JP2022536951A5 - - Google Patents
Info
- Publication number
- JP2022536951A5 JP2022536951A5 JP2021575283A JP2021575283A JP2022536951A5 JP 2022536951 A5 JP2022536951 A5 JP 2022536951A5 JP 2021575283 A JP2021575283 A JP 2021575283A JP 2021575283 A JP2021575283 A JP 2021575283A JP 2022536951 A5 JP2022536951 A5 JP 2022536951A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- days
- level
- cyclic
- polyribonucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025272525A JP2026040556A (ja) | 2019-06-19 | 2025-12-22 | 環状ポリリボヌクレオチドを投与する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962863725P | 2019-06-19 | 2019-06-19 | |
| US62/863,725 | 2019-06-19 | ||
| PCT/US2020/038835 WO2020257727A1 (en) | 2019-06-19 | 2020-06-19 | Methods of dosing circular polyribonucleotides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025272525A Division JP2026040556A (ja) | 2019-06-19 | 2025-12-22 | 環状ポリリボヌクレオチドを投与する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022536951A JP2022536951A (ja) | 2022-08-22 |
| JP2022536951A5 true JP2022536951A5 (https=) | 2023-06-27 |
Family
ID=71842849
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021575283A Withdrawn JP2022536951A (ja) | 2019-06-19 | 2020-06-19 | 環状ポリリボヌクレオチドを投与する方法 |
| JP2025272525A Pending JP2026040556A (ja) | 2019-06-19 | 2025-12-22 | 環状ポリリボヌクレオチドを投与する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025272525A Pending JP2026040556A (ja) | 2019-06-19 | 2025-12-22 | 環状ポリリボヌクレオチドを投与する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20220296729A1 (https=) |
| EP (1) | EP3987038A1 (https=) |
| JP (2) | JP2022536951A (https=) |
| KR (1) | KR20220024647A (https=) |
| CN (1) | CN114096674A (https=) |
| AU (1) | AU2020296190A1 (https=) |
| CA (1) | CA3140594A1 (https=) |
| IL (1) | IL288983A (https=) |
| MA (1) | MA56538A (https=) |
| WO (1) | WO2020257727A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111819185A (zh) | 2017-12-15 | 2020-10-23 | 旗舰创业创新第六有限责任公司 | 包含环状多核糖核苷酸的组合物及其用途 |
| WO2020198403A2 (en) | 2019-03-25 | 2020-10-01 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising modified circular polyribonucleotides and uses thereof |
| CN114981409A (zh) | 2019-09-03 | 2022-08-30 | 美洛德生物医药公司 | 用于基因组整合的方法和组合物 |
| US20230203192A1 (en) * | 2020-05-20 | 2023-06-29 | Flagship Pioneering, Inc. | Compositions and methods for producing human polyclonal antibodies |
| BR112023023642A2 (pt) | 2021-05-11 | 2024-01-30 | Myeloid Therapeutics Inc | Métodos e composições para integração genômica |
| MX2024003262A (es) | 2021-09-17 | 2024-06-19 | Flagship Pioneering Innovations Vi Llc | Composiciones y metodos para producir poliribonucleotidos circulares. |
| KR20240118174A (ko) | 2021-12-17 | 2024-08-02 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 변성 조건 하에서의 원형 rna의 풍부화를 위한 방법 |
| CN121057577A (zh) | 2023-01-27 | 2025-12-02 | 赛欧生物医药股份有限公司 | 经修饰的脂质组合物及其用途 |
| CN116870004B (zh) * | 2023-02-24 | 2025-10-21 | 中南大学 | 以brd7为靶点在防治自身免疫性疾病药物中的应用 |
| CN117070564B (zh) * | 2023-03-30 | 2024-05-10 | 安可来(重庆)生物医药科技有限公司 | 一种用于合成环形rna的质粒及其构建方法与一种环形rna及其体外合成方法 |
| CN120241980A (zh) * | 2023-12-29 | 2025-07-04 | 复旦大学 | 一种基于环状rna的现货型体内原位car与肿瘤疫苗联用的免疫治疗技术及其应用 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5266684A (en) | 1988-05-02 | 1993-11-30 | The Reagents Of The University Of California | Peptide mixtures |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| AU649066B2 (en) | 1990-07-25 | 1994-05-12 | Syngene, Inc. | Circular extension for generating multiple nucleic acid complements |
| US5426180A (en) | 1991-03-27 | 1995-06-20 | Research Corporation Technologies, Inc. | Methods of making single-stranded circular oligonucleotides |
| US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
| US5770358A (en) | 1991-09-18 | 1998-06-23 | Affymax Technologies N.V. | Tagged synthetic oligomer libraries |
| JPH07502898A (ja) | 1992-01-13 | 1995-03-30 | デューク・ユニバーシティー | 酵素ｒｎａ分子 |
