JP2022534809A5 - - Google Patents
Info
- Publication number
- JP2022534809A5 JP2022534809A5 JP2021572556A JP2021572556A JP2022534809A5 JP 2022534809 A5 JP2022534809 A5 JP 2022534809A5 JP 2021572556 A JP2021572556 A JP 2021572556A JP 2021572556 A JP2021572556 A JP 2021572556A JP 2022534809 A5 JP2022534809 A5 JP 2022534809A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- improved
- grna
- protein
- casx
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025147107A JP2025183286A (ja) | 2019-06-07 | 2025-09-04 | 操作されたｃａｓｘシステム |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962858750P | 2019-06-07 | 2019-06-07 | |
| US62/858,750 | 2019-06-07 | ||
| US201962944892P | 2019-12-06 | 2019-12-06 | |
| US62/944,892 | 2019-12-06 | ||
| US202063030838P | 2020-05-27 | 2020-05-27 | |
| US63/030,838 | 2020-05-27 | ||
| PCT/US2020/036505 WO2020247882A1 (en) | 2019-06-07 | 2020-06-05 | Engineered casx systems |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025147107A Division JP2025183286A (ja) | 2019-06-07 | 2025-09-04 | 操作されたｃａｓｘシステム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022534809A JP2022534809A (ja) | 2022-08-03 |
| JP2022534809A5 true JP2022534809A5 (enExample) | 2023-06-12 |
| JP7744011B2 JP7744011B2 (ja) | 2025-09-25 |
Family
ID=71899867
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021572556A Active JP7744011B2 (ja) | 2019-06-07 | 2020-06-05 | 操作されたｃａｓｘシステム |
| JP2025147107A Pending JP2025183286A (ja) | 2019-06-07 | 2025-09-04 | 操作されたｃａｓｘシステム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025147107A Pending JP2025183286A (ja) | 2019-06-07 | 2025-09-04 | 操作されたｃａｓｘシステム |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US11560555B2 (enExample) |
| EP (1) | EP3980533A1 (enExample) |
| JP (2) | JP7744011B2 (enExample) |
| KR (1) | KR20220032050A (enExample) |
| CN (1) | CN114375334B (enExample) |
| AU (1) | AU2020289591B2 (enExample) |
| BR (1) | BR112021024288A2 (enExample) |
| CA (1) | CA3142883A1 (enExample) |
| CL (1) | CL2021003233A1 (enExample) |
| GB (1) | GB2600274B (enExample) |
| IL (1) | IL288738A (enExample) |
| MX (1) | MX2021015058A (enExample) |
| PE (1) | PE20220256A1 (enExample) |
| PH (1) | PH12021553076A1 (enExample) |
| SG (1) | SG11202113253SA (enExample) |
| TW (1) | TW202113074A (enExample) |
| WO (1) | WO2020247882A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3841205A4 (en) * | 2018-08-22 | 2022-08-17 | The Regents of The University of California | VARIANT TYPE V CRISPR/CAS EFFECTOR POLYPEPTIDES AND METHODS OF USE THEREOF |
| SG11202113253SA (en) | 2019-06-07 | 2021-12-30 | Scribe Therapeutics Inc | Engineered casx systems |
| US12551560B2 (en) | 2019-09-09 | 2026-02-17 | Scribe Therapeutics Inc. | Compositions and methods for use in immunotherapy |
| EP4028522A1 (en) | 2019-09-09 | 2022-07-20 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of sod1 |
| WO2021113763A1 (en) | 2019-12-06 | 2021-06-10 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of rhodopsin |
| JP2023510352A (ja) * | 2020-01-10 | 2023-03-13 | スクライブ・セラピューティクス・インコーポレイテッド | Ｐｃｓｋ９の標的化のための組成物および方法 |
| MX2022011460A (es) | 2020-03-18 | 2022-12-15 | Scribe Therapeutics Inc | Composiciones y métodos para el direccionamiento de c9orf72. |
| GB202010075D0 (en) * | 2020-07-01 | 2020-08-12 | Imp College Innovations Ltd | Therapeutic nucleic acids, peptides and uses |
