理研究所 | 一种铱催化氢化不对称合成哌嗪衍生物的方法 |
| EP3609882B1 (en) * | 2017-03-17 | 2022-07-13 | Cardio Therapeutics Pty Ltd | Heterocyclic inhibitors of pcsk9 |
| CN110546149B (zh) * | 2017-04-21 | 2022-11-11 | 深圳信立泰药业股份有限公司 | 作为pcsk9抑制剂的哌啶类化合物 |
-
2020
- 2020-06-12 CA CA3142890A patent/CA3142890A1/en active Pending
- 2020-06-12 WO PCT/US2020/037591 patent/WO2020252383A2/en not_active Ceased
- 2020-06-12 US US17/618,873 patent/US20220267269A1/en not_active Abandoned
- 2020-06-12 AU AU2020291468A patent/AU2020291468A1/en not_active Abandoned
- 2020-06-12 EP EP20823039.1A patent/EP3983392A4/en not_active Withdrawn
- 2020-06-12 CN CN202080050808.4A patent/CN114206843A/zh active Pending
- 2020-06-12 JP JP2021573446A patent/JP2022537140A/ja active Pending
-
2021
- 2021-12-09 IL IL288848A patent/IL288848A/en unknown
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