| US5541061A (en) | 1992-04-29 | 1996-07-30 | Affymax Technologies N.V. | Methods for screening factorial chemical libraries |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US5721099A (en) | 1992-10-01 | 1998-02-24 | Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| US5773244A (en) | 1993-05-19 | 1998-06-30 | Regents Of The University Of California | Methods of making circular RNA |
| US5440016A (en) | 1993-06-18 | 1995-08-08 | Torrey Pines Institute For Molecular Studies | Peptides of the formula (KFmoc) ZZZ and their uses |
| US5593853A (en) | 1994-02-09 | 1997-01-14 | Martek Corporation | Generation and screening of synthetic drug libraries |
| US5688997A (en) | 1994-05-06 | 1997-11-18 | Pharmacopeia, Inc. | Process for preparing intermediates for a combinatorial dihydrobenzopyran library |
| US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5549974A (en) | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
| US5463564A (en) | 1994-09-16 | 1995-10-31 | 3-Dimensional Pharmaceuticals, Inc. | System and method of automatically generating chemical compounds with desired properties |
| US5688696A (en) | 1994-12-12 | 1997-11-18 | Selectide Corporation | Combinatorial libraries having a predetermined frequency of each species of test compound |
| WO1997000887A1 (en) | 1995-06-21 | 1997-01-09 | Martek Biosciences Corporation | Combinatorial libraries of labeled biochemical compounds and methods for producing same |
| US5766903A (en) * | 1995-08-23 | 1998-06-16 | University Technology Corporation | Circular RNA and uses thereof |
| US5731423A (en) | 1996-03-21 | 1998-03-24 | Transcell Technologies, Inc. | Process for preparing sulfoxides |
| US6429301B1 (en) | 1998-04-17 | 2002-08-06 | Whitehead Institute For Biomedical Research | Use of a ribozyme to join nucleic acids and peptides |
| US6210931B1 (en) | 1998-11-30 | 2001-04-03 | The United States Of America As Represented By The Secretary Of Agriculture | Ribozyme-mediated synthesis of circular RNA |
| EP2447370B1 (en) | 2001-09-28 | 2018-07-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | MicroRNA molecules |
| US7683036B2 (en) | 2003-07-31 | 2010-03-23 | Regulus Therapeutics Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs |
| JP5296328B2 (ja) | 2007-05-09 | 2013-09-25 | 独立行政法人理化学研究所 | １本鎖環状ｒｎａおよびその製造方法 |
| WO2010084371A1 (en) | 2009-01-26 | 2010-07-29 | Mitoprod | Novel circular interfering rna molecules |
| WO2015034925A1 (en) * | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| US10407683B2 (en) * | 2014-07-16 | 2019-09-10 | Modernatx, Inc. | Circular polynucleotides |
| EP4219532A3 (en) * | 2015-06-05 | 2023-08-16 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for transient gene therapy with enhanced stability |
| AU2018251187B2 (en) * | 2017-04-14 | 2024-03-28 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for transient gene therapy with enhanced stability |
| US20200131498A1 (en) * | 2017-06-14 | 2020-04-30 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-coa mutase |
| CN111819185A (zh) | 2017-12-15 | 2020-10-23 | 旗舰创业创新第六有限责任公司 | 包含环状多核糖核苷酸的组合物及其用途 |
| CN112399860B (zh) * | 2018-06-06 | 2024-08-16 | 麻省理工学院 | 用于在真核细胞中翻译的环状rna |
| BR112021023411A2 (pt) * | 2019-05-22 | 2022-02-01 | Massachusetts Inst Technology | Composições e métodos de rna circular |
-
2020
- 2020-06-19 KR KR1020227001638A patent/KR20220024647A/ko active Pending
- 2020-06-19 US US17/619,638 patent/US20220296729A1/en active Pending
- 2020-06-19 MA MA056538A patent/MA56538A/fr unknown
- 2020-06-19 CN CN202080044871.7A patent/CN114096674A/zh active Pending
- 2020-06-19 WO PCT/US2020/038835 patent/WO2020257727A1/en not_active Ceased
- 2020-06-19 CA CA3140594A patent/CA3140594A1/en active Pending
- 2020-06-19 JP JP2021575283A patent/JP2022536951A/ja not_active Withdrawn
- 2020-06-19 EP EP20747268.9A patent/EP3987038A1/en active Pending
- 2020-06-19 AU AU2020296190A patent/AU2020296190A1/en active Pending
-
2021
- 2021-12-14 IL IL288983A patent/IL288983A/en unknown
-
2022
- 2022-10-31 US US17/978,030 patent/US20230061936A1/en not_active Abandoned
-
2025
- 2025-12-22 JP JP2025272525A patent/JP2026040556A/ja active Pending
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