| WO2022119957A1 (en) | 2020-12-02 | 2022-06-09 | The Regents Of The University Of California | Crispr-cas effector polypeptides and methods of use thereof |
| AU2021392719B2 (en) | 2020-12-03 | 2025-08-14 | Scribe Therapeutics Inc. | Engineered class 2 type v crispr systems |
| US20240100185A1 (en) | 2020-12-03 | 2024-03-28 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of ptbp1 |
| KR20230129395A (ko) | 2020-12-09 | 2023-09-08 | 스크라이브 테라퓨틱스 인크. | 유전자 편집을 위한 aav 벡터 |
| AU2022234760A1 (en) | 2021-03-09 | 2023-09-14 | Arbor Biotechnologies, Inc. | Compositions comprising a variant polypeptide and uses thereof |
| AU2022284804A1 (en) | 2021-06-01 | 2023-12-07 | Arbor Biotechnologies, Inc. | Gene editing systems comprising a crispr nuclease and uses thereof |
| WO2022261150A2 (en) | 2021-06-09 | 2022-12-15 | Scribe Therapeutics Inc. | Particle delivery systems |
| IL311610A (en) * | 2021-09-21 | 2024-05-01 | Scribe Therapeutics Inc | Engineered CASX suppressor systems |
| EP4405490A2 (en) | 2021-09-23 | 2024-07-31 | Scribe Therapeutics Inc. | Self-inactivating vectors for gene editing |
| CN116497002A (zh) * | 2022-01-19 | 2023-07-28 | 中国科学院动物研究所 | 工程化的CasX核酸酶、效应蛋白及其用途 |
| CA3257824A1 (en) | 2022-06-02 | 2023-12-07 | Scribe Therapeutics Inc. | MODIFIED TYPE V, CLASS 2 CRISPR SYSTEMS |
| WO2023235888A2 (en) | 2022-06-03 | 2023-12-07 | Scribe Therapeutics Inc. | COMPOSITIONS AND METHODS FOR CpG DEPLETION |
| EP4536819A1 (en) | 2022-06-07 | 2025-04-16 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of pcsk9 |
| WO2023240027A1 (en) | 2022-06-07 | 2023-12-14 | Scribe Therapeutics Inc. | Particle delivery systems |
| CN119998446A (zh) * | 2022-06-07 | 2025-05-13 | 斯克里贝治疗公司 | 用于靶向pcsk9的组合物和方法 |
| EP4536286A1 (en) | 2022-06-08 | 2025-04-16 | Scribe Therapeutics Inc. | Aav vectors for gene editing |
| WO2023240157A2 (en) | 2022-06-08 | 2023-12-14 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of dmd |
| US20260139236A1 (en) * | 2022-10-11 | 2026-05-21 | The Broad Institute, Inc. | Reprogramable tnpb polypeptides and use thereof |
| US20260232844A1 (en) | 2023-02-15 | 2026-08-13 | Arbor Biotechnologies, Inc. | Gene editing method for inhibiting aberrant splicing in stathmin 2 (stmn2) transcript |
| WO2024192291A1 (en) | 2023-03-15 | 2024-09-19 | Renagade Therapeutics Management Inc. | Delivery of gene editing systems and methods of use thereof |
| WO2024206620A1 (en) | 2023-03-29 | 2024-10-03 | Scribe Therapeutics Inc. | Messenger rna encoding casx |
| WO2024206676A1 (en) | 2023-03-29 | 2024-10-03 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of lpa |
| WO2024206555A1 (en) * | 2023-03-29 | 2024-10-03 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of pcsk9 |
| TW202444914A (zh) | 2023-03-29 | 2024-11-16 | 美商斯奎柏治療公司 | 抑制子融合蛋白系統 |
| CN116926043B (zh) * | 2023-04-28 | 2024-09-06 | 新乡医学院第三附属医院 | 一种dCasX蛋白核酸酶、重组载体及其应用 |
| WO2024228975A2 (en) * | 2023-05-02 | 2024-11-07 | Inari Agriculture Technology, Inc. | Ribozyme sequences for processing rna |
| JP2026523341A (ja) | 2023-05-15 | 2026-07-14 | エヌクロマ・バイオ，インコーポレーテッド | Ｈｂｖ遺伝子発現のエピジェネティック調節のための組成物および方法 |
| EP4729547A1 (en) * | 2023-06-16 | 2026-04-22 | VCGT Inc. | Zinc finger protein, zinc finger nuclease, vector, and genome editing method using said substances |
| EP4771154A2 (en) | 2023-09-01 | 2026-07-08 | Renagade Therapeutics Management Inc. | Gene editing systems, compositions, and methods for treatment of vexas syndrome |
| WO2025072293A1 (en) | 2023-09-27 | 2025-04-03 | Scribe Therapeutics Inc. | Optimized mrnas encoding casx proteins |
| CN117296799B (zh) * | 2023-11-28 | 2024-02-02 | 四川省医学科学院·四川省人民医院 | 一种视网膜色素变性疾病模型的构建方法及其应用 |
| WO2025171210A1 (en) | 2024-02-09 | 2025-08-14 | Arbor Biotechnologies, Inc. | Compositions and methods for gene editing via homology-mediated end joining |
| WO2025174765A1 (en) | 2024-02-12 | 2025-08-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2025240940A1 (en) | 2024-05-17 | 2025-11-20 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of apolipoprotein c3 |
| WO2026015832A2 (en) | 2024-07-12 | 2026-01-15 | Arbor Biotechnologies, Inc. | Reverse transcriptases and gene editing systems comprising such |
| WO2026015829A2 (en) | 2024-07-12 | 2026-01-15 | Arbor Biotechnologies, Inc. | Small reverse transcriptases and gene editing systems comprising such |
| CN120424908B (zh) * | 2025-07-10 | 2025-09-12 | 南京农业大学 | 一种基于LAMP与CRISPR/Cas的检测方法和应用 |
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| JP2023510352A (ja) | 2020-01-10 | 2023-03-13 | スクライブ・セラピューティクス・インコーポレイテッド | Ｐｃｓｋ９の標的化のための組成物および方法 |
| MX2022011460A (es) | 2020-03-18 | 2022-12-15 | Scribe Therapeutics Inc | Composiciones y métodos para el direccionamiento de c9orf72. |
| AU2021392719B2 (en) | 2020-12-03 | 2025-08-14 | Scribe Therapeutics Inc. | Engineered class 2 type v crispr systems |
| WO2022261150A2 (en) | 2021-06-09 | 2022-12-15 | Scribe Therapeutics Inc. | Particle delivery systems |
| IL311610A (en) | 2021-09-21 | 2024-05-01 | Scribe Therapeutics Inc | Engineered CASX suppressor systems |
| EP4405490A2 (en) | 2021-09-23 | 2024-07-31 | Scribe Therapeutics Inc. | Self-inactivating vectors for gene editing |
| CA3257824A1 (en) | 2022-06-02 | 2023-12-07 | Scribe Therapeutics Inc. | MODIFIED TYPE V, CLASS 2 CRISPR SYSTEMS |
-
2020
- 2020-06-05 SG SG11202113253SA patent/SG11202113253SA/en unknown
- 2020-06-05 CN CN202080056141.9A patent/CN114375334B/zh active Active
- 2020-06-05 PE PE2021002050A patent/PE20220256A1/es unknown
- 2020-06-05 JP JP2021572556A patent/JP7744011B2/ja active Active
- 2020-06-05 AU AU2020289591A patent/AU2020289591B2/en active Active
- 2020-06-05 CA CA3142883A patent/CA3142883A1/en active Pending
- 2020-06-05 PH PH1/2021/553076A patent/PH12021553076A1/en unknown
- 2020-06-05 EP EP20750444.0A patent/EP3980533A1/en active Pending
- 2020-06-05 BR BR112021024288A patent/BR112021024288A2/pt unknown
- 2020-06-05 TW TW109119111A patent/TW202113074A/zh unknown
- 2020-06-05 KR KR1020227000734A patent/KR20220032050A/ko active Pending
- 2020-06-05 MX MX2021015058A patent/MX2021015058A/es unknown
- 2020-06-05 WO PCT/US2020/036505 patent/WO2020247882A1/en not_active Ceased
- 2020-06-05 GB GB2200132.5A patent/GB2600274B/en active Active
-
2021
- 2021-11-23 US US17/533,997 patent/US11560555B2/en active Active
- 2021-12-03 US US17/542,219 patent/US20220220508A1/en not_active Abandoned
- 2021-12-06 CL CL2021003233A patent/CL2021003233A1/es unknown
- 2021-12-06 IL IL288738A patent/IL288738A/en unknown
-
2022
- 2022-11-22 US US18/058,251 patent/US12084692B2/en active Active
-
2024
- 2024-07-19 US US18/778,393 patent/US20250043262A1/en active Pending
- 2024-10-08 US US18/909,093 patent/US20250136962A1/en active Pending
-
2025
- 2025-09-04 JP JP2025147107A patent/JP2025183286A/ja active Pending
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